Signaling to the actin cytoskeleton

Annual Review of Cell and Developmental Biology

Volumn 14, Issue , 1998, Pages 305-338

  Schmidt, Anja ^a   Hall, Michael N ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Actin; GTPase; PI kinase; Rho; Signal transduction

Indexed keywords

ACTIN; ACTIN BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; PROTEIN KINASE; RHO FACTOR;

ACTIN FILAMENT; ACTIN POLYMERIZATION; CELL MOTILITY; CELL SHAPE; CROSS LINKING; CYTOSKELETON; DNA SYNTHESIS; INTERMEDIATE FILAMENT; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; REVIEW; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; CYTOSKELETON; GTP PHOSPHOHYDROLASES; HUMANS; MAMMALS; MICROFILAMENT PROTEINS; RAS PROTEINS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EID: 0032437666     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.14.1.305     Document Type: Review

References (296)

1. Adams AE, Botstein D, Drubin DG. 1991. Requirement of yeast fimbrin for actin organization and morphogenesis in vivo. Nature 354: 404-8
2. Adams AE, Johnson DI, Longnecker RM, Sloat BF, Pringle JR. 1990. CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. J. Cell Biol. 111: 131-42
3. Adams AE, Pringle JR. 1984. Relationship of actin and tubulin distribution to bud growth in wild-type and morphogenetic-mutant Saccharomyces cerevisiae. J. Cell Biol. 98:934-45
4. Adamson P, Marshall CJ, Hall A, Tilbrook PA. 1992. Post-translational modifications of p21rho proteins. J. Biol. Chem. 267:20033-38
5. Amano M, Mukai H, Ono Y, Chihara K, Matsui T, et al. 1996. Identification of a putative target for Rho as the serine-threonine kinase protein kinase N. Science 271:648-50
6. Amatruda JF, Cannon JF, Tatchell K, Hug C, Cooper JA. 1990. Disruption of the actin cytoskeleton in yeast capping protein mutants. Nature 344:352-54
7. Amatruda JF, Gattermeir DJ, Karpova TS, Cooper JA. 1992. Effects of null mutations and overexpression of capping protein on morphogenesis, actin distribution and polarized secretion in yeast. J. Cell Biol. 119: 1151-62
8. Aspenstrom P, Lindberg U, Hall A. 1996. Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome. Curr. Biol. 6:70-75
9. Bahler M. 1996. Myosins on the move to signal transduction. Curr. Opin. Cell Biol. 8:18-22
10. Bearer EL. 1991. Direct observation of actin filament severing by gelsolin and binding by gCap39 and CapZ. J. Cell Biol. 115:1629-38
11. Bender A, Pringle JR. 1989. Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1. Proc. Natl. Acad. Sci. USA 86:9976-80
12. Benedetti H, Raths S, Crausaz F, Riezman H. 1994. The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast. Mol. Biol. Cell 5:1023-37
13. Benton BK, Tinkelenberg A, Gonzalez I, Cross FR. 1997. Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol. Cell Biol. 17:5067-76
14. Bi E, Pringle JR. 1996. ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae. Mol. Cell Biol. 16: 5264-75
15. Bickle M. Delley P-A, Schmidt A, Hall MN. 1998. Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. EMBO J. 17:2235-45
16. Bobola N, Jansen RP, Shin TH, Nasmyth K. 1996. Asymmetric accumulation of Ash1p in postanaphase nuclei depends on a myosin and restricts yeast mating-type switching to mother cells. Cell 84:699-709
17. Bokoch GM, Vlahos CJ, Wang Y, Knaus UG, Traynor-Kaplan AE. 1996. Rac GTPase interacts specifically with phosphatidylinositol 3-kinase. Biochem. J. 315:775-79
18. Bollag G, McCormick F. 1991. Regulators and effectors of ras proteins. Annu. Rev. Cell Biol. 7:601-32
19. Botstein D, Amberg D, Mulholland J, Huffaker T, Adams A, et al. 1997. The yeast cytoskeleton. In Yeast III, pp. 1-80. Cold Spring Harbor, NY: Cold Spring Harbor Lab. Press
20. Bretscher A. 1993. Microfilaments and membranes. Curr. Opin Cell Biol. 5:653-60
21. Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, et al. 1996. The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GT-Pases. Mol. Cell Biol. 16:4869-78
22. Brown JL, Jaquenoud M, Gulli MP, Chant J, Peter M. 1997. Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast. Genes Dev. 11:2972-82
23. Burbelo PD, Drechsel D, Hall A. 1995. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J. Biol. Chem. 270:29071-74
24. Burridge K, Fath K. 1989. Focal contacts: transmembrane links between the extracellular matrix and the cytoskeleton. BioEssays 10: 104-8
25. Burridge K, Nuckolls G, Otey C, Pavalko F, Simon K, Turner C. 1990. Actin-membrane interaction in focal adhesions. Cell Differ. Dev. 32:337-42
26. Caldwell JE, Heiss SG, Mermall V, Cooper JA. 1989. Effects of CapZ, an actin capping protein of muscle, on the polymerization of actin. Biochemistry 28:8506-14
27. Carlsson L, Nystrom LE, Lindberg U, Kannan KK, Cid-Dresdner H, Lovgren S. 1976. Crystallization of a non-muscle actin. J. Mol. Biol. 105:353-66
28. Casella JF, Craig SW, Maack DJ, Brown AE. 1987. Cap Z(36/32), a barbed end actin-capping protein, is a component of the Z-line of skeletal muscle. J. Cell Biol. 105:371-79
29. Cerione RA, Zheng Y. 1996. The Db1 family of oncogenes. Curr. Opin. Cell Biol. 8:216-22
30. Chan AM, Takai S, Yamada K, Miki T. 1996. Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning. Oncogene 12:1259-66
31. Chant J. 1996. Generation of cell polarity in yeast. Curr. Opin. Cell Biol. 8:557-65
32. Chant J, Corrado K, Pringle JR, Herskowitz I. 1991. Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1. Cell 65:1213-24
33. Chant J, Herskowitz I. 1991. Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway. Cell 65:1203-12
34. Chant J, Pringle JR. 1991. Budding and cell polarity in Saccharomyces cerevisiae. Curr. Opin. Genet. Dev. 1:342-50
