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Volumn 29, Issue 1, 2004, Pages 18-24

The AMP-activated protein kinase cascade - A unifying system for energy control

Author keywords

[No Author keywords available]

Indexed keywords

(HYDROXYMETHYLGLUTARYL COA REDUCTASE (NADPH)) KINASE; (HYDROXYMETHYLGLUTARYL-COA REDUCTASE (NADPH)) KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; MULTIENZYME COMPLEX; PROTEIN KINASE; PROTEIN KINASE LKB1; PROTEIN SERINE THREONINE KINASE; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

EID: 0347318052     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2003.11.005     Document Type: Review
Times cited : (995)

References (62)
  • 1
    • 0024546378 scopus 로고
    • The AMP-activated protein kinase-a multisubstrate regulator of lipid metabolism
    • Hardie D.G., et al. The AMP-activated protein kinase-a multisubstrate regulator of lipid metabolism. Trends Biochem. Sci. 14:1989;20-23.
    • (1989) Trends Biochem. Sci. , vol.14 , pp. 20-23
    • Hardie, D.G.1
  • 2
    • 0031007065 scopus 로고    scopus 로고
    • The AMP-activated protein kinase: Fuel gauge of the mammalian cell
    • Hardie D.G., Carling D. The AMP-activated protein kinase: fuel gauge of the mammalian cell. Eur. J. Biochem. 246:1997;259-273.
    • (1997) Eur. J. Biochem. , vol.246 , pp. 259-273
    • Hardie, D.G.1    Carling, D.2
  • 3
    • 0031717105 scopus 로고    scopus 로고
    • The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
    • Hardie D.G., et al. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem. 67:1998;821-855.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 821-855
    • Hardie, D.G.1
  • 4
    • 0038199737 scopus 로고    scopus 로고
    • Management of cellular energy by the AMP-activated protein kinase system
    • Hardie D.G., et al. Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett. 546:2003;113-120.
    • (2003) FEBS Lett. , vol.546 , pp. 113-120
    • Hardie, D.G.1
  • 5
    • 0028406897 scopus 로고
    • Role of the AMP-activated protein kinase in the cellular stress response
    • Corton J.M., et al. Role of the AMP-activated protein kinase in the cellular stress response. Curr. Biol. 4:1994;315-324.
    • (1994) Curr. Biol. , vol.4 , pp. 315-324
    • Corton, J.M.1
  • 6
    • 0032973130 scopus 로고    scopus 로고
    • Dealing with energy demand: The AMP-activated protein kinase
    • Kemp B.E., et al. Dealing with energy demand: the AMP-activated protein kinase. Trends Biochem. Sci. 24:1999;22-25.
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 22-25
    • Kemp, B.E.1
  • 7
    • 0032511053 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes
    • Foretz M., et al. AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes. J. Biol. Chem. 273:1998;14767-14771.
    • (1998) J. Biol. Chem. , vol.273 , pp. 14767-14771
    • Foretz, M.1
  • 8
    • 0032541083 scopus 로고    scopus 로고
    • The AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex
    • Leclerc I., et al. The AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex. FEBS Lett. 431:1998;180-184.
    • (1998) FEBS Lett. , vol.431 , pp. 180-184
    • Leclerc, I.1
  • 9
    • 0035914324 scopus 로고    scopus 로고
    • Regulation of transcription by AMP-activated protein kinase
    • Yang W., et al. Regulation of transcription by AMP-activated protein kinase. J. Biol. Chem. 276:2001;38341-38344.
    • (2001) J. Biol. Chem. , vol.276 , pp. 38341-38344
    • Yang, W.1
  • 10
    • 0033949848 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
    • Winder W., et al. Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle. J. Appl. Physiol. 88:2000;2219-2226.
    • (2000) J. Appl. Physiol. , vol.88 , pp. 2219-2226
    • Winder, W.1
  • 11
    • 0036535031 scopus 로고    scopus 로고
    • Characterisation of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle
    • Fryer L.G.D., et al. Characterisation of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle. Biochem. J. 363:2002;167-174.
