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Volumn 8, Issue 2, 1999, Pages 185-193

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PHOSPHOPROTEIN; PROTEIN SERINE THREONINE KINASE;

EID: 0032898096     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/8.2.185     Document Type: Article
Times cited : (271)

References (53)
  • 1
    • 0027970838 scopus 로고
    • Chromosomal translocations in human cancer
    • Rabbitts, T.H. (1994) Chromosomal translocations in human cancer. Nature, 372, 143-149.
    • (1994) Nature , vol.372 , pp. 143-149
    • Rabbitts, T.H.1
  • 2
    • 0029583620 scopus 로고
    • Further evidence for the lack of correlation between the breakpoint site within M-BCR and CML prognosis and for the occasional involvement of p53 in transformation
    • Aguiar, R.C., Dahia, P.L., Bendit, I., Beitler, B., Dorlhiac, P., Bydlowski, S. and Chamone, D. (1995) Further evidence for the lack of correlation between the breakpoint site within M-BCR and CML prognosis and for the occasional involvement of p53 in transformation. Cancer Genet. Cytogenet., 84, 105-112.
    • (1995) Cancer Genet. Cytogenet. , vol.84 , pp. 105-112
    • Aguiar, R.C.1    Dahia, P.L.2    Bendit, I.3    Beitler, B.4    Dorlhiac, P.5    Bydlowski, S.6    Chamone, D.7
  • 3
    • 0031860559 scopus 로고    scopus 로고
    • Review of alterations of cyclin-dependent kinase inhibitor 1NK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells
    • Drexler, H.G. (1998) Review of alterations of cyclin-dependent kinase inhibitor 1NK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. Leukemia, 12, 845-849.
    • (1998) Leukemia , vol.12 , pp. 845-849
    • Drexler, H.G.1
  • 8
    • 0031001041 scopus 로고    scopus 로고
    • TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor B
    • Li, D.-M. and Sun, H. (1997) TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor B. Cancer Res., 57, 2124-2129.
    • (1997) Cancer Res. , vol.57 , pp. 2124-2129
    • Li, D.-M.1    Sun, H.2
  • 15
    • 0031442631 scopus 로고    scopus 로고
    • PTEN: Sometimes taking it off can be better than putting it on
    • Myers, M.P. and Tonks, N.K. (1997) PTEN: sometimes taking it off can be better than putting it on. Am. J. Hum. Genet., 61, 1234-1238.
    • (1997) Am. J. Hum. Genet. , vol.61 , pp. 1234-1238
    • Myers, M.P.1    Tonks, N.K.2
  • 16
    • 0030728479 scopus 로고    scopus 로고
    • Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain
    • Furnari, F.B., Lin, H., Huang, H.S. and Cavenee, W.K. (1997) Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc. Natl Acad. Sci. USA, 94, 12479-12484.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 12479-12484
    • Furnari, F.B.1    Lin, H.2    Huang, H.S.3    Cavenee, W.K.4
  • 17
    • 0030296632 scopus 로고    scopus 로고
    • Structure and function of the protein tyrosine phosphatases
    • Fauman, E.B. and Saper, M.A. (1996) Structure and function of the protein tyrosine phosphatases. Trends Biochem. Sci., 21, 413-417.
    • (1996) Trends Biochem. Sci. , vol.21 , pp. 413-417
    • Fauman, E.B.1    Saper, M.A.2
  • 18
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidyl-3-OH kinase signal transduction
    • Burgering, B.M. and Coffer, P.J. (1995) Protein kinase B (c-Akt) in phosphatidyl-3-OH kinase signal transduction. Nature, 376, 599-602.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 19
    • 0031034574 scopus 로고    scopus 로고
    • Antiapoptopic signalling by the insulin-like growth factor 1 receptor, phosphatidylinositol 3-kinase, and Akt
    • Kulik, G., Klippel, A. and Weber, M.J. (1997) Antiapoptopic signalling by the insulin-like growth factor 1 receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol., 17, 1595-1606.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1595-1606
    • Kulik, G.1    Klippel, A.2    Weber, M.J.3
  • 21
    • 0029079275 scopus 로고
    • The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    • Franke, T.F., Yang, S.I., Chan, T.O., Datta, K., Kazlauskas, A., Morrison, D.K., Kaplan, D.R. and Tsichlis, P.N. (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell, 81, 727-736.
