-
1
-
-
14844340471
-
-
Reference deleted
-
Reference deleted.
-
-
-
-
2
-
-
0034820160
-
Autophagy in yeast: Mechanistic insights and physiological function
-
Abeliovich, H., and D. J. Klionsky. 2001. Autophagy in yeast: mechanistic insights and physiological function. Microbiol. Mol. Biol. Rev. 65:463-479.
-
(2001)
Microbiol. Mol. Biol. Rev.
, vol.65
, pp. 463-479
-
-
Abeliovich, H.1
Klionsky, D.J.2
-
3
-
-
0042322315
-
mTOR as a positive regulator of tumor cell responses to hypoxia
-
Abraham, R. T. 2004. mTOR as a positive regulator of tumor cell responses to hypoxia. Curr. Top. Microbiol. Immunol. 279:299-319.
-
(2004)
Curr. Top. Microbiol. Immunol.
, vol.279
, pp. 299-319
-
-
Abraham, R.T.1
-
5
-
-
0035196663
-
The target of rapamycin signaling pathway regulates mRNA turnover in the yeast Saccharomyces cerevisiae
-
Albig, A. R., and C. J. Decker. 2001. The target of rapamycin signaling pathway regulates mRNA turnover in the yeast Saccharomyces cerevisiae. Mol. Biol. Cell 12:3428-3438.
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 3428-3438
-
-
Albig, A.R.1
Decker, C.J.2
-
6
-
-
0030982194
-
Translation initiation factor-dependent extracts from yeast Saccharomyces cerevisiae
-
Altmann, M., and H. Trachsel. 1997. Translation initiation factor-dependent extracts from yeast Saccharomyces cerevisiae. Methods 11:343-352.
-
(1997)
Methods
, vol.11
, pp. 343-352
-
-
Altmann, M.1
Trachsel, H.2
-
7
-
-
0042031047
-
A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
-
Arsham, A. M., J. J. Howell, and M. C. Simon. 2003. A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J. Biol. Chem. 278:29655-29660.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 29655-29660
-
-
Arsham, A.M.1
Howell, J.J.2
Simon, M.C.3
-
8
-
-
0347065349
-
Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B
-
Astrinidis, A., W. Senapedis, T. R. Coleman, and E. P. Henske. 2003. Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B. J. Biol. Chem. 278:51372-51379.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 51372-51379
-
-
Astrinidis, A.1
Senapedis, W.2
Coleman, T.R.3
Henske, E.P.4
-
9
-
-
0031888424
-
Germ-line mutational analysis of the TSC2 gene in 90 tuberous-sclerosis patients
-
Au, K. S., J. A. Rodriguez, J. L. Finch, K. A. Volcik, E. S. Roach, M. R. Delgado, E. Rodriguez, Jr., and H. Northrup. 1998. Germ-line mutational analysis of the TSC2 gene in 90 tuberous-sclerosis patients. Am. J. Hum. Genet. 62:286-294.
-
(1998)
Am. J. Hum. Genet.
, vol.62
, pp. 286-294
-
-
Au, K.S.1
Rodriguez, J.A.2
Finch, J.L.3
Volcik, K.A.4
Roach, E.S.5
Delgado, M.R.6
Rodriguez Jr., E.7
Northrup, H.8
-
10
-
-
0035225023
-
The p70 S6 kinase integrates nutrient and growth signals to control translational capacity
-
Avruch, J., C. Belham, Q. Weng, K. Hara, and K. Yonezawa. 2001. The p70 S6 kinase integrates nutrient and growth signals to control translational capacity. Prog. Mol. Subcell. Biol. 26:115-154.
-
(2001)
Prog. Mol. Subcell. Biol.
, vol.26
, pp. 115-154
-
-
Avruch, J.1
Belham, C.2
Weng, Q.3
Hara, K.4
Yonezawa, K.5
-
11
-
-
0029981389
-
Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and rapamycin-sensitive pathways
-
Azpiazu, I., A. R. Saltiel, A. A. DePaoli-Roach, and J. C. Lawrence. 1996. Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and rapamycin-sensitive pathways. J. Biol. Chem. 271:5033-5039.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 5033-5039
-
-
Azpiazu, I.1
Saltiel, A.R.2
DePaoli-Roach, A.A.3
Lawrence, J.C.4
-
12
-
-
0038614742
-
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
-
Baas, A. F., J. Boudeau, G. P. Sapkota, L. Smit, R. Medema, N. A. Morrice, D. R. Alessi, and H. C. Clevers. 2003. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J. 22:3062-3072.
-
(2003)
EMBO J.
, vol.22
, pp. 3062-3072
-
-
Baas, A.F.1
Boudeau, J.2
Sapkota, G.P.3
Smit, L.4
Medema, R.5
Morrice, N.A.6
Alessi, D.R.7
Clevers, H.C.8
-
13
-
-
0030974986
-
Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3′ untranslated region
-
Banholzer, R., A. P. Nair, H. H. Hirsch, X. F. Ming, and C. Moroni. 1997. Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3′ untranslated region. Mol. Cell. Biol. 17:3254-3260.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 3254-3260
-
-
Banholzer, R.1
Nair, A.P.2
Hirsch, H.H.3
Ming, X.F.4
Moroni, C.5
-
14
-
-
0030021524
-
TOR controls translation initiation and early G1 progression in yeast
-
Barbet, N. C., U. Schneider, S. B. Helliwell, I. Stansfield, M. F. Tuite, and M. N. Hall. 1996. TOR controls translation initiation and early G1 progression in yeast. Mol. Biol. Cell 7:25-42.
-
(1996)
Mol. Biol. Cell
, vol.7
, pp. 25-42
-
-
Barbet, N.C.1
Schneider, U.2
Helliwell, S.B.3
Stansfield, I.4
Tuite, M.F.5
Hall, M.N.6
-
15
-
-
0033540030
-
The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
-
Beck, T., and M. N. Hall. 1999. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402:689-692.
-
(1999)
Nature
, vol.402
, pp. 689-692
-
-
Beck, T.1
Hall, M.N.2
-
16
-
-
0033588918
-
Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast
-
Beck, T., A. Schmidt, and M. N. Hall. 1999. Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast. J. Cell Biol. 146:1227-1238.
-
(1999)
J. Cell Biol.
, vol.146
, pp. 1227-1238
-
-
Beck, T.1
Schmidt, A.2
Hall, M.N.3
-
17
-
-
0029856725
-
cAMP counter-regulates insulin-mediated protein phosphatase-2A inactivation in rat skeletal muscle cells
-
Begum, N., and L. Ragolia. 1996. cAMP counter-regulates insulin-mediated protein phosphatase-2A inactivation in rat skeletal muscle cells. J. Biol. Chem. 271:31166-31171.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 31166-31171
-
-
Begum, N.1
Ragolia, L.2
-
18
-
-
17844369428
-
The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
-
Benvenuto, G., S. Li, S. J. Brown, R. Braverman, W. C. Vass, J. P. Cheadle, D. J. Halley, J. R. Sampson, R. Wienecke, and J. E. DeClue. 2000. The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 19:6306-6316.
-
(2000)
Oncogene
, vol.19
, pp. 6306-6316
-
-
Benvenuto, G.1
Li, S.2
Brown, S.J.3
Braverman, R.4
Vass, W.C.5
Cheadle, J.P.6
Halley, D.J.7
Sampson, J.R.8
Wienecke, R.9
DeClue, J.E.10
-
19
-
-
0030066934
-
Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation
-
Beretta, L., A. C. Gingras, Y. V. Svitkin, M. N. Hall, and N. Sonenberg. 1996. Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J. 15:658-664.
-
(1996)
EMBO J.
, vol.15
, pp. 658-664
-
-
Beretta, L.1
Gingras, A.C.2
Svitkin, Y.V.3
Hall, M.N.4
Sonenberg, N.5
-
20
-
-
0001598487
-
Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase
-
Berlanga, J. J., J. Santoyo, and C. De Haro. 1999. Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase. Eur. J. Biochem. 265:754-762.
-
(1999)
Eur. J. Biochem.
, vol.265
, pp. 754-762
-
-
Berlanga, J.J.1
Santoyo, J.2
De Haro, C.3
-
21
-
-
0032516080
-
The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae
-
Berset, C., H. Trachsel, and M. Altmann. 1998. The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 95:4264-4269.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 4264-4269
-
-
Berset, C.1
Trachsel, H.2
Altmann, M.3
-
22
-
-
0142071830
-
Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian. TOR-dependent phosphorylation of initiation factor 4E-binding protein 1
-
Beugnet, A., X. Wang, and C. G. Proud. 2003. Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian. TOR-dependent phosphorylation of initiation factor 4E-binding protein 1. J. Biol. Chem. 278:40717-40722.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 40717-40722
-
-
Beugnet, A.1
Wang, X.2
Proud, C.G.3
-
23
-
-
0028899789
-
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
-
Blommaart, E. F., J. J. Luiken, P. J. Blommaart, G. M. van Woerkom, and A. J. Meijer. 1995. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J. Biol. Chem. 270:2320-2326.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 2320-2326
-
-
Blommaart, E.F.1
Luiken, J.J.2
Blommaart, P.J.3
Van Woerkom, G.M.4
Meijer, A.J.5
-
24
-
-
0035736260
-
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
-
Bodine, S. C., T. N. Stitt, M. Gonzalez, W. O. Kline, G. L. Stover, R. Bauerlein, E. Zlotchenko, A. Serimgeour, J. C. Lawrence, D. J. Glass, and G. D. Yancopoulos. 2001. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat. Cell Biol. 3:1014-1019.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 1014-1019
-
-
Bodine, S.C.1
Stitt, T.N.2
Gonzalez, M.3
Kline, W.O.4
Stover, G.L.5
Bauerlein, R.6
Zlotchenko, E.7
Serimgeour, A.8
Lawrence, J.C.9
Glass, D.J.10
Yancopoulos, G.D.11
-
25
-
-
0037025356
-
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
-
Bolster, D. R., S. J. Crozier, S. R. Kimball, and L. S. Jefferson. 2002. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J. Biol. Chem. 277:23977-23980.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 23977-23980
-
-
Bolster, D.R.1
Crozier, S.J.2
Kimball, S.R.3
Jefferson, L.S.4
-
26
-
-
0141753981
-
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm
-
Boudeau, J., A. F. Baas, M. Deak, N. A. Morrice, A. Kieloch, M. Schutkowski, A. R. Prescott, H. C. Clevers, and D. R. Alessi. 2003. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J. 22:5102-5114.
-
(2003)
EMBO J.
, vol.22
, pp. 5102-5114
-
-
Boudeau, J.1
Baas, A.F.2
Deak, M.3
Morrice, N.A.4
Kieloch, A.5
Schutkowski, M.6
Prescott, A.R.7
Clevers, H.C.8
Alessi, D.R.9
-
27
-
-
0035499454
-
Ten years of protein kinase B signalling: A hard Akt to follow
-
Brazil, D. P., and B. A. Hemmings. 2001. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem. Sci. 26:657-664.
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 657-664
-
-
Brazil, D.P.1
Hemmings, B.A.2
-
28
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
Brown, E. J., M. W. Albers, T. B. Shin, K. Ichikawa, C. T. Keith, W. S. Lane, and S. L. Schreiber. 1994. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369:756-758.
-
(1994)
Nature
, vol.369
, pp. 756-758
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
Ichikawa, K.4
Keith, C.T.5
Lane, W.S.6
Schreiber, S.L.7
-
29
-
-
0029103330
-
Control of p70 s6 kinase by kinase activity of FRAP in vivo
-
Brown, E. J., P. A. Beal, C. T. Keith, J. Chen, T. B. Shin, and S. L. Schreiber. 1995. Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature 377:441-446.
-
(1995)
Nature
, vol.377
, pp. 441-446
-
-
Brown, E.J.1
Beal, P.A.2
Keith, C.T.3
Chen, J.4
Shin, T.B.5
Schreiber, S.L.6
-
30
-
-
1642328617
-
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398
-
Browne, G. J., S. G. Finn, and C. G. Proud. 2004. Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. J. Biol. Chem. 279:1220-1231.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 1220-1231
-
-
Browne, G.J.1
Finn, S.G.2
Proud, C.G.3
-
31
-
-
0041920901
-
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
-
Brugarolas, J. B., F. Vazquez, A. Reddy, W. R. Sellers, and W. G. Kaelin, Jr. 2003. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell 4:147-158.
-
(2003)
Cancer Cell
, vol.4
, pp. 147-158
-
-
Brugarolas, J.B.1
Vazquez, F.2
Reddy, A.3
Sellers, W.R.4
Kaelin Jr., W.G.5
-
32
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
-
Brunn, G. J., C. C. Hudson, A. Sekulic, J. M. Williams, H. Hosoi, P. J. Houghton, J. C. Lawrence, Jr., and R. T. Abraham. 1997. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 277:99-101.
-
(1997)
Science
, vol.277
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
Williams, J.M.4
Hosoi, H.5
Houghton, P.J.6
Lawrence Jr., J.C.7
Abraham, R.T.8
-
33
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
-
Burnett, P. E., R. K. Barrow, N. A. Cohen, S. H. Synder, and D. M. Sabatini. 1998. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. USA 95:1432-1437.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Synder, S.H.4
Sabatini, D.M.5
-
34
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley, L. C., and B. G. Neel. 1999. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. USA 96:4240-4245.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
35
-
-
0033573016
-
The TOR signaling cascade regulates gene expression in response to nutrients
-
Cardenas, M. E., N. S. Cutler, M. C. Lorenz, C. J. Di Como, and J. Heitman. 1999. The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev. 13:3271-3279.
-
(1999)
Genes Dev.
, vol.13
, pp. 3271-3279
-
-
Cardenas, M.E.1
Cutler, N.S.2
Lorenz, M.C.3
Di Como, C.J.4
Heitman, J.5
-
36
-
-
0347318052
-
The AMP-activated protein kinase cascade - A unifying system for energy control
-
Carling, D. 2004. The AMP-activated protein kinase cascade - a unifying system for energy control. Trends Biochem. Sci. 29:18-24.
