-
1
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002;297:353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
2
-
-
1442264828
-
Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
-
Haass C: Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation. EMBO J 2004;23:483-488.
-
(2004)
EMBO J
, vol.23
, pp. 483-488
-
-
Haass, C.1
-
3
-
-
24144441879
-
Uncovering gamma-secretase
-
Steiner H: Uncovering gamma-secretase. Curr Alzheimer Res 2004;1:175-181.
-
(2004)
Curr Alzheimer Res
, vol.1
, pp. 175-181
-
-
Steiner, H.1
-
4
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, et al: Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995;375:754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
-
5
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T, et al: Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 1995;376:775-778.
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
Chi, H.7
Lin, C.8
Holman, K.9
Tsuda, T.10
-
6
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu CE, Jondro PD, Schmidt SD, Wang K, et al: Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995;269:973-977.
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
Pettingell, W.H.6
Yu, C.E.7
Jondro, P.D.8
Schmidt, S.D.9
Wang, K.10
-
7
-
-
0029150716
-
A familial Alzheimer's disease locus on chromosome 1
-
Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KA, Weber JL, Bird TD, Schellenberg GD: A familial Alzheimer's disease locus on chromosome 1. Science 1995;269:970-973.
-
(1995)
Science
, vol.269
, pp. 970-973
-
-
Levy-Lahad, E.1
Wijsman, E.M.2
Nemens, E.3
Anderson, L.4
Goddard, K.A.5
Weber, J.L.6
Bird, T.D.7
Schellenberg, G.D.8
-
8
-
-
27444441308
-
A nine-transmembrane domain topology for presenilin 1
-
Laudon H, Hansson EM, Melen K, Bergman A, Farmery MR, Winblad B, Lendahl U, von Heijne G, Naslund J: A nine-transmembrane domain topology for presenilin 1. J Biol Chem 2005;280:35352-35360.
-
(2005)
J Biol Chem
, vol.280
, pp. 35352-35360
-
-
Laudon, H.1
Hansson, E.M.2
Melen, K.3
Bergman, A.4
Farmery, M.R.5
Winblad, B.6
Lendahl, U.7
Von Heijne, G.8
Naslund, J.9
-
9
-
-
23944511109
-
Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space
-
Oh YS, Turner RJ: Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space. Am J Physiol Cell Physiol 2005;289:C576-581.
-
(2005)
Am J Physiol Cell Physiol
, vol.289
-
-
Oh, Y.S.1
Turner, R.J.2
-
10
-
-
20444481683
-
A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence
-
Henricson A, Kall L, Sonnhammer EL: A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence. FEBS J 2005;272:2727-2733.
-
(2005)
FEBS J
, vol.272
, pp. 2727-2733
-
-
Henricson, A.1
Kall, L.2
Sonnhammer, E.L.3
-
11
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins NA, Copeland NG, Price DL, Sisodia SS: Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 1996;17:181-190.
-
(1996)
Neuron
, vol.17
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
Kim, G.6
Ratovitsky, T.7
Davenport, F.8
Nordstedt, C.9
Seeger, M.10
Hardy, J.11
Levey, A.I.12
Gandy, S.E.13
Jenkins, N.A.14
Copeland, N.G.15
Price, D.L.16
Sisodia, S.S.17
-
12
-
-
0029116848
-
Facilitation of lin12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
-
Levitan D, Greenwald I: Facilitation of lin12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 1995;377:351-354.
-
(1995)
Nature
, vol.377
, pp. 351-354
-
-
Levitan, D.1
Greenwald, I.2
-
13
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S: Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 1996;2:864-870.
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.20
Younkin, S.21
more..
-
14
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F: Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 1998;391:387-390.
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
15
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
-
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ: Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 1999;398:513-517.
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
16
-
-
0033551099
-
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease
-
Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski B, Rahmati T, Donkor IO, Selkoe DJ: Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry 1999;38:4720-4727.
-
(1999)
Biochemistry
, vol.38
, pp. 4720-4727
-
-
Wolfe, M.S.1
Xia, W.2
Moore, C.L.3
Leatherwood, D.D.4
Ostaszewski, B.5
Rahmati, T.6
Donkor, I.O.7
Selkoe, D.J.8
-
17
-
-
0033214070
-
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling
-
Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haass C: A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. J Biol Chem 1999;274:28669-28673.
