-
1
-
-
0034764605
-
PI 3-kinase, mTOR, protein synthesis and cancer
-
Vogt P.K. PI 3-kinase, mTOR, protein synthesis and cancer Trends Mol Med 7 2001 482-484
-
(2001)
Trends Mol. Med.
, vol.7
, pp. 482-484
-
-
Vogt, P.K.1
-
2
-
-
0034974302
-
IGF-I receptor signalling in transformation and differentiation
-
Valentinis B. Baserga R.IGF-I receptor signalling in transformation and differentiation Mol Pathol 54 2001 133-137
-
(2001)
Mol. Pathol.
, vol.54
, pp. 133-137
-
-
Valentinis, B.1
Baserga, R.2
-
3
-
-
0037306190
-
Insulin/IGF and target of rapamycin signaling: A TOR de force in growth control
-
Oldham S. Hafen E. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control Trends Cell Biol 13 2003 79-85
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 79-85
-
-
Oldham, S.1
Hafen, E.2
-
5
-
-
0036817880
-
Clinical development of mammalian target of rapamycin inhibitors
-
Dancey J.E. Clinical development of mammalian target of rapamycin inhibitors Hematol Oncol Clin North Am 16 2002 1101-1114 The author summarizes recent data about CCI-779 from phase I clinical trials.
-
(2002)
Hematol. Oncol. Clin. North Am.
, vol.16
, pp. 1101-1114
-
-
Dancey, J.E.1
-
6
-
-
0036225178
-
Inhibitors of mammalian target of rapamycin as novel antitumor agents: From bench to clinic
-
Huang S. Houghton P.J. Inhibitors of mammalian target of rapamycin as novel antitumor agents: from bench to clinic Curr Opin Investig Drugs 3 2002 295-304
-
(2002)
Curr. Opin. Investig. Drugs
, vol.3
, pp. 295-304
-
-
Huang, S.1
Houghton, P.J.2
-
7
-
-
0036019373
-
Selective killing of cancer cells based on translational control of a suicide gene
-
DeFatta R.J. Li Y. De Benedetti A. Selective killing of cancer cells based on translational control of a suicide gene Cancer Gene Ther 9 2002 573-578
-
(2002)
Cancer Gene Ther.
, vol.9
, pp. 573-578
-
-
DeFatta, R.J.1
Li, Y.2
De Benedetti, A.3
-
9
-
-
0037108682
-
Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
-
Kenerson H.L. Aicher L.D. True L.D. Yeung R.S. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors Cancer Res 62 2002 5645-5650
-
(2002)
Cancer Res.
, vol.62
, pp. 5645-5650
-
-
Kenerson, H.L.1
Aicher, L.D.2
True, L.D.3
Yeung, R.S.4
-
11
-
-
0035312747
-
Regulation of translation initiation by FRAP/mTOR
-
Gingras A.C. Raught B. Sonenberg N. Regulation of translation initiation by FRAP/mTOR Genes Dev 15 2001 807-826
-
(2001)
Genes Dev.
, vol.15
, pp. 807-826
-
-
Gingras, A.C.1
Raught, B.2
Sonenberg, N.3
-
12
-
-
0027311858
-
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
-
Kunz J. Henriquez R. Schneider U. Deuter-Reinhard M. Movva N.R. Hall M.N. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression Cell 73 1993 585-596
-
(1993)
Cell
, vol.73
, pp. 585-596
-
-
Kunz, J.1
Henriquez, R.2
Schneider, U.3
Deuter-Reinhard, M.4
Movva, N.R.5
Hall, M.N.6
-
13
-
-
0037020044
-
Identification of TOR signaling complexes: More TORC for the cell growth engine
-
Abraham R.T. Identification of TOR signaling complexes: more TORC for the cell growth engine Cell 111 2002 9-12
-
(2002)
Cell
, vol.111
, pp. 9-12
-
-
Abraham, R.T.1
-
16
-
-
0036440779
-
Regulation of mammalian translation factors by nutrients
-
Proud C.G. Regulation of mammalian translation factors by nutrients Eur J Biochem 269 2002 5338-5349
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 5338-5349
-
-
Proud, C.G.1
-
17
-
-
0036310982
-
The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
-
Peng T. Golub T.R. Sabatini D.M. The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation Mol Cell Biol 22 2002 5575-5584
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 5575-5584
-
-
Peng, T.1
Golub, T.R.2
Sabatini, D.M.3
-
18
-
-
0035408332
-
Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin
-
Braun-Dullaeus R.C. Mann M.J. Seay U. Zhang L. von Der Leyen H.E. Morris R.E. Dzau V.J. Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin Arterioscler Thromb Vasc Biol 21 2001 1152-1158
-
(2001)
Arterioscler. Thromb. Vasc. Biol.