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 18-24
-
-
Carling, D.1
-
37
-
-
0041356888
-
Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
-
Castro, A. F., J. F. Rebhun, G. J. Clark, and L. A. Quilliam. 2003. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J. Biol. Chem. 278:32493-32496.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 32493-32496
-
-
Castro, A.F.1
Rebhun, J.F.2
Clark, G.J.3
Quilliam, L.A.4
-
38
-
-
0029608743
-
Structural and functional analysis of pp70S6k
-
Cheatham, L., M. Monfar, M. M. Chou, and J. Blenis. 1995. Structural and functional analysis of pp70S6k. Proc. Natl. Acad. Sci. USA 92:11696-11700.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 11696-11700
-
-
Cheatham, L.1
Monfar, M.2
Chou, M.M.3
Blenis, J.4
-
39
-
-
0037732600
-
LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway
-
Chen, E. J., and C. A. Kaiser. 2003. LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J. Cell Biol. 161:333-347.
-
(2003)
J. Cell Biol.
, vol.161
, pp. 333-347
-
-
Chen, E.J.1
Kaiser, C.A.2
-
40
-
-
0036776168
-
A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling
-
Chen, J., and Y. Fang. 2002. A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling: Biochem. Pharmacol. 64:1071-1077.
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 1071-1077
-
-
Chen, J.1
Fang, Y.2
-
41
-
-
0033179296
-
GEFs: Structural basis for their activation of small GTP-binding proteins
-
Cherfils, J., and P. Chardin. 1999. GEFs: structural basis for their activation of small GTP-binding proteins. Trends Biochem. Sci. 24:306-311.
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 306-311
-
-
Cherfils, J.1
Chardin, P.2
-
42
-
-
0037382865
-
Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2
-
Cherkasova, V. A., and A. G. Hinnebusch. 2003. Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2. Genes Dev. 17:859-872.
-
(2003)
Genes Dev.
, vol.17
, pp. 859-872
-
-
Cherkasova, V.A.1
Hinnebusch, A.G.2
-
43
-
-
0028598672
-
RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
-
Chiu, M. I., H. Katz, and V. Berlin. 1994. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc. Natl. Acad. Sci. USA 91:12574-12578.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 12574-12578
-
-
Chiu, M.I.1
Katz, H.2
Berlin, V.3
-
44
-
-
0034644122
-
TOR signaling regulates microtubule structure and function
-
Choi, J. H., N. R. Adames, T. F. Chan, C. Zeng, J. A. Cooper, and X. F. Zheng. 2000. TOR signaling regulates microtubule structure and function. Curr. Biol. 10:861-864.
-
(2000)
Curr. Biol.
, vol.10
, pp. 861-864
-
-
Choi, J.H.1
Adames, N.R.2
Chan, T.F.3
Zeng, C.4
Cooper, J.A.5
Zheng, X.F.6
-
45
-
-
0036774805
-
The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase
-
Choi, J. H., P. G. Bertram, R. Drenan, J. Carvalho, H. H. Zhou, and X. F. Zheng. 2002. The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. EMBO Rep. 3:988-994.
-
(2002)
EMBO Rep.
, vol.3
, pp. 988-994
-
-
Choi, J.H.1
Bertram, P.G.2
Drenan, R.3
Carvalho, J.4
Zhou, H.H.5
Zheng, X.F.6
-
46
-
-
0038482156
-
Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor
-
Choi, K. M., L. P. McMahon, and J. C. Lawrence, Jr. 2003. Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor. J. Biol. Chem. 278:19667-19673.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 19667-19673
-
-
Choi, K.M.1
McMahon, L.P.2
Lawrence Jr., J.C.3
-
47
-
-
0037043329
-
Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: A survival mechanism for carcinoma cells
-
Chung, J., R. E. Bachelder, E. A. Lipscomb, L. M. Shaw, and A. M. Mercurio. 2002. Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. J. Cell Biol. 158:165-174.
-
(2002)
J. Cell Biol.
, vol.158
, pp. 165-174
-
-
Chung, J.1
Bachelder, R.E.2
Lipscomb, E.A.3
Shaw, L.M.4
Mercurio, A.M.5
-
48
-
-
0026659046
-
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
-
Chung, J., C. J. Kuo, G. R. Crabtree, and J. Blenis. 1992. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 69:1227-1236.
-
(1992)
Cell
, vol.69
, pp. 1227-1236
-
-
Chung, J.1
Kuo, C.J.2
Crabtree, G.R.3
Blenis, J.4
-
49
-
-
0030888163
-
The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation
-
Clark, G. J., M. S. Kinch, K. Rogers-Graham, S. M. Sebti, A. D. Hamilton, and C. J. Der. 1997. The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation. J. Biol. Chem. 272:10608-10615.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10608-10615
-
-
Clark, G.J.1
Kinch, M.S.2
Rogers-Graham, K.3
Sebti, S.M.4
Hamilton, A.D.5
Der, C.J.6
-
50
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
Corradetti, M. N., K. Inoki, N. Bardeesy, R. A. DePinho, and K. L. Guan. 2004. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 18:1533-1538.
-
(2004)
Genes Dev.
, vol.18
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
Depinho, R.A.4
Guan, K.L.5
-
51
-
-
0034044544
-
Eaplp, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae
-
Cosentino, G. P., T. Schmelzle, A. Haghighat, S. B. Helliwell, M. N. Hall, and N. Sonenberg. 2000. Eaplp, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae. Mol. Cell. Biol. 20:4604-4613.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 4604-4613
-
-
Cosentino, G.P.1
Schmelzle, T.2
Haghighat, A.3
Helliwell, S.B.4
Hall, M.N.5
Sonenberg, N.6
-
52
-
-
0036899644
-
Elucidating TOR signaling and rapamycin action: Lessons from Saccharomyces cerevisiae
-
Crespo, J. L., and M. N. Hall. 2002. Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 66:579-591.
-
(2002)
Microbiol. Mol. Biol. Rev.
, vol.66
, pp. 579-591
-
-
Crespo, J.L.1
Hall, M.N.2
-
53
-
-
0037076314
-
The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine
-
Crespo, J. L., T. Powers, B. Fowler, and M. N. Hall. 2002. The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc. Natl. Acad. Sci. USA 99:6784-6789.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 6784-6789
-
-
Crespo, J.L.1
Powers, T.2
Fowler, B.3
Hall, M.N.4
-
54
-
-
0033043180
-
Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans
-
Cruz, M. C., L. M. Cavallo, J. M. Gorlach, G. Cox, J. R. Perfect, M. E. Cardenas, and J. Heitman. 1999. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol. Cell. Biol. 19:4101-4112.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 4101-4112
-
-
Cruz, M.C.1
Cavallo, L.M.2
Gorlach, J.M.3
Cox, G.4
Perfect, J.R.5
Cardenas, M.E.6
Heitman, J.7
-
55
-
-
0035664839
-
The TOR signal transduction cascade controls cellular differentiation in response to nutrients
-
Cutler, N. S., X. Pan, J. Heitman, and M. E. Cardenas. 2001. The TOR signal transduction cascade controls cellular differentiation in response to nutrients. Mol. Biol. Cell 12:4103-4113.
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 4103-4113
-
-
Cutler, N.S.1
Pan, X.2
Heitman, J.3
Cardenas, M.E.4
-
56
-
-
0035167932
-
Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs
-
Dabora, S. L., S. Jozwiak, D. N. Franz, P. S. Roberts, A. Nieto, J. Chung, Y. S. Choy, M. P. Reeve, E. Thiele, J. C. Egelhoff, J. Kasprzyk-Obara, D. Domanska-Pakiela, and D. J. Kwiatkowski. 2001. Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am. J. Hum. Genet. 68:64-80.
-
(2001)
Am. J. Hum. Genet.
, vol.68
, pp. 64-80
-
-
Dabora, S.L.1
Jozwiak, S.2
Franz, D.N.3
Roberts, P.S.4
Nieto, A.5
Chung, J.6
Choy, Y.S.7
Reeve, M.P.8
Thiele, E.9
Egelhoff, J.C.10
Kasprzyk-Obara, J.11
Domanska-Pakiela, D.12
Kwiatkowski, D.J.13
-
57
-
-
18544375193
-
PI3K/AKT pathway regulates TSC tumor suppressor complex by phosphorylation of tuberin
-
Dan, H. C., M. Sun, L. Yang, R. I. Feldman, X. M. Sui, R. S. Yeung, D. J. Halley, S. V. Nicosia, W. J. Pledger, and J. Q. Cheng. 2002. PI3K/AKT pathway regulates TSC tumor suppressor complex by phosphorylation of tuberin. J. Biol. Chem. 277:35364-35370.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35364-35370
-
-
Dan, H.C.1
Sun, M.2
Yang, L.3
Feldman, R.I.4
Sui, X.M.5
Yeung, R.S.6
Halley, D.J.7
Nicosia, S.V.8
Pledger, W.J.9
Cheng, J.Q.10
-
58
-
-
0033563235
-
CLN3 expression is sufficient to restore G1-to-S-phase progression in Saccharomyces cerevisiae mutants defective in translation initiation factor eIF4E
-
Danaie, P., M. Altmann, M. N. Hall, H. Trachsel, and S. B. Helliwell. 1999. CLN3 expression is sufficient to restore G1-to-S-phase progression in Saccharomyces cerevisiae mutants defective in translation initiation factor eIF4E. Biochem. J. 340:135-141.
-
(1999)
Biochem. J.
, vol.340
, pp. 135-141
-
-
Danaie, P.1
Altmann, M.2
Hall, M.N.3
Trachsel, H.4
Helliwell, S.B.5
-
59
-
-
0037185021
-
Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome
-
Daniel, T., and D. Carling. 2002. Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome. J. Biol. Chem. 277:51017-51024.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 51017-51024
-
-
Daniel, T.1
Carling, D.2
-
60
-
-
2442669194
-
The GTPase-activating protein Rap1GAP uses a catalytic asparagine
-
Daumke, O., M. Weyand, P. P. Chakrabarti, I. R. Vetter, and A. Wittinghofer. 2004. The GTPase-activating protein Rap1GAP uses a catalytic asparagine. Nature 429:197-201.
-
(2004)
Nature
, vol.429
, pp. 197-201
-
-
Daumke, O.1
Weyand, M.2
Chakrabarti, P.P.3
Vetter, I.R.4
Wittinghofer, A.5
-
61
-
-
0035941266
-
The Npr1 kinase controls biosynthetic and endocytic sorting of the yeast Gap1 permease
-
De Craene, J. O., O. Soetens, and B. Andre. 2001. The Npr1 kinase controls biosynthetic and endocytic sorting of the yeast Gap1 permease. J. Biol. Chem. 276:43939-43948.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 43939-43948
-
-
De Craene, J.O.1
Soetens, O.2
Andre, B.3
-
62
-
-
0035798097
-
Mammalian TOR: A homeostatic ATP sensor
-
Dennis, P. B., A. Jaeschke, M. Saitoh, B. Fowler, S. C. Kozma, and G. Thomas. 2001. Mammalian TOR: a homeostatic ATP sensor. Science 294:1102-1105.
-
(2001)
Science
, vol.294
, pp. 1102-1105
-
-
Dennis, P.B.1
Jaeschke, A.2
Saitoh, M.3
Fowler, B.4
Kozma, S.C.5
Thomas, G.6
-
63
-
-
0023840093
-
Colonic hamartomas in tuberous sclerosis
-
Devroede, G., B. Lemieux, S. Masse, J. Lamarche, and P. S. Herman. 1988. Colonic hamartomas in tuberous sclerosis. Gastroenterology 94:182-188.
-
(1988)
Gastroenterology
, vol.94
, pp. 182-188
-
-
Devroede, G.1
Lemieux, B.2
Masse, S.3
Lamarche, J.4
Herman, P.S.5
-
64
-
-
0029808294
-
Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
-
Di Como, C. J., and K. T. Arndt. 1996. Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev. 10:1904-1916.
-
(1996)
Genes Dev.
, vol.10
, pp. 1904-1916
-
-
Di Como, C.J.1
Arndt, K.T.2
-
65
-
-
0037022532
-
Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae
-
Dilova, I., C. Y. Chen, and T. Powers. 2002. Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae. Curr. Biol. 12:389-395.
-
(2002)
Curr. Biol.
, vol.12
, pp. 389-395
-
-
Dilova, I.1
Chen, C.Y.2
Powers, T.3
-
66
-
-
5444233787
-
Tsc2 is not a critical target of Akt during normal Drosophila development
-
Dong, J., and D. Pan. 2004. Tsc2 is not a critical target of Akt during normal Drosophila development. Genes Dev. 18:2479-2484.
-
(2004)
Genes Dev.
, vol.18
, pp. 2479-2484
-
-
Dong, J.1
Pan, D.2
-
67
-
-
0346422440
-
FKBP12-rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus
-
Drenan, R. M., X. Liu, P. G. Bertram, and X. F. Zheng. 2004. FKBP12-rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus. J. Biol. Chem. 279:772-778.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 772-778
-
-
Drenan, R.M.1
Liu, X.2
Bertram, P.G.3
Zheng, X.F.4
-
68
-
-
17344381954
-
Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast
-
Duvel, K., A. Santhanam, S. Garrett, L. Schneper, and J. R. Broach. 2003. Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast. Mol. Cell 11:1467-1478.
-
(2003)
Mol. Cell
, vol.11
, pp. 1467-1478
-
-
Duvel, K.1
Santhanam, A.2
Garrett, S.3
Schneper, L.4
Broach, J.R.5
-
69
-
-
0141705466
-
Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin
-
El-Hashemite, N., V. Walker, H. Zhang, and D. J. Kwiatkowski. 2003. Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer Res. 63:5173-5177.
-
(2003)
Cancer Res.
, vol.63
, pp. 5173-5177
-
-
El-Hashemite, N.1
Walker, V.2
Zhang, H.3
Kwiatkowski, D.J.4
-
70
-
-
0027770784
-
Identification and characterization of the tuberous sclerosis gene on chromosome 16
-
European Chromosome 16 Tuberous Sclerosis Consortium. 1993. Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 75:1305-1315.