    • (2002) Biochem. J. , vol.363 , pp. 167-174
    • Fryer, L.G.D.1
  • 12
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct pathways
    • Fryer L.G.D., et al. The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct pathways. J. Biol. Chem. 277:2002;25226-25232.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25226-25232
    • Fryer, L.G.D.1
  • 13
    • 0036324142 scopus 로고    scopus 로고
    • The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
    • Hawley S.A., et al. The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes. 51:2002;2420-2425.
    • (2002) Diabetes , vol.51 , pp. 2420-2425
    • Hawley, S.A.1
  • 14
    • 0031425839 scopus 로고    scopus 로고
    • AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
    • Merrill G.F., et al. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am. J. Physiol. 273:1997;E1107-E1112.
    • (1997) Am. J. Physiol. , vol.273
    • Merrill, G.F.1
  • 15
    • 0031849916 scopus 로고    scopus 로고
    • Evidence for AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
    • Hayashi T., et al. Evidence for AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes. 47:1998;1369-1373.
    • (1998) Diabetes , vol.47 , pp. 1369-1373
    • Hayashi, T.1
  • 16
    • 0035947235 scopus 로고    scopus 로고
    • A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle
    • Mu J., et al. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol. Cell. 7:2001;1085-1094.
    • (2001) Mol. Cell. , vol.7 , pp. 1085-1094
    • Mu, J.1
  • 18
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7:2001;941-946.
    • (2001) Nat. Med. , vol.7 , pp. 941-946
    • Yamauchi, T.1
  • 19
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty acid oxidation by activating AMP-activated protein kinase
    • Minokoshi Y., et al. Leptin stimulates fatty acid oxidation by activating AMP-activated protein kinase. Nature. 415:2002;339-343.
    • (2002) Nature , vol.415 , pp. 339-343
    • Minokoshi, Y.1
  • 20
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi T., et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8:2002;1288-1295.
    • (2002) Nat. Med. , vol.8 , pp. 1288-1295
    • Yamauchi, T.1
  • 21
    • 0141905919 scopus 로고    scopus 로고
    • Roles of 5′AMP-activated protein kinase in mammalian glucose homeostasis
    • Rutter G.A., et al. Roles of 5′AMP-activated protein kinase in mammalian glucose homeostasis. Biochem. J. 375:2003;1-16.
    • (2003) Biochem. J. , vol.375 , pp. 1-16
    • Rutter, G.A.1
  • 22
    • 0037251455 scopus 로고    scopus 로고
    • The AMP-activated protein kinase α2 catalytic subunit controls whole body insulin sensitivity
    • Viollet B., et al. The AMP-activated protein kinase α2 catalytic subunit controls whole body insulin sensitivity. J. Clin. Invest. 111:2003;91-98.
    • (2003) J. Clin. Invest. , vol.111 , pp. 91-98
    • Viollet, B.1
  • 23
    • 0033118209 scopus 로고    scopus 로고
    • Glucose repression in yeast
    • Carlson M. Glucose repression in yeast. Curr. Opin. Microbiol. 2:1999;202-207.
    • (1999) Curr. Opin. Microbiol. , vol.2 , pp. 202-207
    • Carlson, M.1
  • 24
    • 0023885305 scopus 로고
    • The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains
    • Hanks S.K., et al. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science. 241:1988;42-52.
    • (1988) Science , vol.241 , pp. 42-52
    • Hanks, S.K.1
  • 25
    • 0032567252 scopus 로고    scopus 로고
    • Functional domains of the α1 catalytic subunit of the AMP-activated protein kinase
    • Crute B.E., et al. Functional domains of the α1 catalytic subunit of the AMP-activated protein kinase. J. Biol. Chem. 273:1998;35347-35354.
    • (1998) J. Biol. Chem. , vol.273 , pp. 35347-35354
    • Crute, B.E.1
  • 26
    • 0029925785 scopus 로고    scopus 로고
    • Characterization of AMP-activated protein kinase β subunit and γ subunit - Assembly of the heterotrimeric complex in vitro
    • Woods A., et al. Characterization of AMP-activated protein kinase β subunit and γ subunit - assembly of the heterotrimeric complex in vitro. J. Biol. Chem. 271:1996;10282-10290.
