Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis

Current Biology

Volumn 12, Issue 16, 2002, Pages 1419-1423

  Horman, Sandrine ^a   Browne, Gareth J ^b   Krause, Ulrike ^a   Patel, Jigna V ^b   Vertommen, Didier ^a   Bertrand, Luc ^a   Lavoinne, Alain ^c   Hue, Louis ^a   Proud, Christopher G ^b   Rider, Mark H ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c Faculté de Médecine Pharmacie   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOIMIDAZOLE CARBOXAMIDE; ANIMAL; CELL HYPOXIA; CELL LINE; DEOXYGLUCOSE; ENZYME ACTIVATION; ENZYME INHIBITORS; HEPATOCYTES; HUMAN; MULTIENZYME COMPLEXES; OLIGOMYCINS; OXYGEN; PEPTIDE CHAIN ELONGATION; PEPTIDE ELONGATION FACTOR 2; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RATS; RIBONUCLEOSIDES; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; ANIMALS; HUMANS; PEPTIDE CHAIN ELONGATION, TRANSLATIONAL;

EUKARYOTA; MAMMALIA;

5 AMINO 4 IMIDAZOLECARBOXAMIDE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; 5' AMP ACTIVATED PROTEIN KINASE; 5'-AMP-ACTIVATED PROTEIN KINASE; DEOXYGLUCOSE; DRUG DERIVATIVE; ELONGATION FACTOR 2; ENZYME INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN; MULTIENZYME COMPLEX; OLIGOMYCIN; OXYGEN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; RIBONUCLEOSIDE;

ANIMAL; ARTICLE; CELL HYPOXIA; CELL LINE; CYTOLOGY; ENZYME ACTIVATION; GENETICS; HUMAN; LIVER CELL; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RAT; RNA TRANSLATION; SIGNAL TRANSDUCTION;

EID: 0037143449     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)01077-1     Document Type: Article

References (18)

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