-
(1993)
Cell
, vol.75
, pp. 1305-1315
-
-
-
71
-
-
0030934285
-
Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes
-
Fadden, P., T. A. Haystead, and J. C. Lawrence, Jr. 1997. Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes. J. Biol. Chem. 272:10240-10247.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10240-10247
-
-
Fadden, P.1
Haystead, T.A.2
Lawrence Jr., J.C.3
-
72
-
-
0035976615
-
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
-
Fang, Y., M. Vilella-Bach, R. Bachmann, A. Flanigan, and J. Chen. 2001. Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 294:1942-1945.
-
(2001)
Science
, vol.294
, pp. 1942-1945
-
-
Fang, Y.1
Vilella-Bach, M.2
Bachmann, R.3
Flanigan, A.4
Chen, J.5
-
73
-
-
2342545519
-
Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
-
Fingar, D. C., and J. Blenis. 2004. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23:3151-3171.
-
(2004)
Oncogene
, vol.23
, pp. 3151-3171
-
-
Fingar, D.C.1
Blenis, J.2
-
74
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
Fingar, D. C., S. Salama, C. Tsou, E. Harlow, and J. Blenis. 2002. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16:1472-1487.
-
(2002)
Genes Dev.
, vol.16
, pp. 1472-1487
-
-
Fingar, D.C.1
Salama, S.2
Tsou, C.3
Harlow, E.4
Blenis, J.5
-
75
-
-
0034982971
-
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
-
Gao, X., and D. Pan. 2001. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev. 15:1383-1392.
-
(2001)
Genes Dev.
, vol.15
, pp. 1383-1392
-
-
Gao, X.1
Pan, D.2
-
76
-
-
0036712905
-
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
-
Gao, X., Y. Zhang, P. Arrazola, O. Hino, T. Kobayashi, R. S. Yeung, B. Ru, and D. Pan. 2002. Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat. Cell Biol. 4:699-704.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 699-704
-
-
Gao, X.1
Zhang, Y.2
Arrazola, P.3
Hino, O.4
Kobayashi, T.5
Yeung, R.S.6
Ru, B.7
Pan, D.8
-
77
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
Garami, A., F. J. Zwartkruis, T. Nobukuni, M. Joaquin, M. Roccio, H. Stocker, S. C. Kozma, E. Hafen, J. L. Bos, and G. Thomas. 2003. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell 11:1457-1466.
-
(2003)
Mol. Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
Zwartkruis, F.J.2
Nobukuni, T.3
Joaquin, M.4
Roccio, M.5
Stocker, H.6
Kozma, S.C.7
Hafen, E.8
Bos, J.L.9
Thomas, G.10
-
79
-
-
1642535431
-
AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression
-
Gera, J. F., I. K. Mellinghoff, Y. Shi, M. B. Rettig, C. Tran, J. H. Hsu, C. L. Sawyers, and A. K. Lichtenstein. 2004. AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression. J. Biol. Chem. 279:2737-2746.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 2737-2746
-
-
Gera, J.F.1
Mellinghoff, I.K.2
Shi, Y.3
Rettig, M.B.4
Tran, C.5
Hsu, J.H.6
Sawyers, C.L.7
Lichtenstein, A.K.8
-
80
-
-
0032520009
-
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
-
Gingras, A. C., S. G. Kennedy, M. A. O'Leary, N. Sonenberg, and N. Hay. 1998. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev. 12:502-513.
-
(1998)
Genes Dev.
, vol.12
, pp. 502-513
-
-
Gingras, A.C.1
Kennedy, S.G.2
O'Leary, M.A.3
Sonenberg, N.4
Hay, N.5
-
81
-
-
0035498939
-
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
-
Gingras, A. C., B. Raught, S. P. Gygi, A. Niedzwiecka, M. Miron, S. K. Burley, R. D. Polakiewicz, A. Wyslouch-Cieszynska, R. Aebersold, and N. Sonenberg. 2001. Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev. 15:2852-2864.
-
(2001)
Genes Dev.
, vol.15
, pp. 2852-2864
-
-
Gingras, A.C.1
Raught, B.2
Gygi, S.P.3
Niedzwiecka, A.4
Miron, M.5
Burley, S.K.6
Polakiewicz, R.D.7
Wyslouch-Cieszynska, A.8
Aebersold, R.9
Sonenberg, N.10
-
82
-
-
0032834055
-
IF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
-
Gingras, A. C., B. Raught, and N. Sonenberg. 1999. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68:913-963.
-
(1999)
Annu. Rev. Biochem.
, vol.68
, pp. 913-963
-
-
Gingras, A.C.1
Raught, B.2
Sonenberg, N.3
-
83
-
-
0032946279
-
Protein phosphatase 2A: Who shall regulate the regulator?
-
Goldberg, Y. 1999. Protein phosphatase 2A: who shall regulate the regulator? Biochem. Pharmacol. 57:321-328.
-
(1999)
Biochem. Pharmacol.
, vol.57
, pp. 321-328
-
-
Goldberg, Y.1
-
84
-
-
0025864035
-
Phenotypes of the tuberous sclerosis complex with a revision of diagnostic criteria
-
Gomez, M. R. 1991. Phenotypes of the tuberous sclerosis complex with a revision of diagnostic criteria. Ann. N. Y. Acad. Sci. 615:1-7.
-
(1991)
Ann. N. Y. Acad. Sci.
, vol.615
, pp. 1-7
-
-
Gomez, M.R.1
-
85
-
-
0037163033
-
Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation
-
Goncharova, E. A., D. A. Goncharov, A. Eszterhas, D. S. Hunter, M. K. Glassberg, R. S. Yeung, C. L. Walker, D. Noonan, D. J. Kwiatkowski, M. M. Chou, R. A. Panettieri, Jr., and V. P. Krymskaya. 2002. Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. J. Biol. Chem. 277:30958-30967.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30958-30967
-
-
Goncharova, E.A.1
Goncharov, D.A.2
Eszterhas, A.3
Hunter, D.S.4
Glassberg, M.K.5
Yeung, R.S.6
Walker, C.L.7
Noonan, D.8
Kwiatkowski, D.J.9
Chou, M.M.10
Panettieri Jr., R.A.11
Krymskaya, V.P.12
-
86
-
-
0029658805
-
The p70S6K signalling pathway: A novel signalling system involved in growth regulation
-
Grammer, T. C., L. Cheatham, M. M. Chou, and J. Blenis. 1996. The p70S6K signalling pathway: a novel signalling system involved in growth regulation. Cancer Surv. 27:271-292.
-
(1996)
Cancer Surv.
, vol.27
, pp. 271-292
-
-
Grammer, T.C.1
Cheatham, L.2
Chou, M.M.3
Blenis, J.4
-
87
-
-
0029120591
-
CAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells
-
Graves, L. M., K. E. Bornfeldt, G. M. Argast, E. G. Krebs, X. Kong, T. A. Lin, and J. C. Lawrence, Jr. 1995. cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells. Proc. Natl. Acad. Sci. USA 92:7222-7226.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 7222-7226
-
-
Graves, L.M.1
Bornfeldt, K.E.2
Argast, G.M.3
Krebs, E.G.4
Kong, X.5
Lin, T.A.6
Lawrence Jr., J.C.7
-
88
-
-
0020774482
-
Inactivation-reactivation process and repression of permease formation regulate several ammonia-sensitive permeases in the yeast Saccharomyces cerevisiae
-
Grenson, M. 1983. Inactivation-reactivation process and repression of permease formation regulate several ammonia-sensitive permeases in the yeast Saccharomyces cerevisiae. Eur. J. Biochem. 133:135-139.
-
(1983)
Eur. J. Biochem.
, vol.133
, pp. 135-139
-
-
Grenson, M.1
-
89
-
-
0020773011
-
Study of the positive control of the general amino-acid permease and other ammonia-sensitive uptake systems by the product of the NPR1 gene in the yeast Saccharomyces cerevisiae
-
Grenson, M. 1983. Study of the positive control of the general amino-acid permease and other ammonia-sensitive uptake systems by the product of the NPR1 gene in the yeast Saccharomyces cerevisiae. Eur. J. Biochem. 133:141-144.
-
(1983)
Eur. J. Biochem.
, vol.133
, pp. 141-144
-
-
Grenson, M.1
-
90
-
-
0033178702
-
Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells
-
Grewe, M., F. Gansauge, R. M. Schmid, G. Adler, and T. Seufferlein. 1999. Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells. Cancer Res. 59:3581-3587.
-
(1999)
Cancer Res.
, vol.59
, pp. 3581-3587
-
-
Grewe, M.1
Gansauge, F.2
Schmid, R.M.3
Adler, G.4
Seufferlein, T.5
-
91
-
-
0029560416
-
A novel approach for expression cloning of small GTPases: Identification, tissue distribution and chromosome mapping of the human homolog of rheb
-
Gromov, P. S., P. Madsen, N. Tomerup, and J. E. Celis. 1995. A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb. FEBS Lett. 377:221-226.
-
(1995)
FEBS Lett.
, vol.377
, pp. 221-226
-
-
Gromov, P.S.1
Madsen, P.2
Tomerup, N.3
Celis, J.E.4
-
92
-
-
0242497664
-
Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI
-
Gstaiger, M., B. Luke, D. Hess, E. J. Oakeley, C. Wirbelauer, M. Blondel, M. Vigneron, M. Peter, and W. Krek. 2003. Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. Science 302:1208-1212.
-
(2003)
Science
, vol.302
, pp. 1208-1212
-
-
Gstaiger, M.1
Luke, B.2
Hess, D.3
Oakeley, E.J.4
Wirbelauer, C.5
Blondel, M.6
Vigneron, M.7
Peter, M.8
Krek, W.9
-
93
-
-
0028786952
-
Repression of cap-dependent translation by 4E-binding protein 1: Competition with p220 for binding to eukaryotic initiation factor-4E
-
Haghighat, A., S. Mader, A. Pause, and N. Sonenberg. 1995. Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J. 14:5701-5709.
-
(1995)
EMBO J.
, vol.14
, pp. 5701-5709
-
-
Haghighat, A.1
Mader, S.2
Pause, A.3
Sonenberg, N.4
-
94
-
-
0029081544
-
Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites
-
Han, J. W., R. B. Pearson, P. B. Dennis, and G. Thomas. 1995. Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites. J. Biol. Chem. 270:21396-21403.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 21396-21403
-
-
Han, J.W.1
Pearson, R.B.2
Dennis, P.B.3
Thomas, G.4
-
95
-
-
0242637318
-
mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF
-
Hannan, K. M., Y. Brandenburger, A. Jenkins, K. Sharkey, A. Cavanaugh, L. Rothblum, T. Moss, G. Poortinga, G. A. McArthur, R. B. Pearson, and R. D. Hannan. 2003. mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Mol. Cell. Biol. 23:8862-8877.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 8862-8877
-
-
Hannan, K.M.1
Brandenburger, Y.2
Jenkins, A.3
Sharkey, K.4
Cavanaugh, A.5
Rothblum, L.6
Moss, T.7
Poortinga, G.8
McArthur, G.A.9
Pearson, R.B.10
Hannan, R.D.11
-
96
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara, K., Y. Manila, X. Long, K. Yoshino, N. Oshiro, S. Hidayat, C. Tokunaga, J. Avruch, and K. Yonezawa. 2002. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110:177-189.
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Manila, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
97
-
-
0032486268
-
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
-
Hara, K., K. Yonezawa, Q. P. Weng, M. T. Kozlowski, C. Belham, and J. Avruch. 1998. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J. Biol. Chem. 273:14484-14494.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14484-14494
-
-
Hara, K.1
Yonezawa, K.2
Weng, Q.P.3
Kozlowski, M.T.4
Belham, C.5
Avruch, J.6
-
98
-
-
0031717105
-
The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
-
Hardie, D. G., D. Carling, and M. Carlson. 1998. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem. 67:821-855.
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 821-855
-
-
Hardie, D.G.1
Carling, D.2
Carlson, M.3
-
99
-
-
0035542970
-
AMP-activated protein kinase: The energy charge hypothesis revisited
-
Hardie, D. G., and S. A. Hawley. 2001. AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays 23:1112-1119.
-
(2001)
Bioessays
, vol.23
, pp. 1112-1119
-
-
Hardie, D.G.1
Hawley, S.A.2
-
100
-
-
0033592983
-
Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins
-
Hardwick, J. S., F. G. Kuruvilla, J. K. Tong, A. F. Shamji, and S. L. Schreiber. 1999. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. Proc. Natl. Acad. Sci. USA 96:14866-14870.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 14866-14870
-
-
Hardwick, J.S.1
Kuruvilla, F.G.2
Tong, J.K.3
Shamji, A.F.4
Schreiber, S.L.5
-
101
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
Harrington, L. S., G. M. Findlay, A. Gray, T. Tolkacheva, S. Wigfleld, H. Rebholz, J. Harriett, N. R. Leslie, S. Cheng, F. R. Shepherd, I. Gout, C. F. Downes, and R. F. Lamb. 2004. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166:213-223.
-
(2004)
J. Cell Biol.
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
Tolkacheva, T.4
Wigfleld, S.5
Rebholz, H.6
Harriett, J.7
Leslie, N.R.8
Cheng, S.9
Shepherd, F.R.10
Gout, I.11
Downes, C.F.12
Lamb, R.F.13
-
102
-
-
0034816272
-
Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation
-
Hartman, M. E., M. Villela-Bach, J. Chen, and G. G. Freund. 2001. Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation. Biochem. Biophys. Res. Commun. 280:776-781.
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.280
, pp. 776-781
-
-
Hartman, M.E.1
Villela-Bach, M.2
Chen, J.3
Freund, G.G.4
-
103
-
-
0034463918
-
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
-
Haruta, T., T. Uno, J. Kawahara, A. Takano, K. Egawa, P. M. Sharma, J. M. Olefsky, and M. Kobayashi. 2000. A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol. Endocrinol. 14:783-794.
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 783-794
-
-
Haruta, T.1
Uno, T.2
Kawahara, J.3
Takano, A.4
Egawa, K.5
Sharma, P.M.6
Olefsky, J.M.7
Kobayashi, M.8
-
104
-
-
0032485937
-
Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability
-
Hashemolhosseini, S., Y. Nagamine, S. J. Morley, S. Desrivieres, L. Mercep, and S. Ferrari. 1998. Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability. J. Biol. Chem. 273:14424-14429.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14424-14429
-
-
Hashemolhosseini, S.1
Nagamine, Y.2
Morley, S.J.3
Desrivieres, S.4
Mercep, L.5
Ferrari, S.6
-
105
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRADalpha/beta and MO25alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley, S. A., J. Boudeau, J. L. Reid, K. J. Mustard, L. Udd, T. P. Makela, D. R. Alessi, and D. G. Hardie. 2003. Complexes between the LKB1 tumor suppressor, STRADalpha/beta and MO25alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2:28.
