Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

Biochemical Journal

Volumn 344, Issue 2, 1999, Pages 427-431

  Navé, Barbara T ^a   Ouwens, D Margriet ^b   Withers, Dominic J ^a   Alessi, Dario R ^c   Shepherd, Peter R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b LEIDEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

eIF4E binding protein 1; p70s6 kinase; Phosphoinositide 3 kinase

Indexed keywords

AMINO ACID; ANTIBODY; INSULIN; PHOSPHOSERINE; PROTEIN KINASE; PROTEIN KINASE B; RAPAMYCIN; WORTMANNIN;

AMINO ACID DEFICIENCY; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG TARGETING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA TRANSLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACIDS; ANDROSTADIENES; INSULIN; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BIOSYNTHESIS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 0033429554     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3440427     Document Type: Article

References (36)

1. Jefferies, H. B. J., Reinhard, C., Kozma, S. C. and Thomas, G. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 4441-4445
2. Beretta, L., Gingras, A., Svitkin, Y. V., Hall, M. N. and Sonenberg, N. (1996) EMBO J. 15, 658-664
3. Lin, T., Kong, X., Saltiel, A. R., Blackshear, P. J. and Lawrence, J. C. (1995) J. Biol. Chem. 270, 18531-18538
4. Diggle, T. A., Moule, S. K., Avison, M. B., Flynn, A., Foulstone, E. J., Proud, C. G. and Denton, R. M. (1996) Biochem. J. 316, 447-453
5. Von-Manteuffel, S. R., Gingras, A. C., Ming, X. F., Sonenberg, N. and Thomas, G. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 4076-4080
6. Brunn, G. J., Hudson, C. C., Sekulic, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C. and Abrahams, R. T. (1997) Science 377, 99-101
7. Hara, K., Yonezawa, K., Kozlowski, M. T., Sugimoto, T., Andrabi, K., Weng, Q., Kasuga, M., Nishimoto, I. and Avruch, J. (1997) J. Biol. Chem. 272, 26457-26463
8. Azpiazu, I., Saltiel, A. R., DePaoli-Roach, A. A. and Lawrence, J. C. (1996) J. Biol. Chem. 271, 5033-5039
9. Chung, J., Keo, C. J., Crabtree, G. R. and Blenis, J. (1992) Cell 69, 1227-1236
10. Kuo, C. J., Chung, J., Fiorentino, D. F., Flanagan, W. M., Blenis, J. and Crabtree, G. R. (1992) Nature (London) 358, 70-73
11. Proud, C. G. and Denton, R. M. (1997) Biochem. J. 328, 329-341
12. Hara, K., Yonezawa, K., Weng, Q., Kozlowski, M. T., Belham, C. and Avruch, J. (1998) J. Biol. Chem. 273, 14484-14494
13. Iiboshi, Y., Papst, P. J., Kawasome, H., Abraham, R. T., Houghton, P. J. and Terada, N. (1999) J. Biol. Chem. 274, 1092-1099
14. Shigemitsu, K., Tsujishita, Y., Hara, K., Nanohoshi, M., Avruch, J. and Yonezawa, K. (1999) J. Biol. Chem. 274, 1058-1065
15. Sabatini, D. M., Erdjument-Bromage, H., Lui, M., Tempst, P. and Snyder, S. H. (1994) Cell 78, 35-43
16. Sabers, C. J., Martin, M. M., Brunn, G. J., Williams, J. M., Dumont, F. J., Wiederrecht, G. and Abraham, R. T. (1995) J. Biol. Chem. 270, 815-822
17. Brown, E. J., Albers, M. W., Shin, T. B., Ichikawa, K., Keith, C. T., Lane, W. S. and Scheiber, S. L. (1994) Nature (London) 369, 756-758
18. Onyango, P., Lubyova, B., Gardellin, P., Kurzbauer, R. and Weith, A. (1998) Genomics 50, 187-198
19. Brunn, G. J., Williams, J., Sabers, C., Wiederrecht, G., Lawrence, J. C. and Abraham, R. T. (1996) EMBO J. 15, 5256-5257
20. Withers, D. J., Ouwens, D. M., Navé, B. T., Zon, G.v.d., Alarcon, C. M., Cardenas, M. E., Heitman, J., Maassen, J. A. and Shepherd, P. R. (1997) Biochem. Biophys. Res. Commun. 241, 704-709
21. Burnett, P. E., Barrow, R. K., Cohen, N. A., Snyder, S. H. and Sabatini, D. M. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 1432-1437
22. Scott, P. H., Brunn, G. J., Kohn, A. D., Roth, R. A. and Lawrence, J. C. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 7772-7777
23. Lin, T. and Lawrence, J. C. (1996) J. Biol. Chem. 271, 30199-30204
24. Petritsch, C., Woscholski, R., Edelmann, H. M., Parker, P. J. and Ballou, L. M. (1995) Eur. J. Biochem. 230, 431-438
25. Chung, J., Grammer, T. C., Lemon, K. P., Kazlauskas, A. and Blenis, J. (1994) Nature (London) 370, 71-75
26. Burgering, B. M. T. and Coffer, P. J. (1995) Nature (London) 376, 599-602
27. Gingras, A., Kennedy, S. G., O'Leary, M. A., Sonenburg, N. and Hay, N. (1998) Genes Dev. 12, 502-513
28. Scott, P. H. and Lawrence, J. C. (1998) J. Biol. Chem. 273, 34496-34501
29. Alessi, D. R., Deak, M., Casomayor, A., Caudwell, F. B., Morrice, N., Norman, D. G., Gaffney, P., Reese, C. B., MacDougall, C. N., Harbison, D., Ashworth, A. and Bownes, M. (1997) Curr. Biol. 7, 776-789
30. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B. and Cohen, P. (1997) Curr. Biol. 7, 261-269
31. Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P. and Hemmings, B. A. (1996) EMBO J. 15, 6541-6551
32. Scott, P. H., Belham, C. M., Alhafidh, J., Chilvers, E. R., Peacock, A. J., Gould, G. W. and Plevin, R. (1996) Biochem. J. 318, 965-971
33. Alessi, D. R., Caudwell, F. B., Andjelkovic, M., Hemmings, B. A. and Cohen, P. (1996) FEBS Lett. 399, 333-338
34. Thomas, G. and Hall, M. N. (1997) Curr. Opin. Cell Biol. 9, 782-787
35. Moule, S. K., Welsh, G. I., Edgell, N. J., Foulstone, E. J., Proud, C. G. and Denton, R. M. (1997) J. Biol. Chem. 272, 7713-7719
36. Jolicoeur, P., Lemay, A., Labrie, F. and Steiner, A. L. (1974) Exp. Cell Res. 89, 231-240