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Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
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The tuberous sclerosis 2 gene is expressed at high levels in the cerebellum and developing spinal cord
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Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity
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The tuberous sclerosis-2 gene product, tuberin, functions as a Rab5GAP in modulating endocytosis
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Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus
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