35. Chardin P, Boquet P, Madaule P, Popoff MR, Rubin EJ, Gill DM 1989. The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells. EMBO J. 8:1087-92
36. Chen GC, Kim YJ, Chan CS. 1997. The Cdc42 GTPase-associated proteins Gic1 and Gic2 are required for polarized cell growth in Saccharomyces cerevisiae. Genes Dev. 11:2958-71
37. Chen GC, Zheng L, Chan CS. 1996a. The LIM domain-containing Dbm1 GTPase-activating protein is required for normal cellular morphogenesis in Saccharomyces cerevisiae. Mol. Cell Biol. 16:1376-90
38. Chen LM, Hobbie S, Galan JE. 19966. Requirement of CDC42 for Salmonlla-induced cytoskeletal and nuclear responses. Science 274:2115-18
39. Chen X, Sullivan DS, Huffaker TC. 1994. Two yeast genes with similarity to TCP-1 are required for microtubule and actin function in vivo. Proc. Natl. Acad. Sci. USA 91:9111-15
40. Chenevert J. 1994. Cell polarization directed by extracellular cues in yeast. Mol. Biol. Cell 5: 1169-75
41. Chenevert J, Corrado K, Bender A, Pringle J, Herskowitz I. 1992. A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains. Nature 356:77-79
42. Chong LD, Traynor-Kaplan A, Bokoch GM, Schwartz MA. 1994. The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell 79:507-13
43. Chowdhury S, Smith KW, Gustin MC. 1992. Osmotic stress and the yeast cytoskeleton: phenotype-specific suppression of an actin mutation. J. Cell Biol. 118:561-71
44. Chrzanowska-Wodnicka M, Burridge K. 1996. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J. Cell Biol. 133:1403-15
45. Cook JG, Bardwell L, Thorner J. 1997. Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway. Nature 390:85-88
46. Coso OA, Chiariello M, Yu JC, Teramoto H, Crespo P, et al. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137-46
47. Cossart P. 1995. Actin-based bacterial motility. Curr. Opin. Cell Biol. 7:94-101
48. Cramer LP, Mitchison TJ, Theriot JA. 1994. Actin-dependent motile forces and cell motility. Curr. Opin. Cell Biol. 6:82-86
49. Cvrckova F, De Virgilio C, Manser E, Pringle JR, Nasmyth K. 1995. Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev. 9:1817-30
50. de Arruda MV, Watson S, Lin CS, Leavitt J, Matsudaira P. 1990. Fimbrin is a homologue of the cytoplasmic phosphoprotein plastin and has domains homologous with calmodulin and actin gelation proteins. J. Cell Biol. 111:1069-79
51. Diekmann D, Abo A, Johnston C, Segal AW, Hall A. 1994. Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity. Science 265:531-33
52. Diekmann D, Brill S, Garrett MD, Totty N, Hsuan J, et al. 1991. Bcr encodes a GTPase-activating protein for p21rac. Nature 351: 400-2
53. Drgonova J, Drgon T, Tanaka K, Kollar R, Chen GC, et al. 1996. Rho1p, a yeast protein at the interface between cell polarization and morphogenesis. Science 272:277-79
54. Drubin DG, Jones HD, Wertman KF. 1993. Actin structure and function: roles in mitochondrial organization and morphogenesis in budding yeast and identification of the phalloidin-binding site. Mol. Biol. Cell 4: 1277-94
55. Dubreuil RR. 1991. Structure and evolution of the actin crosslinking proteins. BioEssays 13: 219-26
56. Dunn TM, Shortle D. 1990. Null alleles of SAC7 suppress temperature-sensitive actin mutations in Saccharomyces cerevisiae. Mol. Cell Biol. 10:2308-14
57. Engel J, Fasold H, Huila FW, Waechter F, Wegner A. 1977. The polymerization reaction of muscle actin. Mol. Cell Biochem. 18:3-13
58. Errede B, Cade RM, Yashar BM, Kamada Y, Levin DE, et al. 1995. Dynamics and organization of MAP kinase signal pathways. Mol. Reprod. Dev. 42:477-85
59. Eva A, Aaronson SA. 1985. Isolation of a new human oncogene from a diffuse B-cell lymphoma. Nature 316:273-75
60. Evangelista M, Blundell K, Longtine MS, Chow CJ, Adames N, et al. 1997. Bnilp, a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesis. Science 276:118-22
61. Farkas V, Kovarik J, Kosinova A, Bauer S. 1974. Autoradiographic study of mannan incorporation into the growing cell walls of Saccharomyces cerevisiae. J. Bacteriol. 117:265-69
62. Foster R, Hu KQ, Lu Y, Nolan KM, Thissen J, Settleman J. 1996. Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Mol. Cell Biol. 16:2689-99
63. Frazier JA, Field CM. 1997. Actin cytoskeleton: Are FH proteins local organizers? Curr. Biol. 7:R414-17
64. Freeman NL, Chen Z, Horenstein J, Weber A, Field J. 1995. An actin monomer binding activity localizes to the carboxyl-terminal half of the Saccharomyces cerevisiae cyclase-associated protein. J. Biol. Chem. 270:5680-85
65. Fukami K. Furuhashi K, Inagaki M, Endo T, Hatano S, Takenawa T. 1992. Requirement of phosphatidylinositol 4,5-bisphosphate for alpha-actinin function. Nature 359:150-52
66. Fukumoto Y, Kaibuchi K, Hori Y, Fujioka H, Araki S, et al. 1990. Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Oncogene 5:1321-28
67. Furuhashi K, Inagaki M, Hatano S, Fukami K, Takenawa T. 1992. Inositol phospholipid-induced suppression of F-actin-gelating activity of smooth muscle filamin. Biochem. Biophys. Res. Commun. 184:1261-65
68. Gale CA, Bendel CM, McClellan M, Hauser M, Becker JM, Berman J, Hostetter MK. 1998. Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1. Science 279:1355-58
69. Gallwitz D, Sures I. 1980. Structure of a split yeast gene: complete nucleotide sequence of the actin gene in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 77:2546-50
70. Gao Y, Thomas JO, Chow RL, Lee GH, Cowan NJ. 1992 A cytoplasmic chaperonin that catalyzes beta-actin folding. Cell 69:1043-50
71. Gao Y, Vainberg IE, Chow RL, Cowan NJ. 1993. Two cofactors and cytoplasmic chaperonin are required for the folding of alpha-and beta-tubulin. Mol. Cell Biol. 13:2478-85