-
(1999)
J Biol Chem
, vol.274
, pp. 28669-28673
-
-
Steiner, H.1
Duff, K.2
Capell, A.3
Romig, H.4
Grim, M.G.5
Lincoln, S.6
Hardy, J.7
Yu, X.8
Picciano, M.9
Fechteler, K.10
Citron, M.11
Kopan, R.12
Pesold, B.13
Keck, S.14
Baader, M.15
Tomita, T.16
Iwatsubo, T.17
Baumeister, R.18
Haass, C.19
-
18
-
-
0033550061
-
Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta- peptide production and requires a critical aspartate residue for its function in amyloidogenesis
-
Leimer U, Lun K, Romig H, Walter J, Grunberg J, Brand M, Haass C: Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta- peptide production and requires a critical aspartate residue for its function in amyloidogenesis. Biochemistry 1999;38:13602-13609.
-
(1999)
Biochemistry
, vol.38
, pp. 13602-13609
-
-
Leimer, U.1
Lun, K.2
Romig, H.3
Walter, J.4
Grunberg, J.5
Brand, M.6
Haass, C.7
-
19
-
-
0034621824
-
Photoactivated g-secretase inhibitors directed to the active site covalently label presenilin 1
-
Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelli JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ: Photoactivated g-secretase inhibitors directed to the active site covalently label presenilin 1. Nature 2000;405:689-694.
-
(2000)
Nature
, vol.405
, pp. 689-694
-
-
Li, Y.M.1
Xu, M.2
Lai, M.T.3
Huang, Q.4
Castro, J.L.5
DiMuzio-Mower, J.6
Harrison, T.7
Lellis, C.8
Nadin, A.9
Neduvelli, J.G.10
Register, R.B.11
Sardana, M.K.12
Shearman, M.S.13
Smith, A.L.14
Shi, X.P.15
Yin, K.C.16
Shafer, J.A.17
Gardell, S.J.18
-
20
-
-
0033780472
-
Transition-state analogue inhibitors of g-secretase bind directly to presenilin-1
-
Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS: Transition-state analogue inhibitors of g-secretase bind directly to presenilin-1. Nature Cell Biol 2000;2:428-433.
-
(2000)
Nature Cell Biol
, vol.2
, pp. 428-433
-
-
Esler, W.P.1
Kimberly, W.T.2
Ostaszewski, B.L.3
Diehl, T.S.4
Moore, C.L.5
Tsai, J.Y.6
Rahmati, T.7
Xia, W.8
Selkoe, D.J.9
Wolfe, M.S.10
-
21
-
-
0033778262
-
Glycine 384 is required for presenilin-1 function and is conserved in polytopic bacterial aspartyl proteases
-
Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim MG, Baumeister R, Fechteler K, Haass C: Glycine 384 is required for presenilin-1 function and is conserved in polytopic bacterial aspartyl proteases. Nature Cell Biol 2000;2:848-851.
-
(2000)
Nature Cell Biol
, vol.2
, pp. 848-851
-
-
Steiner, H.1
Kostka, M.2
Romig, H.3
Basset, G.4
Pesold, B.5
Hardy, J.6
Capell, A.7
Meyn, L.8
Grim, M.G.9
Baumeister, R.10
Fechteler, K.11
Haass, C.12
-
22
-
-
0033978638
-
The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases
-
LaPointe CF, Taylor RK: The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases. J Biol Chem 2000;275:1502-1510.
-
(2000)
J Biol Chem
, vol.275
, pp. 1502-1510
-
-
Lapointe, C.F.1
Taylor, R.K.2
-
23
-
-
0037150672
-
Identification of signal peptide peptidase, a presenilin-type aspartic protease
-
Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B: Identification of signal peptide peptidase, a presenilin-type aspartic protease. Science 2002;296:2215-2218.
-
(2002)
Science
, vol.296
, pp. 2215-2218
-
-
Weihofen, A.1
Binns, K.2
Lemberg, M.K.3
Ashman, K.4
Martoglio, B.5
-
24
-
-
28244456207
-
Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3
-
Krawitz P, Haffner C, Fluhrer R, Steiner H, Schmid B, Haass C: Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. J Biol Chem 2005;280:39515-39523.
-
(2005)
J Biol Chem
, vol.280
, pp. 39515-39523
-
-
Krawitz, P.1
Haffner, C.2
Fluhrer, R.3
Steiner, H.4
Schmid, B.5
Haass, C.6
-
25
-
-
0036898485
-
Alzheimer disease gamma-secretase: A complex story of GxGD-type presenilin proteases
-
Haass C, Steiner H: Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases. Trends Cell Biol 2002;12:556-562.
