Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

Journal of Biological Chemistry

Volumn 273, Issue 23, 1998, Pages 14424-14429

  Hashemolhosseini, Said ^a   Nagamine, Yoshikuni ^b   Morley, Simon J ^c,d   Desrivières, Sylvane ^a,e   Mercep, Luka ^a   Ferrari, Stefano ^a,f  

^a TUMOR BIOLOGY CENTER   (Germany)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e UNIVERSITY OF BASEL   (Switzerland)

^f NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN E; PROTEIN KINASE; PROTEIN P27; PROTEINASE INHIBITOR; RAPAMYCIN; ACETYLLEUCYL LEUCYL NORLEUCINAL; ACETYLLEUCYL-LEUCYL-NORLEUCINAL; CARRIER PROTEIN; CDKN1B PROTEIN, MOUSE; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYSTEINE PROTEINASE INHIBITOR; DNA BINDING PROTEIN; FK 506 BINDING PROTEIN; HEAT SHOCK PROTEIN; IMMUNOSUPPRESSIVE AGENT; LEUPEPTIN; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN; POLYENE; RETINOBLASTOMA PROTEIN; S6 KINASE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL CYCLE G1 PHASE; CELL STRAIN 3T3; CONTROLLED STUDY; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; ANIMAL; APOPTOSIS; CELL CYCLE; DRUG EFFECT; GENETIC TRANSCRIPTION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

3T3 CELLS; ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYSTEINE PROTEINASE INHIBITORS; DNA-BINDING PROTEINS; G1 PHASE; HEAT-SHOCK PROTEINS; IMMUNOSUPPRESSIVE AGENTS; LEUPEPTINS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; PHOSPHORYLATION; POLYENES; RETINOBLASTOMA PROTEIN; RIBOSOMAL PROTEIN S6 KINASES; RNA, MESSENGER; SIROLIMUS; TACROLIMUS BINDING PROTEINS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 0032485937     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.23.14424     Document Type: Article

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