Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration

Science

Volumn 287, Issue 5455, 2000, Pages 1040-4046

  Sasaki, Takehiko ^a   Irie Sasaki, Junko ^a   Jones, Russell G ^a   Oliveira Dos Santos, Antonio J ^a   Stanford, William L ^a   Bolon, Brad ^a   Wakeham, Andrew ^a   Itie, Annick ^a   Bouchard, Dennis ^a   Kozieradzki, Ivona ^a   Joza, Nicholas ^a   Mak, Tak W ^a   Ohashi, Pamela S ^a   Suzuki, Akira ^a   Penninger, Josef M ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; CHEMOATTRACTANT; COMPLEMENT COMPONENT C5A; FORMYLMETHIONYLLEUCYLPHENYLALANINE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN E; INTERLEUKIN 3; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE B; S6 KINASE; STEM CELL FACTOR; THROMBIN; CHEMOTACTIC FACTOR; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; LEUKOCYTE ANTIGEN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE; POLYPHOSPHOINOSITIDE; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM MOBILIZATION; CELL MATURATION; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; INFLAMMATORY DISEASE; LISTERIA MONOCYTOGENES; MAST CELL; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; RESPIRATORY BURST; T LYMPHOCYTE ACTIVATION; THYMOCYTE; ANIMAL; APOPTOSIS; CELL LINE; CYTOLOGY; IMMUNOLOGY; LYMPH NODE; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPLEEN; T LYMPHOCYTE; THYMUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, CD; APOPTOSIS; CELL LINE; CHEMOTACTIC FACTORS; CHEMOTAXIS, LEUKOCYTE; HETEROTRIMERIC GTP-BINDING PROTEINS; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; NEUTROPHILS; PERITONITIS; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RESPIRATORY BURST; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0034635264     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.287.5455.1040     Document Type: Article

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31. We thank M. Saunders, K. Bachmaier, Y. Kong, M. Crackover, E. Griffith, Q. Liu, V. Stambulic, L. Zhang, G. Duncan, C. Krawczyk, and D. Lacey for comments. T.S., J.I.-S., and J.M.P. are supported by the Medical Research Council and National Cancer Institute of Canada and by Amgen.