72. Geiger B, Ginsberg D, Salomon D, Volberg T. 1990. The molecular basis for the assembly and modulation of adherens-type junctions. Cell Differ. Dev. 32:343-53
73. Geli MI, Riezman H. 1996. Role of type I myosins in receptor-mediated endocytosis in yeast. Science 272:533-35
74. Giancotti F. 1997. Integrin signaling: specificity and control of cell survival and cell cycle progression. Curr. Opin. Cell Biol. 9:691
75. Gilmore AP, Burridge K. 1996. Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate. Nature 381:531-35
76. Goldschmidt-Clermont PJ, Furman Ml, Wachsstock D, Safer D, Nachmias VT, Pollard TD. 1992. The control of actin nucleotide exchange by thymosin beta 4 and profilin. A potential regulatory mechanism for actin polymerization in cells. Mol. Biol. Cell 3:1015-24
77. Goodson HV, Anderson BL, Warrick HM, Pon LA, Spudich JA 1996 Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton. J. Cell Biol. 133:1277-91
78. Goodson HV, Spudich JA. 1995. Identification and molecular characterization of a yeast myosin I. Cell Motil. Cytoskelet. 30:73-84
79. Goodson HV, Valetti C, Kreis TE. 1997. Motors and membrane traffic. Curr. Opin. Cell Biol. 9:18-28
80. Gottlieb TA, Ivanov IE, Adesnik M, Sabatini DD. 1993. Actin microfilaments play a critical role in endocytosis at the apical but not the basolateral surface of polarized epithelial cells. J. Cell Biol. 120:695-710
81. Govindan B, Bowser R, Novick P. 1995. The role of Myo2, a yeast class V myosin, in vesicular transport. J. Cell Biol. 128:1055-68
82. Haarer BK, Lillie SH, Adams AE, Magdolen V, Bandlow W, Brown SS. 1990. Purification of profilin from Saccharomyces cerevisiae and analysis of profilin-deficient cells. J. Cell Biol. 110:105-14
83. Haarer BK, Petzold AS, Brown SS. 1993. Mutational analysis of yeast profilin. Mol. Cell Biol. 13:7864-73
84. Hall A. 1994. Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu. Rev. Cell Biol. 1994;10:31-54
85. Han J, Luby-Phelps K, Das B, Shu X, Xia Y, et al. 1998. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279:558-60
86. Harlan JE, Hajduk PJ, Yoon HS, Fesik SW. 1994. Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature 371:168-70
87. Hart MJ, Callow MG, Souza B, Polakis P. 1996. IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J. 15:2997-3005
88. Hart MJ, Eva A, Zangrilli D, Aaronson SA, Evans T, et al. 1994. Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. J. Biol. Chem. 269:62-65
89. Hartwig JH, Bokoch GM, Carpenter CL, Janmey PA, Taylor LA, et al. 1995. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 82:643-53
90. Hartwig JH, Kwiatkowski DJ. 1991. Actin-binding proteins. Curr. Opin. Cell Biol. 3:87-97
91. Hasson T, Mooseker MS. 1995. Molecular motors, membrane movements and physiology: emerging roles for myosins. Curr. Opin. Cell Biol. 7:587-94
92. Hawkins M, Pope B, Maciver SK, Weeds AG. 1993. Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments. Biochemistry 32:9985-93
93. Hawkins PT, Eguinoa A, Qiu RG, Stokoe D, Cooke FT, et al. 1995. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr. Biol. 5:393-403
94. Hayden SM, Miller PS, Brauweiler A, Bamburg JR. 1993. Analysis of the interactions of actin depolymerizing factor with G- and F-actin. Biochemistry 32:9994-10004
95. Heiss SG, Cooper JA. 1991. Regulation of CapZ, an actin capping protein of chicken muscle, by anionic phospholipids. Biochemistry 30:8753-58
96. Helliwell SB, Howald I, Barbet N, Hall MN. 1998. Evidence for two related TOR2 signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Genetics 48:99-112
97. Hill CS, Wynne J, Treisman R. 1995. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81:1159-70
98. Hirano H, Tanaka K, Ozaki K, Imamura H, Kohno H, et al. 1996. ROM7/BEM4 encodes a novel protein that interacts with the Rho1p small GTP-binding protein in Saccharomyces cerevisiae. Mol. Cell Biol. 16:4396-403
99. Holtzman DA, Yang S, Drubin DG. 1993. Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae. J. Cell Biol. 122:635-44
100. Hori Y, Kikuchi A, Isomura M, Katayama M, Miura Y, et al. 1991. Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins. Oncogene 6:515-22
101. Hotchin NA, Hall A. 1995. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J. Cell Biol. 131:1857-65
102. Igual JC, Johnson AL, Johnston LH. 1996. Coordinated regulation of gene expression by the cell cycle transcription factor Swi4 and the protein kinase C MAP kinase pathway for yeast cell integrity. EMBO J. 15:5001-13
103. Iida K, Moriyama K, Matsumoto S, Kawasaki H, Nishida E, Yahara I. 1993. Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-M(r) actin-binding and depolymerizing protein. Gene 124:115-20
104. Imai J, Toh-e A, Matsui Y. 1996. Genetic analysis of the Saccharomyces cerevisiae RHO3 gene, encoding arho-type small GTPase, provides evidence for a role in bud formation. Genetics 142:359-69
105. Imamura H, Tanaka K, Hihara T, Umikawa M, Kamei T, et al. 1997. Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae. EMBO J. 16:2745-55
106. Ireton K, Payrastre B, Chap H, Ogawa W, Sakaue H, et al. 1996. A role for phosphoinositide 3-kinase in bacterial invasion. Science 274:780-82
107. Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, et al. 1996. The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J. 15:1885-93
108. Ishizaki T, Naito M, Fujisawa K, Maekawa M, Watanabe N, et al. 1997. p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett. 404:118-24
109. Isomura M, Kikuchi A, Ohga N, Takai Y. 1991. Regulation of binding of rhoB p20 to membranes by its specific regulatory protein, GDP dissociation inhibitor. Oncogene 6:119-24
