BCAP: The tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation

Immunity

Volumn 13, Issue 6, 2000, Pages 817-827

  Okada, Takaharu ^a,c   Maeda, Akito ^a   Iwamatsu, Akihiro ^b   Gotoh, Kumiko ^a   Kurosaki, Tomohiro ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b KIRIN BREWERY CO LTD   (Japan)

^c NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; B LYMPHOCYTE RECEPTOR; BINDING PROTEIN; BRUTON TYROSINE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCAP; PROTEIN KINASE SYK; PROTEIN P85; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CHICKEN; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME LOCALIZATION; ENZYME SUBSTRATE COMPLEX; GENE DISRUPTION; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS;

EID: 0034507903     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)00079-0     Document Type: Article

References (51)

1. 2+ flux
2. Syk is upstream of phosphoinositide 3-kinase in B cell receptor signaling
3. Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase
4. 2+ mobilization
5. A role for lipid rafts in B cell antigen receptor signaling and antigen targeting
6. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
7. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the Vav proto-oncogene product
8. Cellular survival: A play in three Akts
9. The complexity of signaling pathways activated by the BCR
10. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule
11. Phosphoinositide kinases
12. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α
13. Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling
14. Intermediary signaling effectors coupling the B-cell receptor to the nucleus
15. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
16. Involvement of guanosine triphosphatases and phospholipase C-γ2 in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor
17. Cutting edge: Essential role of phospholipase C-γ2 in B cell development and function
18. BLNK required for coupling Syk to PLC γ 2 and Rac1-JNK in B cells
19. Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
20. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
21. Genetic analysis of B celt antigen receptor signaling
22. Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function
23. Membrane rafts and signaling by the multichain immune recognition receptors
24. Signailing through phosphoinositide 3-kinases: The lipids take centre stage
25. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
26. Prediction and analysis of coiled-coil structures
27. A double-edged kinase Lyn: A positive and negative regulator for antigen receptor-mediated signals
28. Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover
29. The role of phosphoinositide 3-kinase lipid products in cell function
30. Initiation and processing of signals from the B cell antigen receptor
31. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice
32. Ptdlns-3, 4, 5-p3: A regulatory nexus between tyrosine kinases and sustained calcium signals
33. Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation
34. Inhibition of the B cell by CD22: A requirement for Lyn
35. SH2 domains recognize specific phosphopeptide sequences
36. Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav
37. Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCγ, Crk, and Grb2
38. Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1, 4, 5-trisphosphate receptors in signal transduction through the Bcell antigen receptor
39. Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase
40. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-γ 2
41. 2+ mobilization through distinct pathways
42. Antigen receptor signaling: Integration of protein tyrosine kinase functions
43. Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: Regulators of B cell signal transduction
44. The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools
45. Kit signaling through PI 3-kinase and Src kinase pathways: An essential role for rac1 and JNK activation in mast cell proliferation
46. CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase
47. The Drosophila protein Dof is specifically required for FGF signaling
48. IRS-2 coordinates IGF-1 receptor-mediated beta-cell development and peripheral insulin signalling
49. Membrane compartmentation is required for efficient T cell activation
50. Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-γ2 activation by regulating B cell linker protein-PLC-γ2 binding
51. Lat palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation