Dissociated phenotypes in presenilin transgenic mice define functionally distinct γ-secretases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 25, 2005, Pages 8972-8977

  Mastrangelo, Peter ^a   Mathews, Paul M ^b   Chishti, M Azhar ^a   Schmidt, Stephen D ^b   Gu, Yongjun ^a   Yang, Jing ^a   Mazzella, Matthew J ^b   Coomaraswamy, Janaky ^a   Horne, Patrick ^a   Strome, Bob ^a   Pelly, Heather ^a   Levesque, Georges ^c   Ebeling, Chris ^d   Jiang, Ying ^b   Nixon, Ralph A ^b   Rozmahel, Richard ^e   Fraser, Paul E ^a   St George Hyslop, Peter ^a,f   Carlson, George A ^d   Westaway, David ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITÉ LAVAL   (Canada)

^d McLaughin Research Institute   (United States)

^e UNIVERSITY OF WESTERN ONTARIO   (Canada)

^f UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Alzheimer's disease; Endoproteolysis; Notch; PS1; PS2

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; MEMBRANE PROTEIN; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2;

ALLELE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EMBRYO CELL; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE EXPRESSION; GENE MUTATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN SYNTHESIS; TRANSGENE; TRANSGENIC MOUSE; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BONE AND BONES; ENDOPEPTIDASES; HOMOZYGOTE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; PEPTIDE FRAGMENTS; PHENOTYPE; PRESENILIN-1; PRESENILIN-2;

ANIMALIA; MUS MUSCULUS;

EID: 21144447065     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0500940102     Document Type: Article

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