Pen-2 Is Sequestered in the Endoplasmic Reticulum and Subjected to Ubiquitylation and Proteasome-mediated Degradation in the Absence of Presenilin

Journal of Biological Chemistry

Volumn 279, Issue 16, 2004, Pages 16744-16753

  Bergman, Anna ^a   Hansson, Emil M ^a   Pursglove, Sharon E ^a   Farmery, Mark R ^a   Lannfelt, Lars ^b   Lendahl, Urban ^a   Lundkvist, Johan ^a   Näslund, Jan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; COMPLEXATION; COMPOSITION; DEGRADATION; PROTEINS;

ENDOPLASMIC RETICULUM; SUBCELLULAR LOCALIZATION; TRANSMEMBRANE PROTEINS;

BIOCHEMISTRY;

GAMMA SECRETASE; PRESENILIN 1; PROTEASOME; PROTEIN; PROTEIN PEN 2; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CHO CELL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; UBIQUITINATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; HUMANS; MEMBRANE PROTEINS; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN TRANSPORT; UBIQUITINS;

ANIMALIA;

EID: 1642336602     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313999200     Document Type: Article

References (32)

1. Brown, M. S., Ye, J., Rawson, R. B., and Goldstein, J. L. (2000) Cell 100, 391-398
2. Haass, C., and De Strooper, B. (1999) Science 286, 916-919
3. Saxena, M. T., Schroeter, E. H., Mumm, J. S., and Kopan, R. (2001) J. Biol. Chem. 276, 40268-40273
4. Mizutani, T., Taniguchi, Y., Aoki, T., Hashimoto, N., and Honjo, T. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 9026-9031
5. Okamoto, I., Kawano, Y., Murakami, D., Sasayama, T., Araki, N., Miki, T., Wong, A. J., and Saya, H. (2001) J. Cell Biol. 155, 755-762
6. Lammich, S., Okochi, M., Takeda, M., Kaether, C., Capell, A., Zimmer, A.-K., Edbauer, D., Walter, J., Steiner, H., and Haass, C. (2002) J. Biol. Chem. 277, 44754-44759
7. Lee, H.-J., Jung, K.-M., Huang, Y. Z., Bennet, L. B., Lee, J. S., Mei, L., and Kim, T.-W. (2002) J. Biol. Chem. 277, 6318-6323
8. Ni, C.-Y., Murphy, M. P., Golde, T. E., and Carpenter, G. (2001) Science 294, 2179-2181
9. Marambaud, P., Shioi, J., Serban, G., Georgakopolous, A., Sarner, S., Nagy, V., Baki, L., Wen, P., Efthiomopoulos, S., Shao, Z., Wisniewski, T., and Robakis, N. K. (2002) EMBO J. 21, 1948-1956
10. Herreman, A., Serneels, L., Annaert, W., Collen, D., Schoonjans, L., and De Strooper, B. (2000) Nat. Cell Biol. 2, 461-462
11. Yu, G., Nishimura, M., Arawaka, S., Levitan, D., Zhang, L., Tandon, A., Song, Y.-Q., Rogaeva, E., Chen, F., Kawarai, T., Supala, A., Levesque, L., Yu, H., Yang, D.-S., Holmes, E., Milman, P., Liang, Y., Zhang, D. M., Xu, D. H., Sato, C., Rogaev, E., Smith, M., Janus, C., Zhang, Y., Aebersold, R., Farrer, L., Sorbi, S., Bruni, A., Fraser, P., and St George-Hyslop, P. (2000) Nature 407, 48-54
12. Francis, R., McGrath, G., Zhang, J., Ruddy, D. A., Sym, M., Apfeld, J., Nicoll, M., Maxwell, M., Hai, B., Ellis, M. C., Parks, A. L., Xu, W., Li, J., Gurney, M., Myers, R. L., Himes, C. S., Hiebsch, R., Ruble, C., Nye, J. S., and Curtis, D. (2002) Dev. Cell 3, 85-97
13. Edbauer, D., Winkler, E., Regula, J. T., Pesold, B., Steiner, H., and Haass, C. (2003) Nat. Cell Biol. 5, 486-488
14. Goutte, C., Tsunozaki, M., Hale, V., and Priess, J. R. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 775-779
15. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., and Selkoe, D. J. (1999) Nature 398, 513-517
16. Steiner, H., Kostka, M., Romig, H., Basset, G., Pesold, B., Hardy, J., Capell, A., Meyn, L., Grim, M. L., Baumeister, R., Fechteler, K., and Haass, C. (2000) Nat. Cell Biol. 2, 848-851
17. Edbauer, D., Winkler, E., Haass, C., and Steiner, H. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 8666-8671
18. Leem, J.-Y., Vijayan, S., Han, P., Cai, D., Machura, M., Lopes, K. O., Veselits, M. L., Xu, H., and Thinakaran, G. (2002) J. Biol. Chem. 277, 19236-19240
19. Hu, Y., Ye, Y., and Fortini, M. E. (2002) Dev. Cell 2, 69-78
20. Lee, S. F., Shah, S., Li, H., Yu, C., Han, W., and Yu, G. (2002) J. Biol. Chem. 277, 45013-45019
21. Steiner, H., Winkler, E., Edbauer, D., Prokop, S., Basset, G., Yamasaki, A., Kostka, M., and Haass, C. (2002) J. Biol. Chem. 277, 39062-39065
22. Luo, W.-J., Wang, H., Li, H., Kim, B. S., Shah, S., Lee, H.-J., Thinakaran, G., Kim, T.-W., Yu, G., and Xu, H. (2003) J. Biol. Chem. 278, 7850-7854
23. Crystal, A. S., Morais, V. A., Pierson, T. C., Pijak, D. S., Carlin, D., Lee, V. M., and Doms, R. W. (2003) J. Biol. Chem. 278, 20117-20123
24. Donoviel, D. B., Hadjantonakis, A.-K., Ikeda, M., Zheng, H., St George-Hyslop, P., and Bernstein, A. (1999) Genes Dev. 13, 2801-2810
25. Caporaso, G. L., Gandy, S. E., Buxbaum, J. D., Ramabhadran, T. V., and Greengard P. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 3055-3059
26. Mathews, P. M., Jiang, Y., Schmidt, S. D., Grbovic, O. M., Mercken, M., and Nixon, R. A. (2002) J. Biol. Chem. 277, 36415-36424
27. Öberg, C., Li, J., Pauley, A., Wolf, E., Gurney, M., and Lendahl, U. (2001) J. Biol. Chem. 276, 35847-35853
28. Nilsson, I., Sääf, A., Whitley, P., Gafvelin, G., Waller, C., and von Heijne, G. (1998) J. Mol. Biol. 284, 1165-1175
29. Pickart, C. M. (2001) Annu. Rev. Biochem. 70, 503-533
30. Adams, J. (2003) Cancer Treat Rev. 29, Suppl. 1, 3-9
31. Li, J., Pauley, A. M., Myers, R. L., Shuang, R., Brashler, J. R., Yan, R., Buhl, A. E., Ruble, C., and Gurney, M. E. (2002) J. Neurochem. 82, 1540-1548
32. Hampton, R. Y. (2002) Curr. Opin. Cell Biol. 14, 476-482