Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

Journal of Biological Chemistry

Volumn 278, Issue 39, 2003, Pages 37288-37296

  Tee, Andrew R ^a   Anjum, Rana ^a   Blenis, John ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DIMERS; PROTEINS; TUMORS;

TUBEROUS SCLEROSIS COMPLEX (TSC);

GENETIC ENGINEERING;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; BISINDOLYLMALEIMIDE; GENE PRODUCT; HAMARTIN; INITIATION FACTOR 4E; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; RAPAMYCIN; S6 KINASE; SERINE; THREONINE; TUBERIN; WORTMANNIN;

ARTICLE; CONTROLLED STUDY; DIMERIZATION; EMBRYO; ENZYME INHIBITION; GENE INACTIVATION; GENE MUTATION; GENE TARGETING; GENETIC DISORDER; HUMAN; HUMAN CELL; IN VIVO STUDY; MAMMAL; MITOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TSC1 GENE; TSC2 GENE; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR GENE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CARRIER PROTEINS; CELL LINE; EUKARYOTIC INITIATION FACTOR-4E; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REPRESSOR PROTEINS; RIBOSOMAL PROTEIN S6 KINASES; TETRADECANOYLPHORBOL ACETATE; TUMOR SUPPRESSOR PROTEINS;

EUKARYOTA; MAMMALIA;

EID: 0141733228     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303257200     Document Type: Article

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