-
(2003)
J. Biol.
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Makela, T.P.6
Alessi, D.R.7
Hardie, D.G.8
-
106
-
-
0032533173
-
Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111)
-
Heesom, K. J., M. B. Arisen, T. A. Diggle, and R. M. Denton. 1998. Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111). Biochem. J. 336:39-48.
-
(1998)
Biochem. J.
, vol.336
, pp. 39-48
-
-
Heesom, K.J.1
Arisen, M.B.2
Diggle, T.A.3
Denton, R.M.4
-
107
-
-
0025776523
-
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
-
Heitman, J., N. R. Mowa, and M. N. Hall. 1991. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253:905-909.
-
(1991)
Science
, vol.253
, pp. 905-909
-
-
Heitman, J.1
Mowa, N.R.2
Hall, M.N.3
-
108
-
-
0028137771
-
TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast
-
Helliwell, S. B., P. Wagner, J. Kunz, M. Deuter-Reinhard, R. Henriquez, and M. N. Hall. 1994. TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol. Biol. Cell 5:105-118.
-
(1994)
Mol. Biol. Cell
, vol.5
, pp. 105-118
-
-
Helliwell, S.B.1
Wagner, P.2
Kunz, J.3
Deuter-Reinhard, M.4
Henriquez, R.5
Hall, M.N.6
-
109
-
-
0032961871
-
The flat-top gene is required for the expansion and regionalization of the telencephalic primordium
-
Hentges, K., K. Thompson, and A. Peterson. 1999. The flat-top gene is required for the expansion and regionalization of the telencephalic primordium. Development 126:1601-1609.
-
(1999)
Development
, vol.126
, pp. 1601-1609
-
-
Hentges, K.1
Thompson, K.2
Peterson, A.3
-
110
-
-
0009407476
-
Evidence for translational regulation of the activator of general amino acid control in yeast
-
Hinnebusch, A. G. 1984. Evidence for translational regulation of the activator of general amino acid control in yeast. Proc. Natl. Acad. Sci. USA 81:6442-6446.
-
(1984)
Proc. Natl. Acad. Sci. USA
, vol.81
, pp. 6442-6446
-
-
Hinnebusch, A.G.1
-
111
-
-
0030803256
-
Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome
-
Hinnebusch, A. G. 1997. Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome. J. Biol. Chem. 272:21661-21664.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 21661-21664
-
-
Hinnebusch, A.G.1
-
112
-
-
0030977349
-
Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family
-
Hoekstra, M. F. 1997. Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family. Curr. Opin. Genet. Dev. 7:170-175.
-
(1997)
Curr. Opin. Genet. Dev.
, vol.7
, pp. 170-175
-
-
Hoekstra, M.F.1
-
113
-
-
0041305909
-
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
-
Hong, S. P., F. C. Leiper, A. Woods, D. Carting, and M. Carlson. 2003. Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc. Natl. Acad. Sci. USA 100:8839-8843.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8839-8843
-
-
Hong, S.P.1
Leiper, F.C.2
Woods, A.3
Carting, D.4
Carlson, M.5
-
114
-
-
0037143449
-
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis
-
Horman, S., G. Browne, U. Krause, J. Patel, D. Vertommen, L. Bertrand, A. Lavoinne, L. Hue, C. Proud, and M. Rider. 2002. Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr. Biol. 12:1419-1423.
-
(2002)
Curr. Biol.
, vol.12
, pp. 1419-1423
-
-
Horman, S.1
Browne, G.2
Krause, U.3
Patel, J.4
Vertommen, D.5
Bertrand, L.6
Lavoinne, A.7
Hue, L.8
Proud, C.9
Rider, M.10
-
115
-
-
0031755688
-
Studies on the mechanism of resistance to rapamycin in human cancer cells
-
Hosoi, H., M. B. Dilling, L. N. Liu, M. K. Danks, T. Shikata, A. Sekulic, R. T. Abraham, J. C. Lawrence, Jr., and P. J. Houghton. 1998. Studies on the mechanism of resistance to rapamycin in human cancer cells. Mol. Pharmacol. 54:815-824.
-
(1998)
Mol. Pharmacol.
, vol.54
, pp. 815-824
-
-
Hosoi, H.1
Dilling, M.B.2
Liu, L.N.3
Danks, M.K.4
Shikata, T.5
Sekulic, A.6
Abraham, R.T.7
Lawrence Jr., J.C.8
Houghton, P.J.9
-
116
-
-
0041802820
-
Targeting mTOR signaling for cancer therapy
-
Huang, S., and P. J. Houghton. 2003. Targeting mTOR signaling for cancer therapy. Curr. Opin. Pharmacol. 3:371-377.
-
(2003)
Curr. Opin. Pharmacol.
, vol.3
, pp. 371-377
-
-
Huang, S.1
Houghton, P.J.2
-
117
-
-
0035870281
-
p53/p21 (CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin
-
Huang, S., L. N. Liu, H. Hosoi, M. B. Dilling, T. Shikata, and P. J. Houghton. 2001. p53/p21 (CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin. Cancer Res. 61:3373-3381.
-
(2001)
Cancer Res.
, vol.61
, pp. 3373-3381
-
-
Huang, S.1
Liu, L.N.2
Hosoi, H.3
Dilling, M.B.4
Shikata, T.5
Houghton, P.J.6
-
118
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
Hudson, C. C., M. Liu, G. G. Chiang, D. M. Otterness, D. C. Loomis, F. Kaper, A. J. Giaccia, and R. T. Abraham. 2002. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol. Cell. Biol. 22:7004-7014.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
Otterness, D.M.4
Loomis, D.C.5
Kaper, F.6
Giaccia, A.J.7
Abraham, R.T.8
-
119
-
-
0037154264
-
Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin
-
Huffman, T. A., I. Mothe-Satnev, and J. C. Lawrence, Jr. 2002. Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. Proc. Natl. Acad. Sci. USA 99:1047-1052.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 1047-1052
-
-
Huffman, T.A.1
Mothe-Satnev, I.2
Lawrence Jr., J.C.3
-
120
-
-
0037663743
-
Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth
-
Ilyin, G. P., D. Glaise, D. Gilot, G. Baffet, and C. Guguen-Guillouzo. 2003. Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth. Am. J. Physiol. 285:G115-G127.
-
(2003)
Am. J. Physiol.
, vol.285
-
-
Ilyin, G.P.1
Glaise, D.2
Gilot, D.3
Baffet, G.4
Guguen-Guillouzo, C.5
-
121
-
-
0037068783
-
Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells
-
Im, E., F. C. von Lintig, J. Chen, S. Zhuang, W. Qui, S. Chowdhury, P. F. Worley, G. R. Boss, and R. B. Pilz. 2002. Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells. Oncogene 21:6356-6365.
-
(2002)
Oncogene
, vol.21
, pp. 6356-6365
-
-
Im, E.1
Von Lintig, F.C.2
Chen, J.3
Zhuang, S.4
Qui, W.5
Chowdhury, S.6
Worley, P.F.7
Boss, G.R.8
Pilz, R.B.9
-
122
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki, K., Y. Li, T. Xu, and K. L. Guan. 2003. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17:1829-1834.
-
(2003)
Genes Dev.
, vol.17
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
123
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki, K., Y. Li, T. Zhu, J. Wu, and K. L. Guan. 2002. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4:648-657.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
124
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki, K., T. Zhu, and K. L. Guan. 2003. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115:577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
125
-
-
0032528434
-
Ig receptor binding protein 1 (alpha4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A
-
Inui, S., H. Sanjo, K. Maeda, H. Yamamoto, E. Miyamoto, and N. Sakaguchi. 1998. Ig receptor binding protein 1 (alpha4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A. Blood 92:539-546.
-
(1998)
Blood
, vol.92
, pp. 539-546
-
-
Inui, S.1
Sanjo, H.2
Maeda, K.3
Yamamoto, H.4
Miyamoto, E.5
Sakaguchi, N.6
-
126
-
-
0033607531
-
Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
-
Isotani, S., K. Hara, C. Tokunaga, H. Inoue, J. Avruch, and K. Yonezawa. 1999. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro. J. Biol. Chem. 274:34493-34498
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34493-34498
-
-
Isotani, S.1
Hara, K.2
Tokunaga, C.3
Inoue, H.4
Avruch, J.5
Yonezawa, K.6
-
127
-
-
0035930339
-
TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway
-
Jacinto, E., B. Guo, K. T. Arndt, T. Schmelzle, and M. N. Hall. 2001. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Mol. Cell 8:1017-1026.
-
(2001)
Mol. Cell
, vol.8
, pp. 1017-1026
-
-
Jacinto, E.1
Guo, B.2
Arndt, K.T.3
Schmelzle, T.4
Hall, M.N.5
-
128
-
-
0037312507
-
Tor signalling in bugs, brain and brawn
-
Jacinto, E., and M. N. Hall. 2003. Tor signalling in bugs, brain and brawn. Nat. Rev. Mol. Cell Biol. 4:117-126.
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 117-126
-
-
Jacinto, E.1
Hall, M.N.2
-
129
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto, E., R. Loewith, A. Schmidt, S. Lin, M. A. Ruegg, A. Hall, and M. N. Hall. 2004. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6:1122-1128.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
Hall, M.N.7
-
130
-
-
0028207001
-
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family
-
Jefferies, H. B., C. Reinhard, S. C. Kozma, and G. Thomas. 1994. Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Proc. Natl. Acad. Sci. USA 91:4441-4445.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 4441-4445
-
-
Jefferies, H.B.1
Reinhard, C.2
Kozma, S.C.3
Thomas, G.4
-
131
-
-
0033577745
-
Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast
-
Jiang, Y., and J. R. Broach. 1999. Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J. 18:2782-2792.
-
(1999)
EMBO J.
, vol.18
, pp. 2782-2792
-
-
Jiang, Y.1
Broach, J.R.2
-
132
-
-
0023122945
-
Phosphorylation of the Saccharomyces cerevisiae equivalent of ribosomal protein S6 has no detectable effect on growth
-
Johnson, S. P., and J. R. Warner. 1987. Phosphorylation of the Saccharomyces cerevisiae equivalent of ribosomal protein S6 has no detectable effect on growth. Mol. Cell. Biol. 7:1338-1345.
-
(1987)
Mol. Cell. Biol.
, vol.7
, pp. 1338-1345
-
-
Johnson, S.P.1
Warner, J.R.2
-
133
-
-
0034683568
-
Tor-mediated induction of autophagy via an Apg1 protein kinase complex
-
Kamada, Y., T. Funakoshi, T. Shintani, K. Nagano, M. Ohsumi, and Y. Ohsumi. 2000. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J. Cell Biol. 150:1507-1513.
-
(2000)
J. Cell Biol.
, vol.150
, pp. 1507-1513
-
-
Kamada, Y.1
Funakoshi, T.2
Shintani, T.3
Nagano, K.4
Ohsumi, M.5
Ohsumi, Y.6
-
134
-
-
0037108682
-
Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
-
Kenerson, H. L., L. D. Aicher, L. D. True, and R. S. Yeung. 2002. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res. 62:5645-5650.
-
(2002)
Cancer Res.
, vol.62
, pp. 5645-5650
-
-
Kenerson, H.L.1
Aicher, L.D.2
True, L.D.3
Yeung, R.S.4
-
135
-
-
0028012738
-
Amino acid-regulated gene expression in eukaryotic cells
-
Kilberg, M. S., R. G. Hutson, and R. O. Laine. 1994. Amino acid-regulated gene expression in eukaryotic cells. FASEB J. 8:13-19.
-
(1994)
FASEB J.
, vol.8
, pp. 13-19
-
-
Kilberg, M.S.1
Hutson, R.G.2
Laine, R.O.3
-
136
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim, D. H., D. D. Sarbassov, S. M. Ali, J. E. King, R. R. Latek, H. Erdjument-Bromage, P. Tempst, and D. M. Sabatini. 2002. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110:163-175.
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
137
-
-
0037623417
-
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
-
Kim, D. H., D. Sarbassov dos, S. M. Ali, R. R. Latek, K. V. Guntur, H. Erdjument-Bromage, P. Tempst, and D. M. Sabatini. 2003. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol. Cell 11:895-904.
-
(2003)
Mol. Cell
, vol.11
, pp. 895-904
-
-
Kim, D.H.1
Sarbassov Dos, D.2
Ali, S.M.3
Latek, R.R.4
Guntur, K.V.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
138
-
-
0037276069
-
A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
-
Kimura, N., C. Tokunaga, S. Dalai, C. Richardson, K. Yoshino, K. Hara, B. E. Kemp, L. A. Witters, O. Mimura, and K. Yonezawa. 2003. A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Genes Cells 8:65-79.
-
(2003)
Genes Cells
, vol.8
, pp. 65-79
-
-
Kimura, N.1
Tokunaga, C.2
Dalai, S.3
Richardson, C.4
Yoshino, K.5
Hara, K.6
Kemp, B.E.7
Witters, L.A.8
Mimura, O.9
Yonezawa, K.10
-
139
-
-
0033280667
-
Vacuolar import of proteins and organelles from the cytoplasm
-
Klionsky, D. J., and Y. Ohsumi. 1999. Vacuolar import of proteins and organelles from the cytoplasm. Annu. Rev. Cell Dev. Biol. 15:1-32.
-
(1999)
Annu. Rev. Cell Dev. Biol.
, vol.15
, pp. 1-32
-
-
Klionsky, D.J.1
Ohsumi, Y.2
-
140
-
-
0035902509
-
A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
-
Kobayashi, T., O. Minowa, Y. Sugitani, S. Takai, H. Mitani, E. Kobayashi, T. Noda, and O. Hino. 2001. A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc. Natl. Acad. Sci. USA 98:8762-8767.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 8762-8767
-
-
Kobayashi, T.1
Minowa, O.2
Sugitani, Y.3
Takai, S.4
Mitani, H.5
Kobayashi, E.6
Noda, T.7
Hino, O.8
-
141
-
-
0034645038
-
Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors
-
Komeili, A., K. P. Wedaman, E. K. O'Shea, and T. Powers. 2000. Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. J. Cell Biol. 151:863-878.
