-
1
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
Saltiel A.R., Kahn C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 414:2001;799-806.
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
2
-
-
0035719947
-
Distinct and overlapping functions of insulin and IGF-I receptors
-
Nakae J., et al. Distinct and overlapping functions of insulin and IGF-I receptors. Endocr. Rev. 22:2001;818-835.
-
(2001)
Endocr. Rev.
, vol.22
, pp. 818-835
-
-
Nakae, J.1
-
3
-
-
0031740792
-
Genetics of mouse growth
-
Efstratiadis A. Genetics of mouse growth. Int. J. Dev. Biol. 42:1998;955-976.
-
(1998)
Int. J. Dev. Biol.
, vol.42
, pp. 955-976
-
-
Efstratiadis, A.1
-
4
-
-
0025343230
-
Signal transduction by receptors with tyrosine kinase activity
-
Ullrich A., Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell. 61:1990;203-212.
-
(1990)
Cell
, vol.61
, pp. 203-212
-
-
Ullrich, A.1
Schlessinger, J.2
-
5
-
-
0030780254
-
The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action
-
White M.F., Yenush L. The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Curr. Topics in Micro. and Immun. 228:1998;179-208.
-
(1998)
Curr. Topics in Micro. and Immun.
, vol.228
, pp. 179-208
-
-
White, M.F.1
Yenush, L.2
-
6
-
-
0034463086
-
Different subcellular localization and phosphoinositides binding of insulin receptor substrate protein pleckstrin homology domains
-
Razzini G., et al. Different subcellular localization and phosphoinositides binding of insulin receptor substrate protein pleckstrin homology domains. Mol. Endocrinol. 14:2000;823-836.
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 823-836
-
-
Razzini, G.1
-
7
-
-
0027437376
-
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1
-
Sun X.J., et al. Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol. Cell. Biol. 13:1993;7418-7428.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 7418-7428
-
-
Sun, X.J.1
-
8
-
-
0034911881
-
Synthesis and function of 3-phosphorylated inositol lipids
-
Vanhaesebroeck B., et al. Synthesis and function of 3-phosphorylated inositol lipids. Annu. Rev. Biochem. 70:2001;535-602.
-
(2001)
Annu. Rev. Biochem.
, vol.70
, pp. 535-602
-
-
Vanhaesebroeck, B.1
-
9
-
-
0034764605
-
PI 3-kinase, mTOR, protein synthesis and cancer
-
Vogt P.K. PI 3-kinase, mTOR, protein synthesis and cancer. Trends Mol. Med. 7:2001;482-484.
-
(2001)
Trends Mol. Med.
, vol.7
, pp. 482-484
-
-
Vogt, P.K.1
-
10
-
-
0034974302
-
IGF-I receptor signalling in transformation and differentiation
-
Valentinis B., Baserga R. IGF-I receptor signalling in transformation and differentiation. Mol. Pathol. 54:2001;133-137.
-
(2001)
Mol. Pathol.
, vol.54
, pp. 133-137
-
-
Valentinis, B.1
Baserga, R.2
-
12
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell. 100:2000;57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
14
-
-
0033603208
-
Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
-
Böhni R., et al. Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell. 97:1999;865-875.
-
(1999)
Cell
, vol.97
, pp. 865-875
-
-
Böhni, R.1
-
15
-
-
15844387385
-
Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules
-
Tanaka S., et al. Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules. J. Biol. Chem. 271:1996;14610-14616.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 14610-14616
-
-
Tanaka, S.1
-
16
-
-
0027288587
-
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: Implications for insulin control of ras signalling
-
Skolnik E.Y., et al. The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EMBO J. 12:1993;1929-1936.
-
(1993)
EMBO J.
, vol.12
, pp. 1929-1936
-
-
Skolnik, E.Y.1
-
17
-
-
0028231105
-
Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor
-
Giorgetti S., et al. Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor. Eur. J. Biochem. 223:1994;195-202.
-
(1994)
Eur. J. Biochem.
