Endoplasmic reticulum retention of the γ-secretase complex component Pen2 by Rer1

EMBO Reports

Volumn 8, Issue 8, 2007, Pages 743-748

  Kaether, Christoph ^a,b   Scheuermann, Johanna ^a   Fassler, Matthias ^b   Zilow, Sonja ^a   Shirotani, Keiro ^a   Valkova, Christina ^b   Novak, Bozidar ^a   Kacmar, Slavomir ^b   Steiner, Harald ^a   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b FRITZ LIPMANN INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; CELL PROTEIN; CLUSTER OF DIFFERENTIATION 4; GAMMA SECRETASE; MEMBRANE PROTEIN; PS ENHANCER 2; RETENTION IN ENDOPLASMIC RETICULUM 1; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MAMMAL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARAGINE; CELL LINE; ENDOPLASMIC RETICULUM; HUMANS; IMMUNOPRECIPITATION; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; PROTEIN STRUCTURE, TERTIARY;

MAMMALIA;

EID: 34547628712     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7401027     Document Type: Article

References (20)

1. Bergman A, Hansson EM, Pursglove SE, Farmery MR, Lannfelt L, Lendahl U, Lundkvist J, Naslund J (2004) Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin. J Biol Chem 279: 16744-16753
2. Boehm J, Ulrich HD, Ossig R, Schmitt HD (1994) Kex2-dependent invertase secretion as a tool to study the targeting of transmembrane proteins which are involved in ER → Golgi transport in yeast. EMBO J 13 3696-3710
3. Bonifacino JS, Cosson P, Shah N, Klausner RD (1991) Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulum. EMBO J 10: 2783-2793
4. Capell A, Beher D, Prokop S, Steiner H, Kaether C, Shearman MS, Haass C (2005) γ-Secretase complex assembly within the early secretory pathway. J Biol Chem 280: 6471-6478
5. Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ (1992) Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature 360: 672-674
6. Crystal AS, Morais VA, Fortna RR, Carlin D, Pierson TC, Wilson CA, Lee VM, Doms RW (2004) Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation. Biochemistry 43 3555-3563
7. Füllekrug J, Boehm J, Rottger S, Nilsson T, Mieskes G, Schmitt HD (1997) Human Rer1 is localized to the Golgi apparatus and complements the deletion of the homologous Rer1 protein of Saccharomyces cerevisiae. Eur J Cell Biol 74: 31-40
8. Haass C (2004) Take five-BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation. EMBO J 23: 483-488
9. Hennecke S, Cosson P (1993) Role of transmembrane domains in assembly and intracellular transport of the CD8 molecule. J Biol Chem 268: 26607-26612
10. Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C (2002) Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane. J Cell Biol 158: 551-561
11. Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haas C 2004) The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity. EMBO J 23: 4738-4748
12. Kaether C, Haass C, Steiner H (2006) Assembly, trafficking and function of γ-secretase. Neurodegener Dis 3: 275-283
13. Kim SH, Yin YI, Li YM, Sisodia SS (2004) Evidence that assembly of an active γ-secretase complex occurs in the early compartments of the secretory pathway. J Biol Chem 279: 48615-48619
14. Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ (2003) γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci USA 100: 6382-6387
15. Prokop S, Shirotani K, Edbauer D, Haass C, Steiner H (2004) Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the γ-secretase complex. J Biol Chem 279 23255-23261
16. Reth M, Hombach J, Wienands J, Campbell KS, Chien N, Justement LB, Cambier JC (1991) The B-cell antigen receptor complex. Immunol Today 12: 196-201
17. Sato K, Sato M, Nakano A,(2003) Rer 1 p, a retrieval receptor for ER membrane protins, recognizes transmembrane domains in multiple modes. Mol Biol Cell 14: 3605-3616
18. Spasic D, Raemaekers T, Dillèn K, Declerck I, Baert V, Serneels L, Fullekrug J, Annaert W (2007) Rer 1p competes with APH-1 for binding to nicastrin and regulates γ-secretase complex assembly in the early secretory pathway. J Cell Biol 176: 629-640
19. Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T (2003) The role of presenilin cofactors in the γ-secretase complex. Nature 422: 438-441
20. Zerangue N, Schwappach B, Jan YN, Jan LY (1999) A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels. Neuron 22: 537-548