-
(2000)
J. Cell Biol.
, vol.151
, pp. 863-878
-
-
Komeili, A.1
Wedaman, K.P.2
O'Shea, E.K.3
Powers, T.4
-
142
-
-
0036007421
-
Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K
-
Kozma, S. C., and G. Thomas. 2002. Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K. Bioessays 24:65-71.
-
(2002)
Bioessays
, vol.24
, pp. 65-71
-
-
Kozma, S.C.1
Thomas, G.2
-
143
-
-
0036364274
-
Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes
-
Krause, U., L. Bertrand, and L. Hue. 2002. Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes. Eur. J. Biochem. 269:3751-3759.
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 3751-3759
-
-
Krause, U.1
Bertrand, L.2
Hue, L.3
-
144
-
-
0027311858
-
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
-
Kunz, J., R. Henriquez, U. Schneider, M. Deuter-Reinhard, N. R. Mowa, and M. N. Hall. 1993. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 73:585-596.
-
(1993)
Cell
, vol.73
, pp. 585-596
-
-
Kunz, J.1
Henriquez, R.2
Schneider, U.3
Deuter-Reinhard, M.4
Mowa, N.R.5
Hall, M.N.6
-
145
-
-
0035912781
-
Carbon- and nitrogen-quality signaling to translation are mediated by distinct GATA-type transcription factors
-
Kuruvilla, F. G., A. F. Shamji, and S. L. Schreiber. 2001. Carbon- and nitrogen-quality signaling to translation are mediated by distinct GATA-type transcription factors. Proc. Natl. Acad. Sci. USA 98:7283-7288.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 7283-7288
-
-
Kuruvilla, F.G.1
Shamji, A.F.2
Schreiber, S.L.3
-
146
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
-
Kwiatkowski, D. J., H. Zhang, J. L. Bandura, K. M. Heiberger, M. Glogauer, N. el-Hashemite, and H. Onda. 2002. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum. Mol. Genet. 11:525-534.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 525-534
-
-
Kwiatkowski, D.J.1
Zhang, H.2
Bandura, J.L.3
Heiberger, K.M.4
Glogauer, M.5
El-Hashemite, N.6
Onda, H.7
-
147
-
-
0029845130
-
Okadaic acid induces cellular hypertrophy in AKR-2B fibroblasts: Involvement of the p70S6 kinase in the onset of protein and rRNA synthesis
-
Leicht, M., A. Simm, G. Bertsch, and J. Hoppe. 1996. Okadaic acid induces cellular hypertrophy in AKR-2B fibroblasts: involvement of the p70S6 kinase in the onset of protein and rRNA synthesis. Cell Growth Differ. 7:1199-1209.
-
(1996)
Cell Growth Differ.
, vol.7
, pp. 1199-1209
-
-
Leicht, M.1
Simm, A.2
Bertsch, G.3
Hoppe, J.4
-
148
-
-
0347318056
-
TSC2: Filling the GAP in the mTOR signaling pathway
-
Li, Y., M. N. Corradetti, K. Inoki, and K. L. Guan. 2004. TSC2: filling the GAP in the mTOR signaling pathway. Trends Biochem. Sci. 29:32-38.
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 32-38
-
-
Li, Y.1
Corradetti, M.N.2
Inoki, K.3
Guan, K.L.4
-
149
-
-
4444276510
-
Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity
-
Li, Y., K. Inoki, and K. L. Guan. 2004. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mol. Cell. Biol. 24:7965-7975.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 7965-7975
-
-
Li, Y.1
Inoki, K.2
Guan, K.L.3
-
150
-
-
0038190932
-
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 (TSC2) gene product, and enhances its interaction with 14-3-3
-
Li, Y., K. Inoki, P. Vacrasis, and K. L. Guan. 2003. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 (TSC2) gene product, and enhances its interaction with 14-3-3. J. Biol. Chem. 278:13663-13671.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13663-13671
-
-
Li, Y.1
Inoki, K.2
Vacrasis, P.3
Guan, K.L.4
-
151
-
-
0031004088
-
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
-
Liaw, D., D. J. Marsh, J. Li, P. L. Dahia, S. I. Wang, Z. Zheng, S. Bose, K. M. Call, H. C. Tsou, M. Peacocke, C. Eng, and R. Parsons. 1997. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet. 16:64-67
-
(1997)
Nat. Genet.
, vol.16
, pp. 64-67
-
-
Liaw, D.1
Marsh, D.J.2
Li, J.3
Dahia, P.L.4
Wang, S.I.5
Zheng, Z.6
Bose, S.7
Call, K.M.8
Tsou, H.C.9
Peacocke, M.10
Eng, C.11
Parsons, R.12
-
152
-
-
0028126506
-
PHAS-I as a link between mitogen-activated protein kinase and translation initiation
-
Lin, T. A., X. Kong, T. A. Haystead, A. Pause, G. Belsham, N. Sonenberg, and J. C. Lawrence, Jr. 1994. PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science 266:653-656.
-
(1994)
Science
, vol.266
, pp. 653-656
-
-
Lin, T.A.1
Kong, X.2
Haystead, T.A.3
Pause, A.4
Belsham, G.5
Sonenberg, N.6
Lawrence Jr., J.C.7
-
153
-
-
0029095931
-
Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway
-
Lin, T. A., X. Kong, A. R. Saltiel, P. J. Blackshear, and J. C. Lawrence, Jr. 1995. Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway, J. Biol. Chem. 270:18531-18538.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 18531-18538
-
-
Lin, T.A.1
Kong, X.2
Saltiel, A.R.3
Blackshear, P.J.4
Lawrence Jr., J.C.5
-
154
-
-
12144287284
-
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
-
Lizcano, J. M., O. Goransson, R. Toth, M. Deak, N. A. Morrice, J. Boudeau, S. A. Hawley, L. Udd, T. P. Makela, D. G. Hardie, and D. R. Alessi. 2004. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J. 23:833-843.
-
(2004)
EMBO J.
, vol.23
, pp. 833-843
-
-
Lizcano, J.M.1
Goransson, O.2
Toth, R.3
Deak, M.4
Morrice, N.A.5
Boudeau, J.6
Hawley, S.A.7
Udd, L.8
Makela, T.P.9
Hardie, D.G.10
Alessi, D.R.11
-
155
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith, R., E. Jacinto, S. Wullschleger, A. Lorberg, J. L. Crespo, D. Bonenfant, W. Oppliger, P. Jenoe, and M. N. Hall. 2002. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10:457-468.
-
(2002)
Mol. Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
156
-
-
0037015269
-
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation
-
Long, X., C. Spycher, Z. S. Han, A. M. Rose, F. Muller, and J. Avruch. 2002. TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr. Biol. 12:1448-1461.
-
(2002)
Curr. Biol.
, vol.12
, pp. 1448-1461
-
-
Long, X.1
Spycher, C.2
Han, Z.S.3
Rose, A.M.4
Muller, F.5
Avruch, J.6
-
157
-
-
0029664530
-
The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase
-
Luke, M. M., F. Della Seta, C. J. Di Como, H. Sugimoto, R. Kobayashi, and K. T. Arndt. 1996. The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase. Mol. Cell. Biol. 16:2744-2755.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 2744-2755
-
-
Luke, M.M.1
Della Seta, F.2
Di Como, C.J.3
Sugimoto, H.4
Kobayashi, R.5
Arndt, K.T.6
-
158
-
-
0029977949
-
Rapamycin resistance tied to defective regulation of p27Kip1
-
Luo, Y., S. O. Marx, H. Kiyokawa, A. Koff, J. Massague, and A. R. Marks. 1996. Rapamycin resistance tied to defective regulation of p27Kip1. Mol. Cell. Biol. 16:6744-6751.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 6744-6751
-
-
Luo, Y.1
Marx, S.O.2
Kiyokawa, H.3
Koff, A.4
Massague, J.5
Marks, A.R.6
-
159
-
-
0034051278
-
Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation
-
Mach, K. E., K. A. Forge, and C. F. Albright. 2000. Loss of Rhb1, a
-
(2000)
Genetics
, vol.155
, pp. 611-622
-
-
Mach, K.E.1
Forge, K.A.2
Albright, C.F.3
-
160
-
-
0027931137
-
Modulation of transcription of rRNA genes by rapamycin
-
Mahajan, P. B. 1994. Modulation of transcription of rRNA genes by rapamycin. Int. J. Immunopharmacol. 16:711-721.
-
(1994)
Int. J. Immunopharmacol.
, vol.16
, pp. 711-721
-
-
Mahajan, P.B.1
-
161
-
-
0347716759
-
Rheb fills a GAP between TSC and TOR
-
Manning, B. D., and L. C. Cantley. 2003. Rheb fills a GAP between TSC and TOR. Trends Biochem. Sci. 28:573-576.
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 573-576
-
-
Manning, B.D.1
Cantley, L.C.2
-
162
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
-
Manning, B. D., A. R. Tee, M. N. Logsdon, J. Blenis, and L. C. Cantley. 2002. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol. Cell 10:151-162.
-
(2002)
Mol. Cell
, vol.10
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon, M.N.3
Blenis, J.4
Cantley, L.C.5
-
163
-
-
0031203265
-
Germline mutations in PTEN are present in Bannayan-Zonana syndrome
-
Marsh, D. J., P. L. Dahia, Z. Zheng, D. Liaw, R. Parsons, R. J. Gorlin, and C. Eng. 1997. Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat. Genet. 16:333-334.
-
(1997)
Nat. Genet.
, vol.16
, pp. 333-334
-
-
Marsh, D.J.1
Dahia, P.L.2
Zheng, Z.3
Liaw, D.4
Parsons, R.5
Gorlin, R.J.6
Eng, C.7
-
164
-
-
0036021402
-
Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe
-
Matsumoto, S., A. Bandyopadhyay, D. J. Kwiatkowski, U. Maitra, and T. Matsumoto. 2002. Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe. Genetics 161:1053-1063.
-
(2002)
Genetics
, vol.161
, pp. 1053-1063
-
-
Matsumoto, S.1
Bandyopadhyay, A.2
Kwiatkowski, D.J.3
Maitra, U.4
Matsumoto, T.5
-
165
-
-
0030983504
-
Apglp, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae
-
Matsuura, A., M. Tsukada, Y. Wada, and Y. Ohsumi. 1997. Apglp, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Gene 192:245-250.
-
(1997)
Gene
, vol.192
, pp. 245-250
-
-
Matsuura, A.1
Tsukada, M.2
Wada, Y.3
Ohsumi, Y.4
-
166
-
-
1542343973
-
TOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability
-
Mayer, C., J. Zhao, X. Yuan, and I. Grummt. 2004. mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev. 18:423-434.
-
(2004)
Genes Dev.
, vol.18
, pp. 423-434
-
-
Mayer, C.1
Zhao, J.2
Yuan, X.3
Grummt, I.4
-
168
-
-
0037197930
-
Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene
-
Menand, B., T. Desnos, L. Nussaume, F. Berger, D. Bouchez, C. Meyer, and C. Robaglia. 2002. Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene. Proc. Natl. Acad. Sci. USA 99:6422-6427.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 6422-6427
-
-
Menand, B.1
Desnos, T.2
Nussaume, L.3
Berger, F.4
Bouchez, D.5
Meyer, C.6
Robaglia, C.7
-
169
-
-
0033761629
-
Synthesis of the translational apparatus is regulated at the translational level
-
Meyuhas, O. 2000. Synthesis of the translational apparatus is regulated at the translational level. Eur. J. Biochem. 267:6321-6330.
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 6321-6330
-
-
Meyuhas, O.1
-
170
-
-
0032843917
-
Drosophila S6 kinase; a regulator of cell size
-
Montagne, J., M. J. Stewart, H. Stocker, E. Hafen, S. C. Kozma, and G. Thomas. 1999. Drosophila S6 kinase; a regulator of cell size. Science 285:2126-2129.
-
(1999)
Science
, vol.285
, pp. 2126-2129
-
-
Montagne, J.1
Stewart, M.J.2
Stocker, H.3
Hafen, E.4
Kozma, S.C.5
Thomas, G.6
-
171
-
-
0034057277
-
Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression
-
Mothe-Satney, I., D. Yang, P. Fadden, T. A. Haystead, and J. C. Lawrence, Jr. 2000. Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression. Mol. Cell. Biol. 20:3558-3567.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 3558-3567
-
-
Mothe-Satney, I.1
Yang, D.2
Fadden, P.3
Haystead, T.A.4
Lawrence Jr., J.C.5
-
172
-
-
3242721268
-
TOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
-
Murakami, M., T. Ichisaka, M. Maeda, N. Oshiro, K. Hara, F. Edenhofer, H. Kiyama, K. Yonezawa, and S. Yamanaka. 2004. mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol. Cell. Biol. 24:6710-6718.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 6710-6718
-
-
Murakami, M.1
Ichisaka, T.2
Maeda, M.3
Oshiro, N.4
Hara, K.5
Edenhofer, F.6
Kiyama, H.7
Yonezawa, K.8
Yamanaka, S.9
-
173
-
-
0030984108
-
B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A
-
Murata, K., J. Wu, and D. L. Brautigan. 1997. B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A. Proc. Natl. Acad. Sci. USA 94:10624-10629.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 10624-10629
-
-
Murata, K.1
Wu, J.2
Brautigan, D.L.3
-
174
-
-
0032552873
-
Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42
-
Nanahoshi, M., T. Nishiuma, Y. Tsujishita, K. Hara, S. Inui, N. Sakaguchi, and K. Yonezawa. 1998. Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42. Biochem. Biophys. Res. Commun. 251:520-526.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.251
, pp. 520-526
-
-
Nanahoshi, M.1
Nishiuma, T.2
Tsujishita, Y.3
Hara, K.4
Inui, S.5
Sakaguchi, N.6
Yonezawa, K.7
-
175
-
-
0033429554
-
Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
-
Nave, B. T., M. Ouwens, D. J. Withers, D. R. Alessi, and P. R. Shepherd. 1999. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem. J. 344:427-431.
