-
1
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin receptor complex
-
Brown EJ, Albers MW, Shin TB, Ocjlawa K, Keith CT, Lane WS, and Schreiber SL (1994) A mammalian protein targeted by G1-arresting rapamycin receptor complex. Nature (Lond) 369:756-758.
-
(1994)
Nature (Lond)
, vol.369
, pp. 756-758
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
Ocjlawa, K.4
Keith, C.T.5
Lane, W.S.6
Schreiber, S.L.7
-
2
-
-
0030881836
-
Phosphorylation of the eukaryotic initiation factor-4E-binding protein, PHAS-I, by the mammalian target of rapamycin
-
Brunn GJ, Hudson CC, Sekulic A, Williams, JM, Hosoi H, Houghton PJ, Lawrence JC, and Abraham RT (1997) Phosphorylation of the eukaryotic initiation factor-4E-binding protein, PHAS-I, by the mammalian target of rapamycin. Science (Washington DC) 277:99-104.
-
(1997)
Science (Washington DC)
, vol.277
, pp. 99-104
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
Williams, J.M.4
Hosoi, H.5
Houghton, P.J.6
Lawrence, J.C.7
Abraham, R.T.8
-
3
-
-
0029831167
-
Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002
-
Brunn GJ, Williams J, Sabers C, Wiederrecht G, Lawrence JC Jr, and Abraham RT (1996) Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO (Eur Mol Biol Organ) J 15:5256-5267.
-
(1996)
EMBO (Eur Mol Biol Organ) J
, vol.15
, pp. 5256-5267
-
-
Brunn, G.J.1
Williams, J.2
Sabers, C.3
Wiederrecht, G.4
Lawrence Jr., J.C.5
Abraham, R.T.6
-
4
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BPI
-
Burnett PE, Barrow RK, Cohen NA, and Snyder SH (1998) RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BPI. Proc Natl Acad Sci USA 95:1432-1437.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Snyder, S.H.4
-
5
-
-
0028598672
-
RAPT1, a mammalian homolog of yeast TOR interacts with the FKBP/rapamycin complex
-
Chiu MI, Katz H, and Berlin V (1994) RAPT1, a mammalian homolog of yeast TOR interacts with the FKBP/rapamycin complex. Proc Natl Acad Sci USA 91:12574-2578.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 12574-12578
-
-
Chiu, M.I.1
Katz, H.2
Berlin, V.3
-
6
-
-
0028253641
-
CHO cells transformed by the translation factor eIF4E display increased c-myc expression but require overexpression of Max for tumorigenicity
-
DeBenedetti A, Joshi B, Graff JR, and Zimmer SG (1994) CHO cells transformed by the translation factor eIF4E display increased c-myc expression but require overexpression of Max for tumorigenicity. Mol Cell Differ 2:347-371.
-
(1994)
Mol Cell Differ
, vol.2
, pp. 347-371
-
-
DeBenedetti, A.1
Joshi, B.2
Graff, J.R.3
Zimmer, S.G.4
-
7
-
-
0029828590
-
The principal rapamycin-sensitive p70S6k phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases
-
Dennis PB, Pullen N, Kozma SC, and Thomas G (1996) The principal rapamycin-sensitive p70S6k phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases. Mol Cell Biol 16:6242-6251.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 6242-6251
-
-
Dennis, P.B.1
Pullen, N.2
Kozma, S.C.3
Thomas, G.4
-
8
-
-
0026476403
-
Monoclonal antibodies to the myogenic regulatory protein MyoDI: Epitope mapping and diagnostic utility
-
Dias P, Parham DM, Shapiro DN, Tapscott SJ, and Houghton PJ (1992) Monoclonal antibodies to the myogenic regulatory protein MyoDI: epitope mapping and diagnostic utility. Cancer Res 52:6431-6439.
-
(1992)
Cancer Res
, vol.52
, pp. 6431-6439
-
-
Dias, P.1
Parham, D.M.2
Shapiro, D.N.3
Tapscott, S.J.4
Houghton, P.J.5
-
9
-
-
0028328655
-
Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor
-
Dilling MB, Dias P, Shapiro DN, German GS, Johnson RK, and Houghton PJ (1994) Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor. Cancer Res 54:903-907.
