Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

Journal of Biological Chemistry

Volumn 278, Issue 35, 2003, Pages 32493-32496

  Castro, Ariel F ^a   Rebhun, John F ^a   Clark, Geoffrey J ^b   Quilliam, Lawrence A ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; COMPLEXATION; DRUG PRODUCTS; ENZYME KINETICS; PROTEINS;

TUBEROUS SCLEROSIS;

ENZYMES;

GENE PRODUCT; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; POTEIN RAP1; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN TUBEROUS SCLEROSIS COMPLEX 2; RAPAMYCIN; RAS PROTEIN; RHEB PROTEIN; S6 KINASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME BINDING; GENE CONTROL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RIBOSOME; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

ANTINEOPLASTIC AGENTS; CELL LINE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IMMUNOBLOTTING; MONOMERIC GTP-BINDING PROTEINS; NEUROPEPTIDES; PHOSPHORYLATION; PLASMIDS; PROTEIN BINDING; PROTEIN ISOPRENYLATION; PROTEIN KINASES; REPRESSOR PROTEINS; RIBOSOMAL PROTEIN S6 KINASES; SIROLIMUS; TUMOR SUPPRESSOR PROTEINS;

EID: 0041356888     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C300226200     Document Type: Article

References (45)

1. Reuther, G. W., and Der, C. J. (2000) Curr. Opin. Cell Biol. 12, 157-165
2. Quilliam, L. A., Rebhun, J. F., and Castro, A. F. (2002) Prog. Nucleic Acids Res. Mol. Biol. 71, 391-444
3. Gutmann, D. H. (1998) Semin. Pediatr. Neurol. 5, 276-286
4. Dasgupta, B., and Gutmann, D. H. (2003) Curr. Opin. Genet. Dev. 13, 20-27
5. Cheadle, J. P., Reeve, M. P., Sampson, J. R., and Kwiatkowski, D. J. (2000) Hum. Genet. 107, 97-114
6. Sullivan, E. J. (1998) Chest 114, 1689-1703
7. van Slegtenhorst, M., de Hoogt, R., Hermans, C., Nellist, M., Janssen, B., Verhoef, S., Lindhout, D., van den Ouweland, A., Halley, D., Young, J., Burley, M., Jeremiah, S., Woodward, K., Nahmias, J., Fox, M., Ekong, R., Osborne, J., Wolfe, J., Povey, S., Snell, R. G., Cheadle, J. P., Jones, A. C., Tachataki, M., Ravine, D., Kwiatkowski, D. J., et al. (1997) Science 277, 805-808
8. Sato, T., Seyama, K., Fujii, H., Maruyama, H., Setoguchi, Y., Iwakami, S., Fukuchi, Y., and Hino, O. (2002) J. Hum. Genet. 47, 20-28
9. Carsillo, T., Astrinidis, A., and Henske, E. P. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 6085-6090
10. Wienecke, R., Konig, A., and DeClue, J. E. (1995) J. Biol. Chem. 270, 16409-16414
11. Xiao, G. H., Shoarinejad, F., Jin, F., Golemis, E. A., and Yeung, R. S. (1997) J. Biol. Chem. 272, 6097-60100
12. Goncharova, E. A., Goncharov, D. A., Eszterhas, A., Hunter, D. S., Glassberg, M. K., Yeung, R. S., Walker, C. L., Noonan, D., Kwiatkowski., D. J., Chou, M. M., Panettieri, R. A., Jr., and Krymskaya, V. P. (2002) J. Biol. Chem. 277, 30958-30967
13. Inoki, K., Li, Y., Zhu, T., Wu, J., and Guan, K. L. (2002) Nat. Cell Biol. 4, 648-657
14. Jaeschke, A., Hartkamp, J., Saitoh, M., Roworth, W., Nobukuni, T., Hodges, A., Sampson, J., Thomas, G., and Lamb, R. (2002) J. Cell Biol. 159, 217-224
15. Kwiatkowski, D. J. (2003) Ann. Hum. Genet. 67, 87-96
16. Tee, A. R., Fingar, D. C., Manning, B. D., Kwiatkowski, D. J., Cantley, L. C., and Blenis, J. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 13571-13576
