메뉴 건너뛰기




Volumn 13, Issue 12, 1999, Pages 1501-1512

CDK inhibitors: Positive and negative regulators of G1-phase progression

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E;

EID: 0033564697     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.12.1501     Document Type: Review
Times cited : (5282)

References (148)
  • 3
    • 0030477686 scopus 로고    scopus 로고
    • Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
    • Alcorta, D.A., Y. Xiong, D. Phelps, G. Hannon, D. Beach, and J.C. Barrett. 1996. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. 93: 13742-13747.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 13742-13747
    • Alcorta, D.A.1    Xiong, Y.2    Phelps, D.3    Hannon, G.4    Beach, D.5    Barrett, J.C.6
  • 6
    • 0031309361 scopus 로고    scopus 로고
    • Aberrations of the g1- and G1/S-regulating genes in human cancer
    • Bartkova, J., J. Lukas, and J. Bartek. 1997. Aberrations of the G1-and G1/S-regulating genes in human cancer. Prog. Cell Cycle Res. 3: 211-220.
    • (1997) Prog. Cell Cycle Res. , vol.3 , pp. 211-220
    • Bartkova, J.1    Lukas, J.2    Bartek, J.3
  • 8
    • 0025073063 scopus 로고
    • A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts
    • Blow, J.J. and P. Nurse. 1990. A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts. Cell 62: 855-862.
    • (1990) Cell , vol.62 , pp. 855-862
    • Blow, J.J.1    Nurse, P.2
  • 9
    • 0032899038 scopus 로고    scopus 로고
    • Retinoblastoma protein meets chromatin
    • Brehm, A. and T. Kouzarides. 1999. Retinoblastoma protein meets chromatin. Trends Biochem. Sci. 24: 142-145.
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 142-145
    • Brehm, A.1    Kouzarides, T.2
  • 14
    • 0031440272 scopus 로고    scopus 로고
    • Role of cyclin-dependent kinases and their inhibitors in cellular differentiation and development
    • Chellappan, S.P., A. Giordano, and P.B. Fisher. 1998. Role of cyclin-dependent kinases and their inhibitors in cellular differentiation and development. Curr. Top. Microbiol. Immunol. 227: 57-103.
    • (1998) Curr. Top. Microbiol. Immunol. , vol.227 , pp. 57-103
    • Chellappan, S.P.1    Giordano, A.2    Fisher, P.B.3
  • 15
    • 0028899480 scopus 로고
    • Separate domains of p21 involved in the inhibition of cdk kinase and PCNA
    • Chen, J., P.K. Jackson, M.W. Kirschner, and A. Dutta. 1995. Separate domains of p21 involved in the inhibition of cdk kinase and PCNA. Nature 374: 386-388.
    • (1995) Nature , vol.374 , pp. 386-388
    • Chen, J.1    Jackson, P.K.2    Kirschner, M.W.3    Dutta, A.4
  • 19
    • 0029957947 scopus 로고    scopus 로고
    • Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by CDK2 binding and cyclin phosphorylation
    • Clurman, B.E., R.J. Sheaff, K. Thress, M. Groudine, and J.M. Roberts. 1996. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by CDK2 binding and cyclin phosphorylation. Genes & Dev. 10: 1979-1990.
    • (1996) Genes & Dev. , vol.10 , pp. 1979-1990
    • Clurman, B.E.1    Sheaff, R.J.2    Thress, K.3    Groudine, M.4    Roberts, J.M.5
  • 20
    • 0029838168 scopus 로고    scopus 로고
    • Physical interaction of mammalian CDC37 with CDK4
    • Dai, K., R. Kobayashi, and D. Beach. 1996. Physical interaction of mammalian CDC37 with CDK4. J. Biol. Chem. 271: 22030-22034.
    • (1996) J. Biol. Chem. , vol.271 , pp. 22030-22034
    • Dai, K.1    Kobayashi, R.2    Beach, D.3
  • 21
    • 0028978183 scopus 로고
    • Mice lacking p21Cip1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • Deng, C., P. Zhang, J.W. Harper, S.J. Elledge, and P. Leder. 1995. Mice lacking p21Cip1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82: 675-684.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 22
    • 0032533225 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization
    • Diehl, J.A., M. Cheng, M.F. Roussel, and C.J. Sherr. 1998. Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization. Genes & Dev. 12: 192-229.