-
(1994)
Cancer Res
, vol.54
, pp. 903-907
-
-
Dilling, M.B.1
Dias, P.2
Shapiro, D.N.3
German, G.S.4
Johnson, R.K.5
Houghton, P.J.6
-
10
-
-
0025461112
-
Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors
-
El-Badry OM, Minniti C, Kohn EC, Houghton PJ, Daughaday WH, and Helman LJ (1990) Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors. Cell Growth Differ 1:325-331.
-
(1990)
Cell Growth Differ
, vol.1
, pp. 325-331
-
-
El-Badry, O.M.1
Minniti, C.2
Kohn, E.C.3
Houghton, P.J.4
Daughaday, W.H.5
Helman, L.J.6
-
11
-
-
0024465983
-
Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II
-
El-Badry OM, Romanus JA, Helman LJ, Cooper MJ, Rechler MM, and Israel MA (1989) Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II. J Clin Invest 84:829-839.
-
(1989)
J Clin Invest
, vol.84
, pp. 829-839
-
-
El-Badry, O.M.1
Romanus, J.A.2
Helman, L.J.3
Cooper, M.J.4
Rechler, M.M.5
Israel, M.A.6
-
12
-
-
0025871394
-
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A
-
Flanagan WM, Carthésy B, Bram RJ, and Crabtree JR (1991) Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature (Lond) 352:803-807.
-
(1991)
Nature (Lond)
, vol.352
, pp. 803-807
-
-
Flanagan, W.M.1
Carthésy, B.2
Bram, R.J.3
Crabtree, J.R.4
-
13
-
-
0026503434
-
Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A
-
Fruman DA, Klee CB, Bierer BE, and Burakoff SJ (1992) Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci USA 89:3686-3690.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 3686-3690
-
-
Fruman, D.A.1
Klee, C.B.2
Bierer, B.E.3
Burakoff, S.J.4
-
14
-
-
0032520009
-
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway
-
Gingras A-C, Kennedy SG, O'Leary MA, Sonenberg N, and Hay N (1998) 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway. Genes Deu 12:502-513.
-
(1998)
Genes Deu
, vol.12
, pp. 502-513
-
-
Gingras, A.-C.1
Kennedy, S.G.2
O'Leary, M.A.3
Sonenberg, N.4
Hay, N.5
-
15
-
-
0030716488
-
Regulation of eIF-4E BPI phosphorylation by mTOR
-
Hara K, Yonezawa K, Kozlowski MT, Sugimoto T, Andrabi K, Weng QP, Kasuga M, Nishimoto I, and Avruch J (1997) Regulation of eIF-4E BPI phosphorylation by mTOR. J Biol Chem 272:26457-26463.
-
(1997)
J Biol Chem
, vol.272
, pp. 26457-26463
-
-
Hara, K.1
Yonezawa, K.2
Kozlowski, M.T.3
Sugimoto, T.4
Andrabi, K.5
Weng, Q.P.6
Kasuga, M.7
Nishimoto, I.8
Avruch, J.9
-
16
-
-
0025266892
-
Studies on the cellular pharmacology of N-(4-methylphenylsulfonyl)-N′-(4-chlorphenyl)-urea
-
Houghton PJ, Bailey FC, Germain GS, Grindey GB, Howbert JJ, and Houghton JA (1990) Studies on the cellular pharmacology of N-(4-methylphenylsulfonyl)-N′-(4-chlorphenyl)-urea. Biochem Pharmacol 39:1187-1192.
-
(1990)
Biochem Pharmacol
, vol.39
, pp. 1187-1192
-
-
Houghton, P.J.1
Bailey, F.C.2
Germain, G.S.3
Grindey, G.B.4
Howbert, J.J.5
Houghton, J.A.6
-
17
-
-
0028207001
-
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family
-
Jeffries HBJ, Reinhard C, Kozma SC, and Thomas G (1994) Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Proc Natl Acad Sci USA 91:4441-4445.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 4441-4445
-
-
Jeffries, H.B.J.1
Reinhard, C.2
Kozma, S.C.3
Thomas, G.4
-
18
-
-
0027274978
-
Cyclosporin A, FK506 and rapamycin: More than just immunosuppression
-
Kunz J and Hall MN (1993) Cyclosporin A, FK506 and rapamycin: more than just immunosuppression. Trends Biochem Sci 18:334-338.