    • (1995) Cell , vol.81 , pp. 727-736
    • Franke, T.F.1    Yang, S.I.2    Chan, T.O.3    Datta, K.4    Kazlauskas, A.5    Morrison, D.K.6    Kaplan, D.R.7    Tsichlis, P.N.8
  • 24
    • 0031052844 scopus 로고    scopus 로고
    • Differential loss of heterozygosity in the region of the Cowden locus within 10q22-23 in follicular thyroid adenomas and carcinomas
    • Marsh, D.J., Zheng, Z., Zedenius, J., Kremer, H., Padberg, G.W., Larsson, C., Longy, M. and Eng, C. (1997) Differential loss of heterozygosity in the region of the Cowden locus within 10q22-23 in follicular thyroid adenomas and carcinomas. Cancer Res., 57, 500-503.
    • (1997) Cancer Res. , vol.57 , pp. 500-503
    • Marsh, D.J.1    Zheng, Z.2    Zedenius, J.3    Kremer, H.4    Padberg, G.W.5    Larsson, C.6    Longy, M.7    Eng, C.8
  • 25
    • 0030999765 scopus 로고    scopus 로고
    • Occurrence of TEL-AML1 fusion resulting from (12:21) translocation in human early B-lineage leukemia cell lines
    • Uphoff, C.C., MacLeod, R.A., Denkmann, S.A., Golub, T.R., Borkhardt, A., Janssen, J.W. and Drexler, H.G. (1997) Occurrence of TEL-AML1 fusion resulting from (12:21) translocation in human early B-lineage leukemia cell lines. Leukemia, 11, 441-447.
    • (1997) Leukemia , vol.11 , pp. 441-447
    • Uphoff, C.C.1    MacLeod, R.A.2    Denkmann, S.A.3    Golub, T.R.4    Borkhardt, A.5    Janssen, J.W.6    Drexler, H.G.7
  • 27
    • 0028577466 scopus 로고
    • Leukemia cell lines: In vitro models for the study of chronic myeloid leukemia
    • Drexler, H.G. (1994) Leukemia cell lines: in vitro models for the study of chronic myeloid leukemia. Leukemia Res., 18, 919-927.
    • (1994) Leukemia Res. , vol.18 , pp. 919-927
    • Drexler, H.G.1
  • 28
    • 0020580225 scopus 로고
    • Translocation joins c-myc and immunoglobulin gamma 1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogene
    • Hamlyn, P.H. and Rabbitts, T.H. (1983) Translocation joins c-myc and immunoglobulin gamma 1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogene. Nature, 304, 135-139.
    • (1983) Nature , vol.304 , pp. 135-139
    • Hamlyn, P.H.1    Rabbitts, T.H.2
  • 29
    • 0028900889 scopus 로고
    • Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia
    • Sill, H., Goldman, J.M. and Cross, N.C. (1995) Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia. Blood, 85, 2013-2016.
    • (1995) Blood , vol.85 , pp. 2013-2016
    • Sill, H.1    Goldman, J.M.2    Cross, N.C.3
  • 30
    • 0032100506 scopus 로고    scopus 로고
    • Alterations of the MMAC1 PTEN gene in lymphoid malignancies
    • Gronbaek, K., Zeuthen, J., Guldberg, P., Ralfkiaer, E. and Hou-Jensen, K. (1998) Alterations of the MMAC1 PTEN gene in lymphoid malignancies. Blood, 91, 4388-4390.
    • (1998) Blood , vol.91 , pp. 4388-4390
    • Gronbaek, K.1    Zeuthen, J.2    Guldberg, P.3    Ralfkiaer, E.4    Hou-Jensen, K.5
  • 31
    • 0031870959 scopus 로고    scopus 로고
    • PTEN is essential for embryonic development and tumour suppression
    • Di Cristofano, A., Pesce, B., Coron-Cardo, C. and Pandolfi, P.P. (1998) PTEN is essential for embryonic development and tumour suppression. Nature Genet., 19, 348-355.
    • (1998) Nature Genet. , vol.19 , pp. 348-355
    • Di Cristofano, A.1    Pesce, B.2    Coron-Cardo, C.3    Pandolfi, P.P.4
  • 34
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama, T. and Dixon, J.E. (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem., 273, 13375-13378.
    • (1998) J. Biol. Chem. , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 35
    • 0031913246 scopus 로고    scopus 로고
    • Mechanism of activation and function of protein kinase B
    • Alessi, D.R. and Cohen, P. (1998) Mechanism of activation and function of protein kinase B. Curr. Opin. Genet. Dev., 8, 55-62.
    • (1998) Curr. Opin. Genet. Dev. , vol.8 , pp. 55-62
    • Alessi, D.R.1    Cohen, P.2
  • 36
    • 0026095665 scopus 로고
    • A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
    • Bellacosa, A., Testa, J.R., Staal, S.P. and Tsichlis, P.N. (1991) A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science, 254, 274-277.
