메뉴 건너뛰기




Volumn 113, Issue 2, 2000, Pages 207-214

The PI 3-kinase isoforms p110a and p110b have differential roles in PDGF- and insulin-mediated signaling

Author keywords

Cytoskeleton; Insulin; PDGF; PI3 kinase

Indexed keywords

ACTIN; ANTIBODY; G PROTEIN COUPLED RECEPTOR; INSULIN; ISOENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; SYNTHETIC PEPTIDE; TYROSINE KINASE RECEPTOR;

EID: 0033952239     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (70)

References (63)
  • 1
    • 0029913340 scopus 로고    scopus 로고
    • Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain
    • Antonetti, D. A., Algenstaedt, P. and Kahn, C. R. (1996). Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. Mol. Cell Biol. 16, 2195-2203.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 2195-2203
    • Antonetti, D.A.1    Algenstaedt, P.2    Kahn, C.R.3
  • 2
    • 0032007313 scopus 로고    scopus 로고
    • In vivo functions of actin-binding proteins
    • Ayscough, K. R. (1998). In vivo functions of actin-binding proteins. Curr. Opin. Cell Biol. 10, 102-111.
    • (1998) Curr. Opin. Cell Biol. , vol.10 , pp. 102-111
    • Ayscough, K.R.1
  • 3
    • 0032537743 scopus 로고    scopus 로고
    • Lymphocyte signalling: A coordinating role for Vav?
    • Cantrell, D. (1998). Lymphocyte signalling: a coordinating role for Vav? Curr. Biol. 8, R535-538.
    • (1998) Curr. Biol. , vol.8
    • Cantrell, D.1
  • 4
  • 5
    • 0028308412 scopus 로고
    • Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 s6 kinase, DNA synthesis, and glucose transporter translocation
    • Cheatham, B., Vlahos, C. J., Cheatham, L., Wang, L., Blenis, J. and Kahn, C. R. (1994). Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol. Cell Biol. 14, 4902-4911.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 4902-4911
    • Cheatham, B.1    Vlahos, C.J.2    Cheatham, L.3    Wang, L.4    Blenis, J.5    Kahn, C.R.6
  • 6
    • 0018607228 scopus 로고
    • Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factors
    • Chinkers, M., McKanna, J. A. and Cohen, S. (1979). Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factors. J. Cell Biol. 83, 260-265.
    • (1979) J. Cell Biol. , vol.83 , pp. 260-265
    • Chinkers, M.1    McKanna, J.A.2    Cohen, S.3
  • 8
    • 0028589148 scopus 로고
    • Platelet-derived growth factor receptor signals
    • Claesson-Welsh, L. (1994). Platelet-derived growth factor receptor signals. J. Biol. Chem. 269, 32023-6.
    • (1994) J. Biol. Chem. , vol.269 , pp. 32023-32026
    • Claesson-Welsh, L.1
  • 9
    • 0028895654 scopus 로고
    • Modular binding domains in signal transduction proteins
    • Cohen, G. B., Ren, R. and Baltimore, D. (1995). Modular binding domains in signal transduction proteins. Cell 80, 237-248.
    • (1995) Cell , vol.80 , pp. 237-248
    • Cohen, G.B.1    Ren, R.2    Baltimore, D.3
  • 10
    • 0032211844 scopus 로고    scopus 로고
    • Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
    • Corvera, S. and Czech, M. P. (1998). Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction. Trends Cell Biol. 8, 442-446.
    • (1998) Trends Cell Biol. , vol.8 , pp. 442-446
    • Corvera, S.1    Czech, M.P.2
  • 11
    • 0032491398 scopus 로고    scopus 로고
    • A redox-triggered ras-effector interaction. Recruitment of phosphatidylinositol 3′-kinase to ras by redox stress
    • Deora, A. A., Win, T., Vanhaesebroeck, B. and Lander, H. M. (1998). A Redox-triggered Ras-Effector Interaction. Recruitment of phosphatidylinositol 3′-kinase to ras by redox stress. J. Biol. Chem. 273, 29923-29928.
    • (1998) J. Biol. Chem. , vol.273 , pp. 29923-29928
    • Deora, A.A.1    Win, T.2    Vanhaesebroeck, B.3    Lander, H.M.4
  • 12
    • 0026652899 scopus 로고
    • Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways
    • Fantl, W. J., Escobedo, J. A., Martin, G. A., Turck, C. W., del Rosario, M., McCormick, F. and Williams, L. T. (1992). Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell 69, 413-423.
