메뉴 건너뛰기




Volumn 90, Issue 9, 1997, Pages 3322-3331

Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras- transformed cells through a hypoxia inducible factor-1 transcriptional element

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAF PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HIF 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 0030869787     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.9.3322     Document Type: Article
Times cited : (450)

References (57)
  • 2
    • 0028951043 scopus 로고
    • Dormancy of microme-tastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
    • Holmgren L, O'Reilly MS, Folkman J: Dormancy of microme-tastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1:149, 1995
    • (1995) Nat Med , vol.1 , pp. 149
    • Holmgren, L.1    O'Reilly, M.S.2    Folkman, J.3
  • 3
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J: Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1:27, 1995
    • (1995) Nat Med , vol.1 , pp. 27
    • Folkman, J.1
  • 4
    • 0028944106 scopus 로고
    • Molecular insights into cancer invasion: Strategies for prevention and intervention
    • Kohn EC, Liotta LA: Molecular insights into cancer invasion: Strategies for prevention and intervention. Cancer Res 55:1856, 1995
    • (1995) Cancer Res , vol.55 , pp. 1856
    • Kohn, E.C.1    Liotta, L.A.2
  • 5
    • 0029944122 scopus 로고    scopus 로고
    • Angiostatin induces and sustains dormancy of human primary tumors in mice
    • O'Reilly MS, Holmgren L, Chen C, Folkman J: Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 2:689, 1996
    • (1996) Nat Med , vol.2 , pp. 689
    • O'Reilly, M.S.1    Holmgren, L.2    Chen, C.3    Folkman, J.4
  • 9
    • 0028822834 scopus 로고
    • Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
    • Rak J, Mitsuhashi Y, Bayko L, Filmus J, Shirasawa S, Sasazuki T, Kerbel RS: Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis. Cancer Res 55:4575, 1995
    • (1995) Cancer Res , vol.55 , pp. 4575
    • Rak, J.1    Mitsuhashi, Y.2    Bayko, L.3    Filmus, J.4    Shirasawa, S.5    Sasazuki, T.6    Kerbel, R.S.7
  • 10
    • 0028834638 scopus 로고
    • Both v-H-ras and v-raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells
    • Grugel S, Finkenzeller G, Weindel K, Barleon B, Marne D: Both v-H-ras and v-raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J Biol Chem 270:25915, 1995
    • (1995) J Biol Chem , vol.270 , pp. 25915
    • Grugel, S.1    Finkenzeller, G.2    Weindel, K.3    Barleon, B.4    Marne, D.5
  • 11
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo
    • Plate KH, Breier G, Weich HA, Risau W: Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Nature 359:845, 1992
    • (1992) Nature , vol.359 , pp. 845
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 12
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki D, Itin A, Soffer D, Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843, 1992
    • (1992) Nature , vol.359 , pp. 843
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 13
    • 0029068339 scopus 로고
    • Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation
    • Mukhopadhyay D, Tsiokas L, Zhou X, Foster D, Brugge JS, Sukhatme VP: Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature 375:577, 1995
    • (1995) Nature , vol.375 , pp. 577
    • Mukhopadhyay, D.1    Tsiokas, L.2    Zhou, X.3    Foster, D.4    Brugge, J.S.5    Sukhatme, V.P.6
  • 14
    • 0031016301 scopus 로고    scopus 로고
    • Induction of hypoxia-inducible factor- 1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: Evidence against a regulatory role for Src kinase
    • Gleadle JM, Ratcliffe PJ: Induction of hypoxia-inducible factor- 1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: Evidence against a regulatory role for Src kinase. Blood 89:503, 1997
    • (1997) Blood , vol.89 , pp. 503
    • Gleadle, J.M.1    Ratcliffe, P.J.2
  • 15
    • 0028032360 scopus 로고
    • Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2)
    • Koong AC, Chen EY, Mivechi NF, Denko NC, Stambrook P, Giaccia AJ: Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2). Cancer Res 54:5273, 1994
    • (1994) Cancer Res , vol.54 , pp. 5273
    • Koong, A.C.1    Chen, E.Y.2    Mivechi, N.F.3    Denko, N.C.4    Stambrook, P.5    Giaccia, A.J.6
  • 16
    • 0029082384 scopus 로고
    • Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
    • Stein I, Neeman M, Shweiki D, Itin A, Keshet E: Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol Cell Biol 15:5363, 1995
    • (1995) Mol Cell Biol , vol.15 , pp. 5363
    • Stein, I.1    Neeman, M.2    Shweiki, D.3    Itin, A.4    Keshet, E.5
  • 17
    • 0030044039 scopus 로고    scopus 로고
    • Post-transcriptional regulation of vascular endothelial growth factor by hypoxia
    • Levy AP, Levy NS, Goldberg MA: Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J Biol Chem 271:2746, 1996
    • (1996) J Biol Chem , vol.271 , pp. 2746
    • Levy, A.P.1    Levy, N.S.2    Goldberg, M.A.3
  • 18
    • 0027210562 scopus 로고
    • General involvement of hypoxia-inducible factor 1 in transenptional response to hypoxia
    • Wang GL, Semenza GL: General involvement of hypoxia-inducible factor 1 in transenptional response to hypoxia. Proc Natl Acad Sci USA 90:4304, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4304
    • Wang, G.L.1    Semenza, G.L.2
  • 19
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, Semenza GL: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92:5510, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 20
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza GL, Roth PH, Fang H, Wang GL: Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 269:23757, 1994
    • (1994) J Biol Chem , vol.269 , pp. 23757
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.3    Wang, G.L.4
  • 21
    • 0028883178 scopus 로고
    • Phospholipid signaling
    • Divecha N, Irvine RF: Phospholipid signaling. Cell 80:269, 1995
    • (1995) Cell , vol.80 , pp. 269
    • Divecha, N.1    Irvine, R.F.2
  • 23
    • 0028486018 scopus 로고
    • Phosphatidylinositol 3-kinase
    • Kapeller R, Cantley LC: Phosphatidylinositol 3-kinase. BioEssays 16:565, 1994
    • (1994) BioEssays , vol.16 , pp. 565
    • Kapeller, R.1    Cantley, L.C.2
  • 25
    • 0031039024 scopus 로고    scopus 로고
    • Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
    • Franke TF, Kaplan DR, Cantley LC, Toker A: Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275:665, 1997
    • (1997) Science , vol.275 , pp. 665
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3    Toker, A.4
  • 26
    • 0028268629 scopus 로고
    • Hypoxia causes the activation of nuclear factor κB through the phosphorylation of IκBα on tyrosine residue
    • Koong AC, Chen EY, Giaccia AJ: Hypoxia causes the activation of nuclear factor κB through the phosphorylation of IκBα on tyrosine residue. Cancer Res 54:1425, 1994
    • (1994) Cancer Res , vol.54 , pp. 1425
    • Koong, A.C.1    Chen, E.Y.2    Giaccia, A.J.3
  • 27
    • 0029830747 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-independent signal transduction pathway for platelet-derived growth factor-induced chemotaxis
    • Higaki M, Sakaue H, Ogawa W, Kasuga M, Shimokado K: Phosphatidylinositol 3-kinase-independent signal transduction pathway for platelet-derived growth factor-induced chemotaxis. J Biol Chem 271:29342, 1996
    • (1996) J Biol Chem , vol.271 , pp. 29342
    • Higaki, M.1    Sakaue, H.2    Ogawa, W.3    Kasuga, M.4    Shimokado, K.5
  • 31
    • 0028074621 scopus 로고
    • Ras-dependent growth factor regulation of MEK kinase in PC12 cells
    • Lange-Carter CA, Johnson GL: Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science 265:1458, 1994
    • (1994) Science , vol.265 , pp. 1458
    • Lange-Carter, C.A.1    Johnson, G.L.2
  • 33
    • 0028340166 scopus 로고
    • Mammalian mitogen-activated protein kinase kinase kinase (MEKK) can function in a yeast mitogen-activated protein kinase pathway downstream of protein kinase C
    • Blumer KJ, Johnson GL, Lange-Carter CA: Mammalian mitogen-activated protein kinase kinase kinase (MEKK) can function in a yeast mitogen-activated protein kinase pathway downstream of protein kinase C. Proc Natl Acad Sci USA 91:4925, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4925
    • Blumer, K.J.1    Johnson, G.L.2    Lange-Carter, C.A.3
  • 34
    • 0027994002 scopus 로고
    • An osmosensing signal transduction pathway in mammalian cells
    • Galcheva-Gargova Z, Derijard B, Wu IH, Davis RJ: An osmosensing signal transduction pathway in mammalian cells. Science 265:806, 1994
    • (1994) Science , vol.265 , pp. 806