    • (1998) Genes & Dev. , vol.12 , pp. 192-229
    • Diehl, J.A.1    Cheng, M.2    Roussel, M.F.3    Sherr, C.J.4
  • 23
    • 0026698263 scopus 로고
    • Association of human cyclin E with a periodic G1-S phase protein kinase
    • Dulic, V., E. Lees, and S.I. Reed. 1992. Association of human cyclin E with a periodic G1-S phase protein kinase. Science 257: 1958-1961.
    • (1992) Science , vol.257 , pp. 1958-1961
    • Dulic, V.1    Lees, E.2    Reed, S.I.3
  • 24
    • 0028220204 scopus 로고
    • P53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • Dulic, V., W.K. Kaufmann, S.J. Wilson, T.D. Tlsty, E. Lees, J.W. Harper, S.J. Elledge, and S.I. Reed. 1994. p53-Dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76: 1013-1023.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Wilson, S.J.3    Tlsty, T.D.4    Lees, E.5    Harper, J.W.6    Elledge, S.J.7    Reed, S.I.8
  • 26
    • 0032146274 scopus 로고    scopus 로고
    • The regulation of E2F by pRB-family proteins
    • Dyson, N. 1998. The regulation of E2F by pRB-family proteins. Genes & Dev. 12: 2245-2262.
    • (1998) Genes & Dev. , vol.12 , pp. 2245-2262
    • Dyson, N.1
  • 28
    • 0028075611 scopus 로고
    • CDK inhibitors: On the threshold of check points and development
    • Elledge, S.J. and J.W. Harper. 1994. CDK inhibitors: On the threshold of check points and development. Curr. Opin. Cell. Biol. 6: 847-852.
    • (1994) Curr. Opin. Cell. Biol. , vol.6 , pp. 847-852
    • Elledge, S.J.1    Harper, J.W.2
  • 30
    • 0027229136 scopus 로고
    • Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
    • Ewen, M.E., H.K. Sluss, C.J. Sherr, H. Matsushime, J.-Y. Kato, and D.M. Livingston. 1993. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73: 487-497.
    • (1993) Cell , vol.73 , pp. 487-497
    • Ewen, M.E.1    Sluss, H.K.2    Sherr, C.J.3    Matsushime, H.4    Kato, J.-Y.5    Livingston, D.M.6
  • 31
    • 0030924438 scopus 로고    scopus 로고
    • Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb
    • Ezhevsky, S.A., H. Nagahara, A.M. Vocero-Akbani, D.R. Gius, M.C. Wei, and S.F. Dowdy. 1997. Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc. Natl. Acad. Sci. 94: 10699-10704.
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 10699-10704
    • Ezhevsky, S.A.1    Nagahara, H.2    Vocero-Akbani, A.M.3    Gius, D.R.4    Wei, M.C.5    Dowdy, S.F.6
  • 32
    • 0025831974 scopus 로고
    • Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes
    • Fang, F. and J.W. Newport. 1991. Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes. Cell 66: 731-742.
    • (1991) Cell , vol.66 , pp. 731-742
    • Fang, F.1    Newport, J.W.2
  • 33
    • 0028889751 scopus 로고
    • Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
    • Fantl, V., G. Stamp, A. Andrews, I. Rosewell, and C. Dickson. 1995. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes & Dev. 9: 2364-2372.
    • (1995) Genes & Dev. , vol.9 , pp. 2364-2372
    • Fantl, V.1    Stamp, G.2    Andrews, A.3    Rosewell, I.4    Dickson, C.5
  • 36
    • 0026320075 scopus 로고
    • Cyclin A is required for the onset of DNA replication in mammalian fibroblasts
    • Girard, F., U. Strausfeld, A. Fernandez, and N.J.C. Lamb. 1991. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67: 1169-1179.
    • (1991) Cell , vol.67 , pp. 1169-1179
    • Girard, F.1    Strausfeld, U.2    Fernandez, A.3    Lamb, N.J.C.4
  • 37
    • 0027731971 scopus 로고
    • Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
    • Gu, Y., C.W. Turek, and D.O. Morgan. 1993. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 366: 707-710.
    • (1993) Nature , vol.366 , pp. 707-710
    • Gu, Y.1    Turek, C.W.2    Morgan, D.O.3
  • 39
    • 0030861110 scopus 로고    scopus 로고
    • Mutual requirement of CDK4 and Myc in malignant transformation: Evidence for cyclin D1/CDK4 and p16INK4a as upstream regulators of Myc
    • Haas, K., P. Staller, C. Geisen, J. Bartek, M. Eilers, and T. Moroy. 1997. Mutual requirement of CDK4 and Myc in malignant transformation: evidence for cyclin D1/CDK4 and p16INK4a as upstream regulators of Myc. Oncogene 15: 179-192.