110. Janmey PA. 1994. Phosphoinositides and calcium as regulators of cellular actin assembly and disassembly. Annu. Rev. Physiol. 56: 169-91
111. Janmey PA, Chaponnier C. 1995. Medical aspects of the actin cytoskeleton. Curr. Opin. Cell Biol. 7:111-17
112. Janmey PA, Iida K, Yin HL, Stossel TP. 1987. Polyphosphoinositide micelles and polyphosphoinositide-containing vesicles dissociate endogenous gelsolin-actin complexes and promote actin assembly from the fast-growing end of actin filaments blocked by gelsolin. J. Biol. Chem. 262:12228-36
113. Jansen RP, Dowzer C, Michaelis C, Galova M, Nasmyth K. 1996. Mother cell-specific HO expression in budding yeast depends on the unconventional myosin myo4p and other cytoplasmic proteins. Cell 84:687-97
114. Johnson DI, Pringle JR. 1990. Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J. Cell Biol. 111:143-52
115. Johnston GC, Prendergast JA, Singer RA. 1991. The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesicles. J. Cell Biol. 113:539-51
116. Joneson T, McDonough M, Bar-Sagi D, Van Aelst L. 1996. RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. Science 274:1374-76
117. Juliano RL, Haskill S. 1993. Signal transduction from the extracellular matrix. J. Cell Biol. 120:577-85
118. Kamada Y, Qadota H, Python CP, Anraku Y, Ohya Y, Levin DE. 1996. Activation of yeast protein kinase C by Rhol GTPase. J. Biol. Chem. 271:9193-96
119. Katayama M, Kawata M, Yoshida Y, Horiuchi H, Yamamoto T, et al. 1991. The posttranslationally modified C-terminal structure of bovine aortic smooth muscle rhoA p21. J. Biol. Chem. 266:12639-45
120. Kaufmann S, Kas J, Goldmann WH, Sackmann E, Isenberg G. 1992. Talin anchors and nucleates actin filaments at lipid membranes. A direct demonstration. FEBS Lett. 314:203-5
121. Keely PJ, Westwick JK, Whitehead IP, Der CJ, Parise LV. 1997. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through Pl(3)K. Nature 390:632-36
122. Kelleher JF, Atkinson SJ, Pollard TD. 1995. Sequences, structural models, and cellular localization of the actin-related proteins Arp2 and Arp3 from Acanthamoeba. J. Cell Biol. 131:385-97
123. Khosravi-Far R, Solski PA. Clark GJ, Kinch MS, Der CJ. 1995. Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol. Cell Biol. 15:6443-53
124. Kilmartin JV, Adams AE. 1984. Structural rearrangements of tubulin and actin during the cell cycle of the yeast Saccharomyces. J. Cell Biol. 98:922-33
125. Kim HB, Haarer BK, Pringle JR. 1991. Cellular morphogenesis in the Saccharomyces cerevisiae cell cycle: localization of the CDC3 gene product and the timing of events at the budding site. J. Cell Biol. 112:535-44
126. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, et al. 1996. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273:245-48
127. Kitayama C, Sugimoto A, Yamamoto M. 1997. Type II myosin heavy chain encoded by the myo2 gene composes the contractile ring during cytokinesis in Schizosaccharomyces pombe. J. Cell Biol. 137:1309-19
128. Kohno H, Tanaka K, Mino A, Umikawa M, Imamura H, et al. 1996. Bnilp implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J. 15:6060-88
129. Kotani K, Yonezawa K, Hara K, Ueda H, Kitamura Y, et al. 1994. Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling. EMBO J. 13: 2313-21
130. Kozma R, Ahmed S, Best A, Lim L. 1995. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell Biol. 15:1942-52
131. Kozma R, Ahmed S, Best A, Lim L. 1996. The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia. Mol. Cell Biol. 16:5069-80
132. Kron SJ, Drubin DG, Botstein D, Spudich JA. 1992. Yeast actin filaments display ATP-dependent sliding movement over surfaces coated with rabbit muscle myosin. Proc. Natl. Acad. Sci. USA 89:4466-70
133. Kron SJ, Gow NA. 1995. Budding yeast morphogenesis: signalling, cytoskeleton and cell cycle. Curr. Opin. Cell Biol. 7:845-55
134. Kubler E, Riezman H. 1993. Actin and fimbrin are required for the internalization step of endocytosis in yeast. EMBO J. 12:2855-62
135. Kumagai N, Morii N, Fujisawa K, Nemoto Y, Narumiya S. 1993. ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. J. Biol. Chem. 268: 24535-38
136. Lamarche N, Hall A. 1994. GAPs for rho-related GTPases. Trends Genet. 10:436-40
137. Lamarche N, Tapon N, Stowers L, Burbelo PD, Aspenstrom P, et al. 1996. Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell 87: 519-29
138. 2+ requirement. J. Biol. Chem. 268:8999-9004
139. Lassing I, Lindberg U. 1985. Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin. Nature 314: 472-74
140. Lazzarino DA, Boldogh I, Smith MG, Rosand J, Pon LA. 1994. Yeast mitochondria contain ATP-sensitive, reversible actin-binding activity. Mol. Biol. Cell 5:807-18
141. Leberer E, Chenevert J, Leeuw T, Harcus D, Herskowitz I, Thomas DY. 1996. Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity. Mol. Gen. Genet. 252:608-21
142. Leberer E, Thomas DY, Whiteway M. 1997a. Pheromone signalling and polarized morphogenesis in yeast. Curr. Opin. Genet. Dev. 7: 59-66
143. Leberer E, Wu C, Leeuw T, Fourest-Lieuvin A, Segall JE, Thomas DY. 1997b. Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase. EMBO J. 16:83-97
144. Leeuw T, Fourest-Lieuvin A, Wu C, Chenevert J, Clark K, et al. 1995. Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin. Science 270:1210-13
145. Leonard D, Hart MJ, Platko JV, Eva A, Henzel W, et al. 1992. The identification and characterization of a GDP-dissociation inhibitor (GDI) for the CDC42Hs protein. J. Biol. Chem. 267:22860-68
146. Leung T, Chen XQ, Manser E, Lim L. 1996. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol. Cell Biol. 16:5313-27