17. Radimerski, T., Montagne, J., Hemmings-Mieszczak, M., and Thomas, G. (2002) Genes Dev. 16, 2627-2632
18. Gao, X., Zhang, Y., Arrazola, P., Hino, O., Kobayashi, T., Yeung, R. S., Ru, B., and Pan, D. (2002) Nat. Cell Biol. 4, 699-704
19. Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., and Cantley, L. C. (2002) Mol. Cell 10, 151-162
20. Potter, C. J., Pedraza, L. G., and Xu, T. (2002) Nat. Cell Biol. 4, 658-665
21. Dan, H. C., Sun, M., Yang, L., Feldman, R. I., Sui, X. M., Ou, C. C., Nellist, M., Yeung, R. S., Halley, D. J., Nicosia, S. V., Pledger, W. J., and Cheng, J. Q. (2002) J. Biol. Chem. 277, 35364-35370
22. Jin, F., Wienecke, R., Xiao, G. H., Maize, J. C., Jr., DeClue, J. E., and Yeung, R. S. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 9154-9159
23. Momose, S., Kobayashi, T., Mitani, H., Hirabayashi, M., Ito, K., Ueda, M., Nabeshima, Y., and Hino, O. (2002) Hum. Mol. Genet. 11, 2997-3006
24. Clark, G. J., Kinch, M. S., Rogers-Graham, K., Sebti, S. M., Hamilton, A. D., and Der, C. J. (1997) J. Biol. Chem. 272, 10608-10615
25. Rebhun, J. F., Castro, A. F., and Quilliam, L. A. (2000) J. Biol. Chem. 275, 34901-34908
26. Rubinfeld, B., Munemitsu, S., Clark, R., Conroy, L., Watt, K., Crosier, W. J., McCormick, F., and Polakis, P. (1991) Cell 65, 1033-1042
27. Im, E., von Lintig, F. C., Chen, J., Zhuang, S., Qui, W., Chowdhury, S., Worley, P. F., Boss, G. R., and Pilz, R. B. (2002) Oncogene 21, 6356-6365
28. Yee, W. M., and Worley, P. F. (1997) Mol. Cell Biol. 17, 921-933
29. Mach, K. E., Furge, K. A., and Albright, C. F. (2000) Genetics 155, 611-622
30. Urano, J., Tabancay, A. P., Yang, W., and Tamanoi, F. (2000) J. Biol. Chem. 275, 11198-11206
31. Matsumoto, S., Bandyopadhyay, A., Kwiatkowski, D. J., Maitra, U., and Matsumoto, T. (2002) Genetics 161, 1053-1063
32. Dufner, A., and Thomas, G. (1999) Exp. Cell Res. 253, 100-109
33. Gingras, A. C., Raught, B., and Sonenberg, N. (2001) Genes Dev., 15, 807-826
34. Kim, D. H., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2002) Cell 110, 163-175
35. Dennis, P. B., Jaeschke, A., Saitoh, M., Fowler, B., Kozma, S. C., and Thomas, G. (2001) Science 294, 1102-1105
36. Peterson, R. T., Desai, B. N., Hardwick, J. S., and Schreiber, S. L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4438-4442
37. Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A., and Pan, D. (2003) Nat Cell Biol. 5, 578-581
38. Stocker, H., Radimerski, T., Schindelholz, B., Wittwer, F., Belawat, P., Daram, P., Breuer, S., Thomas, G., and Hafen, E. (2003) Nat. Cell Biol. 5, 559-566
39. Saucedo, L. J., Gao, X., Chiarelli, D. A., Li, L., Pan, D., and Edgar, B. A. (2003) Nat. Cell Biol. 5, 566-571
40. Garami, A., Zwartkruis, F. J., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L., and Thomas, G. (2003) Mol. Cell 11, 1457-1466
41. Yang, W., Tabancay, A. P., Jr., Urano, J., and Tamanoi, F. (2001) Mol. Microbiol. 41, 1339-1347
42. Cox, A. D., and Der, C. J. (2002) Curr. Opin. Pharmacol. 2, 383-393
43. Prendergast, G. C., and Rane, N. (2001) Expert Opin. Investig. Drugs 10, 2105-2116
44. Tamanoi, F., Kato-Stankiewicz, J., Jiang, C., Machado, I., and Thapar, N. (2001) J. Cell Biochem. Suppl. 37, 64-70
45. Law, B. K., Norgaard, P., and Moses, H. L. (2000) J. Biol. Chem. 275, 10796-10801