    • (1997) Oncogene , vol.15 , pp. 179-192
    • Haas, K.1    Staller, P.2    Geisen, C.3    Bartek, J.4    Eilers, M.5    Moroy, T.6
  • 40
    • 0028875086 scopus 로고
    • Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins
    • Hall, M., S. Bates, and G. Peters. 1995. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. Oncogene 11: 1581-1588.
    • (1995) Oncogene , vol.11 , pp. 1581-1588
    • Hall, M.1    Bates, S.2    Peters, G.3
  • 41
    • 0028168242 scopus 로고
    • INK4b is a potential effector of TGFβ-induced cell cycle arrest
    • INK4b is a potential effector of TGFβ-induced cell cycle arrest. Nature 371: 257-261.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 43
    • 0027496935 scopus 로고
    • The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J.W., G.R. Adami, N. Wei, K. Keyomarsi, and S.J. Elledge. 1993. The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 45
    • 0028169237 scopus 로고
    • Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein
    • Hatakeyama, M., J.A. Brill, G.R. Fink, and R.A. Weinberg. 1994. Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. Genes & Dev. 8: 1759-1771.
    • (1994) Genes & Dev. , vol.8 , pp. 1759-1771
    • Hatakeyama, M.1    Brill, J.A.2    Fink, G.R.3    Weinberg, R.A.4
  • 47
    • 0032535375 scopus 로고    scopus 로고
    • Cip1
    • Cip1. Genes & Dev. 12: 3882-3888.
    • (1998) Genes & Dev. , vol.12 , pp. 3882-3888
  • 48
    • 0029863840 scopus 로고    scopus 로고
    • Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts
    • Herrera, R.E., V.P. Sah, B.O. Williams, T.P. Makela, R.A. Weinberg, and T. Jacks. 1996. Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol. Cell. Biol. 16: 2402-2407.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2402-2407
    • Herrera, R.E.1    Sah, V.P.2    Williams, B.O.3    Makela, T.P.4    Weinberg, R.A.5    Jacks, T.6
  • 49
    • 0026802989 scopus 로고
    • Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
    • Hinds, P.W., S. Mittnacht, V. Dulic, A. Arnold, S.I. Reed, and R.A. Weinberg. 1992. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70: 993-1006.
    • (1992) Cell , vol.70 , pp. 993-1006
    • Hinds, P.W.1    Mittnacht, S.2    Dulic, V.3    Arnold, A.4    Reed, S.I.5    Weinberg, R.A.6
  • 50
    • 0028918388 scopus 로고
    • Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
    • Hirai, H., M.F. Roussel, J. Kato, R.A. Ashmun, and C.J. Sherr. 1995. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell. Biol. 15: 2672-2681.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2672-2681
    • Hirai, H.1    Roussel, M.F.2    Kato, J.3    Ashmun, R.A.4    Sherr, C.J.5
  • 51
    • 0345718747 scopus 로고    scopus 로고
    • pRB and P107/p130 are required for the regulated expression of different sets of E2F responsive genes
    • Hurford, R.K.J., D. Cobrinik, M.-H. Lee, and N. Dyson. 1997. pRB and P107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes & Dev. 9: 2364-2372.
    • (1997) Genes & Dev. , vol.9 , pp. 2364-2372
    • Hurford, R.K.J.1    Cobrinik, D.2    Lee, M.-H.3    Dyson, N.4
  • 52
    • 0029125622 scopus 로고
    • Early events in DNA replication require cyclin E and are blocked by p21CIP1
    • Jackson, P.K., S. Chevalier, M. Philippe, and M.W. Kirschner. 1995. Early events in DNA replication require cyclin E and are blocked by p21CIP1. J. Cell Biol. 130: 755-769.
    • (1995) J. Cell Biol. , vol.130 , pp. 755-769
    • Jackson, P.K.1    Chevalier, S.2    Philippe, M.3    Kirschner, M.W.4
  • 54
    • 0027491775 scopus 로고
    • Expression of transcription factor E2F1 induces quiescent cells to enter S phase
    • Johnson, D.G., J.K. Schwarz, W.D. Cress, and J.R. Nevins. 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365: 349-352.
    • (1993) Nature , vol.365 , pp. 349-352
    • Johnson, D.G.1    Schwarz, J.K.2    Cress, W.D.3    Nevins, J.R.4
  • 55
    • 0027288908 scopus 로고
    • Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase, CDK4
    • Kato, J.-Y., H. Matsushime, S.W. Hiebert, M.E. Ewen, and C.J. Sherr. 1993. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase, CDK4. Genes & Dev. 7: 331-342.