-
(1999)
Biochem. J.
, vol.344
, pp. 427-431
-
-
Nave, B.T.1
Ouwens, M.2
Withers, D.J.3
Alessi, D.R.4
Shepherd, P.R.5
-
176
-
-
0035660247
-
TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex
-
Nellist, M., B. Verbaaf, M. A. Goedbloed, A. J. Reuser, A. M. van den Ouweland, and D. J. Halley. 2001. TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex. Hum. Mol. Genet. 10:2889-2898.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 2889-2898
-
-
Nellist, M.1
Verbaaf, B.2
Goedbloed, M.A.3
Reuser, A.J.4
Van Den Ouweland, A.M.5
Halley, D.J.6
-
177
-
-
17944377486
-
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
-
Neshat, M. S., I. K. Mellinghoff, C. Tran, B. Stiles, G. Thomas, R. Petersen, P. Frost, J. J. Gibbons, H. Wu, and C. L. Sawyers. 2001. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc. Natl. Acad. Sci. USA 98:10314-10319.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10314-10319
-
-
Neshat, M.S.1
Mellinghoff, I.K.2
Tran, C.3
Stiles, B.4
Thomas, G.5
Petersen, R.6
Frost, P.7
Gibbons, J.J.8
Wu, H.9
Sawyers, C.L.10
-
178
-
-
0032512636
-
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
-
Noda, T., and Y. Ohsumi. 1998. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J. Biol. Chem. 273:3963-3966.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 3963-3966
-
-
Noda, T.1
Ohsumi, Y.2
-
179
-
-
0037507252
-
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
-
Nojima, H., C. Tokunaga, S. Eguchi, N. Oshiro, S. Hidayat, K. Yoshino, K. Hara, N. Tanaka, J. Avruch, and K. Yonezawa. 2003. The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J. Biol. Chem. 278:15461-15464.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 15461-15464
-
-
Nojima, H.1
Tokunaga, C.2
Eguchi, S.3
Oshiro, N.4
Hidayat, S.5
Yoshino, K.6
Hara, K.7
Tanaka, N.8
Avruch, J.9
Yonezawa, K.10
-
180
-
-
0028172867
-
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
-
Nourse, J., E. Firpo, W. M. Flanagan, S. Coats, K. Polyak, M. H. Lee, J. Massague, G. R. Crabtree, and J. M. Roberts. 1994. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570-573.
-
(1994)
Nature
, vol.372
, pp. 570-573
-
-
Nourse, J.1
Firpo, E.2
Flanagan, W.M.3
Coats, S.4
Polyak, K.5
Lee, M.H.6
Massague, J.7
Crabtree, G.R.8
Roberts, J.M.9
-
181
-
-
0037306190
-
Insulin/IGF and target of rapamycin signaling: A TOR de force in growth control
-
Oldham, S., and E. Hafen. 2003. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol. 13:79-85.
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 79-85
-
-
Oldham, S.1
Hafen, E.2
-
182
-
-
0034312279
-
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
-
Oldham, S., J. Montagne, T. Radimerski, G. Thomas, and E. Hafen. 2000. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev. 14:2689-2694.
-
(2000)
Genes Dev.
, vol.14
, pp. 2689-2694
-
-
Oldham, S.1
Montagne, J.2
Radimerski, T.3
Thomas, G.4
Hafen, E.5
-
183
-
-
0032741978
-
Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background
-
Onda, H., A. Lueck, P. W. Marks, H. B. Warren, and D. J. Kwiatkowski. 1999. Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J. Clin. Investig. 104:687-695.
-
(1999)
J. Clin. Investig.
, vol.104
, pp. 687-695
-
-
Onda, H.1
Lueck, A.2
Marks, P.W.3
Warren, H.B.4
Kwiatkowski, D.J.5
-
184
-
-
0033520995
-
Mammalian TOR controls one of two kinase pathways acting upon nPKC-delta and nPKCepsilon
-
Parekh, D., W. Ziegler, K. Yonezawa, K. Hara, and P. J. Parker. 1999. Mammalian TOR controls one of two kinase pathways acting upon nPKC-delta and nPKCepsilon. J. Biol. Chem. 274:34758-34764.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34758-34764
-
-
Parekh, D.1
Ziegler, W.2
Yonezawa, K.3
Hara, K.4
Parker, P.J.5
-
185
-
-
0035447688
-
Glucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1
-
Patel, J., X. Wang, and C. G. Proud. 2001. Glucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1. Biochem. J. 358:497-503.
-
(2001)
Biochem. J.
, vol.358
, pp. 497-503
-
-
Patel, J.1
Wang, X.2
Proud, C.G.3
-
186
-
-
0028034233
-
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
-
Pause, A., G. J. Belsham, A. C. Gingras, O. Donze, T. A. Lin, J. C. Lawrence, Jr., and N. Sonenberg. 1994. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371:762-767.
-
(1994)
Nature
, vol.371
, pp. 762-767
-
-
Pause, A.1
Belsham, G.J.2
Gingras, A.C.3
Donze, O.4
Lin, T.A.5
Lawrence Jr., J.C.6
Sonenberg, N.7
-
187
-
-
0028802451
-
The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain
-
Pearson, R. B., P. B. Dennis, J. W. Han, N. A. Williamson, S. C. Kozma, R. E. Wettenhall, and G. Thomas. 1995. The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J. 14:5279-5287.
-
(1995)
EMBO J.
, vol.14
, pp. 5279-5287
-
-
Pearson, R.B.1
Dennis, P.B.2
Han, J.W.3
Williamson, N.A.4
Kozma, S.C.5
Wettenhall, R.E.6
Thomas, G.7
-
188
-
-
11144356304
-
S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
-
Pende, M., S. H. Um, V. Mieulet, M. Sticker, V. L. Goss, J. Mestan, M. Mueller, S. Fumagalli, S. C. Kozma, and G. Thomas. 2004. S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol. Cell. Biol. 24:3112-3124.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 3112-3124
-
-
Pende, M.1
Um, S.H.2
Mieulet, V.3
Sticker, M.4
Goss, V.L.5
Mestan, J.6
Mueller, M.7
Fumagalli, S.8
Kozma, S.C.9
Thomas, G.10
-
189
-
-
0036310982
-
The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
-
Peng, T., T. R. Golub, and D. M. Sabatini. 2002. The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol. Cell. Biol. 22:5575-5584.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 5575-5584
-
-
Peng, T.1
Golub, T.R.2
Sabatini, D.M.3
-
190
-
-
0034629365
-
FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions
-
Peterson, R. T., P. A. Beal, M. J. Comb, and S. L. Schreiber. 2000. FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions. J. Biol. Chem. 275:7416-7423.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 7416-7423
-
-
Peterson, R.T.1
Beal, P.A.2
Comb, M.J.3
Schreiber, S.L.4
-
191
-
-
0033551234
-
Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycin-associated protein
-
Peterson, R. T., B. N. Desai, J. S. Hardwick, and S. L. Schreiber. 1999. Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycin-associated protein. Proc. Natl. Acad. Sci. USA 96:4438-4442.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 4438-4442
-
-
Peterson, R.T.1
Desai, B.N.2
Hardwick, J.S.3
Schreiber, S.L.4
-
192
-
-
0032213545
-
Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles
-
Plank, T. L., R. S. Yeung, and E. P. Henske. 1998. Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer Res. 58:4766-4770.
-
(1998)
Cancer Res.
, vol.58
, pp. 4766-4770
-
-
Plank, T.L.1
Yeung, R.S.2
Henske, E.P.3
-
193
-
-
17944368972
-
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- Mice
-
Podsypanina, K., R. T. Lee, C. Politis, I. Hennessy, A. Crane, J. Puc, M. Neshat, H. Wang, L. Yang, J. Gibbons, P. Frost, V. Dreisbach, J. Blenis, Z. Gaciong, P. Fisher, C. Sawyers, L. Hedrick-Ellenson, and R. Parsons. 2001. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc. Natl. Acad. Sci. USA 98:10320-10325.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10320-10325
-
-
Podsypanina, K.1
Lee, R.T.2
Politis, C.3
Hennessy, I.4
Crane, A.5
Puc, J.6
Neshat, M.7
Wang, H.8
Yang, L.9
Gibbons, J.10
Frost, P.11
Dreisbach, V.12
Blenis, J.13
Gaciong, Z.14
Fisher, P.15
Sawyers, C.16
Hedrick-Ellenson, L.17
Parsons, R.18
-
194
-
-
0035805162
-
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
-
Potter, C. J., H. Huang, and T. Xu. 2001. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 105:357-368.
-
(2001)
Cell
, vol.105
, pp. 357-368
-
-
Potter, C.J.1
Huang, H.2
Xu, T.3
-
195
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
Potter, C. J., L. G. Pedraza, and T. Xu. 2002. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4:658-665.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 658-665
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
197
-
-
0032915417
-
Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae
-
Powers, T., and P. Walter. 1999. Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Mol. Biol. Cell 10:987-1000.
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 987-1000
-
-
Powers, T.1
Walter, P.2
-
198
-
-
0026759874
-
Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
-
Price, D. J., J. R. Grove, V. Calvo, J. Avruch, and B. E. Bierer. 1992. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science 257:973-977.
-
(1992)
Science
, vol.257
, pp. 973-977
-
-
Price, D.J.1
Grove, J.R.2
Calvo, V.3
Avruch, J.4
Bierer, B.E.5
-
199
-
-
0036440779
-
Regulation of mammalian translation factors by nutrients
-
Proud, C. G. 2002. Regulation of mammalian translation factors by nutrients. Eur. J. Biochem. 269:5338-5349.
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 5338-5349
-
-
Proud, C.G.1
-
200
-
-
2642586352
-
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
-
Ravikumar, B., C. Vacher, Z. Berger, J. E. Davies, S. Luo, L. G. Oroz, F. Scaravilli, D. F. Easton, R. Duden, C. J. O'Kane, and D. C. Rubinsztein. 2004. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat. Genet. 36:585-595.
-
(2004)
Nat. Genet.
, vol.36
, pp. 585-595
-
-
Ravikumar, B.1
Vacher, C.2
Berger, Z.3
Davies, J.E.4
Luo, S.5
Oroz, L.G.6
Scaravilli, F.7
Easton, D.F.8
Duden, R.9
O'Kane, C.J.10
Rubinsztein, D.C.11
-
201
-
-
0029966106
-
Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway
-
Redpath, N. T., E. J. Foulstone, and C. G. Proud. 1996. Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway. EMBO J. 15:2291-2297.
-
(1996)
EMBO J.
, vol.15
, pp. 2291-2297
-
-
Redpath, N.T.1
Foulstone, E.J.2
Proud, C.G.3
-
202
-
-
2442605728
-
TOR complex 1 (TORC1) includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in S. cerevisiae
-
Retake, A., S. Anderson, J. M. McCaffery, J. Yates, 3rd, S. Aronova, S. Chu, S. Fairclough, C. Iverson, K. P. Wedaman, and T. Powers. 2004. TOR complex 1 (TORC1) includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in S. cerevisiae. J. Biol. Chem. 279:14752-14762.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 14752-14762
-
-
Retake, A.1
Anderson, S.2
McCaffery, J.M.3
Yates III, J.4
Aronova, S.5
Chu, S.6
Fairclough, S.7
Iverson, C.8
Wedaman, K.P.9
Powers, T.10
-
203
-
-
0037123438
-
Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load
-
Reynolds, T. H. IV, S. C. Bodine, and J. C. Lawrence, Jr. 2002. Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. J. Biol. Chem. 277:17657-17662.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 17657-17662
-
-
Reynolds IV, T.H.1
Bodine, S.C.2
Lawrence Jr., J.C.3
-
204
-
-
0026265892
-
Protein synthesis, cell growth and oncogenesis
-
Rhoads, R. E. 1991. Protein synthesis, cell growth and oncogenesis. Curr. Opin. Cell Biol. 3:1019-1024.
-
(1991)
Curr. Opin. Cell Biol.
, vol.3
, pp. 1019-1024
-
-
Rhoads, R.E.1
-
205
-
-
4544384577
-
Tumorpromoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
-
Roux, P. P., B. A. Ballif, R. Anjum, S. P. Gygi, and J. Blenis. 2004. Tumorpromoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc. Natl. Acad. Sci. USA 101:13489-13494.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 13489-13494
-
-
Roux, P.P.1
Ballif, B.A.2
Anjum, R.3
Gygi, S.P.4
Blenis, J.5
-
206
-
-
0033553624
-
Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling
-
Sabatini, D. M., R. K. Barrow, S. Blackshaw, P. E. Burnett, M. M. Lai, M. E. Field, B. A. Bahr, J. Kirsch, H. Betz, and S. H. Snyder. 1999. Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling. Science 284:1161-1164.
-
(1999)
Science
, vol.284
, pp. 1161-1164
-
-
Sabatini, D.M.1
Barrow, R.K.2
Blackshaw, S.3
Burnett, P.E.4
Lai, M.M.5
Field, M.E.6
Bahr, B.A.7
Kirsch, J.8
Betz, H.9
Snyder, S.H.10
-
207
-
-
0028239893
-
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
-
Sabatini, D. M., H. Erdjument-Bromage, M. Lui, P. Tempst, and S. H. Snyder. 1994. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78:35-43.
-
(1994)
Cell
, vol.78
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
Tempst, P.4
Snyder, S.H.5
-
208
-
-
0037205409
-
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
-
Saitoh, M., N. Pullen, P. Brennan, D. Cantrell, P. B. Dennis, and G. Thomas. 2002. Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. J. Biol. Chem. 277:20104-20112.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 20104-20112
-
-
Saitoh, M.1
Pullen, N.2
Brennan, P.3
Cantrell, D.4
Dennis, P.B.5
Thomas, G.6
-
209
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov dos, D., S. M. Ali, D. H. Kim, D. A. Guertin, R. R. Latek, H. Erdjument-Bromage, P. Tempst, and D. M. Sabatini. 2004. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14:1296-1302.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1296-1302
-
-
Sarbassov Dos, D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
210
-
-
0038643484
-
Rheb promotes cell growth as a component of the insulin/TOR signalling network
-
Saucedo, L. J., X. Gao, D. A. Chiarelli, L. Li, D. Pan, and B. A. Edgar. 2003. Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat. Cell Biol. 5:566-571.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 566-571
-
-
Saucedo, L.J.1
Gao, X.2
Chiarelli, D.A.3
Li, L.4
Pan, D.5
Edgar, B.A.6
-
211
-
-
0344063370
-
Will mTOR inhibitors make it as cancer drugs?
