Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K

Journal of Biological Chemistry

Volumn 278, Issue 41, 2003, Pages 39921-39930

  Tabancay Jr , Angel P ^a   Gau, Chia Ling ^a   Machado, Iara M P ^a,c   Uhlmann, Erik J ^b   Gutmann, David H ^b   Guo, Lea ^a   Tamanoi, Fuyuhiko ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL CULTURE; GENES; GROWTH KINETICS; MUTAGENESIS; PROTEINS;

MAMMALIAN CELLS;

BIOCHEMISTRY;

AMINO ACID; ASPARTIC ACID; FUNGAL PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; MUTANT PROTEIN; PEPTIDE LIBRARY; RAS PROTEIN; RHEB PROTEIN; RHEB1D60K PROTEIN; RHEBD60V PROTEIN; S6 KINASE; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL GROWTH; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVATION; FNX1 GENE; FUNGAL GENE; GENE EXPRESSION; GENE INDUCTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RHEB1 GENE; RHEB2 GENE; SCHIZOSACCHAROMYCES POMBE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; DROSOPHILA PROTEINS; ENZYME ACTIVATION; HUMANS; MOLECULAR SEQUENCE DATA; MONOMERIC GTP-BINDING PROTEINS; MUTAGENESIS; MUTATION; NEUROPEPTIDES; PROTEIN KINASES; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

ANIMALIA; MAMMALIA; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE; TOR;

EID: 0141925647     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306553200     Document Type: Article

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