, vol.223
, pp. 195-202
-
-
Giorgetti, S.1
-
18
-
-
0036713481
-
The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels
-
Oldham S., et al. The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels. Development. 129:2002;4103-4109.
-
(2002)
Development
, vol.129
, pp. 4103-4109
-
-
Oldham, S.1
-
19
-
-
0034725626
-
Characterization of Drosophila insulin receptor substrate
-
Poltilove R.M., et al. Characterization of Drosophila insulin receptor substrate. J. Biol. Chem. 275:2000;23346-23354.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 23346-23354
-
-
Poltilove, R.M.1
-
20
-
-
0030002820
-
The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis
-
Yenush L., et al. The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis. Mol. Cell. Biol. 16:1996;2509-2517.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 2509-2517
-
-
Yenush, L.1
-
21
-
-
0029830237
-
The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth
-
Leevers S.J., et al. The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J. 1:1996;6584-6594.
-
(1996)
EMBO J.
, vol.1
, pp. 6584-6594
-
-
Leevers, S.J.1
-
22
-
-
0033598201
-
Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor
-
Weinkove D., et al. Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor. Curr. Biol. 9:1999;1019-1029.
-
(1999)
Curr. Biol.
, vol.9
, pp. 1019-1029
-
-
Weinkove, D.1
-
23
-
-
0036484062
-
Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions
-
Britton J.S., et al. Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev. Cell. 2:2002;239-249.
-
(2002)
Dev. Cell
, vol.2
, pp. 239-249
-
-
Britton, J.S.1
-
24
-
-
0034213075
-
The conserved phosphoinositide 3-kinase pathway determines heart size in mice
-
Shioi T., et al. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J. 19:2000;2537-2548.
-
(2000)
EMBO J.
, vol.19
, pp. 2537-2548
-
-
Shioi, T.1
-
25
-
-
0032904432
-
PTEN: A tumour suppressor that functions as a phospholipid phosphatase
-
Maehama T., Dixon J.E. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol. 9:1999;125-128.
-
(1999)
Trends Cell Biol.
, vol.9
, pp. 125-128
-
-
Maehama, T.1
Dixon, J.E.2
-
26
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley L.C., Neel B.G. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. U.S.A. 96:1999;4240-4245.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
27
-
-
0034681264
-
The multiple roles of PTEN in tumor suppression
-
Di Cristofano A., Pandolfi P.P. The multiple roles of PTEN in tumor suppression. Cell. 100:2000;387-390.
-
(2000)
Cell
, vol.100
, pp. 387-390
-
-
Di Cristofano, A.1
Pandolfi, P.P.2
-
28
-
-
0035499454
-
Ten years of protein kinase B signalling: A hard Akt to follow
-
Brazil D.P., Hemmings B.A. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem. Sci. 26:2001;657-664.
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 657-664
-
-
Brazil, D.P.1
Hemmings, B.A.2
-
29
-
-
0032189381
-
Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
-
Coffer P.J., et al. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem. J. 335:1998;1-13.
-
(1998)
Biochem. J.
, vol.335
, pp. 1-13
-
-
Coffer, P.J.1
-
30
-
-
0033258521
-
Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
-
Verdu J., et al. Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat. Cell Biol. 1:1999;500-506.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 500-506
-
-
Verdu, J.1
-
31
-
-
0034680008
-
The conserved PI3′K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila
-
Scanga S.E., et al. The conserved PI3′K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene. 19:2000;3971-3977.
-
(2000)
Oncogene
, vol.19
, pp. 3971-3977
-
-
Scanga, S.E.1
-
32
-
-
0037086001
-
Living with lethal PIP3 levels: Viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
-
Stocker H., et al. Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science. 295:2002;2088-2091.
-
(2002)
Science
, vol.295
, pp. 2088-2091
-
-
Stocker, H.1
-
33
-
-
0033856462
-
PI3-kinase inhibition: A target for drug development?
-
Stein R.C., Waterfield M.D. PI3-kinase inhibition: a target for drug development? Mol. Med. Today. 6:2000;347-357.