    • (1992) Cell , vol.69 , pp. 413-423
    • Fantl, W.J.1    Escobedo, J.A.2    Martin, G.A.3    Turck, C.W.4    Del Rosario, M.5    McCormick, F.6    Williams, L.T.7
  • 13
    • 0031022582 scopus 로고    scopus 로고
    • Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes
    • Frevert, E. U. and Kahn, B. B. (1997). Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes. Mol. Cell Biol. 17, 190-198.
    • (1997) Mol. Cell Biol. , vol.17 , pp. 190-198
    • Frevert, E.U.1    Kahn, B.B.2
  • 14
    • 0028095620 scopus 로고
    • Structure, regulation and function of phosphoinositide 3-kinases
    • Fry, M. J. (1994). Structure, regulation and function of phosphoinositide 3-kinases. Biochim. Biophys. Acta 1226, 237-268.
    • (1994) Biochim. Biophys. Acta , vol.1226 , pp. 237-268
    • Fry, M.J.1
  • 15
    • 0025308055 scopus 로고
    • The actin-binding protein prufilin binds to PIP2 and inhibits its hydrolysis by phospholipase C
    • Goldschmidt-Clermont, P. J., Machesky, L. M., Baldassare, J. J. and Pollard, T. D. (1990). The actin-binding protein prufilin binds to PIP2 and inhibits its hydrolysis by phospholipase C. Science 247, 1575-1578.
    • (1990) Science , vol.247 , pp. 1575-1578
    • Goldschmidt-Clermont, P.J.1    Machesky, L.M.2    Baldassare, J.J.3    Pollard, T.D.4
  • 16
    • 0025760751 scopus 로고
    • Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation
    • Goldschmidt-Clermont, P. J., Kim, J. W., Machesky, L. M., Rhee, S. G. and Pollard, T. D. (1991). Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation. Science 251, 1231-1233.
    • (1991) Science , vol.251 , pp. 1231-1233
    • Goldschmidt-Clermont, P.J.1    Kim, J.W.2    Machesky, L.M.3    Rhee, S.G.4    Pollard, T.D.5
  • 17
    • 0028951464 scopus 로고
    • Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85α with actin filaments and focal adhesion kinase
    • Guinebault, C., Payrastre, B., Racaud-Sultan, C., Mazarguil, H., Breton, M., Mauco, G., Plantavid, M. and Chap, H. (1995). Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85α with actin filaments and focal adhesion kinase. J. Cell Biol. 129, 831-842.
    • (1995) J. Cell Biol. , vol.129 , pp. 831-842
    • Guinebault, C.1    Payrastre, B.2    Racaud-Sultan, C.3    Mazarguil, H.4    Breton, M.5    Mauco, G.6    Plantavid, M.7    Chap, H.8
  • 18
    • 0029117595 scopus 로고
    • Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets
    • Hartwig, J. H., Bokoch, G. M., Carpenter, C. L., Janmey, P. A., Taylor, L. A., Toker, A. and Stossel, T. P. (1995). Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 82, 643-653.
    • (1995) Cell , vol.82 , pp. 643-653
    • Hartwig, J.H.1    Bokoch, G.M.2    Carpenter, C.L.3    Janmey, P.A.4    Taylor, L.A.5    Toker, A.6    Stossel, T.P.7
  • 19
    • 0032547385 scopus 로고    scopus 로고
    • Signal transduction via platelet-derived growth factor receptors
    • Heldin, C. H., Östman, A. and Rönnstrand, L. (1998). Signal transduction via platelet-derived growth factor receptors. Biochim. Biophys. Acta 1378, F79-113.
    • (1998) Biochim. Biophys. Acta , vol.1378
    • Heldin, C.H.1    Östman, A.2    Rönnstrand, L.3
  • 22
    • 0031214960 scopus 로고    scopus 로고
    • Involvement of phosphatidylinositide 3′-kinase and rac in platelet-derived growth factor-induced actin reorganization and chemotaxis
    • Hooshmand-Rad, R., Claesson-Welsh, L., Wennström, S., Yokote, K., Siegbahn, A. and Heldin, C. H. (1997). Involvement of phosphatidylinositide 3′-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis. Exp. Cell Res. 234, 434-441.