147. Leung T, How BE, Manser E, Lim L. 1993. Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis. J. Biol. Chem. 268:3813-16
148. Leung T, Manser E, Tan L, Lim L. 1995. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. J. Biol. Chem. 270:29051-54
149. Levin DE, Bowers B, Chen CY, Kamada Y, Watanabe M. 1994. Dissecting the protein kinase C/MAP kinase signalling pathway of Saccharomyces cerevisiae. Cell Mol. Biol. Res. 40:229-39
150. Levin DE, Errede B. 1995. The proliferation of MAP kinase signaling pathways in yeast. Curr. Opin. Cell Biol. 7:197-202
151. Lew DJ, Marini NJ, Reed SI. 1992. Different G1 cyclins control the timing of cell cycle commitment in mother and daughter cells of the budding yeast S. cerevisiae. Cell 69:317-27
152. Lew DJ, Reed SI. 1993. Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins. J. Cell Biol. 120:1305-20
153. Lew DJ, Reed SI. 1995. Cell cycle control of morphogenesis in budding yeast. Curr. Opin. Genet. Dev. 5:17-23
154. Li R. 1997. Beel, a yeast protein with homology to Wiscott-Aldrich syndrome protein, is critical for the assembly of cortical actin cytoskeleton. J. Cell Biol. 136:649-58
155. Li WZ, Lin P, Frydman J, Boal TR, Cardillo TS, et al. 1994. Tcp20, asubunit of the eukaryotic TRiC chaperonin from humans and yeast. J. Biol. Chem. 269:18616-22
156. Lim L, Manser E, Leung T, Hall C. 1996. Reg-ulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways. Eur. J. Biochem. 242:171-85
157. Long RM, Singer RH, Meng X, Gonzalez I, Nasmyth K, Jansen RP. 1997. Mating type switching in yeast controlled by asymmetric localization of ASH1 mRNA. Science 277:383-87
158. Luna EJ, Hitt AL. 1992. Cytoskeleton-plasma membrane interactions. Science 258:955-64
159. Lyons DM, Mahanty SK, Choi KY, Manandhar M, Elion EA. 1996. The SH3-domain protein Bem1 coordinates mitogen-activated protein kinase cascade activation with cell cycle control in Saccharomyces cerevisiae. Mol. Cell Biol. 16:4095-106
160. Machesky LM. 1997. Cell motility: complex dynamics at the leading edge. Curr. Biol. 7: R164-67
161. Machesky LM, Atkinson SJ, Ampe C, Vandekerckhove J, Pollard TD. 1994. Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose. J. Cell Biol. 127:107-15
162. Mack D, Nishimura K, Dennehey BK, Arbogast T, Parkinson J, et al. 1996. Identification of the bud emergence gene BEM4 and its interactions with rho-type GTPases in Saccharomyces cerevisiae. Mol. Cell Biol. 16:4387-95
163. Madaule P, Axel R, Myers AM. 1987. Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae. Proc. Nail. Acad. Sci. USA 84:779-83
164. Madaule P, Furuyashiki T, Reid T, Ishizaki T, Watanabe G, et al. 1995. A novel partner for the GTP-bound forms of rho and rac. FEBS Lett. 377:243-48
165. Madhani HD, Styles CA, Fink GR. 1997. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell 91:673-84
166. Magdolen V, Drubin DG, Mages G, Bandlow W. 1993. High levels of profilin suppress the lethality caused by overproduction of actin in yeast cells. FEBS Lett. 316:41-47
167. Magdolen V, Oechsner U, Müller G, Bandlow W. 1988. The intron-containing gene for yeast profilin (PFY) encodes a vital function. Mol. Cell Biol. 8:5108-15
168. Manning BD, Padmanabha R, Snyder M. 1997. The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae. Mol. Biol. Cell 8:1829-44
169. Marshall CJ. 1993. Protein prenylation: a mediator of protein-protein interactions. Science 259:1865-66
170. Masuda T, Tanaka K, Nonaka H, Yamochi W, Maeda A, Takai Y. 1994. Molecular cloning and characterization of yeast rho GDP dissociation inhibitor. J. Biol. Chem. 269:19713-18
171. Matsudaira P. 1991. Modular organization of actin crosslinking proteins. Trends Biochem. Sci. 16:87-92
172. Matsudaira P. 1994. Actin crosslinking proteins at the leading edge. Semin. Cell Biol. 5:165-74
173. Matsudaira P, Janmey P. 1988. Pieces in the actin-severing protein puzzle. Cell 54:139-40
174. Matsui T, Amano M, Yamamoto T, Chihara K, Nakafuku M, et al. 1996. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J. 15:2208-16
175. Matsui Y, Toh-e A. 1992a. Yeast RHO3 and RHO4 ras superfamily genes are necessary for bud growth, and their defect is suppressed by a high dose of bud formation genes CDC42 and BEM1. Mol. Cell Biol. 12:5690-99
176. Matsui Y, Toh-e A. 1992b. Isolation and characterization of two novel ras superfamily genes in Saccharomyces cerevisiae. Gene 114:43-49
177. Mazzoni C, Zarov P, Rambourg A, Mann C. 1993 The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae. J. Cell Biol. 123: 1821-33
178. McCollum D, Feoktistova A, Morphew M, Balasubramanian M, Gould KL. 1996. The Schizosaccharomyces pombe actin-related protein, Arp3, is a component of the conical actin cytoskeleton and interacts with profilin. EMBO J. 15:6438-46
179. Michiels F, Habets GG, Stam JC, van der Kammen RA, Collard JG. 1995. A role for Rac in Tiam1-induced membrane ruffling and invasion. Nature 375:338-40
180. Miklos D, Caplan S, Mertens D, Hynes G, Pitluk Z, et al. 1994. Primary structure and function of a second essential member of the heterooligomeric TCP1 chaperonin complex of yeast, TCP1 beta. Proc. Natl. Acad. Sci. USA 91:2743-47
181. Minden A, Lin A, Claret FX, Abo A, Karin M. 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147-57
182. Mizuno T, Kaibuchi K, Yamamoto T, Kawamura M, Sakoda T, et al. 1991. A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. Proc. Natl. Acad. Sci. USA 88:6442-46
183. Moon A, Drubin DG. 1995. The ADF/cofilin proteins: stimulus-responsive modulators of actin dynamics. Mol. Biol. Cell 6:1423-31