, vol.21
, pp. 1152-1158
-
-
Braun-Dullaeus, R.C.1
Mann, M.J.2
Seay, U.3
Zhang, L.4
von Der Leyen, H.E.5
Morris, R.E.6
Dzau, V.J.7
-
19
-
-
0036399363
-
The S6 kinase signaling pathway in the control of development and growth
-
Thomas G. The S6 kinase signaling pathway in the control of development and growth Biol Res 35 2002 305-313
-
(2002)
Biol. Res.
, vol.35
, pp. 305-313
-
-
Thomas, G.1
-
20
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin
-
Hudson C.C. Liu M. Chiang G.G. Otterness D.M. Loomis D.C. Kaper F. Giaccia A.J. Abraham R.T. Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin Mol Cell Biol 22 2002 7004-7014
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
Otterness, D.M.4
Loomis, D.C.5
Kaper, F.6
Giaccia, A.J.7
Abraham, R.T.8
-
21
-
-
0037008770
-
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
-
Treins C. Giorgetti-Peraldi S. Murdaca J. Semenza G.L. Van Obberghen E. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway J Biol Chem 277 2002 27975-27981
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 27975-27981
-
-
Treins, C.1
Giorgetti-Peraldi, S.2
Murdaca, J.3
Semenza, G.L.4
Van Obberghen, E.5
-
22
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis : Involvement of vascular endothelial growth factor
-
Guba M. von Breitenbuch P. Steinbauer M. Koehl G. Flegel S. Hornung M. Bruns C.J. Zuelke C. Farkas S. Anthuber M. et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor Nat Med 8 2002 128-135 The authors show that rapamycin can inhibit tumour growth in vivo more potently because of its anti-angiogenesis effects.
-
(2002)
Nat. Med.
, vol.8
, pp. 128-135
-
-
Guba, M.1
von Breitenbuch, P.2
Steinbauer, M.3
Koehl, G.4
Flegel, S.5
Hornung, M.6
Bruns, C.J.7
Zuelke, C.8
Farkas, S.9
Anthuber, M.10
-
24
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim D.H. Sarbassov D.D. Ali S.M. King J.E. Latek R.R. Erdjument-Bromage H. Tempst P.Sabatini D.M.mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery Cell 110 2002 163-175
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
25
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara K. Maruki Y. Long X. Yoshino K. Oshiro N. Hidayat S. Tokunaga C. Avruch J. Yonezawa K.Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action Cell 110 2002 177-189.
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
26
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith R. Jacinto E. Wullschleger S. Lorberg A. Crespo J.L. Bonenfant D. Oppliger W. Jenoe P. Hall M.N. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control Mol Cell 10 2002 457-468
-
(2002)
Mol. Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
27
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K. Li Y. Zhu T. Wu J. Guan K.L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Nat Cell Biol 4 2002 648-657.
-
(2002)
Nat. Cell. Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
28
-
-
0036712905
-
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
-
Gao X. Zhang Y. Arrazola P. Hino O. Kobayashi T. Yeung R.S. Ru B. Pan D. Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling Nat Cell Biol 4 2002 699-704
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 699-704
-
-
Gao, X.1
Zhang, Y.2
Arrazola, P.3
Hino, O.4
Kobayashi, T.5
Yeung, R.S.6
Ru, B.7
Pan, D.8
-
29
-
-
0037108750
-
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
-
Tee A.R. Fingar D.C. Manning B.D. Kwiatkowski D.J. Cantley L.C. Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling Proc Natl Acad Sci USA 99 2002 13571-13576
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 13571-13576
-
-
Tee, A.R.1
Fingar, D.C.2
Manning, B.D.3
Kwiatkowski, D.J.4
Cantley, L.C.5
Blenis, J.6
-
30
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
Potter C.J. Pedraza L.G. Xu T. Akt regulates growth by directly phosphorylating Tsc2 Nat Cell Biol 4 2002 658-665
-
(2002)
Nat Cell Biol
, vol.4
, pp. 658-665
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
31
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
-
Manning B.D. Tee A.R. Logsdon M.N. Blenis J. Cantley L.C. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway Mol Cell 10 2002 151-162
-
(2002)
Mol. Cell
, vol.10
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon, M.N.3
Blenis, J.4
Cantley, L.C.5
-
32
-
-
0037108151
-
Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling
-
Radimerski T. Montagne J. Hemmings-Mieszczak M. Thomas G. Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling Genes Dev 16 2002 2627-2632
-
(2002)
Genes Dev.