    • (1996) J. Biol. Chem. , vol.271 , pp. 10282-10290
    • Woods, A.1
  • 27
    • 0038814313 scopus 로고    scopus 로고
    • A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias
    • Hudson E.R., et al. A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias. Curr. Biol. 13:2003;861-866.
    • (2003) Curr. Biol. , vol.13 , pp. 861-866
    • Hudson, E.R.1
  • 28
    • 0037799908 scopus 로고    scopus 로고
    • AMPK β subunit targets metabolic stress sensing to glycogen
    • Polekhina G., et al. AMPK β subunit targets metabolic stress sensing to glycogen. Curr. Biol. 13:2003;867-871.
    • (2003) Curr. Biol. , vol.13 , pp. 867-871
    • Polekhina, G.1
  • 29
    • 0024335432 scopus 로고
    • The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase
    • Carling D., Hardie D.G. The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase. Biochim. Biophys. Acta. 1012:1989;81-86.
    • (1989) Biochim. Biophys. Acta , vol.1012 , pp. 81-86
    • Carling, D.1    Hardie, D.G.2
  • 30
    • 0036064261 scopus 로고    scopus 로고
    • Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle
    • Wojtaszewski J.F.P., et al. Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle. Diabetes. 51:2002;284-292.
    • (2002) Diabetes , vol.51 , pp. 284-292
    • Wojtaszewski, J.F.P.1
  • 31
    • 0031016272 scopus 로고    scopus 로고
    • The structure of a domain common to archaebacteria and the homocystinuria disease protein
    • Bateman A. The structure of a domain common to archaebacteria and the homocystinuria disease protein. Trends Biochem. Sci. 22:1997;12-13.
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 12-13
    • Bateman, A.1
  • 32
    • 0034654362 scopus 로고    scopus 로고
    • Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
    • Cheung P.C.F., et al. Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding. Biochem. J. 346:2000;659-669.
    • (2000) Biochem. J. , vol.346 , pp. 659-669
    • Cheung, P.C.F.1
  • 33
    • 0037328991 scopus 로고    scopus 로고
    • Identification and characterization of AMPK γ3 mutations in the pig
    • Andersson L. Identification and characterization of AMPK γ3 mutations in the pig. Biochem. Soc. Trans. 31:2003;232-235.
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 232-235
    • Andersson, L.1
  • 34
    • 0034685949 scopus 로고    scopus 로고
    • A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle
    • Milan D., et al. A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle. Science. 288:2000;1248-1251.
    • (2000) Science , vol.288 , pp. 1248-1251
    • Milan, D.1
  • 35
    • 0035872209 scopus 로고    scopus 로고
    • Mutations in the γ2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: Evidence for the central role of energy compromise in disease pathogenesis
    • Blair E., et al. Mutations in the γ2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis. Hum. Mol. Genet. 10:2001;1215-1220.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1215-1220
    • Blair, E.1
  • 36
    • 0035859215 scopus 로고    scopus 로고
    • Identification of a gene responsible for familial Wolff-Parkinson-White syndrome
    • Gollob M.H., et al. Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. N. Engl. J. Med. 344:2001;1823-1831.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1823-1831
    • Gollob, M.H.1
  • 37
    • 0035910109 scopus 로고    scopus 로고
    • Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophy
    • Gollob M.H., et al. Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophy. Circulation. 104:2001;3030-3033.
    • (2001) Circulation , vol.104 , pp. 3030-3033
    • Gollob, M.H.1
  • 38
    • 0036167225 scopus 로고    scopus 로고
    • Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy
    • Arad M., et al. Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy. J. Clin. Invest. 109:2002;357-362.
    • (2002) J. Clin. Invest. , vol.109 , pp. 357-362
    • Arad, M.1
  • 39
    • 0034541333 scopus 로고    scopus 로고
    • Molecular cloning, genomic organization, and mapping of PRKAG2, a heart abundant γ2 subunit of 5′-AMP-activated protein kinase, to chromosome 7q36
    • Lang T., et al. Molecular cloning, genomic organization, and mapping of PRKAG2, a heart abundant γ2 subunit of 5′-AMP-activated protein kinase, to chromosome 7q36. Genomics. 70:2000;258-263.