184. Moon AL, Janmey PA, Louie KA, Drubin DG. 1993. Cofilin is an essential component of the yeast cortical cytoskeleton. J. Cell Biol. 120: 421-35
185. Moreau V, Madania A, Martin RP, Winson B. 1996. The Saccharomyces cerevisiae actin-related protein Arp2 is involved in the actin cytoskeleton. J. Cell Biol. 134:117-32
186. Morgan TE, Lockerbie RO, Minamide LS, Browning MD, Hamburg JR. 1993. Isolation and characterization of a regulated form of actin depolymerizing factor. J. Cell Biol. 122: 623-33
187. Mösch HU, Roberts RL, Fink GR. 1996. Ras2 signals via the Cdc42/Ste20/mitogen-activated protein kinase module to induce filamentous growth in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 93:5352-56
188. Mulholland J, Preuss D, Moon A, Wong A, Drubin D, Botstein D. 1994. Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J. Cell Biol. 125: 381-91
189. Müller L, Xu G, Wells R, Hollenberg CP, Piepersberg W. 1994. LRG1 is expressed during sporulation in Saccharomyces cerevisiae and contains motifs similar to LIM and rho/racGAP domains. Nucleic Acids Res. 22: 3151-54
190. Musacchio A, Gibson T, Rice P, Thompson J, Saraste M. 1993. The PH domain: a common piece in the structural patchwork of signalling proteins. Trends Biochem. Sci. 18:343-48
191. Nachmias VT. 1993. Small actin-binding proteins: the beta-thymosin family. Curr. Opin. Cell Biol. 5:56-62
192. Narumiya S, Ishizaki T, Watanabe N, 1997. Rho effectors and reorganization of actin cytoskeleton. FEBS Lett. 410:68-72
193. Nefsky B, Bretscher A. 1992. Yeast actin is relatively well behaved. Eur. J. Biochem. 206: 949-55
194. Nern A, Arkowitz RA. 1998. A GTP-exchange factor required for cell orientation. Nature 391:195-98
195. Ng R, Abelson J. 1980. Isolation and sequence of the gene for actin in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 77:3912-16
196. Nimnual AS, Yatsula BA, Bar-Sagi D. 1998. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science 279:560-63
197. Nohes CD, Hall A. 1995. Rho, rac. and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53-62
198. Nobes CD, Hawkins P, Stephens L, Hall A. 1995. Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J. Cell Sci. 108:225-33
199. Noegel A, Witke W, Schleicher M. 1987. Calcium-sensitive non-muscle alpha-actinin contains EF-hand structures and highly conserved regions. FEBS Lett. 221:391-96
200. Nonaka H, Tanaka K, Hirano H, Fujiwara T, Kohno H, et al. 1995. A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae. EMBO J. 14:5931-38
201. Novick P, Botstein D. 1985. Phenotypic analysis of temperature-sensitive yeast actin mutants. Cell 40:405-16
202. Ohga N, Kikuchi A, Ueda T, Yamamoto J. Takai Y. 1989. Rabbit intestine contains a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein. Biochem. Biophys. Res. Commun. 163:1523-33
203. Ohya Y, Qadota H, Anraku Y, Pringle JR, Botstein D. 1993. Suppression of yeast geranylgeranyl transferase I defect by alternative prenylation of two target GTPases, Rho1p and Cdc42p. Mol. Biol. Cell 4:1017-25
204. Olson MF, Ashworth A, Hall A. 1995. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269:1270-72
205. Ozaki K, Tanaka K, Imamura H, Hihara T, Kameyama T, et al. 1996. Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J. 15:2196-207
206. Palmer RE, Sullivan DS, Huffaker T, Koshland D. 1992. Role of astral microtubules and actin in spindle orientation and migration in the budding yeast, Saccharomyces cerevisiae. J. Cell Biol. 119:583-93
207. Pantaloni D, Carlier MF. 1993. How profilin promotes actin filament assembly in the presence of thymosin beta 4. Cell 75:1007-14
208. Park HO, Bi E, Pringle JR, Herskowitz I. 1997. Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity. Proc. Natl. Acad. Sci. USA 94:4463-68
209. Paterson HF, Self AJ, Garrett MD, Just I, Aktories K, Hall A. 1990. Microinjection of recombinant p21rho induces rapid changes in cell morphology. J. Cell Biol. 111:1001-7
210. Perona R, Montaner S, Saniger L, Sanchez-Perez I, Bravo R, Lacal JC. 1997. Activation of the nuclear factor-κ B by Rho, CDC42, and Rac-1 proteins. Genes Dev. 11:463-75
211. Peter M, Neiman AM, Park HO, van Lohuizen M, Herskowitz I. 1996. Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. EMBO J. 15:7046-59
212. Peterson J, Zheng Y, Bender L, Myers A, Cerione R, Bender A. 1994. Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast. J. Cell Biol. 127:1395-406
213. Pollard TD, Cooper JA. 1986. Actin and actin-binding proteins. A critical evaluation of mechanisms and functions. Annu. Rev. Biochem. 55:987-1035
214. Powers S, Gonzales E, Christensen T, Cubert J, Broek D. 1991. Functional cloning of BUD5, a CDC25-related gene from S. cerevisiae that can suppress a dominant-negative RAS2 mutant. Cell 65:1225-31
215. Qadota H, Anraku Y, Botstein D, Ohya Y. 1994. Conditional lethality of a yeast strain expressing human RHOA in place of RHO1. Proc. Natl. Acad. Sci. USA 91:9317-21
216. Qadota H, Python CP, Inoue SB, Arisawa M, Anraku Y, et al. 1996. Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase. Science 272:279-81
217. Qiu RG, Abo A, McCormick F, Symons M. 1997. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation. Mol. Cell Biol. 17:3449-58
218. Qiu RG, Chen J, McCormick F, Symons M. 1995. A role for Rho in Ras transformation. Proc. Natl. Acad. Sci. USA 92:11781-85
219. Quilliam LA, Khosravi-Far R, Huff SY, Der CJ. 1995. Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. BioEssays 17:395-404
220. Quilliam LA, Lambert QT, Mickelson-Young LA, Westwick JK, Sparks AB, et al. 1996. Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. J. Biol. Chem. 271:28772-76