-
(2000)
Mol. Med. Today
, vol.6
, pp. 347-357
-
-
Stein, R.C.1
Waterfield, M.D.2
-
34
-
-
0035964367
-
Linking molecular therapeutics to molecular diagnostics: Inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo
-
Mills G.B., et al. Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo. Proc. Natl. Acad. Sci. U. S. A. 98:2001;10031-10033.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 10031-10033
-
-
Mills, G.B.1
-
35
-
-
0036463405
-
A matter of life and death
-
Green D.R., Evan G.I. A matter of life and death. Cancer Cell. 1:2002;19-30.
-
(2002)
Cancer Cell
, vol.1
, pp. 19-30
-
-
Green, D.R.1
Evan, G.I.2
-
36
-
-
0035253744
-
Growth regulation by oncogenes - New insights from model organisms
-
Prober D.A., Edgar B.A. Growth regulation by oncogenes - new insights from model organisms. Curr. Opin. Genet. Dev. 11:2001;19-26.
-
(2001)
Curr. Opin. Genet. Dev.
, vol.11
, pp. 19-26
-
-
Prober, D.A.1
Edgar, B.A.2
-
37
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell. 103:2000;253-262.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
38
-
-
0037020044
-
Identification of TOR signaling complexes: More TORC for the cell growth engine
-
Abraham R.T. Identification of TOR signaling complexes: More TORC for the cell growth engine. Cell. 111:2002;9-12.
-
(2002)
Cell
, vol.111
, pp. 9-12
-
-
Abraham, R.T.1
-
39
-
-
0034306249
-
Amino acid regulation of gene expression
-
Fafournoux P., et al. Amino acid regulation of gene expression. Biochem. J. 351:2000;1-12.
-
(2000)
Biochem. J.
, vol.351
, pp. 1-12
-
-
Fafournoux, P.1
-
40
-
-
0034329612
-
Amino-acid-dependent signal transduction
-
van Sluijters D.A., et al. Amino-acid-dependent signal transduction. Biochem. J. 351:2000;545-550.
-
(2000)
Biochem. J.
, vol.351
, pp. 545-550
-
-
Van Sluijters, D.A.1
-
41
-
-
0033604521
-
Ribosomal S6 kinase signaling and the control of translation
-
Dufner A., Thomas G. Ribosomal S6 kinase signaling and the control of translation. Exp. Cell Res. 253:1999;100-109.
-
(1999)
Exp. Cell Res.
, vol.253
, pp. 100-109
-
-
Dufner, A.1
Thomas, G.2
-
42
-
-
0028788935
-
The 70 kDa S6 kinase: Regulation of a kinase with multiple roles in mitogenic signalling
-
Chou M.M., Blenis J. The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling. Curr. Opin. Cell Biol. 7:1995;806-814.
-
(1995)
Curr. Opin. Cell Biol.
, vol.7
, pp. 806-814
-
-
Chou, M.M.1
Blenis, J.2
-
43
-
-
0035225023
-
The p70 S6 kinase integrates nutrient and growth signals to control translational capacity
-
Avruch J., et al. The p70 S6 kinase integrates nutrient and growth signals to control translational capacity. Prog. Mol. Subcell. Biol. 26:2001;115-154.
-
(2001)
Prog. Mol. Subcell. Biol.
, vol.26
, pp. 115-154
-
-
Avruch, J.1
-
44
-
-
0033761629
-
Synthesis of the translational apparatus is regulated at the translational level
-
Meyuhas O. Synthesis of the translational apparatus is regulated at the translational level. Eur. J. Biochem. 267:2000;6321-6330.
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 6321-6330
-
-
Meyuhas, O.1
-
45
-
-
0032054816
-
The mRNA 5′ cap-binding protein eIF4E and control of cell growth
-
Sonenberg N., Gingras A.C. The mRNA 5′ cap-binding protein eIF4E and control of cell growth. Curr. Opin. Cell Biol. 10:1998;268-275.
