Signalling through the lipid products of phosphoinositide-3-OH kinase

Nature

Volumn 387, Issue 6634, 1997, Pages 673-676

  Toker, Alex ^a   Cantley, Lewis C ^b  

^a BOSTON BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; CELL MEMBRANE; CHEMOTAXIS; CYTOSKELETON; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE REARRANGEMENT; LIPID METABOLISM; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD PROTEINS; CALCIUM-BINDING PROTEINS; ENZYME ACTIVATION; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE LIPIDS; NERVE TISSUE PROTEINS; PHOSPHATIDYLINOSITOLS; PHOSPHOPROTEINS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SECOND MESSENGER SYSTEMS; SRC HOMOLOGY DOMAINS; SYNAPTOTAGMINS;

EID: 0030992837     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/42648     Document Type: Review

References (47)

1. Whitman, M., Downes, C. P., Keeler, M., Keller, T. & Cantley, L. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 332, 644-646 (1988).
2. Traynor-Kaplan, A. E., Harris, A. L., Thompson, B. L., Taylor, P. & Sklar, L. A. An inositol tetrakisphosphate-containing phospholipid in activated neutrophils. Nature 334, 353-356 (1988).
3. Franke, T. F. et al. PI3K: downstream AKTion blocks apoptosis. Cell 88, 435-437 (1977).
4. Chang, H. W. et al. The retroviral oncogene p3k is homologus to the gene encoding for the catalytic subunit of phosphoinositide 3-kinase. Science (in the press).
5. Morris, J. Z., Tissenbaum, H. A. & Ruvkun, G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis eleguns, Nature 382, 536-539 (1996).
6. Rodriguez, V. P. et al. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370, 527-532 (1994).
7. Rameh, L., Chen, C.-S. & Cantley, L., C. Phosphatidylinositol-3,4,5-P3 interacts with SH2 domains and modulates phosphoinositide 3-kinase association with tyrosine-phosphorylated proteins. Cell 83, 821-830(1995).
8. Franke, T. F. et al. The protein kinase encoded the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 1-20 (1995).
9. Burgering, B. M. & Coffer, P. J. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376, 599-602 (1995).
10. Kohn, A. D., Takeuchi, F. & Roth, R. A. Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation. J. Biol. Chem. 271, 21920-21926 (1996).
11. Franke, T. F., Kaplan, D. R., Cantley, L. C. & Toker, A. Direct regulation of the Akt protooncogene product by PI34P2. Science 275, 665-668 (1997).
12. Klippel, A., Kavanaugh, W. M., Pot, D. & Williams, L. T. A specific product of PI 3-K directly activates the protein kinase Akt through its pleckstrin homology domain. Mol Cell Biol. 17, 338-344 (1997).
13. Frech, M. et al. High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity. J. Biol. Chem. 272, 8474-8481 (1997).
14. Alessi, D. R. et al. Characterisation of a 3-phosphoinositide-dependent protein kinase which phosphorates and activates PKB-α Curr. Biol. 7, 261-269 (1997).
15. Konishi, H. et al. Activation of RAC-protein Kinase by heat shock and hyperosmolarity stress through a pathway independent of PI 3-K. Proc. Natl Acad. Sci. U.S.A. 93, 7639-7643 (1996).
16. Salim, K. et al. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Btk. EMBO J. 15, 6241-6250 (1996).
17. Fukuda, M., Kojima, T., Kabayama, H. & Mikoshiba, K. Mutation of the pleckstrin homology domain of BTK in immunodeficiency impaired IP4 binding capacity. J. Biol. Chem. 271, 30303-30306 (1996).
18. Klarulund, J. K. et al. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 Homology domains. Science 275, 1927-1930 (1997).
19. Kolanus, W. et al. Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. Cell 86, 233-242 (1996).
20. Chardin, P. et al. A human exchange factor for ARF contains Sec7 and PH domains. Nature 384, 481-484 (1996).
21. Zhou, M.-M. et al. Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Nature 378, 584-592 (1995).