-
(2002)
Trends Cell Biol
, vol.12
, pp. 556-562
-
-
Haass, C.1
Steiner, H.2
-
26
-
-
12644290265
-
Evidence for phosphorylation and oligomeric assembly of presenilin 1
-
Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S: Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc Natl Acad Sci USA 1997;94:5090-5094.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 5090-5094
-
-
Seeger, M.1
Nordstedt, C.2
Petanceska, S.3
Kovacs, D.M.4
Gouras, G.K.5
Hahne, S.6
Fraser, P.7
Levesque, L.8
Czernik, A.J.9
George-Hyslop, P.S.10
Sisodia, S.S.11
Thinakaran, G.12
Tanzi, R.E.13
Greengard, P.14
Gandy, S.15
-
27
-
-
0032488995
-
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
-
Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C: The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J Biol Chem 1998;273:3205-3211.
-
(1998)
J Biol Chem
, vol.273
, pp. 3205-3211
-
-
Capell, A.1
Grunberg, J.2
Pesold, B.3
Diehlmann, A.4
Citron, M.5
Nixon, R.6
Beyreuther, K.7
Selkoe, D.J.8
Haass, C.9
-
28
-
-
0032568821
-
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains b-catenin
-
Yu G, Chen F, Levesque G, Nishimura M, Zhang DM, Levesque L, Rogaeva E, Xu D, Liang Y, Duthie M, St George-Hyslop PH, Fraser PE: The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains b-catenin. J Biol Chem 1998;273:16470-16475.
-
(1998)
J Biol Chem
, vol.273
, pp. 16470-16475
-
-
Yu, G.1
Chen, F.2
Levesque, G.3
Nishimura, M.4
Zhang, D.M.5
Levesque, L.6
Rogaeva, E.7
Xu, D.8
Liang, Y.9
Duthie, M.10
St George-Hyslop, P.H.11
Fraser, P.E.12
-
29
-
-
0343819757
-
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
-
Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, Shi XP, Yin KC, Shafer JA, Gardell SJ: Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc Natl Acad Sci USA 2000;97:6138-6143.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 6138-6143
-
-
Li, Y.M.1
Lai, M.T.2
Xu, M.3
Huang, Q.4
DiMuzio-Mower, J.5
Sardana, M.K.6
Shi, X.P.7
Yin, K.C.8
Shafer, J.A.9
Gardell, S.J.10
-
30
-
-
0030667426
-
Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors
-
Thinakaran G, Harris CL, Ratovitski T, Davenport F, Slunt HH, Price DL, Borchelt DR, Sisodia SS: Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors. J Biol Chem 1997;272:28415-28422.
-
(1997)
J Biol Chem
, vol.272
, pp. 28415-28422
-
-
Thinakaran, G.1
Harris, C.L.2
Ratovitski, T.3
Davenport, F.4
Slunt, H.H.5
Price, D.L.6
Borchelt, D.R.7
Sisodia, S.S.8
-
31
-
-
0033610863
-
Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation
-
Steiner H, Capell A, Pesold B, Citron M, Kloetzel PM, Selkoe DJ, Romig H, Mendla K, Haass C: Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. J Biol Chem 1998;273:32322-32331.
-
(1998)
J Biol Chem
, vol.273
, pp. 32322-32331
-
-
Steiner, H.1
Capell, A.2
Pesold, B.3
Citron, M.4
Kloetzel, P.M.5
Selkoe, D.J.6
Romig, H.7
Mendla, K.8
Haass, C.9
-
32
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and beta-APP processing
-
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P: Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and beta-APP processing. Nature 2000;407:48-54.
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
Tandon, A.6
Song, Y.Q.7
Rogaeva, E.8
Chen, F.9
Kawarai, T.10
Supala, A.11
Levesque, L.12
Yu, H.13
Yang, D.S.14
Holmes, E.15
Milman, P.16
Liang, Y.17
Zhang, D.M.18
Xu, D.H.19
Sato, C.20
Rogaev, E.21
Smith, M.22
Janus, C.23
Zhang, Y.24
Aebersold, R.25
Farrer, L.S.26
Sorbi, S.27
Bruni, A.28
Fraser, P.29
St George-Hyslop, P.30
more..
