Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae

Gene

Volumn 192, Issue 2, 1997, Pages 245-250

  Matsuura, Akira ^a,c   Tsukada, Miki ^a   Wada, Yoh ^a   Ohsumi, Yoshinori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

APG1; Autophagy; Starvation; Vacuole; Yeast

Indexed keywords

PROTEIN SERINE THREONINE KINASE;

ARTICLE; AUTOPHAGY; CAENORHABDITIS ELEGANS; CELL MEMBRANE; CELL ORGANELLE; CELL VACUOLE; CONTROLLED STUDY; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; AUTOPHAGY; FUNGAL PROTEINS; GENES, FUNGAL; GENETIC COMPLEMENTATION TEST; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE;

EID: 0030983504     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(97)00084-X     Document Type: Article

References (22)

1. Baba, M., Takeshige, K., Baba, N., Ohsumi, Y., 1994. Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization. J. Cell Biol. 124, 903-913.
2. Bissinger, P.H., Wieser, R., Hamilton, B., Ruis, H., 1989. Control of Saccharomyces cerevisiae catalase T gene (CTTI) expression by nutrient supply via the RAS-cyclic AMP pathway. Mol. Cell. Biol. 9, 1309-1315.
3. Dunn Jr., W.A., 1994. Autophagy and related mechanisms of lysosome-mediated protein degradation. Trends Cell Biol. 4, 139-143.
4. Finley, D., Özaynak, E., Varshavsky, A., 1987. The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses. Cell 48, 1035-1046.
5. Hanks, S.K., Quinn, A.M., Hunter, T., 1988. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241, 42-52.
6. Holen, I., Stromhaug, P.E., Gordon, P.B., Fengsrud, M., Berg, T.O., Seglen, P.O., 1995. Inhibition of autophagy and multiple steps in asialoglycoprotein endocytosis by inhibitors of tyrosine protein kinases (tyrphostins). J. Biol. Chem. 275, 12823-12831.
7. Jentsch, S., 1992. Ubiquitin-dependent protein degradation: a cellular perspective. Trends Cell Biol. 2, 98-103.
8. Jones, J.S., Prakash, L., 1990. Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkers. Yeast 6, 363-366.
9. Klionsky, D.J., Herman, P.K., Emr, S.D., 1990. The fungal vacuole: composition, function, and biogenesis. Microbiol. Rev. 54, 266-292.
10. Kunkel, T.A., 1985. Rapid and efficient site-specific mutagenesis without phenotypic analysis. Proc. Natl. Acad. Sci. USA 82, 488-492.
11. McIntire, S.L., Garriga, G., White, J., Jacobson, D., Horvitz, H.R., 1992. Genes necessary for directed axonal elongation or fasciculation in C. elegans. Neuron 8, 307-322.
12. Mortimore, G.E., 1987. Mechanism and regulation of induced and basal protein degradation in liver. In: Glaumann, H., Ballard, F.J. (Eds.), Lysosomes: Their Role in Protein Breakdown. Academic Press, London, pp. 415-443.
13. Noda, T., Matsuura, A., Wada, Y., Ohsumi, Y., 1995. Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 210, 126-132.
14. Ogura, K., Wicky, C., Magnenat, L., Tobler, H., Mori, I., Müller, F., Ohshima, Y., 1994. Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase. Genes Dev. 8, 2389-2400.
15. Rothblatt, J., Schekman, R., 1989. A hitchhiker's guide to analysis of the secretory pathway in yeast. Methods Cell Biol. 32, 3-36.
16. Sikorski, R.S., Hieter, P., 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27.
17. Smith, D.B., Johnson, K.S., 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67, 31-40.
18. Takeshige, K., Baba, M., Tsuboi, S., Noda, T., Ohsumi, Y., 1992. Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. J. Cell Biol. 119, 301-311.
19. Tanaka, K., Matsumoto, K., Toh-e, A., 1988. Dual regulation of the expression of the polyubiquitin gene by cyclic AMP and heat shock in yeast. EMBO J. 7, 495-502.
20. Tanaka, K., Nakafuku, M., Tamanoi, F., Kaziro, Y., Matsumoto, K., Toh-e, A., 1990. IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein. Mol. Cell. Biol. 10, 4303-4313.
21. Toda, T., Cameron, S., Sass, P., Zoller, M., Scott, J.D., McMullen, B., Hurwitz, M., Krebs, E.G., Wigler, M., 1990. Cloning and characterization of BCYI, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Mol. Cell. Biol. 7, 1371-1377.
22. Tsukada, M., Ohsumi, Y., 1993. Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett. 133, 169-174.