    • (1993) Genes & Dev. , vol.7 , pp. 331-342
    • Kato, J.-Y.1    Matsushime, H.2    Hiebert, S.W.3    Ewen, M.E.4    Sherr, C.J.5
  • 57
    • 0032478177 scopus 로고    scopus 로고
    • Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein
    • Kelly, B.L., K.G. Wolfe, and J.M. Roberts. 1998. Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein. Proc. Natl. Acad. Sci. 95: 2535-2540.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 2535-2540
    • Kelly, B.L.1    Wolfe, K.G.2    Roberts, J.M.3
  • 58
    • 0030901947 scopus 로고    scopus 로고
    • Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1
    • Kerkhoff, E. and U.R. Rapp. 1997. Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1. Mol. Cell. Biol. 17: 2576-2586.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2576-2586
    • Kerkhoff, E.1    Rapp, U.R.2
  • 61
    • 0031451323 scopus 로고    scopus 로고
    • Roles of cyclin-dependent kinase inhibitors: Lessons from knockout mice
    • Kiyokawa, H. and A. Koff. 1998. Roles of cyclin-dependent kinase inhibitors: Lessons from knockout mice. Curr. Top. Microbiol. Immunol. 227: 105-120.
    • (1998) Curr. Top. Microbiol. Immunol. , vol.227 , pp. 105-120
    • Kiyokawa, H.1    Koff, A.2
  • 62
    • 0028358931 scopus 로고
    • Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis and is required for the arrest of cell proliferation
    • Knoblich, J.A., K. Sauer, L. Jones, H. Richardson, R. Saint, and C.F. Lehner. 1994. Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis and is required for the arrest of cell proliferation. Cell 77: 107-120.
    • (1994) Cell , vol.77 , pp. 107-120
    • Knoblich, J.A.1    Sauer, K.2    Jones, L.3    Richardson, H.4    Saint, R.5    Lehner, C.F.6
  • 63
    • 0025734356 scopus 로고
    • Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family
    • Koff, A., F. Cross, A. Fisher, J. Schumacher, K. Leguellec, M. Philippe, and J.M. Roberts. 1991. Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell 66: 1217-1228.
    • (1991) Cell , vol.66 , pp. 1217-1228
    • Koff, A.1    Cross, F.2    Fisher, A.3    Schumacher, J.4    Leguellec, K.5    Philippe, M.6    Roberts, J.M.7
  • 65
    • 0027318843 scopus 로고
    • Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGF-β
    • Koff, A., M. Ohtsuki, K Polyak, J.M. Roberts, and J. Massagué. 1993. Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-β. Science 260: 536-539.
    • (1993) Science , vol.260 , pp. 536-539
    • Koff, A.1    Ohtsuki, M.2    Polyak, K.3    Roberts, J.M.4    Massagué, J.5
  • 66
    • 0029052951 scopus 로고
    • Tumour-derived p16 alleles encoding proteins defective in cell cycle inhibition
    • Koh, J., G.H. Enders, B.D. Dynlacht, and E. Harlow. 1995. Tumour-derived p16 alleles encoding proteins defective in cell cycle inhibition. Nature 375: 506-510.
    • (1995) Nature , vol.375 , pp. 506-510
    • Koh, J.1    Enders, G.H.2    Dynlacht, B.D.3    Harlow, E.4
  • 67
    • 0030887999 scopus 로고    scopus 로고
    • Cyclin/ cdk-dependent initiation of DNA replication in a human cell-free system
    • Krude, T., M. Jackman, J. Pines, and R.A. Laskey. 1997. Cyclin/ cdk-dependent initiation of DNA replication in a human cell-free system. Cell 88: 109-119.
    • (1997) Cell , vol.88 , pp. 109-119
    • Krude, T.1    Jackman, M.2    Pines, J.3    Laskey, R.A.4
  • 70
    • 0029941446 scopus 로고    scopus 로고
    • Inhibition of p53-mediated growth arrest by overexpression of cyclin-dependent kinases
    • Latham, K.M., S.E. Eastman, A. Wong, and P.W. Hinds. 1996. Inhibition of p53-mediated growth arrest by overexpression of cyclin-dependent kinases. Mol. Cell. Biol. 16: 4445-4455.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4445-4455
    • Latham, K.M.1    Eastman, S.E.2    Wong, A.3    Hinds, P.W.4
  • 72
    • 0028988158 scopus 로고
    • Kip2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution
    • Kip2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes & Dev. 9: 639-649.