-
(1998)
Curr. Opin. Cell Biol.
, vol.10
, pp. 268-275
-
-
Sonenberg, N.1
Gingras, A.C.2
-
46
-
-
0030883848
-
PHAS/4E-BPs as regulators of mRNA translation and cell proliferation
-
Lawrence J.C. Jr, Abraham R.T. PHAS/4E-BPs as regulators of mRNA translation and cell proliferation. Trends Biochem. Sci. 22:1997;345-349.
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 345-349
-
-
Lawrence J.C., Jr.1
Abraham, R.T.2
-
47
-
-
0031613939
-
The Minute genes in Drosophila and their molecular functions
-
Lambertsson A. The Minute genes in Drosophila and their molecular functions. Adv. Genet. 38:1998;69-134.
-
(1998)
Adv. Genet.
, vol.38
, pp. 69-134
-
-
Lambertsson, A.1
-
48
-
-
0036178103
-
Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth
-
Lachance P.E., et al. Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth. Mol. Cell. Biol. 22:2002;1656-1663.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 1656-1663
-
-
Lachance, P.E.1
-
49
-
-
0032843917
-
Drosophila S6 kinase: A regulator of cell size
-
Montagne J., et al. Drosophila S6 kinase: a regulator of cell size. Science. 285:1999;2126-2129.
-
(1999)
Science
, vol.285
, pp. 2126-2129
-
-
Montagne, J.1
-
50
-
-
0034976004
-
The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila
-
Miron M., et al. The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nat. Cell Biol. 3:2001;596-601.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 596-601
-
-
Miron, M.1
-
51
-
-
0032538890
-
s6k gene reveals a small mouse phenotype and a new functional S6 kinase
-
s6k gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 17:1998;6649-6659.
-
(1998)
EMBO J.
, vol.17
, pp. 6649-6659
-
-
Shima, H.1
-
52
-
-
0034312279
-
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
-
Oldham S., et al. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev. 14:2000;2689-2694.
-
(2000)
Genes Dev.
, vol.14
, pp. 2689-2694
-
-
Oldham, S.1
-
53
-
-
0034312315
-
Regulation of cellular growth by the Drosophila target of rapamycin dTOR
-
Zhang H., et al. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev. 14:2000;2712-2724.
-
(2000)
Genes Dev.
, vol.14
, pp. 2712-2724
-
-
Zhang, H.1
-
54
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
Fingar D.C., et al. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16:2002;1472-1487.
-
(2002)
Genes Dev.
, vol.16
, pp. 1472-1487
-
-
Fingar, D.C.1
-
55
-
-
0035940680
-
Insulin signaling: Lessons from the Drosophila tuberous sclerosis complex, a tumor suppressor
-
Montagne J., et al. Insulin signaling: lessons from the Drosophila tuberous sclerosis complex, a tumor suppressor. Sci. STKE. 2001;E36-E39.
-
(2001)
Sci. STKE
, pp. 36-E39
-
-
Montagne, J.1
-
56
-
-
0037108151
-
Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling
-
Radimerski T., et al. Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling. Genes Dev. 16:2002;2627-2632.
-
(2002)
Genes Dev.
, vol.16
, pp. 2627-2632
-
-
Radimerski, T.1
-
57
-
-
0036712905
-
Tsc tumour suppressor proteins antagonize amino-acid TOR signalling
-
Gao X., et al. Tsc tumour suppressor proteins antagonize amino-acid TOR signalling. Nat. Cell Biol. 4:2002;699-704.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 699-704
-
-
Gao, X.1
-
58
-
-
0035902509
-
A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
-
Kobayashi T., et al. A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc. Natl. Acad. Sci. U.S.A. 98:2001;8762-8767.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 8762-8767
-
-
Kobayashi, T.1
-
59
-
-
0034982971
-
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
-
Gao X., Pan D. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev. 15:2001;1383-1392.
-
(2001)
Genes Dev.
