Impaired activation of phosphoinositide 3-kinase by insulin in fibroblasts from patients with severe insulin resistance and pseudoacromegaly: A disorder characterized by selective postreceptor insulin resistance

Journal of Clinical Investigation

Volumn 101, Issue 5, 1998, Pages 1111-1120

  Dib, Karim ^a,b   Whitehead, Jonathan P ^a,b   Humphreys, Phillippa J ^a,b   Soos, Maria A ^a,b   Baynes, Kevin C R ^a,b   Kumar, Sudhesh ^c   Harvey, Timothy ^d   O'Rahilly, Stephen ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^d MANOR HOSPITAL   (United Kingdom)

Author keywords

Insulin receptor; Insulin resistance; Phosphoinositide 3 kinase; Pseudoacromegaly; Signal transduction

Indexed keywords

INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE;

ACROMEGALY; ADULT; ARTICLE; CASE REPORT; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN METABOLISM; INSULIN RESISTANCE; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PSEUDOACROMEGALY; RECEPTOR BINDING; SCHOOL CHILD; SIGNAL TRANSDUCTION;

EID: 0032030910     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119884     Document Type: Article

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