Internalized antibodies to the Aβ domain of APP reduce neuronal Aβ and protect against synaptic alterations

Journal of Biological Chemistry

Volumn 282, Issue 26, 2007, Pages 18895-18906

  Tampellini, Davide ^a   Magrané, Jordi ^a   Takahashi, Reisuke H ^a   Li, Feng ^a   Lin, Michael T ^a   Almeida, Cláudia G ^a   Gouras, Gunnar K ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN MODELS; CELL MEMBRANES; DISEASES; NEURONS; RATS;

ALZHEIMER DISEASE (AD); COGNITIVE FUNCTIONS; SYNAPTIC ALTERATIONS; TRANSGENIC MOUSE MODELS;

ANTIBODIES;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID PRECURSOR PROTEIN; MONOCLONAL ANTIBODY; SECRETASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; MOUSE; NERVE CELL; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SYNAPSE; ANIMAL; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY COMPLEX; CHEMISTRY; ENDOCYTOSIS; IMMUNIZATION; IMMUNOLOGY; METABOLISM; METHODOLOGY; NEUROBLASTOMA; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; TEMPERATURE; TRANSGENIC MOUSE; TUMOR CELL LINE;

MUS MUSCULUS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY COMPLEX; CELL LINE, TUMOR; ENDOCYTOSIS; IMMUNIZATION; MICE; MICE, TRANSGENIC; NEUROBLASTOMA; NEURONS; PROTEIN STRUCTURE, TERTIARY; SYNAPSES; TEMPERATURE;

EID: 34547110577     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M700373200     Document Type: Article

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