The mechanism of γ-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals

Journal of Biological Chemistry

Volumn 277, Issue 51, 2002, Pages 50198-50205

  Takasugi, Nobumasa ^a   Takahashi, Yasuko ^a   Morohashi, Yuichi ^a   Tomita, Taisuke ^a   Iwatsubo, Takeshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; DISEASES; GENES; GENETIC ENGINEERING; MOLECULAR WEIGHT; PATHOLOGY;

SECRETASE ACTIVITIES;

BIOCHEMISTRY;

PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE MUTATION; MAMMAL; MOUSE; NONHUMAN; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CAENORHABDITIS ELEGANS; CELL LINE; DNA, COMPLEMENTARY; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENDOPEPTIDASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MEMBRANE PROTEINS; MICE; MUTATION; PEPTIDES; PHENOTYPE; PLASMIDS; POINT MUTATION; PRESENILIN-1; PRESENILIN-2; PROTEIN BINDING; RECEPTORS, NOTCH; RNA INTERFERENCE; TUMOR CELLS, CULTURED;

ANIMALIA; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER;

EID: 0037147220     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205352200     Document Type: Article

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