-
Sawyers, C. L. 2003. Will mTOR inhibitors make it as cancer drugs? Cancer Cell 4:343-348.
-
(2003)
Cancer Cell
, vol.4
, pp. 343-348
-
-
Sawyers, C.L.1
-
212
-
-
0037117409
-
Identification of a conserved motif required for mTOR signaling
-
Schalm, S. S., and J. Blenis. 2002. Identification of a conserved motif required for mTOR signaling. Curr. Biol. 12:632-639.
-
(2002)
Curr. Biol.
, vol.12
, pp. 632-639
-
-
Schalm, S.S.1
Blenis, J.2
-
213
-
-
0037718389
-
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
-
Schalm, S. S., D. C. Fingar, D. M. Sabatini, and J. Blenis. 2003. TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr. Biol. 13:797-806.
-
(2003)
Curr. Biol.
, vol.13
, pp. 797-806
-
-
Schalm, S.S.1
Fingar, D.C.2
Sabatini, D.M.3
Blenis, J.4
-
214
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzte, T., and M. N. Hall. 2000. TOR, a central controller of cell growth. Cell 103:253-262.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzte, T.1
Hall, M.N.2
-
215
-
-
0032403058
-
The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease
-
Schmidt, A., T. Beck, A. Koller, J. Kunz, and M. N. Hall. 1998. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J. 17:6924-6931.
-
(1998)
EMBO J.
, vol.17
, pp. 6924-6931
-
-
Schmidt, A.1
Beck, T.2
Koller, A.3
Kunz, J.4
Hall, M.N.5
-
216
-
-
0030906569
-
The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2
-
Schmidt, A., M. Bickle, T. Beck, and M. N. Hall. 1997. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88:531-542.
-
(1997)
Cell
, vol.88
, pp. 531-542
-
-
Schmidt, A.1
Bickle, M.2
Beck, T.3
Hall, M.N.4
-
217
-
-
0036644975
-
Guanine nucleotide exchange factors for Rho GTPases: Turning on the switch
-
Schmidt, A., and A. Hall. 2002. Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev. 16:1587-1609.
-
(2002)
Genes Dev.
, vol.16
, pp. 1587-1609
-
-
Schmidt, A.1
Hall, A.2
-
219
-
-
0030479340
-
TOR2 is required for organization of the actin cytoskeleton in yeast
-
Schmidt, A., J. Kunz, and M. N. Hall. 1996. TOR2 is required for organization of the actin cytoskeleton in yeast. Proc. Natl. Acad. Sci. USA 93:13780-13785.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13780-13785
-
-
Schmidt, A.1
Kunz, J.2
Hall, M.N.3
-
220
-
-
0033551378
-
The role of c-myc in cellular growth control
-
Schmidt, E. V. 1999. The role of c-myc in cellular growth control. Oncogene 18:2988-2996.
-
(1999)
Oncogene
, vol.18
, pp. 2988-2996
-
-
Schmidt, E.V.1
-
221
-
-
0032560521
-
Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
-
Scott, P. H., G. J. Brunn, A. D. Kohn, R. A. Roth, and J. C. Lawrence, Jr. 1998. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc. Natl. Acad. Sci. USA 95:7772-7777.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7772-7777
-
-
Scott, P.H.1
Brunn, G.J.2
Kohn, A.D.3
Roth, R.A.4
Lawrence Jr., J.C.5
-
222
-
-
0036200999
-
RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]
-
Sekito, T., Z. Liu, J. Thornton, and R. A. Butow. 2002. RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]. Mol. Biol. Cell 13:795-804.
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 795-804
-
-
Sekito, T.1
Liu, Z.2
Thornton, J.3
Butow, R.A.4
-
223
-
-
0034234924
-
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
-
Sekulic, A., C. C. Hudson, J. L. Homme, P. Yin, D. M. Otterness, L. M. Karnitz, and R. T. Abraham. 2000. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 60:3504-3513.
-
(2000)
Cancer Res.
, vol.60
, pp. 3504-3513
-
-
Sekulic, A.1
Hudson, C.C.2
Homme, J.L.3
Yin, P.4
Otterness, D.M.5
Karnitz, L.M.6
Abraham, R.T.7
-
224
-
-
4544343980
-
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
-
Shah, O. J., Z. Wang, and T. Hunter. 2004. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14:1650-1656.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1650-1656
-
-
Shah, O.J.1
Wang, Z.2
Hunter, T.3
-
225
-
-
0034649569
-
Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins
-
Shamji, A. F., F. G. Kuruvilla, and S. L. Schreiber. 2000. Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins. Curr. Biol. 10:1574-1581.
-
(2000)
Curr. Biol.
, vol.10
, pp. 1574-1581
-
-
Shamji, A.F.1
Kuruvilla, F.G.2
Schreiber, S.L.3
-
226
-
-
0141923009
-
Integration of growth factor and nutrient signaling: Implications for cancer biology
-
003
-
Shamji, A. F., P. Nghiem, and S. L. Schreiber. 003. Integration of growth factor and nutrient signaling: implications for cancer biology. Mol. Cell 12:271-280.
-
Mol. Cell
, vol.12
, pp. 271-280
-
-
Shamji, A.F.1
Nghiem, P.2
Schreiber, S.L.3
-
227
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
Shaw, R. J., N. Bardeesy, B. D. Manning, L. Lopez, M. Kosmatka, R. A. DePinho, and L. C. Cantley. 2004. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6:91-99.
-
(2004)
Cancer Cell
, vol.6
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
Depinho, R.A.6
Cantley, L.C.7
-
228
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw, R. J., M. Kosmatka, N. Bardeesy, R. L. Hurley, L. A. Witters, R. A. DePinho, and L. C. Cantley. 2004. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. USA 101:3329-3335.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
Depinho, R.A.6
Cantley, L.C.7
-
229
-
-
0028797745
-
Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: Evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase
-
Shepherd, P. R., B. T. Nave, and K. Siddle. 1995. Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase. Biochem. J.305:25-28.
-
(1995)
Biochem. J.
, vol.305
, pp. 25-28
-
-
Shepherd, P.R.1
Nave, B.T.2
Siddle, K.3
-
230
-
-
0033534734
-
Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells
-
Shigemitsu, K., Y. Tsujishita, K. Hara, M. Nanahoshi, J. Avruch, and K. Yonezawa. 1999. Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells. J. Biol. Chem. 274:1058-1065.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 1058-1065
-
-
Shigemitsu, K.1
Tsujishita, Y.2
Hara, K.3
Nanahoshi, M.4
Avruch, J.5
Yonezawa, K.6
-
231
-
-
0032538890
-
Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenorype and a new functional S6 kinase
-
Shima, H., M. Pende, Y. Chen, S. Fumagalli, G. Thomas, and S. C. Kozma. 1998. Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenorype and a new functional S6 kinase. EMBO J. 17:6649-6659.
-
(1998)
EMBO J.
, vol.17
, pp. 6649-6659
-
-
Shima, H.1
Pende, M.2
Chen, Y.3
Fumagalli, S.4
Thomas, G.5
Kozma, S.C.6
-
232
-
-
0022555872
-
Transcription of cloned eukaryotic ribosomal RNA genes
-
Sollner-Webb, B., and J. Tower. 1986. Transcription of cloned eukaryotic ribosomal RNA genes. Annu. Rev. Biochem. 55:801-830.
-
(1986)
Annu. Rev. Biochem.
, vol.55
, pp. 801-830
-
-
Sollner-Webb, B.1
Tower, J.2
-
233
-
-
0033962298
-
A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha
-
Sood, R., A. C. Porter, D. A. Olsen, D. R. Cavener, and R. C. Wek. 2000. A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics 154:787-801.
-
(2000)
Genetics
, vol.154
, pp. 787-801
-
-
Sood, R.1
Porter, A.C.2
Olsen, D.A.3
Cavener, D.R.4
Wek, R.C.5
-
234
-
-
0038304516
-
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
-
Stocker, H., T. Radimerski, B. Schindelholz, F. Wittwer, P. Belawat, P. Daram, S. Breuer, G. Thomas, and E. Hafen. 2003. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat. Cell Biol. 5:559-565.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 559-565
-
-
Stocker, H.1
Radimerski, T.2
Schindelholz, B.3
Wittwer, F.4
Belawat, P.5
Daram, P.6
Breuer, S.7
Thomas, G.8
Hafen, E.9
-
235
-
-
0036889291
-
Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation
-
Stolovich, M., H. Tang, E. Hornstein, G. Levy, R. Cohen, S. S. Bae, M. J. Birnbaum, and O. Meyuhas. 2002. Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation. Mol. Cell. Biol. 22:8101-8113.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 8101-8113
-
-
Stolovich, M.1
Tang, H.2
Hornstein, E.3
Levy, G.4
Cohen, R.5
Bae, S.S.6
Birnbaum, M.J.7
Meyuhas, O.8
-
237
-
-
0141925647
-
Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K
-
Tabancay, A. P., Jr., C. L. Gau, I. M. Machado, E. J. Uhlmann, D. H. Gutmann, L. Guo, and F. Tamanoi. 2003. Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. J. Biol. Chem. 278:39921-39930.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 39921-39930
-
-
Tabancay Jr., A.P.1
Gau, C.L.2
Machado, I.M.3
Uhlmann, E.J.4
Gutmann, D.H.5
Guo, L.6
Tamanoi, F.7
-
239
-
-
0034947869
-
Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin
-
Takano, A., I. Usui, T. Haruta, J. Kawahara, T. Uno, M. Iwata, and M. Kobayashi. 2001. Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol. Cell. Biol. 21:5050-5062.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5050-5062
-
-
Takano, A.1
Usui, I.2
Haruta, T.3
Kawahara, J.4
Uno, T.5
Iwata, M.6
Kobayashi, M.7
-
240
-
-
0035200856
-
Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation
-
Tang, H., E. Hornstein, M. Stolovich, G. Levy, M. Livingstone. D. Templeton, J. Avruch, and O. Meyuhas. 2001. Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation. Mol. Cell. Biol. 21:8671-8683.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 8671-8683
-
-
Tang, H.1
Hornstein, E.2
Stolovich, M.3
Levy, G.4
Livingstone, M.5
Templeton, D.6
Avruch, J.7
Meyuhas, O.8
-
241
-
-
0035805180
-
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
-
Tapon, N., N. Ito, B. J. Dickson, J. E. Treisman, and I. K. Hariharan. 2001. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105:345-355.
-
(2001)
Cell
, vol.105
, pp. 345-355
-
-
Tapon, N.1
Ito, N.2
Dickson, B.J.3
Treisman, J.E.4
Hariharan, I.K.5
-
242
-
-
0141733228
-
Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase (PI3K)/Akt-dependent and -independent phosphorylation of tuberin
-
Tee, A. R., R. Anjum, and J. Blenis. 2003. Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase (PI3K)/Akt-dependent and -independent phosphorylation of tuberin. J. Biol. Chem. 278:37288-37296.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 37288-37296
-
-
Tee, A.R.1
Anjum, R.2
Blenis, J.3
-
243
-
-
0037108750
-
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
-
Tee, A. R., D. C. Fingar, B. D. Manning, D. J. Kwiatkowski, L. C. Cantley, and J. Blenis. 2002. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc. Natl. Acad. Sci. USA 99:13571-13576.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 13571-13576
-
-
Tee, A.R.1
Fingar, D.C.2
Manning, B.D.3
Kwiatkowski, D.J.4
Cantley, L.C.5
Blenis, J.6
-
244
-
-
0042701991
-
Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
Tee, A. R., B. D. Manning, P. P. Roux, L. C. Cantley, and J. Blenis. 2003. Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 13:1259-1268.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
245
-
-
0036181011
-
Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif
-
Tee, A. R., and C. G. Proud. 2002. Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Mol. Cell. Biol. 22:1674-1683.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 1674-1683
-
-
Tee, A.R.1
Proud, C.G.2
-
246
-
-
0028032355
-
Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins
-
Terada, N., H. R. Patel, K. Takase, K. Kohno, A. C. Nairn, and E. W. Gelfand. 1994. Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc. Natl. Acad. Sci. USA 91:11477-11481.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 11477-11481
-
-
Terada, N.1
Patel, H.R.2
Takase, K.3
Kohno, K.4
Nairn, A.C.5
Gelfand, E.W.6
-
247
-
-
0036399363
-
The S6 kinase signaling pathway in the control of development and growth
-
Thomas, G. 2002. The S6 kinase signaling pathway in the control of development and growth. Biol. Res. 35:305-313.
-
(2002)
Biol. Res.
, vol.35
, pp. 305-313
-
-
Thomas, G.1
-
248
-
-
0037008770
-
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
-
Treins, C., S. Giorgetti-Peraldi, J. Murdaca, G. L. Semenza, and E. Van Obberghen. 2002. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J. Biol. Chem. 277:27975-27981.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 27975-27981
-
-
Treins, C.1
Giorgetti-Peraldi, S.2
Murdaca, J.3
Semenza, G.L.4
Van Obberghen, E.5
-
249
-
-
0345305803
-
Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR
-
Tsang, C. K., P. G. Bertram, W. Ai, R. Drenan, and X. F. Zheng. 2003. Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR. EMBO J. 22:6045-6056.
-
(2003)
EMBO J.
, vol.22
, pp. 6045-6056
-
-
Tsang, C.K.1
Bertram, P.G.2
Ai, W.3
Drenan, R.4
Zheng, X.F.5
-
250
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
Um, S. H., F. Frigerio, M. Watanabe, F. Picard, M. Joaquin, M. Sticker, S. Fumagalli, P. R. Allegrini, S. C. Kozma, J. Auwerx, and G. Thomas. 2004, Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431:200-205.