, vol.15
, pp. 1383-1392
-
-
Gao, X.1
Pan, D.2
-
60
-
-
0035805162
-
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
-
Potter C.J., et al. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell. 105:2001;357-368.
-
(2001)
Cell
, vol.105
, pp. 357-368
-
-
Potter, C.J.1
-
61
-
-
0035805180
-
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
-
Tapon N., et al. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell. 105:2001;345-355.
-
(2001)
Cell
, vol.105
, pp. 345-355
-
-
Tapon, N.1
-
62
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K., et al. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4:2002;648-657.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
-
63
-
-
0037191045
-
Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
-
Jaeschke A., et al. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. J. Cell Biol. 159:2002;217-224.
-
(2002)
J. Cell Biol.
, vol.159
, pp. 217-224
-
-
Jaeschke, A.1
-
64
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
-
Manning B.D., et al. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol. Cell. 10:2002;151-162.
-
(2002)
Mol. Cell
, vol.10
, pp. 151-162
-
-
Manning, B.D.1
-
65
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
Potter C.J., et al. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4:2002;658-665.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 658-665
-
-
Potter, C.J.1
-
66
-
-
0036119219
-
DS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1
-
Radimerski T., et al. dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nat. Cell Biol. 4:2002;251-255.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 251-255
-
-
Radimerski, T.1
-
67
-
-
0032752063
-
Cellular survival: A play in three Akts
-
Datta S.R., et al. Cellular survival: a play in three Akts. Genes Dev. 13:1999;2905-2927.
-
(1999)
Genes Dev.
, vol.13
, pp. 2905-2927
-
-
Datta, S.R.1
-
68
-
-
0034234924
-
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
-
Sekulic A., et al. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 60:2000;3504-3513.
-
(2000)
Cancer Res.
, vol.60
, pp. 3504-3513
-
-
Sekulic, A.1
-
69
-
-
0031860687
-
Environmental control of the cell cycle in Drosophila: Nutrition activates mitotic and endoreplicative cells by distinct mechanisms
-
Britton J.S., Edgar B.A. Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms. Development. 125:1998;2149-2158.
-
(1998)
Development
, vol.125
, pp. 2149-2158
-
-
Britton, J.S.1
Edgar, B.A.2
-
70
-
-
0036742659
-
Inhibition of cellular growth and proliferation by dTOR overexpression in, Drosophila
-
Hennig K.M., Neufeld T.P. Inhibition of cellular growth and proliferation by dTOR overexpression in, Drosophila. Genesis. 34:2002;107-110.
-
(2002)
Genesis
, vol.34
, pp. 107-110
-
-
Hennig, K.M.1
Neufeld, T.P.2
-
71
-
-
0037015269
-
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation
-
Long X., et al. TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr. Biol. 12:2002;1448-1461.
-
(2002)
Curr. Biol.
, vol.12
, pp. 1448-1461
-
-
Long, X.1
-
72
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P., Hunter T. Oncogenic kinase signalling. Nature. 411:2001;355-365.
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
73
-
-
0034722888
-
The rapamycin-sensitive signal transduction pathway as a target of cancer therapy
-
Hidalgo M., Rowinsky E.K. The rapamycin-sensitive signal transduction pathway as a target of cancer therapy. Oncogene. 19:2000;6680-6686.
-
(2000)
Oncogene
, vol.19
, pp. 6680-6686
-
-
Hidalgo, M.1
Rowinsky, E.K.2
-
74
-
-
0034867233
-
Interplay between insulin and nutrients in the regulation of translation factors
-
Proud C.G., et al. Interplay between insulin and nutrients in the regulation of translation factors. Biochem. Soc. Trans. 29:2001;541-547.
-
(2001)
Biochem. Soc. Trans.
, vol.29
, pp. 541-547
-
-
Proud, C.G.1
-
75
-
-
0037197930
-
Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene
-
Menand B., et al. Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene. Proc. Natl. Acad. Sci. U. S. A. 99:2002;6422-6427.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 6422-6427
-
-
Menand, B.1
|