-
(1993)
Trends Biochem Sci
, vol.18
, pp. 334-338
-
-
Kunz, J.1
Hall, M.N.2
-
19
-
-
0025893168
-
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
-
Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, and Schreiber SL (1991) Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66:807-815.
-
(1991)
Cell
, vol.66
, pp. 807-815
-
-
Liu, J.1
Farmer Jr., J.D.2
Lane, W.S.3
Friedman, J.4
Weissman, I.5
Schreiber, S.L.6
-
20
-
-
0027432388
-
Isolation of the cyclosporin-sensitive T-cell transcription factor NFATp
-
McCaffrey PG, Luo C, Kerpola TK, Jain J, Badalian TM, Ho AM, Burgeon E, Lane WS, Lambert JN, Curran T, Verdine GL, Rao A, and Hogan PG (1993) Isolation of the cyclosporin-sensitive T-cell transcription factor NFATp. Science (Washington DC) 262:750-754.
-
(1993)
Science (Washington DC)
, vol.262
, pp. 750-754
-
-
McCaffrey, P.G.1
Luo, C.2
Kerpola, T.K.3
Jain, J.4
Badalian, T.M.5
Ho, A.M.6
Burgeon, E.7
Lane, W.S.8
Lambert, J.N.9
Curran, T.10
Verdine, G.L.11
Rao, A.12
Hogan, P.G.13
-
21
-
-
0028982138
-
Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway
-
Nielsen FC, Ostergaard L, Nielsen J, and Christiansen J (1995) Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway. Nature (Lond) 377:358-362.
-
(1995)
Nature (Lond)
, vol.377
, pp. 358-362
-
-
Nielsen, F.C.1
Ostergaard, L.2
Nielsen, J.3
Christiansen, J.4
-
22
-
-
0028802451
-
The principal target of rapamycin-induced p70S6K inactivation is a novel phosphorylation site within a conserved hydrophobic domain
-
Pearson RB, Dennis PB, Han JW, Williamson NA, Kozma SC, Wettenhall REH, and Thomas G (1995) The principal target of rapamycin-induced p70S6K inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO (Eur Mol Biol Organ) J 14:5279-5287.
-
(1995)
EMBO (Eur Mol Biol Organ) J
, vol.14
, pp. 5279-5287
-
-
Pearson, R.B.1
Dennis, P.B.2
Han, J.W.3
Williamson, N.A.4
Kozma, S.C.5
Wettenhall, R.E.H.6
Thomas, G.7
-
23
-
-
0032578998
-
Phosphorylation and activation of p70S6K by PDK1
-
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, and Thomas G (1998) Phosphorylation and activation of p70S6K by PDK1. Science (Washington DC) 279:707-710.
-
(1998)
Science (Washington DC)
, vol.279
, pp. 707-710
-
-
Pullen, N.1
Dennis, P.B.2
Andjelkovic, M.3
Dufner, A.4
Kozma, S.C.5
Hemmings, B.A.6
Thomas, G.7
-
24
-
-
0029166967
-
Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and posttranscriptional levels
-
Rosenwald IB, Kaspar R, Rousseau D, Gehrke L, Leboulch P, Chen JJ, Schmidt EV, Sonenberg N, and London IM (1995) Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and posttranscriptional levels. J Biol Chem 270:21176-21180.
-
(1995)
J Biol Chem
, vol.270
, pp. 21176-21180
-
-
Rosenwald, I.B.1
Kaspar, R.2
Rousseau, D.3
Gehrke, L.4
Leboulch, P.5
Chen, J.J.6
Schmidt, E.V.7
Sonenberg, N.8
London, I.M.9
-
25
-
-
0028239893
-
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
-
Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, and Snyder SH (1994) RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78:35-43.
-
(1994)
Cell
, vol.78
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
Tempst, P.4
Snyder, S.H.5
-
26
-
-
0026030568
-
Chemistry and biology of the immunophilins and their immunosuppressive ligands
-
Schreiber SL (1991) Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science (Washington DC) 251:283-287.