    • (1995) Genes & Dev. , vol.9 , pp. 639-649
    • Lee, M.H.1    Reynisdóttir, I.2    Massagué, J.3
  • 74
    • 0031048236 scopus 로고    scopus 로고
    • Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
    • Loda, M., B. Cukor, S.W. Tam, P. Lavin, M. Fiorentino, G.F. Draetta, J.M. Jessup, and M. Pagano. 1997. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat. Med. 3: 231-234.
    • (1997) Nat. Med. , vol.3 , pp. 231-234
    • Loda, M.1    Cukor, B.2    Tam, S.W.3    Lavin, P.4    Fiorentino, M.5    Draetta, G.F.6    Jessup, J.M.7    Pagano, M.8
  • 75
    • 0025060176 scopus 로고
    • The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T
    • Ludlow, J.W., J. Shon, J.M. Pipas, D.M. Livingston, and J.A. DeCaprio. 1990. The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell 60: 387-396.
    • (1990) Cell , vol.60 , pp. 387-396
    • Ludlow, J.W.1    Shon, J.2    Pipas, J.M.3    Livingston, D.M.4    DeCaprio, J.A.5
  • 77
    • 0028279059 scopus 로고
    • DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1
    • Lukas, J., H. Muller, J. Bartkova, D. Spitkovsky, A.A. Kjerulff, P. Jansen-Durr, M. Strauss, and J. Bartek. 1994. DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1. J. Cell Biol. 125: 625-638.
    • (1994) J. Cell Biol. , vol.125 , pp. 625-638
    • Lukas, J.1    Muller, H.2    Bartkova, J.3    Spitkovsky, D.4    Kjerulff, A.A.5    Jansen-Durr, P.6    Strauss, M.7    Bartek, J.8
  • 78
    • 0028925360 scopus 로고
    • Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells, independent of CDK4 activity
    • Lukas, J., J. Bartkova, M. Rohde, M. Strauss, and J. Bartek. 1995a. Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells, independent of CDK4 activity. Mol. Cell. Biol. 15: 2600-2611.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2600-2611
    • Lukas, J.1    Bartkova, J.2    Rohde, M.3    Strauss, M.4    Bartek, J.5
  • 81
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-CDK complexes
    • Lundberg, A.S. and R.A. Weinberg. 1998. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-CDK complexes. Mol. Cell. Biol. 18: 753-761.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 753-761
    • Lundberg, A.S.1    Weinberg, R.A.2
  • 82
    • 0032485070 scopus 로고    scopus 로고
    • Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells
    • Mahony, D., D.A. Parry, and E. Lees. 1998. Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells. Oncogene 13: 603-611.
    • (1998) Oncogene , vol.13 , pp. 603-611
    • Mahony, D.1    Parry, D.A.2    Lees, E.3
  • 87
    • 0032981481 scopus 로고    scopus 로고
    • INK4a inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes
    • INK4a inhibits both CDK4-and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes. Mol. Cell. Biol. 19: 1981-1989.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1981-1989
    • McConnell, B.B.1    Gregory, F.J.2    Stott, F.J.3    Hara, E.4    Peters, G.5
  • 89
    • 0028181760 scopus 로고
    • Identification of a G1 kinase activity for cdk6, a novel cyclin D partner
    • Meyerson, M. and E. Harlow. 1994. Identification of a G1 kinase activity for cdk6, a novel cyclin D partner. Mol. Cell. Biol. 14: 2077-2086.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 2077-2086
    • Meyerson, M.1    Harlow, E.2
  • 91
    • 0028032069 scopus 로고
    • Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation
    • Mittnacht, S., J.A. Lees, D. Desai, E. Harlow, D.O. Morgan, and R.A. Weinberg. 1994. Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation. EMBO J. 13: 118-127.
    • (1994) EMBO J. , vol.13 , pp. 118-127
    • Mittnacht, S.1    Lees, J.A.2    Desai, D.3    Harlow, E.4    Morgan, D.O.5    Weinberg, R.A.6
  • 92
    • 0030891628 scopus 로고    scopus 로고
    • Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6
    • Morse, L., D. Chen, D. Franklin, Y. Xiong, and S. Chen-Kiang. 1997. Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6. Immunity 6: 47-56.