, vol.16
, pp. 2627-2632
-
-
Radimerski, T.1
Montagne, J.2
Hemmings-Mieszczak, M.3
Thomas, G.4
-
33
-
-
0037191045
-
These results suggest that TSC proteins may regulate S6K1 in paralell to mTOR, which is in contrast to other reports
-
Jaeschke A. Hartkamp J. Saitoh M. Roworth W. Nobukuni T. Hodges A. Sampson J. Thomas G. Lamb R. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent J Cell Biol 159 2002 217-224
-
(2002)
J. Cell. Biol.
, vol.159
, pp. 217-224
-
-
Jaeschke, A.1
Hartkamp, J.2
Saitoh, M.3
Roworth, W.4
Nobukuni, T.5
Hodges, A.6
Sampson, J.7
Thomas, G.8
Lamb, R.9
-
34
-
-
0035965295
-
The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism
-
Erbay E. Chen J. The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism J Biol Chem 276 2001 36079-36082
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 36079-36082
-
-
Erbay, E.1
Chen, J.2
-
35
-
-
0037053334
-
Myogenic differentiation is dependent on both the kinase function and the N-terminal sequence of mammalian target of rapamycin
-
Shu L. Zhang X. Houghton P.J. Myogenic differentiation is dependent on both the kinase function and the N-terminal sequence of mammalian target of rapamycin J Biol Chem 277 2002 16726-16732
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 16726-16732
-
-
Shu, L.1
Zhang, X.2
Houghton, P.J.3
-
37
-
-
0035928843
-
Bench to bedside: The development of rapamycin and its application to stent restenosis
-
Marx S.O. Marks A.R. Bench to bedside: the development of rapamycin and its application to stent restenosis Circulation 104 2001 852-855
-
(2001)
Circulation
, vol.104
, pp. 852-855
-
-
Marx, S.O.1
Marks, A.R.2
-
38
-
-
0034901515
-
Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition
-
Dudkin L. Dilling M.B. Cheshire P.J. Harwood F.C. Hollingshead M. Arbuck S.G. Travis R. Sausville E.A. Houghton P.J. Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition Clin Cancer Res 7 2001 1758-1764
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1758-1764
-
-
Dudkin, L.1
Dilling, M.B.2
Cheshire, P.J.3
Harwood, F.C.4
Hollingshead, M.5
Arbuck, S.G.6
Travis, R.7
Sausville, E.A.8
Houghton, P.J.9
-
39
-
-
0034790016
-
mTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
-
Yu K. Toral-Barza L. Discafani C. Zhang W.G. Skotnicki J. Frost P. Gibbons J.J. mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer Endocr Relat Cancer 8 2001 249-258
-
(2001)
Endocr. Relat. Cancer.
, vol.8
, pp. 249-258
-
-
Yu, K.1
Toral-Barza, L.2
Discafani, C.3
Zhang, W.G.4
Skotnicki, J.5
Frost, P.6
Gibbons, J.J.7
-
40
-
-
17944377486
-
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
-
Neshat M.S. Mellinghoff I.K. Tran C. Stiles B. Thomas G. Petersen R. Frost P. Gibbons J.J. Wu H. Sawyers C.L. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR Proc Natl Acad Sci USA 98 2001 10314-10319
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10314-10319
-
-
Neshat, M.S.1
Mellinghoff, I.K.2
Tran, C.3
Stiles, B.4
Thomas, G.5
Petersen, R.6
Frost, P.7
Gibbons, J.J.8
Wu, H.9
Sawyers, C.L.10
-
41
-
-
17944368972
-
+/- mice
-
+/- mice Proc Natl Acad Sci USA 98 2001 10320-10325.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10320-10325
-
-
Podsypanina, K.1
Lee, R.T.2
Politis, C.3
Hennessy, I.4
Crane, A.5
Puc, J.6
Neshat, M.7
Wang, H.8
Yang, L.9
Gibbons, J.10
-
43
-
-
0035694808
-
Resistance to rapamycin: A novel anticancer drug
-
Huang S. Houghton P.J. Resistance to rapamycin: a novel anticancer drug Cancer Metastasis Rev 20 2001 69-78
-
(2001)
Cancer Metastasis Rev.
