Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: Differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase

Biochemical Journal

Volumn 346, Issue 3, 2000, Pages 827-833

  Leslie, Nick R ^a   Gray, Alex ^a   Pass, Ian ^a   Orchiston, Elaine A ^a   Downes, C Peter ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

PDZ domain; Phosphatase; Phosphoinositide signalling; Tumour suppressor

Indexed keywords

MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MEMBRANE STRUCTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BASE SEQUENCE; CATALYTIC DOMAIN; CELL LINE; DNA PRIMERS; HUMANS; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA;

EID: 0034654298     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3460827     Document Type: Article

References (47)

1. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R. et al. (1997) Science 275, 1943-1947
2. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T. et al. (1997) Nat. Genet. 15, 356-362
3. Teng, D. H., Hu, R., Lin, H., Davis, T., Iliev, D., Frye, C., Swedlund, B., Hansen, K. L., Vinson, V. L., Gumpper, K. L. et al. (1997) Cancer Res. 57, 5221-5225
4. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacocke, et al. (1997) Nat. Genet. 16, 64-67
5. Nelen, M. R., van Staveren, W. C., Peeters, E. A., Hassel, M. B., Gorlin, R. J., Hamm, H., Lindboe, C. F., Fryns, J. P., Sijmons, R. H., Woods, D. G. et al. (1997) Hum. Mol. Genet. 6, 1383-1387
6. Marsh, D. J., Dahia, P. L., Zheng, Z., Liaw, D., Parsons, R., Gorlin, R. J. and Eng, C. (1997) Nat. Genet. 16, 333-334
7. Di Cristofano, A., Pesce, B., Cordon-Cardo, C. and Pandolfi, P. P. (1998) Nat. Genet. 19, 348-355
8. Podsypanina, K., Ellenson, L. H., Nemes, A., Gu, J., Tamura, M., Yamada, K. M., Cordon-Cardo, C., Catoretti, G., Fisher, P. E. and Parsons, R. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 1563-1568
9. Suzuki, A., de la Pompa, J. L., Stambolic, V., Elia, A. J., Sasaki, T., del Barco Barrantes, I., Ho, A., Wakeham, A., Itie, A., Khoo, W. et al. (1998) Curr. Biol. 8, 1169-1178
10. Li, D. M. and Sun, H. (1997) Cancer Res. 57, 2124-2129
11. Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H. W., Parsons, R. and Tonks, N. K. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 9052-9057
12. Maehama, T. and Dixon, J. E. (1998) J. Biol. Chem. 273, 13375-13378
13. Myers, M. P., Pass, I., Batty, I. H., Van der Kaay, J., Stolarov, J. P., Hemmings, B. A., Wigler, M. H., Downes, C. P. and Tonks, N. K. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 13513-13518
14. Li, D. M. and Sun, H. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 15406-15411
15. Li, J., Simpson, L., Takahashi, M., Miliaresis, C., Myers, M. P., Tonks, N. and Parsons, R. (1998) Cancer Res, 58, 5667-5672
16. Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P. and Mak, T. W. (1998) Cell 95, 29-39
17. Haas-Kogan, D., Shalev, N., Wong, M., Mills, G., Yount, G. and Stokoe, D. (1998) Curr. Biol. 8, 1195-1198
18. Furnari, F. B., Huang, H. J. and Cavenee, W. K. (1998) Cancer Res. 58, 5002-5008
19. Ogg, S. and Ruvkun, G. (1998) Mol. Cell 2, 887-893
20. Maehama, T. and Dixon, J. E. (1999) Trends Cell Biol. 9, 125-128
21. Cantley, L. C. and Neel, B. G. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 4240-4245
22. Bondeva, T., Pirola, L., Bulgarelli-Leva, G., Rubio, I., Wetzker, R. and Wymann, M. P. (1998) Science 282, 293-296
23. Gu, J., Tamura, M., Pankov, R., Danen, E. H., Takino, T., Matsumoto, K. and Yamada, K. M. (1999) J. Cell Biol. 146, 389-404
24. Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R. and Yamada, K. M. (1998) Science 280, 1614-1617
25. Lee, J. O., Yang, H., Georgescu, M. M., Di Cristofano, A., Maehama, T., Shi, Y., Dixon, J. E., Pandolti, P. and Pavletich, N. P. (1999) Cell 99, 323-334
26. Songyang, Z., Fanning, A. S., Fu, C., Xu, J., Marfatia, S. M., Chishti, A. H., Crompton, A., Chan, A. C., Anderson, J. M. and Cantley, L. C. (1997) Science 275, 73-77
27. Craven, S. E., El-Husseini, A. E. and Bredt, D. S. (1999) Neuron 22, 497-509
28. Fanning, A. S. and Anderson, J. M. (1999) J. Clin. Invest 103, 767-772
29. Montell, C. (1998) Curr. Opin. Neurobiol. 8, 389-397
30. Nemoto, Y. and De Camilli, P. (1999) EMBO J. 18, 2991-3006
31. Ali, I. U., Schriml, L. M. and Dean, M. (1999) J. Natl. Cancer Inst. 91, 1922-1932
32. Morimoto, A. M., Berson, A. E., Fujii, G. H., Teng, D. H., Tavtigian, S. V., Bookstein, R., Steck, P. A. and Bolen, J. B. (1999) Oncogene 18, 1261-1266
33. Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P. and Hemmings, B. A. (1996) EMBO J. 15, 6541-6551
34. Balendran, A., Casamayor, A., Deak, M., Paterson, A., Gaffney, P., Currie, R., Downes, C. P. and Alessi, D. R. (1999) Curr. Biol. 9, 393-404
35. Davies, M. A., Lu, Y., Sano, T., Fang, X., Tang, P., LaPushin, R., Koul, D., Bookstein, R., Stokoe, D., Yung, W. K. et al. (1998) Cancer Res. 58, 5285-5290
36. Furnari, F. B., Lin, H., Huang, H. S. and Cavenee, W. K. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 12479-12484
37. Ramaswamy, S., Nakamura, N., Vazquez, F., Batt, D. B., Perera, S., Roberts, T. M. and Sellers, W. R. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 2110-2115
38. Wu, X., Senechal, K., Neshat, M. S., Whang, Y. E. and Sawyers, C. L. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 15587-15591
39. Welch, H., Eguinoa, A., Stephens, L. R. and Hawkins, P. T. (1998) J. Biol. Chem. 273, 11248-11256
40. Wennstrom, S., Hawkins, P., Cooke, F., Hara, K., Yonezawa, K., Kasuga, M., Jackson, T., Claesson-Welsh, L. and Stephens, L. (1994) Curr. Biol. 4, 385-393
41. Georgescu, M. M., Kirsch, K. H., Akagi, T., Shishido, T. and Hanafusa, H. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 10182-10187
42. van Weering, D. H., de Rooij, J., Marte, B., Downward, J., Bos, J. L. and Burgering, B. M. (1998) Mol. Cell Biol. 18, 1802-1811
43. Franke, T. F., Yang, S. I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R. and Tsichlis, P. N. (1995) Cell 81, 727-736
44. Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. and Hall, A. (1992) Cell 70, 401-410
45. Wymann, M. P. and Pirola, L. (1998) Biochim. Biophys. Acta 1436, 127-150
46. Vanhaesebroeck, B., Leevers, S. J., Panayotou, G. and Waterfield, M. D. (1997) Trends Biochem. Sci. 22, 267-272
47. Shaw, L. M., Rabinovitz, I., Wang, H. H., Toker, A. and Mercurio, A. M. (1997) Cell 91, 949-960