    • Galcheva-Gargova, Z.1    Derijard, B.2    Wu, I.H.3    Davis, R.J.4
  • 38
  • 39
    • 0025979335 scopus 로고
    • Raf-1 protein kinase is required for growth of induced NIH/3T3 cells
    • Kolch W, Heidecker G, Lloyd P, Rapp UR: Raf-1 protein kinase is required for growth of induced NIH/3T3 cells. Nature 349:426, 1991
    • (1991) Nature , vol.349 , pp. 426
    • Kolch, W.1    Heidecker, G.2    Lloyd, P.3    Rapp, U.R.4
  • 40
    • 0025883047 scopus 로고
    • Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras
    • Stacey DW, Feig LA, Gibbs JB: Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras. Mol Cell Biol 11:4053, 1991
    • (1991) Mol Cell Biol , vol.11 , pp. 4053
    • Stacey, D.W.1    Feig, L.A.2    Gibbs, J.B.3
  • 42
    • 0025008667 scopus 로고
    • DNA-mediated gene transfer into adult rat hepatocytes in primary culture
    • Rippe RA, Brenner DA, Leffert HL: DNA-mediated gene transfer into adult rat hepatocytes in primary culture. Mol Cell Biol 10:689, 1990
    • (1990) Mol Cell Biol , vol.10 , pp. 689
    • Rippe, R.A.1    Brenner, D.A.2    Leffert, H.L.3
  • 43
    • 0029744885 scopus 로고    scopus 로고
    • Sounding the alarm: Protein kinase cascades activated by stress and inflammation
    • Kyriakis JM, Avruch J: Sounding the alarm: Protein kinase cascades activated by stress and inflammation. J Biol Chem 271:24313, 1996
    • (1996) J Biol Chem , vol.271 , pp. 24313
    • Kyriakis, J.M.1    Avruch, J.2
  • 45
    • 0028986629 scopus 로고
    • Tumor necrosis factor α rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1 -independent fashion in mouse macrophages
    • Winston BW, Lange-Carter CA, Gardner AM, Johnson GL, Riches DWH: Tumor necrosis factor α rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1 -independent fashion in mouse macrophages. Proc Natl Acad Sci USA 92:1614, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1614
    • Winston, B.W.1    Lange-Carter, C.A.2    Gardner, A.M.3    Johnson, G.L.4    Riches, D.W.H.5
  • 46
    • 0029070887 scopus 로고
    • Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
    • Minden A, Lin A, Claret F, Abo A, Karin M: Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147, 1995
    • (1995) Cell , vol.81 , pp. 1147
    • Minden, A.1    Lin, A.2    Claret, F.3    Abo, A.4    Karin, M.5
  • 47
    • 0028239893 scopus 로고
    • RAFT l : A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
    • Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH: RAFT l : A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78:35, 1994
    • (1994) Cell , vol.78 , pp. 35
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Lui, M.3    Tempst, P.4    Snyder, S.H.5
  • 49
    • 0028947199 scopus 로고
    • Phosphoinositide 3-kinase as an upstream regulator of the small GTP-binding protein Rac in the insulin signaling of membrane ruffling
    • Kotani K, Hara K, Kotani K, Yonezawa K, Kasuga M: Phosphoinositide 3-kinase as an upstream regulator of the small GTP-binding protein Rac in the insulin signaling of membrane ruffling. Biochem Biophys Res Commun 208:985, 1995
    • (1995) Biochem Biophys Res Commun , vol.208 , pp. 985
    • Kotani, K.1    Hara, K.2    Kotani, K.3    Yonezawa, K.4    Kasuga, M.5
  • 51
    • 0031015986 scopus 로고    scopus 로고
    • A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain
    • Klippel A, Kavanaugh WM, Pot D, Williams LT: A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol Cell Biol 17:338, 1997
    • (1997) Mol Cell Biol , vol.17 , pp. 338
    • Klippel, A.1    Kavanaugh, W.M.2    Pot, D.3    Williams, L.T.4
  • 53
    • 0028000069 scopus 로고
    • Signal-transduction therapy. A novel approach to disease management
    • Levitzki A: Signal-transduction therapy. A novel approach to disease management. Eur J Biochem 1994
    • (1994) Eur J Biochem
    • Levitzki, A.1
  • 55
    • 0028918408 scopus 로고
    • Ras-dependent induction of cellular responses by constitutive active phosphatidylinositol-3 kinase
    • Hu Q, Klippel A, Muslin AJ, Fantl WJ, Williams LT: Ras-dependent induction of cellular responses by constitutive active phosphatidylinositol-3 kinase. Science 268:100, 1995
    • (1995) Science , vol.268 , pp. 100
    • Hu, Q.1    Klippel, A.2    Muslin, A.J.3    Fantl, W.J.4    Williams, L.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.