-
33
-
-
18444417998
-
Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D: Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 2002;3:85-97.
-
(2002)
Dev Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
Ruddy, D.A.4
Sym, M.5
Apfeld, J.6
Nicoll, M.7
Maxwell, M.8
Hai, B.9
Ellis, M.C.10
Parks, A.L.11
Xu, W.12
Li, J.13
Gurney, M.14
Myers, R.L.15
Himes, C.S.16
Hiebsch, R.17
Ruble, C.18
Nye, J.S.19
Curtis, D.20
more..
-
34
-
-
0037154158
-
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
-
Goutte C, Tsunozaki M, Hale VA, Priess JR: APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc Natl Acad Sci USA 2002;99:775-779.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 775-779
-
-
Goutte, C.1
Tsunozaki, M.2
Hale, V.A.3
Priess, J.R.4
-
35
-
-
0037131218
-
PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin
-
Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C: PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. J Biol Chem 2002;277:39062-39065.
-
(2002)
J Biol Chem
, vol.277
, pp. 39062-39065
-
-
Steiner, H.1
Winkler, E.2
Edbauer, D.3
Prokop, S.4
Basset, G.5
Yamasaki, A.6
Kostka, M.7
Haass, C.8
-
36
-
-
0037160063
-
Mammalian APH-1 interacts with presenilin and nicastrin and is required for intra-membrane proteolysis of amyloid-beta precursor protein and Notch
-
Lee SF, Shah S, Li H, Yu C, Han W, Yu G: Mammalian APH-1 interacts with presenilin and nicastrin and is required for intra-membrane proteolysis of amyloid-beta precursor protein and Notch. J Biol Chem 2002;277:45013-45019.
-
(2002)
J Biol Chem
, vol.277
, pp. 45013-45019
-
-
Lee, S.F.1
Shah, S.2
Li, H.3
Yu, C.4
Han, W.5
Yu, G.6
-
37
-
-
0038664363
-
Reconstitution of gamma-secretase activity
-
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C: Reconstitution of gamma-secretase activity. Nat Cell Biol 2003;5:486-488.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 486-488
-
-
Edbauer, D.1
Winkler, E.2
Regula, J.T.3
Pesold, B.4
Steiner, H.5
Haass, C.6
-
38
-
-
0141483380
-
Regulated hyperaccumulation of presenilin-1 and the 'gamma-secretase' complex. Evidence for differential intramembranous processing of transmembrane subatrates
-
Kim SH, Ikeuchi T, Yu C, Sisodia SS: Regulated hyperaccumulation of presenilin-1 and the 'gamma-secretase' complex. Evidence for differential intramembranous processing of transmembrane subatrates. J Biol Chem 2003;278:33992-34002.
-
(2003)
J Biol Chem
, vol.278
, pp. 33992-34002
-
-
Kim, S.H.1
Ikeuchi, T.2
Yu, C.3
Sisodia, S.S.4
-
39
-
-
0038652102
-
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2
-
Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ: Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci USA 2003;100:6382-6387.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 6382-6387
-
-
Kimberly, W.T.1
LaVoie, M.J.2
Ostaszewski, B.L.3
Ye, W.4
Wolfe, M.S.5
Selkoe, D.J.6
-
40
-
-
0037468759
-
The role of presenilin cofactors in the gamma-secretase complex
-
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T: The role of presenilin cofactors in the gamma-secretase complex. Nature 2003;422:438-441.
-
(2003)
Nature
, vol.422
, pp. 438-441
-
-
Takasugi, N.1
Tomita, T.2
Hayashi, I.3
Tsuruoka, M.4
Niimura, M.5
Takahashi, Y.6
Thinakaran, G.7
Iwatsubo, T.8
-
41
-
-
3042520872
-
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: Identification of nicastrin mutants that selectively interact with APH-1
-
Shirotani K, Edbauer D, Kostka M, Steiner H, Haass C: Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1. J Neurochem 2004;89:1520-1527.
-
(2004)
J Neurochem
, vol.89
, pp. 1520-1527
-
-
Shirotani, K.1
Edbauer, D.2
Kostka, M.3
Steiner, H.4
Haass, C.5
-
42
-
-
5144224126
-
Coordinated and widespread expression of gamma-secretase in vivo: Evidence for size and molecular heterogeneity
-
Hebert SS, Serneels L, Dejaegere T, Horre K, Dabrowski M, Baert V, Annaert W, Hartmann D, De Strooper B: Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiol Dis 2004;17:260-272.