    • (1997) Exp. Cell Res. , vol.234 , pp. 434-441
    • Hooshmand-Rad, R.1    Claesson-Welsh, L.2    Wennström, S.3    Yokote, K.4    Siegbahn, A.5    Heldin, C.H.6
  • 23
    • 0027361002 scopus 로고
    • Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85
    • Hu, P., Mondino, A., Skolnik, E. Y. and Schlessinger, J. (1993). Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Mol. Cell Biol. 13, 7677-7688.
    • (1993) Mol. Cell Biol. , vol.13 , pp. 7677-7688
    • Hu, P.1    Mondino, A.2    Skolnik, E.Y.3    Schlessinger, J.4
  • 24
    • 0031473726 scopus 로고    scopus 로고
    • Phosphorylation of cb1 after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase
    • Hunter, S., Koch, B. L. and Anderson, S. M. (1997). Phosphorylation of cb1 after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase. Mol. Endocrinol. 11, 1213-1222.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 1213-1222
    • Hunter, S.1    Koch, B.L.2    Anderson, S.M.3
  • 25
    • 0030615068 scopus 로고    scopus 로고
    • p85α gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase). P50α, p55α, and p85α, with different PI 3-kinase activity elevating responses to insulin
    • Inukai, K., Funaki, M., Ogihara, T., Katagiri, H., Kanda, A., Anai, M., Fukushima, Y., Hosaka, T., Suzuki, M., Shin, B. C., Takata, K., Yazaki, Y., Kikuchi, M., Oka, Y. and Asano, T. (1997). p85α gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase). p50α, p55α, and p85α, with different PI 3-kinase activity elevating responses to insulin. J. Biol. Chem. 272, 7873-7882.
    • (1997) J. Biol. Chem. , vol.272 , pp. 7873-7882
    • Inukai, K.1    Funaki, M.2    Ogihara, T.3    Katagiri, H.4    Kanda, A.5    Anai, M.F.Y.6    Hosaka, T.7    Suzuki, M.8    Shin, B.C.9    Takata, K.10    Yazaki, Y.11    Kikuchi, M.12    Oka, Y.13    Asano, T.14
  • 26
    • 0028143039 scopus 로고
    • Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression
    • Jhun, B. H., Rose, D. W., Seely, B. L., Rameh, L., Cantley, L., Saltiel, A. R. and Olefsky, J. M. (1994). Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression. Mol. Cell Biol. 14, 7466-7475.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 7466-7475
    • Jhun, B.H.1    Rose, D.W.2    Seely, B.L.3    Rameh, L.4    Cantley, L.5    Saltiel, A.R.6    Olefsky, J.M.7
  • 27
    • 0031917412 scopus 로고    scopus 로고
    • Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: Dominant negative p85 expression blocks differentiation of L6E9 muscle cells. Mol
    • Kaliman, P., Canicio, J., Shepherd, P. R., Beeton, C. A., Testar, X., Palacin, M. and Zorzano, A. (1998). Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells. Mol. Endocrinol. 12, 66-77.
    • (1998) Endocrinol. , vol.12 , pp. 66-77
    • Kaliman, P.1    Canicio, J.2    Shepherd, P.R.3    Beeton, C.A.4    Testar, X.5    Palacin, M.6    Zorzano, A.7
  • 28
    • 0026664293 scopus 로고
    • GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit
    • Kazlauskas, A., Kashishian, A., Cooper, J. A. and Valius, M. (1992). GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit. Mol. Cell Biol. 12, 2534-2544.
    • (1992) Mol. Cell Biol. , vol.12 , pp. 2534-2544
    • Kazlauskas, A.1    Kashishian, A.2    Cooper, J.A.3    Valius, M.4
  • 29
    • 2642683510 scopus 로고    scopus 로고
    • Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
    • Kerouz, N. J., Horsch, D., Pons, S. and Kahn, C. R. (1997). Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. J. Clin. Invest. 100, 3164-3172.