22. Rameh, L. E. et al. Phosphoinositide binding specificity of plekcastrin homology domains; the Btk domain specifically binds to PIP3. J. Biol. Chem. (in the press).
23. Palmer, R. H. et al. Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphospate. J. Biol. Chem. 270, 22412-22416 (1995).
24. Toker, A. et al. Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. J. Biol. Chem. 269, 32358-32367 (1994).
25. Nakanishi, H., Brewer, K. A. & Exton, J. H. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 268, 13-16 (1993).
26. Moriya, S. et al. Platelet-derived growth factor activates protein kinase C-ε through redundant and independent signaling pathways involving phospholipase C-γ or phosphatidylinositol 3-kinase. Proc. Natl Acad. Sci. USA 93, 151-155 (1996).
27. Akimoto, K. et al. EGF or PDGF receptors activate atypical PKCλ through phosphatidylinositol 3-kinase. EMBO J. 15, 788-798 (1996).
28. Sossin, W. S., Chen, C.-S. & Toker, A. Stimulation of an insulin receptor activates and downregulates the Ca-indepcndent protein kinase C, Apl II, through a wortmannin sensitive signaling pathway in Aplysia. J. Neurochem. 67, 220-228 (1996).
29. Toker, A. et al. Phosphorylation of the platelet p47 phosphorprotein is mediated by the lipid products of phosphoinositide 3-kinase. J. Biol.Chem. 270, 29525-29531 (1995).
30. Lu, P. J. & Chen, C.-S. Selective recognition of PIP3 by a synthetic peptide, J. Biol. Chem. 272, 466-472 (1997).
31. Derman, M. P. et al. The lipid products of phosphoinositide 3-kinase mediate chemotaxis through protein kinase. J. Biol. Chem. 272, 6465-6470 (1995).
32. Cross, D. A. et al. The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell Une L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. Biochem. J. 303, 21-26 (1994).
33. Lopez-Ilasaca, M., Crespo, P., Pellici, P. G., Gutkind, J. S. & Wetzker, R. Linkage of G protein coupled receptors to the MAPK signaling pathway through PI 3-Kγ. Science 275, 394-397 (1997).
34. Klippel, A. et al. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathway. Mol Cell Biol. 16, 4117-4127 (1996).
35. Schu, P. V. et al. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 260, 88-91 (1993).
36. Rapaport, I. et al. Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes. EMBO J. 16, 2240-2250 (1997).
37. Hao, W. et al. Regulation of AP-3 function by inositides: identification of PIP3 as a potent ligand. J. Biol. Chem. 272, 6393-6398 (1997).
38. Joly, M., Kazlauskas, A., Fay, F. S. & Corvera, S. Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites. Science 263, 684-687 (1994).
39. Frevert, E. U. & Kahn, B. B. Differential effects of constitutively active PI 3-K on glucose transport, glycogen synthase activity and DNA synthesis in 3T3-L1 adipocytes. Mol Cell Biol. 17, 190-198 (1997).
40. Schiavo, G., Gu, Q.-M., Prestwich, G. D., Sollner, T. H. & Rothman, J. E. Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin. Proc. Natl Acad. Sci. USA 93, 13327-13332 (1996).
41. Hammonds-Odie, L. P. et al. Identification and cloning of centaurin-α. J. Biol. Chem. 271, 18859-18868 (1996).
42. Lu, P. J., Shieh, W.-R., Rhee, S. G., Yin, H. L. & Chen, C.-C. Lipid products of Pi 3-K bind profilin with high affinity. Biochemistry 35, 14027-14034 (1997).
43. Hartwig, J. H. et al. D3 phosphoinositides and outside-in integrin signaling by GPIIbIIIa mediate platelet actin assembly and filpidial extension induced by PMA. J. Biol. Chem. 271, 32986-32993 (1996).
44. Hartwig, J. H. et al. Thrombin receptor-ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 82, 1-20 (1995).
45. Wennstrom, S. et al. Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr. Biol. 4, 385-393 (1994).
46. Hawkins, P. T. et al. PDGF stimulates an increase in GTP-rac via activation of phosphoinositide 3-kinase. Curr. Biol. 5, 393-403 (1995).
47. Reif, K., Nobes, C. D., Thomas, G., Hall, A. & Cantrell, D. A. PI 3-K signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 6, 1445-1455 (1996).