A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling

Biochemical Pharmacology

Volumn 64, Issue 7, 2002, Pages 1071-1077

  Chen, Jie ^a   Fang, Yimin ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Mammalian target of rapamycin (mTOR); Phosphatidic acid; Phosphatidylinositol 3 kinase (PI3K); Phospholipase D (PLD); Rapamycin

Indexed keywords

ANTINEOPLASTIC AGENT; ARF PROTEIN; CALCIUM ION; CELL PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDIC ACID; PHOSPHOLIPASE D; PROTEIN KINASE C; RAPAMYCIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

DRUG INHIBITION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG TARGETING; ENZYME ACTIVITY; HUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

EID: 0036776168     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01263-7     Document Type: Note

References (67)

1. Serruys P.W., Regar E., Carter A.J. Rapamycin eluting stent: the onset of a new era in interventional cardiology. Heart. 87:2002;305-307.
2. Vogt P.K. PI 3-kinase, mTOR, protein synthesis and cancer. Trends Mol. Med. 7:2001;482-484.
3. Hidalgo M., Rowinsky E.K. The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene. 19:2000;6680-6686.
4. Cafferkey R., Young P.R., McLaughlin M.M., Bergsma D.J., Koltin Y., Sathe G.M., Faucette L., Eng W.K., Johnson R.K., Livi G.P. Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. Mol. Cell. Biol. 13:1993;6012-6023.
5. Helliwell S.B., Wagner P., Kunz J., Deuter-Reinhard M., Henriquez R., Hall M.N. TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol. Biol. Cell. 5:1994;105-118.
6. 1 progression. Cell. 73:1993;585-596.
7. Oldham S., Montagne J., Radimerski T., Thomas G., Hafen E. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev. 14:2000;2689-2694.
8. Zhang H., Stallock J.P., Ng J.C., Reinhard C., Neufeld T.P. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev. 14:2000;2712-2724.
9. Brown E.J., Albers M.W., Shin T.B., Ichikawa K., Keith C.T., Lane W.S., Schreiber S.L. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature. 369:1994;756-758.
10. Sabatini D.M., Erdjument-Bromage H., Lui M., Tempst P., Snyder S.H. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell. 78:1994;35-43.
11. Sabers C.J., Martin M.M., Brunn G.J., Williams J.M., Dumont F.J., Wiederrecht G., Abraham R.T. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J. Biol. Chem. 270:1995;815-822.
12. Chiu M.I., Katz H., Berlin V. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc. Natl. Acad. Sci. U.S.A. 91:1994;12574-12578.
13. Keith C.T., Schreiber S.L. PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science. 270:1995;50-51.
14. Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell. 103:2000;253-262.
15. Gingras A.C., Raught B., Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15:2001;807-826.
16. Jefferies H.B., Reinhard C., Kozma S.C., Thomas G. Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Proc. Natl. Acad. Sci. U.S.A. 91:1994;4441-4445.
17. Terada N., Patel H.R., Takase K., Kohno K., Nairn A.C., Gelfand E.W. Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc. Natl. Acad. Sci. U.S.A. 91:1994;11477-11481.
18. Terada N., Takase K., Papst P., Nairn A.C., Gelfand E.W. Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes. J. Immunol. 155:1995;3418-3426.
19. Fumagalli S, Thomas G. S6 phosphorylation and signal transduction. In: Sonenberg N, Hershey JWB, Mathews MB, editors. Translational Control of Gene Expression. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2000. p. 695-718.
20. Gingras A.C., Raught B., Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68:1999;913-963.
21. Brown E.J., Beal P.A., Keith C.T., Chen J., Shin T.B., Schreiber S.L. Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature. 377:1995;441-446.
22. Brunn G.J., Hudson C.C., Sekulic A., Williams J.M., Hosoi H., Houghton P.J., Lawrence J.C. Jr., Abraham R.T. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science. 277:1997;99-101.
23. Hara K., Yonezawa K., Weng Q.-P., Kozlowski M.T., Belham C., Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J. Biol. Chem. 273:1998;14484-14494.
24. s6k. Involvement of tRNA aminoacylation in the regulation. J. Biol. Chem. 274:1999;1092-1099.
25. Xu G., Kwon G., Marshall C.A., Lin T.-A., Lawrence J.C. Jr., McDaniel M.L. Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic β-cells. A possible role in protein translation and mitogenic signaling. J. Biol. Chem. 273:1998;28178-28184.
26. Dennis P.B., Jaeschke A., Saitoh M., Fowler B., Kozma S.C., Thomas G. Mammalian TOR: a homeostatic ATP sensor. Science. 294:2001;1102-1105.
27. Burnett P.E., Barrow R.K., Cohen N.A., Snyder S.H., Sabatini D.M. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. U.S.A. 95:1998;1432-1437.
28. Scott P.H., Brunn G.J., Kohn A.D., Roth R.A., Lawrence J.C. Jr. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc. Natl. Acad. Sci. U.S.A. 95:1998;7772-7777.
29. Navé B.T., Ouwens M., Withers D.J., Alessi D.R., Shepherd P.R. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem. J. 344:1999;427-431.
30. Sekulic A., Hudson C.C., Homme J.L., Yin P., Otterness D.M., Karnitz L.M., Abraham R.T. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 60:2000;3504-3513.
31. Weng Q.P., Andrabi K., Kozlowski M.T., Grove J.R., Avruch J. Multiple independent inputs are required for activation of the p70 S6 kinase. Mol. Cell. Biol. 15:1995;2333-2340.