    • (2000) Genomics , vol.70 , pp. 258-263
    • Lang, T.1
  • 40
    • 0037185021 scopus 로고    scopus 로고
    • Functional analysis of mutations in the γ2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome
    • Daniel T., Carling D. Functional analysis of mutations in the γ2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome. J. Biol. Chem. 277:2002;51017-51024.
    • (2002) J. Biol. Chem. , vol.277 , pp. 51017-51024
    • Daniel, T.1    Carling, D.2
  • 41
    • 0037782349 scopus 로고    scopus 로고
    • Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy
    • Arad M., et al. Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. Circulation. 107:2003;2850-2856.
    • (2003) Circulation , vol.107 , pp. 2850-2856
    • Arad, M.1
  • 42
    • 0029910018 scopus 로고    scopus 로고
    • Characterisation of the AMP-activated protein kinase kinase from rat liver and identification of threonine-172 as the major site at which it phosphorylates AMP-activated protein kinase
    • Hawley S.A., et al. Characterisation of the AMP-activated protein kinase kinase from rat liver and identification of threonine-172 as the major site at which it phosphorylates AMP-activated protein kinase. J. Biol. Chem. 271:1996;27879-27887.
    • (1996) J. Biol. Chem. , vol.271 , pp. 27879-27887
    • Hawley, S.A.1
  • 43
    • 0029993727 scopus 로고    scopus 로고
    • Active and inactive protein kinases: Structural basis for regulation
    • Johnson L.N., et al. Active and inactive protein kinases: structural basis for regulation. Cell. 85:1996;149-158.
    • (1996) Cell , vol.85 , pp. 149-158
    • Johnson, L.N.1
  • 44
    • 0043210478 scopus 로고    scopus 로고
    • Identification of phosphorylation sites in AMP-activated protein kinase for upstream AMP-activated protein kinase kinases and study of their roles by site-directed mutagenesis
    • Woods A., et al. Identification of phosphorylation sites in AMP-activated protein kinase for upstream AMP-activated protein kinase kinases and study of their roles by site-directed mutagenesis. J. Biol. Chem. 278:2003;28434-28442.
    • (2003) J. Biol. Chem. , vol.278 , pp. 28434-28442
    • Woods, A.1
  • 45
    • 0034141355 scopus 로고    scopus 로고
    • The regulation of AMP-activated protein kinase phosphorylation
    • Stein S.C., et al. The regulation of AMP-activated protein kinase phosphorylation. Biochem. J. 345:2000;437-443.
    • (2000) Biochem. J. , vol.345 , pp. 437-443
    • Stein, S.C.1
  • 46
    • 0141925771 scopus 로고    scopus 로고
    • Akt activity negatively regulates phosphorylation of AMPK in the heart
    • Kovacic S., et al. Akt activity negatively regulates phosphorylation of AMPK in the heart. J. Biol. Chem. 278:2003;39422-39427.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39422-39427
    • Kovacic, S.1
  • 47
    • 0035929337 scopus 로고    scopus 로고
    • Insulin antagonizes AMP-activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides
    • Beauloye C., et al. Insulin antagonizes AMP-activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides. FEBS Lett. 505:2001;348-352.
    • (2001) FEBS Lett. , vol.505 , pp. 348-352
    • Beauloye, C.1
  • 48
    • 0041305909 scopus 로고    scopus 로고
    • Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
    • Hong S.P., et al. Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc. Natl. Acad. Sci. U. S. A. 100:2003;8839-8843.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 8839-8843
    • Hong, S.P.1
  • 49
    • 0041700137 scopus 로고    scopus 로고
    • Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex
    • Sutherland C.M., et al. Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex. Curr. Biol. 13:2003;1299-1305.