    • (1997) Immunity , vol.6 , pp. 47-56
    • Morse, L.1    Chen, D.2    Franklin, D.3    Xiong, Y.4    Chen-Kiang, S.5
  • 94
    • 0032410285 scopus 로고    scopus 로고
    • Cip/Kip cyclin-dependent kinase inhibitors: Brakes of the cell cycle engine during development
    • Nakayama, K. 1998. Cip/Kip cyclin-dependent kinase inhibitors: brakes of the cell cycle engine during development. BioEssays 12: 1020-1029.
    • (1998) BioEssays , vol.12 , pp. 1020-1029
    • Nakayama, K.1
  • 95
    • 0031815596 scopus 로고    scopus 로고
    • Toward an understanding of the functional complexity of the E2F and retinoblastoma families
    • Nevins, J.R. 1998. Toward an understanding of the functional complexity of the E2F and retinoblastoma families. Cell Growth Differ. 9: 585-593.
    • (1998) Cell Growth Differ. , vol.9 , pp. 585-593
    • Nevins, J.R.1
  • 96
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda, A., Y. Ning, S.F. Venable, O.M. Pereira-Smith, and J.R. Smith. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell. Res. 211: 90-98.
    • (1994) Exp. Cell. Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 99
    • 0026583746 scopus 로고
    • Cyclin A is required at two points in the human cell cycle
    • Pagano, M., R. Pepperkok, F. Verde, W. Ansorge, and G. Draetta. 1992. Cyclin A is required at two points in the human cell cycle. EMBO J. 11: 961-971.
    • (1992) EMBO J. , vol.11 , pp. 961-971
    • Pagano, M.1    Pepperkok, R.2    Verde, F.3    Ansorge, W.4    Draetta, G.5
  • 100
    • 0030612753 scopus 로고    scopus 로고
    • Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status
    • Palmero, I., B. McConnell, D. Parry, S. Brookes, E. Hara, S. Bates, P. Jat, and G. Peters. 1997. Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status. Oncogene 15: 495-503.
    • (1997) Oncogene , vol.15 , pp. 495-503
    • Palmero, I.1    McConnell, B.2    Parry, D.3    Brookes, S.4    Hara, E.5    Bates, S.6    Jat, P.7    Peters, G.8
  • 102
    • 0032980425 scopus 로고    scopus 로고
    • Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors
    • Parry, D.A., D. Mahony, K. Wills, and E. Lees. 1999. Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors. Mol. Cell. Biol. 19: 1775-1783.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1775-1783
    • Parry, D.A.1    Mahony, D.2    Wills, K.3    Lees, E.4
  • 104
    • 0031772952 scopus 로고    scopus 로고
    • SCF and APC: The Yin and Yang of cell cycle regulated proteolysis
    • Peters, J.-M. 1998. SCF and APC: The Yin and Yang of cell cycle regulated proteolysis. Curr. Opin. Cell Biol. 10: 759-768.
    • (1998) Curr. Opin. Cell Biol. , vol.10 , pp. 759-768
    • Peters, J.-M.1
  • 105
    • 0031949217 scopus 로고    scopus 로고
    • Coupled transcriptional and translational control of cyclin-dependent kinase inhibitor p18INK4c expression during myogenesis
    • Phelps, D.E., K.M. Hsiao, Y. Li, N. Hu, D.S. Franklin, E. Westphal, E.Y. Lee, and Y. Xiong. 1998. Coupled transcriptional and translational control of cyclin-dependent kinase inhibitor p18INK4c expression during myogenesis. Mol. Cell. Biol. 18: 2334-2343.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 2334-2343
    • Phelps, D.E.1    Hsiao, K.M.2    Li, Y.3    Hu, N.4    Franklin, D.S.5    Westphal, E.6    Lee, E.Y.7    Xiong, Y.8
  • 108
    • 0031048716 scopus 로고    scopus 로고
    • Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
    • Porter, P.L., K.E. Malone, P.J. Heagerty, G.M. Alexander, L.A. Gatti, F.J. Firpo, J.R. Daling, and J.M. Roberts. 1997. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nat. Med. 3: 222-225.
    • (1997) Nat. Med. , vol.3 , pp. 222-225
    • Porter, P.L.1    Malone, K.E.2    Heagerty, P.J.3    Alexander, G.M.4    Gatti, L.A.5    Firpo, F.J.6    Daling, J.R.7    Roberts, J.M.8
  • 109
    • 0027947383 scopus 로고
    • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
    • Qin, X.Q., D.M. Livingston, W.G. Kaelin, Jr., and P.D. Adams. 1994. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. 91: 10918-19022.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 10918-19022
    • Qin, X.Q.1    Livingston, D.M.2    Kaelin W.G., Jr.3    Adams, P.D.4
  • 111
    • 0030614715 scopus 로고    scopus 로고
    • Kip1 coordinate their inhibitory interactions with cdk4 and cdk2
    • Kip1 coordinate their inhibitory interactions with cdk4 and cdk2. Genes & Dev. 11: 492-503.