-
(2004)
Neurobiol Dis
, vol.17
, pp. 260-272
-
-
Hebert, S.S.1
Serneels, L.2
Dejaegere, T.3
Horre, K.4
Dabrowski, M.5
Baert, V.6
Annaert, W.7
Hartmann, D.8
De Strooper, B.9
-
43
-
-
13344282063
-
Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
-
Kovacs DM, Fausett HJ, Page KJ, Kim TW, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE, Wasco W: Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med 1996;2:224-229.
-
(1996)
Nat Med
, vol.2
, pp. 224-229
-
-
Kovacs, D.M.1
Fausett, H.J.2
Page, K.J.3
Kim, T.W.4
Moir, R.D.5
Merriam, D.E.6
Hollister, R.D.7
Hallmark, O.G.8
Mancini, R.9
Felsenstein, K.M.10
Hyman, B.T.11
Tanzi, R.E.12
Wasco, W.13
-
44
-
-
1842532328
-
The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective
-
Pasternak SH, Callahan JW, Mahuran DJ: The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective. J Alzheimers Dis 2004;6:53-65.
-
(2004)
J Alzheimers Dis
, vol.6
, pp. 53-65
-
-
Pasternak, S.H.1
Callahan, J.W.2
Mahuran, D.J.3
-
45
-
-
0033214675
-
Presenilins: Molecular switches between proteolysis and signal transduction
-
Annaert W, De Strooper B: Presenilins: molecular switches between proteolysis and signal transduction. Trends Neurosci 1999;22:439-443.
-
(1999)
Trends Neurosci
, vol.22
, pp. 439-443
-
-
Annaert, W.1
De Strooper, B.2
-
46
-
-
0036327098
-
Presenilin-1 affects trafficking and processing of beta APP and is targeted in a complex with nicastrin to the plasma membrane
-
Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C: Presenilin-1 affects trafficking and processing of beta APP and is targeted in a complex with nicastrin to the plasma membrane. J Cell Biol 2002;158:551-561.
-
(2002)
J Cell Biol
, vol.158
, pp. 551-561
-
-
Kaether, C.1
Lammich, S.2
Edbauer, D.3
Ertl, M.4
Rietdorf, J.5
Capell, A.6
Steiner, H.7
Haass, C.8
-
47
-
-
14244268498
-
Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage
-
Chyung JH, Raper DM, Selkoe DJ: Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage. J Biol Chem 2005;280:4383-4392.
-
(2005)
J Biol Chem
, vol.280
, pp. 4383-4392
-
-
Chyung, J.H.1
Raper, D.M.2
Selkoe, D.J.3
-
48
-
-
0037698096
-
Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane
-
Pasternak SH, Bagshaw RD, Guiral M, Zhang S, Ackerley CA, Pak BJ, Callahan JW, Mahuran DJ: Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane. J Biol Chem 2003;278:26687-26694.
-
(2003)
J Biol Chem
, vol.278
, pp. 26687-26694
-
-
Pasternak, S.H.1
Bagshaw, R.D.2
Guiral, M.3
Zhang, S.4
Ackerley, C.A.5
Pak, B.J.6
Callahan, J.W.7
Mahuran, D.J.8
-
49
-
-
33644862462
-
APP and Notch intracellular domains are generated after transport of their precursors to the cell surface
-
in press
-
Kaether C, Schmitt S, Willem M, Haass C: APP and Notch intracellular domains are generated after transport of their precursors to the cell surface. Traffic 2006, in press.
-
(2006)
Traffic
-
-
Kaether, C.1
Schmitt, S.2
Willem, M.3
Haass, C.4
-
50
-
-
0037173115
-
Presenilin and nicastrin regulate each other and determine amyloid beta -peptide production via complex formation
-
Edbauer D, Winkler E, Haass C, Steiner H: Presenilin and nicastrin regulate each other and determine amyloid beta -peptide production via complex formation. Proc Natl Acad Sci USA 2002;99:8666-8671.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 8666-8671
-
-
Edbauer, D.1
Winkler, E.2
Haass, C.3
Steiner, H.4
-
51
-
-
2542454942
-
Requirement of PEN-2 for stabilization of the presenilin NTF/CTF heterodimer within the gamma-secretase complex
-
Prokop S, Shirotani K, Edbauer D, Haass C, Steiner H: Requirement of PEN-2 for stabilization of the presenilin NTF/CTF heterodimer within the gamma-secretase complex. J Biol Chem 2004;279:23255-23261.