    • (1991) Science , vol.254 , pp. 274-277
    • Bellacosa, A.1    Testa, J.R.2    Staal, S.P.3    Tsichlis, P.N.4
  • 37
    • 0031039024 scopus 로고    scopus 로고
    • Direct regulation of the Akt proto-oncogene product by phosphatidylinositol 3,4-bisphosphate
    • Franke, T.F., Kaplan, D.R., Cantley, L.C. and Toker, A. (1997) Direct regulation of the Akt proto-oncogene product by phosphatidylinositol 3,4-bisphosphate. Science, 275, 665-668.
    • (1997) Science , vol.275 , pp. 665-668
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3    Toker, A.4
  • 38
    • 0031806103 scopus 로고    scopus 로고
    • Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport
    • Kitamura, T., Ogawa, W., Sakaue, H., Hino, Y., Kuroda, S., Takata, M., Matsumoto, M., Maeda, T., Konishi, H., Kikkawa, U. and Kasuga, M. (1998) Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport. Mol. Cell. Biol., 18, 3708-3717.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 3708-3717
    • Kitamura, T.1    Ogawa, W.2    Sakaue, H.3    Hino, Y.4    Kuroda, S.5    Takata, M.6    Matsumoto, M.7    Maeda, T.8    Konishi, H.9    Kikkawa, U.10    Kasuga, M.11
  • 41
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta, S.R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y. and Greenberg, M.E. (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91, 231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 42
    • 0030785701 scopus 로고    scopus 로고
    • Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27
    • Konishi, H., Matsuzaki, H., Tanaka, M., Takemura, Y., Kuroda, S., Ono, Y. and Kikkawa, U. (1997) Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27. FEBS Lett., 410, 493-498.
    • (1997) FEBS Lett. , vol.410 , pp. 493-498
    • Konishi, H.1    Matsuzaki, H.2    Tanaka, M.3    Takemura, Y.4    Kuroda, S.5    Ono, Y.6    Kikkawa, U.7
  • 44
    • 0001457668 scopus 로고    scopus 로고
    • Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
    • Cheng, J.Q., Ruggeri, B., Klein, W.M., Sonoda, G., Altomare, D.A., Watson, D.K. and Testa, J.R. (1996) Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc. Natl Acad. Sci. USA, 93, 3636-3641.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 3636-3641
    • Cheng, J.Q.1    Ruggeri, B.2    Klein, W.M.3    Sonoda, G.4    Altomare, D.A.5    Watson, D.K.6    Testa, J.R.7
  • 45
    • 0030744134 scopus 로고    scopus 로고
    • Role of phosphatases in lymphocyte activation
    • Neel, B.G. (1997) Role of phosphatases in lymphocyte activation. Curr. Opin. Immunol., 9, 405-420.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 405-420
    • Neel, B.G.1
  • 46
    • 0030800121 scopus 로고    scopus 로고
    • The motheaten mutation rescues B cell signaling and development in CD45-deficient mice
    • Pani, G., Siminovitch, K.A. and Paige, C.J. (1997) The motheaten mutation rescues B cell signaling and development in CD45-deficient mice. J. Exp. Med., 186, 581-588.
    • (1997) J. Exp. Med. , vol.186 , pp. 581-588
    • Pani, G.1    Siminovitch, K.A.2    Paige, C.J.3
  • 47
    • 0032486198 scopus 로고    scopus 로고
    • Inhibition of cell migration, spreading, and focal adhesion by tumor suppressor PTEN
    • Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R. and Yamada, K.M. (1998) Inhibition of cell migration, spreading, and focal adhesion by tumor suppressor PTEN. Science, 280, 1614-1617.
    • (1998) Science , vol.280 , pp. 1614-1617
    • Tamura, M.1    Gu, J.2    Matsumoto, K.3    Aota, S.4    Parsons, R.5    Yamada, K.M.6
  • 52
    • 0028787221 scopus 로고
    • CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine
    • Otterson, G.A., Khleif, S.N., Chen, W., Coxon, A.B. and Kaye, F.J. (1995) CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine. Oncogene, 11, 1211-1216.
    • (1995) Oncogene , vol.11 , pp. 1211-1216
    • Otterson, G.A.1    Khleif, S.N.2    Chen, W.3    Coxon, A.B.4    Kaye, F.J.5
  • 53
    • 0029664548 scopus 로고    scopus 로고
    • Frequent loss of the p16INK4a gene product in human pituitary tumors
    • Woloschak, M., Yu, A., Xiao, J. and Post, K.D. (1996) Frequent loss of the p16INK4a gene product in human pituitary tumors. Cancer Res., 56, 2493-2496.
    • (1996) Cancer Res. , vol.56 , pp. 2493-2496
    • Woloschak, M.1    Yu, A.2    Xiao, J.3    Post, K.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.