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
Picard, F.4
Joaquin, M.5
Sticker, M.6
Fumagalli, S.7
Allegrini, P.R.8
Kozma, S.C.9
Auwerx, J.10
Thomas, G.11
-
251
-
-
0034991191
-
Characterization of Rheb functions using yeast and mammalian systems
-
Urano, J., C. Ellis, G. J. Clark, and F. Tamanoi. 2001. Characterization of Rheb functions using yeast and mammalian systems. Methods Enzymol. 333:217-231.
-
(2001)
Methods Enzymol.
, vol.333
, pp. 217-231
-
-
Urano, J.1
Ellis, C.2
Clark, G.J.3
Tamanoi, F.4
-
252
-
-
0034646618
-
The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake
-
Urano, J., A. P. Tabancay, W. Yang, and F. Tamanoi. 2000. The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake. J. Biol. Chem. 275:11198-11206.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 11198-11206
-
-
Urano, J.1
Tabancay, A.P.2
Yang, W.3
Tamanoi, F.4
-
253
-
-
0034682970
-
Retinoblastoma protein phosphorylation via PI 3-kinase and mTOR pathway regulates adipocyte differentiation
-
Usui, I., T. Haruta, M. Iwata, A. Takano, T. Uno, J. Kawahara, E. Ueno, T. Sasaoka, and M. Kobayashi. 2000. Retinoblastoma protein phosphorylation via PI 3-kinase and mTOR pathway regulates adipocyte differentiation. Biochem. Biophys. Res. Commun. 275:115-120.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.275
, pp. 115-120
-
-
Usui, I.1
Haruta, T.2
Iwata, M.3
Takano, A.4
Uno, T.5
Kawahara, J.6
Ueno, E.7
Sasaoka, T.8
Kobayashi, M.9
-
254
-
-
0023217215
-
Isolation of the NPR1 gene responsible for the reactivation of ammonia-sensitive amino-acid permeases in Saccharomyces cerevisiae. RNA analysis and gene dosage effects
-
Vandenbol, M., J. C. Jauniaux, S. Vissers, and M. Grenson. 1987. Isolation of the NPR1 gene responsible for the reactivation of ammonia-sensitive amino-acid permeases in Saccharomyces cerevisiae. RNA analysis and gene dosage effects. Eur. J. Biochem. 164:607-612.
-
(1987)
Eur. J. Biochem.
, vol.164
, pp. 607-612
-
-
Vandenbol, M.1
Jauniaux, J.C.2
Vissers, S.3
Grenson, M.4
-
255
-
-
0035697321
-
14-3-3 Proteins are essential for regulation of RTG3-dependent transcription in Saccharomyces cerevisiae
-
van Heusden, G. P., and H. Y. Steensma. 2001. 14-3-3 Proteins are essential for regulation of RTG3-dependent transcription in Saccharomyces cerevisiae. Yeast 18:1479-1491.
-
(2001)
Yeast
, vol.18
, pp. 1479-1491
-
-
Van Heusden, G.P.1
Steensma, H.Y.2
-
256
-
-
1842424927
-
Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe
-
Van Slegtenhorst, M., E. Carr, R. Stoyanova, W. Kniger, and E. P. Henske. 2004. Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. J. Biol. Chem. 279:12706-12713.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 12706-12713
-
-
Van Slegtenhorst, M.1
Carr, E.2
Stoyanova, R.3
Kniger, W.4
Henske, E.P.5
-
257
-
-
0030879277
-
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
-
van Slegtenhorst, M., R. de Hoogt, C. Hermans, M. Nellist, B. Janssen, S. Verhoef, D. Lindhout, A. van den Ouweland, D. Halley, J. Young, M. Burley, S. Jeremiah, K. Woodward, J. Nahmias, M. Fox, R. Ekong, J. Osborne, J. Wolfe, S. Povey, R. G. Snell, J. P. Cheadle, A. C. Jones, M. Tachataki, D. Ravine, D. J. Kwiatkowski, et al. 1997. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 277:805-808.
-
(1997)
Science
, vol.277
, pp. 805-808
-
-
Van Slegtenhorst, M.1
De Hoogt, R.2
Hermans, C.3
Nellist, M.4
Janssen, B.5
Verhoef, S.6
Lindhout, D.7
Van Den Ouweland, A.8
Halley, D.9
Young, J.10
Burley, M.11
Jeremiah, S.12
Woodward, K.13
Nahmias, J.14
Fox, M.15
Ekong, R.16
Osborne, J.17
Wolfe, J.18
Povey, S.19
Snell, R.G.20
Cheadle, J.P.21
Jones, A.C.22
Tachataki, M.23
Ravine, D.24
Kwiatkowski, D.J.25
more..
-
258
-
-
7144255533
-
Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products
-
van Slegtenhorst, M., M. Nellist, B. Nagelkerken, J. Cheadle, R. Snell, A. van den Ouweland, A. Reuser, J. Sampson, D. Halley, and P. van der Sluijs. 1998. Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. Hum. Mol. Genet. 7:1053-1057.
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 1053-1057
-
-
Van Slegtenhorst, M.1
Nellist, M.2
Nagelkerken, B.3
Cheadle, J.4
Snell, R.5
Van Den Ouweland, A.6
Reuser, A.7
Sampson, J.8
Halley, D.9
Van Der Sluijs, P.10
-
259
-
-
0026646041
-
Inactivation of the protein phosphatase 2A regulatory subunit a results in morphological and transcriptional defects in Saccharomyces cerevisiae
-
van Zyl, W., W. Huang, A. A. Sneddon, M. Stark, S. Gamier, M. Werner, C. Marck, A. Sentenac, and J. R. Broach. 1992. Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae. Mol. Cell. Biol. 12:4946-4959.
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 4946-4959
-
-
Van Zyl, W.1
Huang, W.2
Sneddon, A.A.3
Stark, M.4
Gamier, S.5
Werner, M.6
Marck, C.7
Sentenac, A.8
Broach, J.R.9
-
260
-
-
0032528917
-
Amino acid availability regulates p70 S6 kinase and multiple translation factors
-
Wang, X., L. E. Campbell, C. M. Miller, and C. G. Proud. 1998. Amino acid availability regulates p70 S6 kinase and multiple translation factors. Biochem. J. 334:261-267.
-
(1998)
Biochem. J.
, vol.334
, pp. 261-267
-
-
Wang, X.1
Campbell, L.E.2
Miller, C.M.3
Proud, C.G.4
-
261
-
-
0037373346
-
The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation
-
Wang, X., W. Li, J. L. Parra, A. Beugnet, and C. G. Proud. 2003. The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. Mol. Cell. Biol. 23:1546-1557.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 1546-1557
-
-
Wang, X.1
Li, W.2
Parra, J.L.3
Beugnet, A.4
Proud, C.G.5
-
262
-
-
0033229970
-
The economics of ribosome biosynthesis in yeast
-
Warner, J. R. 1999. The economics of ribosome biosynthesis in yeast. Trends Biochem. Sci. 24:437-440.
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 437-440
-
-
Warner, J.R.1
-
263
-
-
0037345059
-
Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae
-
Wedaman, K. P., A. Reinke, S. Anderson, J. Yates III, J. M. McCaffery, and T. Powers. 2003. Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol. Biol. Cell 14:1204-1220.
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 1204-1220
-
-
Wedaman, K.P.1
Reinke, A.2
Anderson, S.3
Yates III, J.4
McCaffery, J.M.5
Powers, T.6
-
264
-
-
0024381444
-
Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability
-
Wek, R. C., B. M. Jackson, and A. G. Hinnebusch. 1989. Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability. Proc. Natl. Acad. Sci. USA 86:4579-4583.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 4579-4583
-
-
Wek, R.C.1
Jackson, B.M.2
Hinnebusch, A.G.3
-
265
-
-
0029117304
-
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
-
Wen, Z., Z. Zhong, and J. E. Darnell. Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241-250.
-
(1995)
Cell
, vol.82
, pp. 241-250
-
-
Wen, Z.1
Zhong, Z.2
Darnell Jr., J.E.3
-
266
-
-
0028939115
-
Multiple independent inputs are required for activation of the p70 S6 kinase
-
Weng, Q. P., K. Andrabi, M. T. Kozlowski, J. R. Grove, and J. Avruch. 1995. Multiple independent inputs are required for activation of the p70 S6 kinase. Mol. Cell. Biol. 15:2333-2340.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 2333-2340
-
-
Weng, Q.P.1
Andrabi, K.2
Kozlowski, M.T.3
Grove, J.R.4
Avruch, J.5
-
267
-
-
0029129557
-
Serine/threonine protein phosphatases
-
Wera, S., and B. A. Hemmings. 1995. Serine/threonine protein phosphatases. Biochem. J. 311:17-29.
-
(1995)
Biochem. J.
, vol.311
, pp. 17-29
-
-
Wera, S.1
Hemmings, B.A.2
-
268
-
-
0033517116
-
Sin1: An evolutionarily conserved component of the eukaryotic SAPK pathway
-
Wilkinson, M. G., T. S. Pino, S. Tournier, V. Buck, H. Martin, J. Christiansen, D. G. Wilkinson, and J. B. Millar. 1999. Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway. EMBO J. 18:4210-4221.
-
(1999)
EMBO J.
, vol.18
, pp. 4210-4221
-
-
Wilkinson, M.G.1
Pino, T.S.2
Tournier, S.3
Buck, V.4
Martin, H.5
Christiansen, J.6
Wilkinson, D.G.7
Millar, J.B.8
-
269
-
-
10744230065
-
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
-
Woods, A., S. R. Johnstone, K. Dickerson, F. C. Leiper, L. G. Fryer, D. Neumann, U. Schlattner, T. Wallimann, M. Carlson, and D. Carling. 2003. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol. 13:2004-2008.
-
(2003)
Curr. Biol.
, vol.13
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.5
Neumann, D.6
Schlattner, U.7
Wallimann, T.8
Carlson, M.9
Carling, D.10
-
270
-
-
0025253274
-
Subunits shared by eukaryotic nuclear RNA polymerases
-
Woychik, N. A., S. M. Liao, P. A. Kolodziej, and R. A. Young. 1990. Subunits shared by eukaryotic nuclear RNA polymerases. Genes Dev. 4:313-323.
-
(1990)
Genes Dev.
, vol.4
, pp. 313-323
-
-
Woychik, N.A.1
Liao, S.M.2
Kolodziej, P.A.3
Young, R.A.4
-
271
-
-
0032561348
-
Branched-chain amino acids are essential in the regulation of PHAS-1 and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling
-
Xu, G., G. Kwon, C. A. Marshall, T. A. Lin, J. C. Lawrence, Jr., and M. L. McDaniel. 1998. Branched-chain amino acids are essential in the regulation of PHAS-1 and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling. J. Biol. Chem. 273:28178-28184.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 28178-28184
-
-
Xu, G.1
Kwon, G.2
Marshall, C.A.3
Lin, T.A.4
Lawrence Jr., J.C.5
McDaniel, M.L.6
-
272
-
-
0028237671
-
rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein
-
Yamagata, K., L. K. Sanders, W. E. Kaufmann, W. Yee, C. A. Barnes, D. Nathans, and P. F. Worley. 1994. rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. J. Biol. Chem. 269:16333-16339.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 16333-16339
-
-
Yamagata, K.1
Sanders, L.K.2
Kaufmann, W.E.3
Yee, W.4
Barnes, C.A.5
Nathans, D.6
Worley, P.F.7
-
273
-
-
0034797345
-
Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant
-
Yang, W., A. P. Tabancay, Jr., J. Urano, and F. Tamanoi. 2001. Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant. Mol. Microbiol. 41:1339-1347.
-
(2001)
Mol. Microbiol.
, vol.41
, pp. 1339-1347
-
-
Yang, W.1
Tabancay Jr., A.P.2
Urano, J.3
Tamanoi, F.4
-
274
-
-
0031039427
-
Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals
-
Yee, W. M., and P. F. Worley. 1997. Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals. Mol. Cell. Biol. 17:921-933.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 921-933
-
-
Yee, W.M.1
Worley, P.F.2
-
275
-
-
0033968596
-
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
-
Yokogami, K., S. Wakisaka, J. Avruch, and S. A. Reeves. 2000. Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr. Biol. 10:47-50.
-
(2000)
Curr. Biol.
, vol.10
, pp. 47-50
-
-
Yokogami, K.1
Wakisaka, S.2
Avruch, J.3
Reeves, S.A.4
-
276
-
-
0034790016
-
mTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
-
Yu, K., L. Toral-Barza, C. Discafani, W. G. Zhang, J. Skotnicki, P. Frost, and J. J. Gibbons. 2001. mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr. Relat. Cancer 8:249-258.
-
(2001)
Endocr. Relat. Cancer
, vol.8
, pp. 249-258
-
-
Yu, K.1
Toral-Barza, L.2
Discafani, C.3
Zhang, W.G.4
Skotnicki, J.5
Frost, P.6
Gibbons, J.J.7
-
278
-
-
0029898894
-
Protein prenylation: Molecular mechanisms and functional consequences
-
Zhang, F. L., and P. J. Casey. 1996. Protein prenylation: molecular mechanisms and functional consequences. Annu. Rev. Biochem. 65:241-269.
-
(1996)
Annu. Rev. Biochem.
, vol.65
, pp. 241-269
-
-
Zhang, F.L.1
Casey, P.J.2
-
279
-
-
0034312315
-
Regulation of cellular growth by the Drosophila target of rapamycin dTOR
-
Zhang, H., J. P. Stallock, J. C. Ng, C. Reinhard, and T. P. Neufeld. 2000. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev. 14:2712-2724.
-
(2000)
Genes Dev.
, vol.14
, pp. 2712-2724
-
-
Zhang, H.1
Stallock, J.P.2
Ng, J.C.3
Reinhard, C.4
Neufeld, T.P.5
-
280
-
-
0038141979
-
Rheb is a direct target of the tuberous sclerosis tumor suppressor proteins
-
Zhang, Y., X. Gao, L. J. Saucedo, B. Ru, B. A. Edgar, and D. Pan. 2003. Rheb is a direct target of the tuberous sclerosis tumor suppressor proteins. Nat. Cell Biol. 5:578-581.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 578-581
-
-
Zhang, Y.1
Gao, X.2
Saucedo, L.J.3
Ru, B.4
Edgar, B.A.5
Pan, D.6
|