-
(2004)
J Biol Chem
, vol.279
, pp. 23255-23261
-
-
Prokop, S.1
Shirotani, K.2
Edbauer, D.3
Haass, C.4
Steiner, H.5
-
52
-
-
0038607071
-
Gamma-secretase activity is associated with a conformational change of nicastrin
-
Shirotani K, Edbauer D, Capell A, Schmitz J, Steiner H, Haass C: Gamma-secretase activity is associated with a conformational change of nicastrin. J Biol Chem 2003;278:16474-16477.
-
(2003)
J Biol Chem
, vol.278
, pp. 16474-16477
-
-
Shirotani, K.1
Edbauer, D.2
Capell, A.3
Schmitz, J.4
Steiner, H.5
Haass, C.6
-
53
-
-
0037424275
-
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1
-
Luo WJ, Wang H, Li H, Kim BS, Shah S, Lee HJ, Thinakaran G, Kim TW, Yu G, Xu H: PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J Biol Chem 2003;278:7850-7854.
-
(2003)
J Biol Chem
, vol.278
, pp. 7850-7854
-
-
Luo, W.J.1
Wang, H.2
Li, H.3
Kim, B.S.4
Shah, S.5
Lee, H.J.6
Thinakaran, G.7
Kim, T.W.8
Yu, G.9
Xu, H.10
-
54
-
-
0037166349
-
Presenilin 1 is required for maturation and cell surface accumulation of nicastrin
-
Leem JY, Vijayan S, Han P, Cai D, Machura M, Lopes KO, Veselits ML, Xu H, Thinakaran G: Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. J Biol Chem 2002;277:19236-19240.
-
(2002)
J Biol Chem
, vol.277
, pp. 19236-19240
-
-
Leem, J.Y.1
Vijayan, S.2
Han, P.3
Cai, D.4
Machura, M.5
Lopes, K.O.6
Veselits, M.L.7
Xu, H.8
Thinakaran, G.9
-
55
-
-
4444221162
-
Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1
-
Edbauer D, Kaether C, Steiner H, Haass C: Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1. J Biol Chem 2004;279:37311-37315.
-
(2004)
J Biol Chem
, vol.279
, pp. 37311-37315
-
-
Edbauer, D.1
Kaether, C.2
Steiner, H.3
Haass, C.4
-
56
-
-
10744223903
-
A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex
-
Lee SF, Shah S, Yu C, Wigley WC, Li H, Lim M, Pedersen K, Han W, Thomas P, Lundkvist J, Hao YH, Yu G: A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex. J Biol Chem 2004;279:4144-4152.
-
(2004)
J Biol Chem
, vol.279
, pp. 4144-4152
-
-
Lee, S.F.1
Shah, S.2
Yu, C.3
Wigley, W.C.4
Li, H.5
Lim, M.6
Pedersen, K.7
Han, W.8
Thomas, P.9
Lundkvist, J.10
Hao, Y.H.11
Yu, G.12
-
57
-
-
21344463310
-
Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments
-
Prokop S, Haass C, Steiner H: Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments. J Neurochem 2005;94:57-62.
-
(2005)
J Neurochem
, vol.94
, pp. 57-62
-
-
Prokop, S.1
Haass, C.2
Steiner, H.3
-
58
-
-
8744291081
-
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes
-
Hasegawa H, Sanjo N, Chen F, Gu YJ, Shier C, Petit A, Kawarai T, Katayama T, Schmidt SD, Mathews PM, Schmitt-Ulms G, Fraser PE, St George-Hyslop P: Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes. J Biol Chem 2004;279:46455-46463.
-
(2004)
J Biol Chem
, vol.279
, pp. 46455-46463
-
-
Hasegawa, H.1
Sanjo, N.2
Chen, F.3
Gu, Y.J.4
Shier, C.5
Petit, A.6
Kawarai, T.7
Katayama, T.8
Schmidt, S.D.9
Mathews, P.M.10
Schmitt-Ulms, G.11
Fraser, P.E.12
St George-Hyslop, P.13
-
59
-
-
10344243551
-
Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway
-
Kim SH, Yin YI, Li YM, Sisodia SS: Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway. J Biol Chem 2004;279:48615-48619.