221. Quinn MT, Evans T, Loetterle LR, Jesaitis AJ, Bokoch GM. 1993. Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components. J. Biol. Chem. 268:20983-87
222. Read EB, Okamura HH, Drubin DG. 1992. Actin- and tubulin-dependent functions during Saccharomyces cerevisiae mating projection formation. Mol. Biol. Cell 3:429-44
223. Reid T, Furuyashiki T, Ishizaki T, Watanabe G, Watanabe N, et al. 1996. Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. J. Biol. Chem. 271:13556-60
224. Reif K, Nobes CD, Thomas G, Hall A, Cantrell DA. 1996. Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 6: 1445-55
225. Ren XD, Bokoch GM, Traynor-Kaplan A, Jenkins GH, Anderson RA, Schwartz MA. 1996. Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. Mol. Biol. Cell 7:435-42
226. Ridley AJ. 1995. Rho-related proteins: actin cytoskeleton and cell cycle. Curr. Opin. Genet. Dev. 5:24-30
227. Ridley AJ. 1996. Rho: theme and variations. Curr. Biol. 6:1256-64
228. Ridley AJ, Hall A. 1992. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389-99
229. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A. 1992. The small GTP-binding protein rac regulates growth factor- induced membrane ruffling. Cell 70:401-10
230. Roberts RL, Mõsch H-U, Fink GR. 1997. 14-3-3 proteins are essential for RAS/MAPK cascade signaling during pseudohyphal development in S. cerevisiae. Cell 89:1055-65
231. Rodriguez JR, Paterson BM. 1990. Yeast myosin heavy chain mutant: maintenance of the cell type specific budding pattern and the normal deposition of chitin and cell wall components requires an intact myosin heavy chain gene. Cell Motil. Cytoskelet. 17:301-8
232. Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, et al. 1997. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89:457-67
233. Ron D, Zannini M, Lewis M, Wickner RB, Hunt LT, et al, 1991. A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr. New Biol. 3:372-79
234. Ruppel KM, Spudich JA. 1995. Myosin motor function: structural and mutagenic approaches. Curr. Opin. Cell Biol. 7:89-93
235. Safer D, Elzinga M, Nachmias VT. 1991. Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. J. Biol. Chem. 266:4029-32
236. Safer D, Nachmias VT. 1994. Beta thymosins as actin binding peptides. BioEssays 16:473-79
237. Salmon ED. 1989. Cytokinesis in animal cells. Curr. Opin. Cell Biol. 1:541-47
238. Santos B, Snyder M. 1997. Targeting of chitin synthase 3 to polarized growth sites in yeast requires Chs5p and Myo2p. J. Cell Biol. 136:95-110
239. Sasaki T, Kato M, Takai Y. 1993. Consequences of weak interaction of rho GDI with the GTP-bound forms of rho p21 and rac p21. J. Biol. Chem. 268:23959-63
240. Schafer DA, Cooper JA. 1995. Control of actin assembly at filament ends. Annu. Rev. Cell Dev. Biol. 11:497-518
241. Schmidt A, Bickle M, Beck T, Hall MN. 1997. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88:531-42
242. Segal AW, Abo A. 1993. The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem. Sci. 18:43-47
243. Shortle D, Novick P, Botstein D. 1984. Construction and genetic characterization of temperature-sensitive mutant alleles of the yeast actin gene. Proc. Natl. Acad. Sci. USA 81:4889-93
244. Simon MN, De Virgilio C, Souza B, Pringle JR, Abo A, Reed SI. 1995. Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway. Nature 376:702-5
245. Simon VR, Swayne TC. Pon LA. 1995. Actin- dependent mitochondrial motility in mitotic yeast and cell-free systems: identification of a motor activity on the mitochondrial surface. J. Cell Biol. 130:345-54
246. Sloat BF, Adams A, Pringle JR. 1981. Roles of the CDC24 gene product in cellular morphogenesis during the Saccharomyces cerevisiae cell cycle. J. Cell Biol. 89:395-405
247. Sohn RH, Goldschmidt-Clermont PJ. 1994. Profilin: at the crossroads of signal transduction and the actin cytoskeleton. BioEssays 16: 465-72
248. Sternlicht H, Farr GW, Sternlicht ML, Driscoll JK, Willison K, Yaffe MB. 1993. The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo. Proc. Natl. Acad. Sci. USA 90:9422-26
249. Stevenson BJ, Ferguson B, De Virgilio C, Bi E, Pringle JR, et al. 1995. Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone- response pathway in the yeast Saccharomyces cerevisiae. Genes Dev. 9:2949-63
250. Stoldt V, Rademacher F, Kehren V, Ernst JF, Pearce DA. Sherman F. 1996. Review: the Cct eukaryotic chaperonin subunits of Saccharomyces cerevisiae and other yeasts. Yeast 12:523-29
251. Stössel TP. 1993. On the crawling of animal cells. Science 260:1086-94
252. Sun HQ, Kwiatkowska K, Yin HL. 1995. Actin monomer binding proteins. Curr. Opin. Cell Biol. 7:102-10
253. Sweeney FP, Pocklington MJ, Orr E. 1991. The yeast type II myosin heavy chain: analysis of its predicted polypeptide sequence. J. Muscle Res. Cell Motil 12:61-68
254. Symons M, Derry JM, Korlak B, Jiang S, Lemahieu V, et al. 1996. Wiskott-Aldrich syndrome protein, a novel effector for the GT-Pase CDC42HS, is implicated in actin polymerization. Cell 84:723-34
255. Takai Y, Sasaki T, Tanaka K, Nakanishi H. 1995. Rho as a regulator of the cytoskeleton. Trends Biochem. Sci. 20:227-31
256. Takizawa PA, Sil A, Swedlow JR, Herskowitz I, Vale RD. 1997. Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast. Nature 389:90-93
257. Tapon N, Hall A. 1997. Rho, Rac and Cdc42 GT-Pases regulate the organization of the actin cytoskeleton. Curr. Opin. Cell Biol. 9:86-92
258. Titus MA. 1993. Myosins. Curr. Opin. Cell Biol. 5:77-81
259. Tkacz JS, Lampen JO. 1972. Wall replication in Saccharomyces species: use of fluorescein-conjugated concanavalin A to reveal the site of mannan insertion. J. Gen. Microbiol. 72: 243-47