    • (1997) J. Clin. Invest. , vol.100 , pp. 3164-3172
    • Kerouz, N.J.1    Horsch, D.2    Pons, S.3    Kahn, C.R.4
  • 30
    • 0028198330 scopus 로고
    • The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity
    • Klippel, A., Escobedo, J. A., Hirano, M. and Williams, L. T. (1994). The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Mol. Cell Biol. 14, 2675-2685.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 2675-2685
    • Klippel, A.1    Escobedo, J.A.2    Hirano, M.3    Williams, L.T.4
  • 33
    • 0030869757 scopus 로고    scopus 로고
    • Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide
    • Kurosu, H., Maehama, T., Okada, T., Yamamoto, T., Hoshino, S., Fukui, Y., Ui, M., Hazeki, O. and Katada, T. (1997). Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide. J. Biol. Chem. 272, 24252-24256.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24252-24256
    • Kurosu, H.1    Maehama, T.2    Okada, T.3    Yamamoto, T.4    Hoshino, S.5    Fukui, Y.6    Ui, M.7    Hazeki, O.8    Katada, T.9
  • 34
    • 0021919105 scopus 로고
    • Specific interaction between phosphatidylinositol 4, 5-bisphosphate and profilactin
    • Lassing, I. and Lindberg, U. (1985). Specific interaction between phosphatidylinositol 4, 5-bisphosphate and profilactin. Nature 314, 472-474.
    • (1985) Nature , vol.314 , pp. 472-474
    • Lassing, I.1    Lindberg, U.2
  • 35
    • 0027214258 scopus 로고
    • The v-Src SH3 domain binds phosphatidylinositol 3′-kinase
    • Liu, X., Marengere, L. E., Koch, C. A. and Pawson, T. (1993). The v-Src SH3 domain binds phosphatidylinositol 3′-kinase. Mol. Cell Biol. 13, 5225-5232.
    • (1993) Mol. Cell Biol. , vol.13 , pp. 5225-5232
    • Liu, X.1    Marengere, L.E.2    Koch, C.A.3    Pawson, T.4
  • 36
    • 0029946425 scopus 로고    scopus 로고
    • Lipid products of phosphoinositide 3-kinase bind human profilin with high affinity
    • Lu, P. J., Shieh, W. R., Rhee, S. G., Yin, H. L. and Chen, C. S. (1996). Lipid products of phosphoinositide 3-kinase bind human profilin with high affinity. Biochemistry 35, 14027-14034.
    • (1996) Biochemistry , vol.35 , pp. 14027-14034
    • Lu, P.J.1    Shieh, W.R.2    Rhee, S.G.3    Yin, H.L.4    Chen, C.S.5
  • 37
    • 0031035636 scopus 로고    scopus 로고
    • Specific activation of p85-p110 phosphatidylinositol 3′-kinase stimulates DNA synthesis by ras- and p70 s6 kinase-dependent pathways
    • McIlroy, J., Chen, D., Wjasow, C., Michaeli, T. and Backer, J. M. (1997). Specific activation of p85-p110 phosphatidylinositol 3′-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways. Mol. Cell Biol. 17, 248-255.
    • (1997) Mol. Cell Biol. , vol.17 , pp. 248-255
    • McIlroy, J.1    Chen, D.2    Wjasow, C.3    Michaeli, T.4    Backer, J.M.5
  • 39
    • 0029811141 scopus 로고    scopus 로고
    • Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes
    • Nave, B. T., Haigh, R. J., Hayward, A. C., Siddle, K. and Shepherd, P. R. (1996). Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes. Biochem. J. 318, 55-60.
    • (1996) Biochem. J. , vol.318 , pp. 55-60
    • Nave, B.T.1    Haigh, R.J.2    Hayward, A.C.3    Siddle, K.4    Shepherd, P.R.5
  • 40
    • 0028837170 scopus 로고
    • Activation of the small GTP-binding proteins rho and rac by growth factor receptors
    • Nobes, C. D., Hawkins, P., Stephens, L. and Hall, A. (1995). Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J. Cell Sci. 108, 225-233.
    • (1995) J. Cell Sci. , vol.108 , pp. 225-233
    • Nobes, C.D.1    Hawkins, P.2    Stephens, L.3    Hall, A.4
  • 41
    • 0028198388 scopus 로고
    • Activation of phosphatidylinositol-3′ kinase by Src-family kinase SH3 binding to the p85 subunit
    • Pleiman, C. M., Hertz, W. M. and Cambier, J. C. (1994). Activation of phosphatidylinositol-3′ kinase by Src-family kinase SH3 binding to the p85 subunit. Science 263, 1609-1612.
    • (1994) Science , vol.263 , pp. 1609-1612
    • Pleiman, C.M.1    Hertz, W.M.2    Cambier, J.C.3
  • 42
    • 0028584245 scopus 로고
    • The phosphatidylinositol 3-kinase α is required for DNA synthesis induced by some, but not all, growth factors
    • Roche, S., Koegl, M. and Courtneidge, S. A. (1994). The phosphatidylinositol 3-kinase α is required for DNA synthesis induced by some, but not all, growth factors. Proc. Nat. Acad. Sci. USA 91, 9185-9189.