-
(2004)
J Biol Chem
, vol.279
, pp. 48615-48619
-
-
Kim, S.H.1
Yin, Y.I.2
Li, Y.M.3
Sisodia, S.S.4
-
60
-
-
0346732290
-
Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain
-
Capell A, Kaether C, Edbauer D, Shirotani K, Merkl S, Steiner H, Haass C: Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain. J Biol Chem 2003;278:52519-52523.
-
(2003)
J Biol Chem
, vol.278
, pp. 52519-52523
-
-
Capell, A.1
Kaether, C.2
Edbauer, D.3
Shirotani, K.4
Merkl, S.5
Steiner, H.6
Haass, C.7
-
61
-
-
0242321985
-
The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex
-
Morais VA, Crystal AS, Pijak DS, Carlin D, Costa J, Lee VM, Doms RW: The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex. J Biol Chem 2003;278:43284-43291.
-
(2003)
J Biol Chem
, vol.278
, pp. 43284-43291
-
-
Morais, V.A.1
Crystal, A.S.2
Pijak, D.S.3
Carlin, D.4
Costa, J.5
Lee, V.M.6
Doms, R.W.7
-
62
-
-
11244272819
-
The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity
-
Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haass C: The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity. EMBO J 2004;23:4738-4748.
-
(2004)
EMBO J
, vol.23
, pp. 4738-4748
-
-
Kaether, C.1
Capell, A.2
Edbauer, D.3
Winkler, E.4
Novak, B.5
Steiner, H.6
Haass, C.7
-
63
-
-
8544219758
-
The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity
-
Bergman A, Laudon H, Winblad B, Lundkvist J, Naslund J: The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity. J Biol Chem 2004;279:45564-45572.
-
(2004)
J Biol Chem
, vol.279
, pp. 45564-45572
-
-
Bergman, A.1
Laudon, H.2
Winblad, B.3
Lundkvist, J.4
Naslund, J.5
-
64
-
-
29644435433
-
Evidence that the 'NF' motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2
-
Kim SH, Sisodia SS: Evidence that the 'NF' motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2. J Biol Chem 2005;280:41953-41966.
-
(2005)
J Biol Chem
, vol.280
, pp. 41953-41966
-
-
Kim, S.H.1
Sisodia, S.S.2
-
65
-
-
29644432040
-
Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1
-
Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T: Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1. J Biol Chem 2005;280:41967-41975.
-
(2005)
J Biol Chem
, vol.280
, pp. 41967-41975
-
-
Watanabe, N.1
Tomita, T.2
Sato, C.3
Kitamura, T.4
Morohashi, Y.5
Iwatsubo, T.6
-
66
-
-
14844286856
-
Gamma-secretase complex assembly within the early secretory pathway
-
Capell A, Beher D, Prokop S, Steiner H, Kaether C, Shearman MS, Haass C: Gamma-secretase complex assembly within the early secretory pathway. J Biol Chem 2005;280:6471-6478.
-
(2005)
J Biol Chem
, vol.280
, pp. 6471-6478
-
-
Capell, A.1
Beher, D.2
Prokop, S.3
Steiner, H.4
Kaether, C.5
Shearman, M.S.6
Haass, C.7
-
67
-
-
0141856357
-
Rer1p, a retrieval receptor for ER membrane proteins, recognizes transmembrane domains in multiple modes
-
Sato K, Sato M, Nakano A: Rer1p, a retrieval receptor for ER membrane proteins, recognizes transmembrane domains in multiple modes. Mol Biol Cell 2003;14:3605-3616.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 3605-3616
-
-
Sato, K.1
Sato, M.2
Nakano, A.3
-
68
-
-
1842410168
-
Human Rer1 is localized to the Golgi apparatus and complements the deletion of the homologous Rer1 protein of Saccharomyces cerevisiae
-
Füllekrug J, Boehm J, Rottger S, Nilsson T, Mieskes G, Schmitt HD: Human Rer1 is localized to the Golgi apparatus and complements the deletion of the homologous Rer1 protein of Saccharomyces cerevisiae. Eur J Cell Biol 1997;74:31-40.
-
(1997)
Eur J Cell Biol
, vol.74
, pp. 31-40
-
-
Füllekrug, J.1
Boehm, J.2
Rottger, S.3
Nilsson, T.4
Mieskes, G.5
Schmitt, H.D.6
-
69
-
-
18844378852
-
Presenilin function and gamma-secretase activity
-
Brunkan AL, Goate AM: Presenilin function and gamma-secretase activity. J Neurochem 2005;93:769-792.