32. Fang Y., Vilella-Bach M., Bachmann R., Flanigan A., Chen J. Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science. 294:2001;1942-1945.
33. English D., Cui Y., Siddiqui R.A. Messenger functions of phosphatidic acid. Chem. Phys. Lipids. 80:1996;117-132.
34. Exton J.H. Regulation of phospholipase D. Biochim. Biophys. Acta. 1439:1999;121-133.
35. Yang S.F., Freer S., Benson A.A. Transphosphatidylation by phospholipase D. J. Biol. Chem. 242:1967;477-484.
36. Willard F.S., Berven L.A., Crouch M.F. Lysophosphatidic acid activates the 70-kDa S6 kinase via the lipoxygenase pathway. Biochem. Biophys. Res. Commun. 287:2001;607-613.
37. Park I, Bachmann R, Shirazi H, Chen J. Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin. J Biol Chem, in press.
38. Chen J., Zheng X.F., Brown E.J., Schreiber S.L. Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc. Natl. Acad. Sci. U.S.A. 92:1995;4947-4951.
39. 1 progression. J. Biol. Chem. 274:1999;4266-4272.
40. Choi J., Chen J., Schreiber S.L., Clardy J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science. 273:1996;239-242.
41. Segrest J.P., Jones M.K., De Loof H., Brouillette C.G., Venkatachalapathi Y.V., Anantharamaiah G.M. The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function. J. Lipid Res. 33:1992;141-166.
42. Desai B.N., Myers B.R., Schreiber S.L. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc. Natl. Acad. Sci. U.S.A. 99:2002;4319-4324.
43. Sabatini D.M., Barrow R.K., Blackshaw S., Burnett P.E., Lai M.M., Field M.E., Bahr B.A., Kirsch J., Betz H., Snyder S.H. Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling. Science. 284:1999;1161-1164.
44. Withers D.J., Ouwens D.M., Nave B.T., van der Zon G.C., Alarcon C.M., Cardenas M.E., Heitman J., Maassen J.A., Shepherd P.R. Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells. Biochem. Biophys. Res. Commun. 241:1997;704-709.
45. Kunz J., Schneider U., Howald I., Schmidt A., Hall M.N. HEAT repeats mediate plasma membrane localization of Tor2p in yeast. J. Biol. Chem. 275:2000;37011-37020.
46. Schmidt A., Kunz J., Hall M.N. TOR2 is required for organization of the actin cytoskeleton in yeast. Proc. Natl. Acad. Sci. U.S.A. 93:1996;13780-13785.
47. Zheng X.F., Florentino D., Chen J., Crabtree G.R., Schreiber S.L. TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell. 82:1995;121-130.
48. Erbay E., Chen J. The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism. J. Biol. Chem. 276:2001;36079-36082.
49. Frohman M.A., Sung T.C., Morris A.J. Mammalian phospholipase D structure and regulation. Biochim. Biophys. Acta. 1439:1999;175-186.
50. Meier K.E., Gibbs T.C., Knoepp S.M., Ella K.M. Expression of phospholipase D isoforms in mammalian cells. Biochim. Biophys. Acta. 1439:1999;199-213.
51. Sung T.C., Roper R.L., Zhang Y., Rudge S.A., Temel R., Hammond S.M., Morris A.J., Moss B., Engebrecht J., Frohman M.A. Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. EMBO J. 16:1997;4519-4530.
52. Chung J., Kuo C.J., Crabtree G.R., Blenis J. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kDa S6 protein kinases. Cell. 69:1992;1227-1236.
53. Chou M.M., Blenis J. The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. Cell. 85:1996;573-583.
54. Alessi D.R., Kozlowski M.T., Weng Q.-P., Morrice N., Avruch J. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr. Biol. 8:1998;69-81.
55. Peterson R.T., Schreiber S.L. Translation control: connecting mitogens and the ribosome. Curr. Biol. 8:1998;R248-R250.
56. Houle M.G., Bourgoin S. Regulation of phospholipase D by phosphorylation-dependent mechanisms. Biochim. Biophys. Acta. 1439:1999;135-149.
57. Du G., Altshuller Y.M., Kim Y., Han J.M., Ryu S.H., Morris A.J., Frohman M.A. Dual requirement for rho and protein kinase C in direct activation of phospholipase D1 through G protein-coupled receptor signaling. Mol. Biol. Cell. 11:2000;4359-4368.
58. Zhang Y., Altshuller Y.M., Hammond S.M., Hayes F., Morris A.J., Frohman M.A. Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C. EMBO J. 18:1999;6339-6348.
59. Graves L.M., He Y., Lambert J., Hunter D., Li X., Earp H.S. An intracellular calcium signal activates p70 but not p90 ribosomal S6 kinase in liver epithelial cells. J. Biol. Chem. 272:1997;1920-1928.
60. Buckland A.G., Wilton D.C. Anionic phospholipids, interfacial binding and the regulation of cell functions. Biochim. Biophys. Acta. 1483:2000;199-216.
61. 2+ interaction, or an allosteric effect? J. Biol. Chem. 273:1998;12195-12202.
62. van Blitterswijk W.J., Houssa B. Properties and functions of diacylglycerol kinases. Cell Signal. 12:2000;595-605.
63. Leung D.W. The structure and functions of human lysophosphatidic acid acyltransferases. Front. Biosci. 6:2001;D944-D953.
64. Blume-Jensen P., Hunter T. Oncogenic kinase signalling. Nature. 411:2001;355-365.
65. Aoki M., Blazek E., Vogt P.K. A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. Proc. Natl. Acad. Sci. U.S.A. 98:2001;136-141.
66. Neshat M.S., Mellinghoff I.K., Tran C., Stiles B., Thomas G., Petersen R., Frost P., Gibbons J.J., Wu H., Sawyers C.L. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc. Natl. Acad. Sci. U.S.A. 98:2001;10314-10319.
67. +/- mice. Proc. Natl. Acad. Sci. U.S.A. 98:2001;10320-10325.