-
(1991)
Science (Washington DC)
, vol.251
, pp. 283-287
-
-
Schreiber, S.L.1
-
27
-
-
3643056162
-
Rapamycin induces Rb hypophosphorylation and G1/S block in the PC3 prostate carcinoma cell line
-
Senderowicz AM, Carlson BA, Malspies L, Sauseville EA, and Worland PJ (1995) Rapamycin induces Rb hypophosphorylation and G1/S block in the PC3 prostate carcinoma cell line. Proc Am Assoc Cancer Res 36:2360A.
-
(1995)
Proc Am Assoc Cancer Res
, vol.36
-
-
Senderowicz, A.M.1
Carlson, B.A.2
Malspies, L.3
Sauseville, E.A.4
Worland, P.J.5
-
28
-
-
0024442393
-
A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
-
Siekierka JJ, Hung SHY, Poe M, Lin CS, and Sigal NH (1989) A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature (Lond) 341:755-757.
-
(1989)
Nature (Lond)
, vol.341
, pp. 755-757
-
-
Siekierka, J.J.1
Hung, S.H.Y.2
Poe, M.3
Lin, C.S.4
Sigal, N.H.5
-
29
-
-
0028271504
-
Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation
-
Shantz LM and Pegg AE (1994) Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation. Cancer Res 54:2313-2316.
-
(1994)
Cancer Res
, vol.54
, pp. 2313-2316
-
-
Shantz, L.M.1
Pegg, A.E.2
-
30
-
-
0028086553
-
Anti-sense-mediated reduction in insulin-like growth factor-1 receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma
-
Shapiro DN, Jones BG, Shapiro LH, Dias P, and Houghton PJ (1994) Anti-sense-mediated reduction in insulin-like growth factor-1 receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma. J Clin Invest 94:1235-1242.
-
(1994)
J Clin Invest
, vol.94
, pp. 1235-1242
-
-
Shapiro, D.N.1
Jones, B.G.2
Shapiro, L.H.3
Dias, P.4
Houghton, P.J.5
-
31
-
-
0027231244
-
Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase
-
Terada N, Franklin RA, Lucas JJ, Blenis J, and Gelfand EW (1993) Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase. J Biol Chem 268:12062-12068.
-
(1993)
J Biol Chem
, vol.268
, pp. 12062-12068
-
-
Terada, N.1
Franklin, R.A.2
Lucas, J.J.3
Blenis, J.4
Gelfand, E.W.5
-
32
-
-
0028032355
-
Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins
-
Terada N, Patel HR, Takase K, Kohno K, Nairn AC, and Gelfand EW (1994) Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc Natl Acad Sci USA 91:11477-11481.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 11477-11481
-
-
Terada, N.1
Patel, H.R.2
Takase, K.3
Kohno, K.4
Nairn, A.C.5
Gelfand, E.W.6
-
33
-
-
0030806524
-
The insulin-induced signaling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70S6K
-
von Manteuffel SR, Dennis PB, Pullen N, Gingras A-C, Sonenberg N, and Thomas G (1997) The insulin-induced signaling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70S6K. Mol Cell Biol 17:5426-5436.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 5426-5436
-
-
Manteuffel, S.R.1
Dennis, P.B.2
Pullen, N.3
Gingras, A.-C.4
Sonenberg, N.5
Thomas, G.6
-
34
-
-
0029984354
-
4E-BPI phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase
-
von Manteuffel SR, Gingras AC, Ming XF, Sonenberg N, and Thomas G (1996) 4E-BPI phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase. Proc Natl Acad Sci USA 93:4076-4080.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 4076-4080
-
-
Manteuffel, S.R.1
Gingras, A.C.2
Ming, X.F.3
Sonenberg, N.4
Thomas, G.5
-
35
-
-
0032514376
-
Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathways
-
West MJ, Stonely M, and Willis AE (1998) Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathways. Oncogene 17:769-780.
-
(1998)
Oncogene
, vol.17
, pp. 769-780
-
-
West, M.J.1
Stonely, M.2
Willis, A.E.3
|