260. Tolias KF, Cantley LC, Carpenter CL. 1995. Rho family GTPases bind to phosphoinositide kinases. J. Biol. Chem. 270:17656-59
261. Trybus KM. 1994. Role of myosin light chains. J. Muscle Res. Cell Motil. 15:587-94
262. Turner CE, Burridge K. 1991. Transmembrane molecular assemblies in cell-extracellular matrix interactions. Curr. Opin. Cell Biol. 3: 849-53
263. Ueda T, Kikuchi A, Ohga N, Yamamoto J, Takai Y. 1990. Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21 -like GTP-binding protein. J. Biol. Chem. 265:9373-80
264. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, et al. 1997. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389:990-94
265. Ursic D, Culbertson MR. 1991. The yeast homolog to mouse Tcp-1 affects microtubule-mediated processes. Mol. Cell Biol. 11:2629-40
266. Ursic D, Sedbrook JC, Himmel KL, Culbertson MR. 1994. The essential yeast Tcp1 protein affects actin and microtubules. Mol. Biol. Cell 5:1065-80
267. Van Aelst L, D'Souza-Schorey C. 1997. Rho GTPases and signaling networks. Genes Dev. 11:2295-322
268. Vincent S, Settleman J. 1997. The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization. Mol. Cell Biol. 17:2247-56
269. Vinh DB, Welch MD, Corsi AK, Wertman KF, Drubin DG. 1993. Genetic evidence for functional interactions between actin noncomplementing (Anc) gene products and actin cytoskeletal proteins in Saccharomyces cerevisiae. Genetics 135:275-86
270. Walsh TP, Weber A, Davis K, Bonder E, Mooseker M. 1984. Calcium dependence of villin-induced actin depolymerization. Biochemistry 23:6099-102
271. Watanabe G, Saito Y, Madaule P, Ishizaki T, Fujisawa K, et al. 1996. Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science 271:645-48
272. Watanabe N, Madaule P, Reid T, Ishizaki T, Watanabe G, et al. 1997. p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J. 16:3044-56
273. Watts FZ, Shiels G, Orr E. 1987. The yeast MYO1 gene encoding a myosin-like protein required for cell division. EMBO J. 6:3499-505
274. Weiss A, Leinwand LA. 1996. The mammalian myosin heavy chain gene family. Annu. Rev. Cell Dev. Biol. 1996;12:417-39
275. Welch MD, Hollzman DA, Drubin DG. 1994. The yeast actin cytoskeleton. Curr. Opin. Cell Biol. 6:110-19
276. Wennstrom S, Hawkins P, Cooke F, Hara K, Yonezawa K, et al. 1994. Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr. Biol. 4: 385-93
277. Whitehead IP, Campbell S, Rossman KL, Der CJ. 1997. Db1 family proteins. Biochim. Biophys. Acta 1332:F1-23
278. Whitehead IP, Khosravi-Far R, Kirk H, Trigo-Gonzalez G, Der CJ, Kay R. 1996. Expression cloning of Isc, a novel oncogene with structural similarities to the Db1 family of guanine nucleotide exchange factors. J. Biol. Chem. 271:18643-50
279. Whitehead IP, Kirk H, Tognon C, Trigo-Gonzalez G, Kay R. 1995. Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C. J. Biol. Chem. 270:18388-95
280. Winsor B, Schiebel E. 1997. Review: an overview of the Saccharomyces cerevisiae microtubule and microfilament cytoskeleton. Yeast 13:399-434
281. Winter D, Podtelejnikov AV, Mann M, Li R. 1997. The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. Curr. Biol. 7:519-29
282. Witke W, Hofmann A, Koppel B, Schleicher M, Noegel AA. 1993. The Ca(2+)-binding domains in non-muscle type alpha-actinin: biochemical and genetic analysis. J. Cell Biol. 121:599-606
283. Yaffe MB, Farr GW, Miklos D, Horwich AL, Sternlicht ML, Sternlicht H. 1992. TCP1 complex is a molecular chaperone in tubulin biogenesis. Nature 358:245-48
284. Yaku H, Sasaki T, Takai Y. 1994. The Db1 oncogene product as a GDP/GTP exchange protein for the Rho family: its properties in comparison with those of Smg GDS. Biochem. Biophys. Res. Commun. 198:811-17
285. Yamada KM, Geiger B. 1997. Molecular interactions in cell adhesion complexes. Curr. Opin. Cell Biol. 9:76-85
286. Yamochi W, Tanaka K, Nonaka H, Maeda A, MushaT, Takai Y. 1994. Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae. J. Cell Biol. 125:1077-93
287. Yonezawa N, Nishida E, Iida K, Yahara I, Sakai H. 1990. Inhibition of the interactions of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides. J. Biol. Chem. 265:8382-86
288. Zarzov P, Mazzoni C, Mann C. 1996. The SLT2(MPK1) MAP kinase is activated during periods of polarized cell growth in yeast. EMBO J. 15:83-91
289. Zhang J, King WG, Dillon S, Hall A, Feig L, Rittenhouse SE. 1993. Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho. J. Biol. Chem. 268:22251-54
290. Zhao ZS, Leung T, Manser E, Lim L. 1995. Pheromone signalling in Saccharomyces cerevisiae requires the small GTP-binding protein Cdc42p and its activator CDC24. Mol. Cell Biol. 15:5246-57
291. Zheng Y, Bagrodia S, Cerione RA. 1994a. Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. J. Biol. Chem. 269:18727-30
292. Zheng Y, Bender A, Cerione RA. 1995. Interactions among proteins involved in bud-site selection and bud-site assembly in Saccharomyces cerevisiae. J. Biol. Chem. 270:626-30
293. Zheng Y, Cenone R, Bender A. 1994b. Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3. J. Biol. Chem. 269:2369-72
294. Zheng Y, Hart MJ, Shinjo K, Evans T, Bender A, Cerione RA. 1993. Biochemical comparisons of the Saccharomyces cerevisiae Bem2 and Bem3 proteins. Delineation of a limit Cdc42 GTPase-activating protein domain. J. Biol. Chem. 268:24629-34
295. Zheng Y, Zangrilli D, Cerione RA, Eva A. 1996. The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting. J. Biol. Chem. 271:19017-20
296. Ziman M, Preuss D, Mulholland J, O'Brien JM, Botstein D, Johnson DI. 1993. Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Mol. Biol. Cell 4: 1307-16