The TOR signalling pathway controls nuclear localization of nutrient- regulated transcription factors

Nature

Volumn 402, Issue 6762, 1999, Pages 689-692

  Beck, Thomas ^a   Hall, Michael N ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; CELL GROWTH; GENETIC TRANSCRIPTION; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SYNTHESIS; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION;

14-3-3 PROTEINS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL NUCLEUS; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; FUNGAL PROTEINS; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; NITROGEN; ORGANIC ANION TRANSPORTERS; PRIONS; PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TYROSINE 3-MONOOXYGENASE;

EID: 0033540030     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/45287     Document Type: Article

References (25)

1. Thomas, G. & Hall, M. N. TOR signalling and control of cell growth. Curr. Opin. Cell Biol. 9, 782-787 (1997).
2. Barbet, N. C. et al. TOR controls translation initiation and early G1 progression in yeast. Mol. Biol. Cell 7, 25-42 (1996).
3. Noda, T. & Ohsumi, Y. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J. Biol. Chem. 273, 3963-3966 (1998).
4. Beck, T., Schmidt, A. & Hall, M. N. Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast. J. Cell Biol. 146, 1227-1237 (1999).
5. Dennis, P. B., Fumagalli, S. & Thomas, G. Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation. Curr. Opin. Genet. Dev. 9, 49-54 (1999).
6. Di Como, C. J. & Arndt, K. T. Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev. 10, 1904-1916 (1996).
7. Schmidt, A., Beck, T., Koller, A., Kunz, J. & Hall, M. N. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J. 17, 6924-6931 (1998).
8. Jiang, Y. & Broach, J. R. Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J. 18, 2782-2792 (1999).
9. Marzluf, G. A. Genetic regulation of nitrogen metabolism in the fungi. Microbiol. Mol. Biol. Rev. 61, 17-32 (1997).
10. Marini, A. M., Soussi-Boudekou, S., Vissers, S. & Andre, B. A family of ammonium transporters in Saccharomyces cerevisiae. Mol. Cell. Biol. 17, 4282-4293 (1997).
11. Magasanik, B. in The Molecular and Cellular Biology of the Yeast Saccharomyces (eds Jones, E. W., Pringe, J. R. & Broach, J. R.) 283-317 (Cold Spring Harbor Laboratory Press, New York, 1992).
12. Blinder, D., Coschigano, P. W. & Magasanik, B. Interaction of the GATA factor Gln3p with the nitrogen regulator Ure2p in Saccharomyces cerevisiae. J. Bacteriol. 178, 4734-4736 (1996).
13. Coschigano, P. W. & Magasanik, B. The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione S-transferases. Mol. Cell. Biol. 11, 822-832 (1991).
14. Heitman, J., Movva, N. R. & Hall, M. N. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253, 905-909 (1991).
15. Smith, A., Ward, M. P. & Garrett, S. Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation. EMBO J. 17, 3556-3564 (1998).
16. Gorner, W. et al. Nuclear localization of the C2H2 zinc finger protein MsN2p is regulated by stress and protein kinase A activity. Genes Dev. 12, 586-597 (1998).
17. Boy-Marcotte, E., Perrot, M., Bussereau, F., Boucherie, H. & Jacquet, M. Msn2p and Msn4p control a large number of genes induced at the diauxic transition which are repressed by cyclic AMP in Saccharomyces cerevisiae. J. Bacteriol. 180, 1044-1052 (1998).
18. Brunet, A. et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868 (1999).
19. Bertram, P. G., Zeng, C., Thorson, J., Shaw, A. S. & Zheng, X. F. The 14-3-3 proteins positively regulate rapamycin-sensitive signaling. Curr. Biol. 8, 1259-1267 (1998).
20. Kops, G. J. et al. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398, 630-634 (1999).
21. Hara, K. et al. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J. Biol. Chem. 273, 14484-14494 (1998); erratum, 22160 (1998).
22. Wach, A., Brachat, A., Pohlmann, R. & Philippsen, P. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10, 1793-1808 (1994).
23. Longtine, M. S. et al. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14, 953-961 (1998).
24. Sherman, F. in Guide to Yeast Genetics and Molecular Biology (eds Guthrie, C. & Fink, G. R.) 3-21 (Academic, San Diego, 1991).
25. Ausubel, F. M. et al. (eds) Current Protocols in Molecular Biology (John Wiley & Sons, New York, 1998).