, vol.20
, pp. 69-78
-
-
Huang, S.1
Houghton, P.J.2
-
44
-
-
0035870281
-
CIP1 cooperate in enforcing rapamycin-induced G1 arrest and determine the cellular response to rapamycin
-
CIP1 cooperate in enforcing rapamycin-induced G1 arrest and determine the cellular response to rapamycin Cancer Res 61 2001 3373-3381 A paper showing that, under serum-free conditions, the response of tumour cells lacking functional p53 to rapamycin is apoptosis, whereas the response of normal cells is cytostasis.
-
(2001)
Cancer Res.
, vol.61
, pp. 3373-3381
-
-
Huang, S.1
Liu, L.N.2
Hosoi, H.3
Dilling, M.B.4
Shikata, T.5
Houghton, P.J.6
-
46
-
-
0037439835
-
Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3′-kinase-Akt signaling pathways
-
Thimmaiah K.N. Easton J. Huang S. Veverka K.A. Germain G.S. Harwood F.C. Houghton P.J. Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3′-kinase-Akt signaling pathways Cancer Res 63 2003 364-374
-
(2003)
Cancer Res.
, vol.63
, pp. 364-374
-
-
Thimmaiah, K.N.1
Easton, J.2
Huang, S.3
Veverka, K.A.4
Germain, G.S.5
Harwood, F.C.6
Houghton, P.J.7
-
48
-
-
0036888908
-
Rapamycin potentiates transforming growth factor β-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells
-
Law B.K. Chytil A. Dumont N. Hamilton E.G. Waltner-Law M.E. Aakre M.E. Covington C. Moses H.L. Rapamycin potentiates transforming growth factor β-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells Mol Cell Biol 22 2002 8184-8198
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 8184-8198
-
-
Law, B.K.1
Chytil, A.2
Dumont, N.3
Hamilton, E.G.4
Waltner-Law, M.E.5
Aakre, M.E.6
Covington, C.7
Moses, H.L.8
-
50
-
-
0038094504
-
Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21Cip1
-
In press
-
Huang S, Shu L, Dilling MB, Easton J, Harwood FC, Ichijo H, Houghton PJ: Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21Cip1. Mol Cell 2003, in press.
-
(2003)
Mol. Cell
-
-
Huang, S.1
Shu, L.2
Dilling, M.B.3
Easton, J.4
Harwood, F.C.5
Ichijo, H.6
Houghton, P.J.7
-
51
-
-
0035744033
-
Mechanisms of resistance to rapamycins
-
Huang S. Houghton P.J. Mechanisms of resistance to rapamycins Drug Resist Updat 4 2001 378-391
-
(2001)
Drug Resist. Updat.
, vol.4
, pp. 378-391
-
-
Huang, S.1
Houghton, P.J.2
-
52
-
-
0037134480
-
4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin
-
Dilling M.B. Germain G.S. Dudkin L. Jayaraman A.L. Zhang X. Harwood F.C. Houghton P.J. 4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin J Biol Chem 277 2002 13907-13917
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 13907-13917
-
-
Dilling, M.B.1
Germain, G.S.2
Dudkin, L.3
Jayaraman, A.L.4
Zhang, X.5
Harwood, F.C.6
Houghton, P.J.7
-
53
-
-
0035866358
-
Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy
-
Geoerger B. Kerr K. Tang C.B. Fung K.M. Powell B. Sutton L.N. Phillips P.C. Janss A.J. Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy Cancer Res 61 2001 1527-1532
-
(2001)
Cancer Res.
, vol.61
, pp. 1527-1532
-
-
Geoerger, B.1
Kerr, K.2
Tang, C.B.3
Fung, K.M.4
Powell, B.5
Sutton, L.N.6
Phillips, P.C.7
Janss, A.J.8
|