    • (1997) Genes & Dev. , vol.11 , pp. 492-503
    • Reynisdóttir, I.1    Massagué, J.2
  • 112
    • 0029153609 scopus 로고
    • Kip/Cip and Ink4 cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β
    • Reynisdóttir, I., K. Polyak, A. Iavarone, and J. Massagué. 1995. Kip/Cip and Ink4 cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes & Dev. 9: 1831-1845.
    • (1995) Genes & Dev. , vol.9 , pp. 1831-1845
    • Reynisdóttir, I.1    Polyak, K.2    Iavarone, A.3    Massagué, J.4
  • 113
    • 0032517341 scopus 로고    scopus 로고
    • INK4a/CDKN2A tumor suppressor and its relatives
    • INK4a/CDKN2A tumor suppressor and its relatives. B.B.A. Rev. Cancer 1378: F115-F177.
    • (1998) B.B.A. Rev. Cancer , vol.1378
    • Ruas, M.1    Peters, G.2
  • 114
    • 0029665852 scopus 로고    scopus 로고
    • Crystal structure of the p27Kip1 cyclin-dependent kinase inhibitor bound to the cyclin A-cdk2 complex
    • Russo, A.A., P.D. Jeffrey, A.K. Patten, J. Massagué, and N.P. Pavletich. 1996. Crystal structure of the p27Kip1 cyclin-dependent kinase inhibitor bound to the cyclin A-cdk2 complex. Nature 382: 325-331.
    • (1996) Nature , vol.382 , pp. 325-331
    • Russo, A.A.1    Jeffrey, P.D.2    Patten, A.K.3    Massagué, J.4    Pavletich, N.P.5
  • 115
    • 0027769876 scopus 로고
    • A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano, M., G.J. Hannon, and D. Beach. 1993. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 117
    • 0028061670 scopus 로고
    • Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
    • Shan, B. and W.H. Lee. 1994. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol. 14: 8166-8173.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 8166-8173
    • Shan, B.1    Lee, W.H.2
  • 119
    • 0027336491 scopus 로고
    • Mammalian G, cyclins
    • Sherr, C.J. 1993. Mammalian G, cyclins. Cell 73: 1059-1065.
    • (1993) Cell , vol.73 , pp. 1059-1065
    • Sherr, C.J.1
  • 120
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • _. 1996. Cancer cell cycles. Science 274: 1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
  • 125
    • 0029665779 scopus 로고    scopus 로고
    • Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4
    • Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. Genes & Dev. 10: 1491-1502.
    • (1996) Genes & Dev. , vol.10 , pp. 1491-1502
    • Stepanova, L.1    Leng, X.2    Parker, S.B.3    Harper, J.W.4
  • 126
    • 0029810269 scopus 로고    scopus 로고
    • Cell cycle control of DNA replication
    • Stillman, B. 1996. Cell cycle control of DNA replication. Science 274: 1659-1664.
    • (1996) Science , vol.274 , pp. 1659-1664
    • Stillman, B.1
  • 128
    • 0030697223 scopus 로고    scopus 로고
    • Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins
    • Swanton, C., D.J. Mann, B. Fleckenstein, F. Neipel, G. Peters, and N. Jones. 1997. Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins. Nature 390: 184-187.
    • (1997) Nature , vol.390 , pp. 184-187
    • Swanton, C.1    Mann, D.J.2    Fleckenstein, B.3    Neipel, F.4    Peters, G.5    Jones, N.6
  • 129
    • 0031016121 scopus 로고    scopus 로고
    • RB kinases and RB-binding proteins: New points of view
    • Taya, Y. 1997. RB kinases and RB-binding proteins: New points of view. Trends Biochem. Sci. 22: 14-17.
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 14-17
    • Taya, Y.1
  • 130
    • 0028363519 scopus 로고
    • p27, a novel inhibitor of G1 cyclin/cdk protein kinase activity, is related to p21
    • Toyoshima, H. and T. Hunter. 1994. p27, a novel inhibitor of G1 cyclin/cdk protein kinase activity, is related to p21. Cell 78: 67-74.