    • (2003) Curr. Biol. , vol.13 , pp. 1299-1305
    • Sutherland, C.M.1
  • 50
    • 0038583957 scopus 로고    scopus 로고
    • Yeast Pak1 kinase associates with and activates Snf1
    • Nath N., et al. Yeast Pak1 kinase associates with and activates Snf1. Mol. Cell. Biol. 23:2003;3909-3917.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 3909-3917
    • Nath, N.1
  • 51
    • 0028845251 scopus 로고
    • 2+/calmodulin activates the calmodulin-dependent protein kinase-I cascade, via 3 independent mechanisms
    • 2+/calmodulin activates the calmodulin- dependent protein kinase-I cascade, via 3 independent mechanisms. J. Biol. Chem. 270:1995;27186-27191.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27186-27191
    • Hawley, S.A.1
  • 52
    • 0032495530 scopus 로고    scopus 로고
    • A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
    • Hemminki A., et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature. 391:1998;184-187.
    • (1998) Nature , vol.391 , pp. 184-187
    • Hemminki, A.1
  • 53
    • 0031974516 scopus 로고    scopus 로고
    • Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
    • Jenne D.E., et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat. Genet. 18:1998;38-43.
    • (1998) Nat. Genet. , vol.18 , pp. 38-43
    • Jenne, D.E.1
  • 54
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley S.A., et al. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2:2003;28.
    • (2003) J. Biol. , vol.2 , pp. 28
    • Hawley, S.A.1
  • 55
    • 10744230065 scopus 로고    scopus 로고
    • LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
    • Woods A., et al. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol. 13:2003;2004-2008.
    • (2003) Curr. Biol. , vol.13 , pp. 2004-2008
    • Woods, A.1
  • 56
    • 0038035142 scopus 로고    scopus 로고
    • Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function
    • Wang W., et al. Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. J. Biol. Chem. 278:2003;27016-27023.
    • (2003) J. Biol. Chem. , vol.278 , pp. 27016-27023
    • Wang, W.1
  • 57
    • 0030870168 scopus 로고    scopus 로고
    • Post-translational modifications of the 5′-AMP-activated protein kinase β1 subunit
    • Mitchelhill K.I., et al. Post-translational modifications of the 5′-AMP-activated protein kinase β1 subunit. J. Biol. Chem. 272:1997;24475-24479.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24475-24479
    • Mitchelhill, K.I.1
  • 58
    • 0027932717 scopus 로고
    • Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase
    • Mitchelhill K.I., et al. Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase. J. Biol. Chem. 269:1994;2361-2364.
    • (1994) J. Biol. Chem. , vol.269 , pp. 2361-2364
    • Mitchelhill, K.I.1
  • 59
    • 0028310837 scopus 로고
    • Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism
    • Carling D., et al. Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism. J. Biol. Chem. 269:1994;11442-11448.
    • (1994) J. Biol. Chem. , vol.269 , pp. 11442-11448
    • Carling, D.1
  • 60
    • 13344285343 scopus 로고    scopus 로고
    • Mammalian AMP-activated protein kinase subfamily
    • Stapleton D., et al. Mammalian AMP-activated protein kinase subfamily. J. Biol. Chem. 271:1996;611-614.
    • (1996) J. Biol. Chem. , vol.271 , pp. 611-614
    • Stapleton, D.1
  • 61
    • 0029944966 scopus 로고    scopus 로고
    • Regulation of AMP-activated protein kinase activity by the noncatalytic β and γ subunits
    • Dyck J.R.B., et al. Regulation of AMP-activated protein kinase activity by the noncatalytic β and γ subunits. J. Biol. Chem. 271:1996;17798-17803.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17798-17803
    • Dyck, J.R.B.1
  • 62
    • 0032524622 scopus 로고    scopus 로고
    • Identification of a novel AMP-activated protein kinase β isoform which is highly expressed in skeletal muscle
    • Thornton C., et al. Identification of a novel AMP-activated protein kinase β isoform which is highly expressed in skeletal muscle. J. Biol. Chem. 273:1998;12443-12450.
    • (1998) J. Biol. Chem. , vol.273 , pp. 12443-12450
    • Thornton, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.