Tor-mediated induction of autophagy via an Apg1 protein kinase complex

Journal of Cell Biology

Volumn 150, Issue 6, 2000, Pages 1507-1513

  Kamada, Yoshiaki ^a,b   Funakoshi, Tomoko ^a,d   Shintani, Takahiro ^a   Nagano, Kazuya ^c   Ohsumi, Mariko ^c   Ohsumi, Yoshinori ^a,b  

^a NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^c TEIKYO UNIVERSITY OF SCIENCE   (Japan)

^d NIHON UNIVERSITY   (Japan)

Author keywords

Cvt; Phosphorylation; Rapamycin; Starvation; Yeast

Indexed keywords

APG1 PROTEIN; APG13 PROTEIN; APG17 PROTEIN; CVT9 PROTEIN; PHOSPHATIDYLINOSITOL KINASE RELATED KINASE; PROTEIN KINASE; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CELL VACUOLE; ENZYME ACTIVATION; LYSOSOME; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; STARVATION;

ANTIBIOTICS, ANTIFUNGAL; ANTIBODIES; AUTOPHAGY; CYTOPLASM; DROSOPHILA PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HEAT-SHOCK PROTEINS; MUTAGENESIS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR PROTEIN-TYROSINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; SIROLIMUS; STARVATION; VACUOLES;

SACCHAROMYCES CEREVISIAE;

EID: 0034683568     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.150.6.1507     Document Type: Article

References (27)

1. Cytoplasm to vacuole trafficking of aminopeptidase I requires a t-SNARE-Sec1p complex composed of Tlg2p and Vps45p
2. Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome
3. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
4. Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast
5. The TOR signaling cascade regulates gene expression in response to nutrients
6. Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
7. Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae
8. Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway
9. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins
10. Genomic libraries and a host strain designated for highly efficient two-hybrid selection in yeast
11. Tor proteins and protein phosphatase 2A reciprocally regulated Tap42 in controlling cell growth in yeast
12. The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response
13. Vacuolar import of proteins and organelles from the cytoplasm
14. Target of rapamycin in yeast. TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
15. Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae
16. A protein conjugation system essential for autophagy
17. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
18. Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae
19. Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase
20. Physiological regulation of membrane protein sorting late in the secretory pathway of Saccharomyces cerevisiae
21. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease
22. Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole
23. Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells
24. TOR signalling and control of cell growth
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26. Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51