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 131
    • 0032980308 scopus 로고    scopus 로고
    • The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer
    • Tsihlias, J., L. Kapusta, and J. Slingerland. 1999. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. Annu. Rev. Med. 50: 401-423.
    • (1999) Annu. Rev. Med. , vol.50 , pp. 401-423
    • Tsihlias, J.1    Kapusta, L.2    Slingerland, J.3
  • 132
    • 0027742184 scopus 로고
    • Distinct roles for cyclin-dependent kinases in cell cycle control
    • van den Heuvel, S. and E. Harlow. 1993. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262: 2050-2054.
    • (1993) Science , vol.262 , pp. 2050-2054
    • Van Den Heuvel, S.1    Harlow, E.2
  • 136
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R.A. 1995. The retinoblastoma protein and cell cycle control. Cell 81: 323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 137
    • 0032532951 scopus 로고    scopus 로고
    • WAF1/ CIP1 mutants deficient in inhibiting cyclin-dependent (CDKs) can promote assembly of active cyclin D/CDK4(6) complexes in human tumor cells
    • WAF1/ CIP1 mutants deficient in inhibiting cyclin-dependent (CDKs) can promote assembly of active cyclin D/CDK4(6) complexes in human tumor cells. Cancer Res. 58: 5053-5056.
    • (1998) Cancer Res. , vol.58 , pp. 5053-5056
    • Welcker, M.1    Lukas, J.2    Strauss, M.3    Bartek, J.4
  • 138
    • 0030042598 scopus 로고    scopus 로고
    • Regulation of the cell cycle machinery by oncogenic ras
    • Winston, J.T., S.R. Coats, Y.-Z. Wang, and W.J. Pledger. 1996. Regulation of the cell cycle machinery by oncogenic ras. Oncogene 12: 127-134.
    • (1996) Oncogene , vol.12 , pp. 127-134
    • Winston, J.T.1    Coats, S.R.2    Wang, Y.-Z.3    Pledger, W.J.4
  • 139
    • 0029737650 scopus 로고    scopus 로고
    • Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E
    • Won, K.-A. and S.I. Reed. 1996. Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. EMBO J. 15: 4182-4193.
    • (1996) EMBO J. , vol.15 , pp. 4182-4193
    • Won, K.-A.1    Reed, S.I.2
  • 141
    • 0027301324 scopus 로고
    • Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation
    • Xiong, Y., H. Zhang, and D. Beach. 1993b. Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes & Dev. 7: 1572-1583.
    • (1993) Genes & Dev. , vol.7 , pp. 1572-1583
    • Xiong, Y.1    Zhang, H.2    Beach, D.3
  • 142
    • 0028169236 scopus 로고
    • p21-containing cyclin kinases exist in both active and inactive states
    • Zhang, H., G.J. Hannon, and D. Beach. 1994. p21-containing cyclin kinases exist in both active and inactive states. Genes & Dev. 8: 1750-1758.
    • (1994) Genes & Dev. , vol.8 , pp. 1750-1758
    • Zhang, H.1    Hannon, G.J.2    Beach, D.3
  • 144
    • 0032520093 scopus 로고    scopus 로고
    • Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry
    • Zhao, J., B. Dynlacht, T. Imai, T. Hori, and E. Harlow. 1998. Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. Genes & Dev. 12: 456-461.
    • (1998) Genes & Dev. , vol.12 , pp. 456-461
    • Zhao, J.1    Dynlacht, B.2    Imai, T.3    Hori, T.4    Harlow, E.5
  • 146
    • 0030612349 scopus 로고    scopus 로고
    • INK4a tumor suppressor versus other INK4 family members during mouse development and aging
    • INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15: 203-211.
    • (1997) Oncogene , vol.15 , pp. 203-211
    • Zindy, F.1    Quelle, D.E.2    Roussel, M.F.3    Sherr, C.J.4
  • 147
    • 0030784943 scopus 로고    scopus 로고
    • Expression of INK4 inhibitors in cyclin D-dependent kinases during mouse brain development
    • Zindy, F., H. Soares, K.-H. Herzog, J. Morgan, C.J. Sherr, and M.F. Roussel. 1997b. Expression of INK4 inhibitors in cyclin D-dependent kinases during mouse brain development. Cell Growth Differ. 8: 1139-1150.
    • (1997) Cell Growth Differ. , vol.8 , pp. 1139-1150
    • Zindy, F.1    Soares, H.2    Herzog, K.-H.3    Morgan, J.4    Sherr, C.J.5    Roussel, M.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.