-
(2005)
J Neurochem
, vol.93
, pp. 769-792
-
-
Brunkan, A.L.1
Goate, A.M.2
-
70
-
-
0031108103
-
Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing
-
Baumeister R, Leimer U, Zweckbronner I, Jakubek C, Grunberg J, Haass C: Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing. Genes Funct 1997;1:149-159.
-
(1997)
Genes Funct
, vol.1
, pp. 149-159
-
-
Baumeister, R.1
Leimer, U.2
Zweckbronner, I.3
Jakubek, C.4
Grunberg, J.5
Haass, C.6
-
71
-
-
0033583047
-
The biological and pathological function of the presenilin-1delta exon 9 mutation is independent of its defect to undergo proteolytic processing
-
Steiner H, Romig H, Grim MG, Philipp U, Pesold B, Citron M, Baumeister R, Haass C: The biological and pathological function of the presenilin-1delta exon 9 mutation is independent of its defect to undergo proteolytic processing. J Biol Chem 1999;274:7615-7618.
-
(1999)
J Biol Chem
, vol.274
, pp. 7615-7618
-
-
Steiner, H.1
Romig, H.2
Grim, M.G.3
Philipp, U.4
Pesold, B.5
Citron, M.6
Baumeister, R.7
Haass, C.8
-
72
-
-
0033783140
-
Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch
-
Capell A, Steiner H, Romig H, Keck S, Baader M, Grim MG, Baumeister R, Haass C: Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch. Nature Cell Biol 2000;2:205-211.
-
(2000)
Nature Cell Biol
, vol.2
, pp. 205-211
-
-
Capell, A.1
Steiner, H.2
Romig, H.3
Keck, S.4
Baader, M.5
Grim, M.G.6
Baumeister, R.7
Haass, C.8
-
73
-
-
18644367748
-
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1
-
Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C: Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. EMBO J 2002;21:5408-5416.
-
(2002)
EMBO J
, vol.21
, pp. 5408-5416
-
-
Okochi, M.1
Steiner, H.2
Fukumori, A.3
Tanii, H.4
Tomita, T.5
Tanaka, T.6
Iwatsubo, T.7
Kudo, T.8
Takeda, M.9
Haass, C.10
-
74
-
-
0347785491
-
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta - Like peptide
-
Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C: Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta - like peptide. J Biol Chem 2002;277:44754-44759.
-
(2002)
J Biol Chem
, vol.277
, pp. 44754-44759
-
-
Lammich, S.1
Okochi, M.2
Takeda, M.3
Kaether, C.4
Capell, A.5
Zimmer, A.K.6
Edbauer, D.7
Walter, J.8
Steiner, H.9
Haass, C.10
-
75
-
-
22844434140
-
Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase
-
Lleo A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O: Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. J Biol Chem 2005;280:27303-27309.
-
(2005)
J Biol Chem
, vol.280
, pp. 27303-27309
-
-
Lleo, A.1
Waldron, E.2
Von Arnim, C.A.3
Herl, L.4
Tangredi, M.M.5
Peltan, I.D.6
Strickland, D.K.7
Koo, E.H.8
Hyman, B.T.9
Pietrzik, C.U.10
Berezovska, O.11
-
76
-
-
0033639117
-
Requirements for presenilin-dependent cleavage of Notch and other transmembrane proteins
-
Struhl G, Adachi A: Requirements for presenilin-dependent cleavage of Notch and other transmembrane proteins. Mol Cell 2000;6:625-636.
-
(2000)
Mol Cell
, vol.6
, pp. 625-636
-
-
Struhl, G.1
Adachi, A.2
-
77
-
-
23744491374
-
Nicastrin functions as a gamma-secretase-substrate receptor
-
Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, Ball H, Dann CE, 3rd, Sudhof T, Yu G: Nicastrin functions as a gamma-secretase-substrate receptor. Cell 2005;122:435-447.
-
(2005)
Cell
, vol.122
, pp. 435-447
-
-
Shah, S.1
Lee, S.F.2
Tabuchi, K.3
Hao, Y.H.4
Yu, C.5
Laplant, Q.6
Ball, H.7
Dann III, C.E.8
Sudhof, T.9
Yu, G.10
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