    • (1994) Proc. Nat. Acad. Sci. USA , vol.91 , pp. 9185-9189
    • Roche, S.1    Koegl, M.2    Courtneidge, S.A.3
  • 43
    • 0031725052 scopus 로고    scopus 로고
    • A function for phosphatidylinositol 3-kinase beta (p85α-p110β) in fibroblasts during mitogenesis: Requirement for insulin- and lysophosphatidic acid-mediated signal transduction
    • Roche, S., Downward, J., Raynal, P. and Courtneidge, S. A. (1998). A function for phosphatidylinositol 3-kinase beta (p85α-p110β) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction. Mol. Cell Biol. 18, 7119-7129.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 7119-7129
    • Roche, S.1    Downward, J.2    Raynal, P.3    Courtneidge, S.A.4
  • 45
    • 0028050414 scopus 로고
    • Phosphatidylinositol 3-kinase binds to α-actinin through the p85 subunit
    • Shibasaki, F., Fukami, K., Fukui, Y. and Takenawa, T. (1994). Phosphatidylinositol 3-kinase binds to α-actinin through the p85 subunit. Biochem. J. 302, 551-557.
    • (1994) Biochem. J. , vol.302 , pp. 551-557
    • Shibasaki, F.1    Fukami, K.2    Fukui, Y.3    Takenawa, T.4
  • 46
    • 0032517624 scopus 로고    scopus 로고
    • Distinct roles for the p110α and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis. J
    • Siddhanta, U., McIlroy, J., Shah, A., Zhang, Y. and Backer, J. M. (1998). Distinct roles for the p110α and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis. J. Cell Biol. 143, 1647-1659.
    • (1998) Cell Biol. , vol.143 , pp. 1647-1659
    • Siddhanta, U.1    McIlroy, J.2    Shah, A.3    Zhang, Y.4    Backer, J.M.5
  • 47
    • 0030475263 scopus 로고    scopus 로고
    • Profilin and gelsolin stimulate phosphatidylinositol 3-kinase activity
    • Singh, S. S., Chauhan, A., Murakami, N. and Chauhan, V. P. (1996). Profilin and gelsolin stimulate phosphatidylinositol 3-kinase activity. Biochemistry 35, 16544-16549.
    • (1996) Biochemistry , vol.35 , pp. 16544-16549
    • Singh, S.S.1    Chauhan, A.2    Murakami, N.3    Chauhan, V.P.4
  • 48
    • 0019840118 scopus 로고
    • Organization of actin in the leading edge of cultured cells: Influence of osmium tetroxide and dehydration on the ultrastructure of actin meshworks
    • Small, J. V. (1981). Organization of actin in the leading edge of cultured cells: influence of osmium tetroxide and dehydration on the ultrastructure of actin meshworks. J. Cell Biol. 91, 695-705.
    • (1981) J. Cell Biol. , vol.91 , pp. 695-705
    • Small, J.V.1
  • 50
    • 0027366440 scopus 로고
    • Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: A new intracellular signalling system?
    • Stephens, L. R., Jackson, T. R. and Hawkins, P. T. (1993). Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? Biochim. Biophys. Acta 1179, 27-75.
    • (1993) Biochim. Biophys. Acta , vol.1179 , pp. 27-75
    • Stephens, L.R.1    Jackson, T.R.2    Hawkins, P.T.3
  • 51
    • 0028334738 scopus 로고
    • A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits
    • Stephens, L., Smrcka, A., Cooke, F. T., Jackson, T. R., Sternweis, P. C. and Hawkins, P. T. (1994). A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits. Cell 77, 83-93.
    • (1994) Cell , vol.77 , pp. 83-93
    • Stephens, L.1    Smrcka, A.2    Cooke, F.T.3    Jackson, T.R.4    Sternweis, P.C.5    Hawkins, P.T.6
  • 53
    • 0029080520 scopus 로고
    • Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells
    • Tomiyama, K., Nakata, H., Sasa, H., Arimura, S., Nishio, E. and Watanabe, Y. (1995). Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells. Biochem. Biophys Res. Commun. 212, 263-269.
    • (1995) Biochem. Biophys Res. Commun. , vol.212 , pp. 263-269
    • Tomiyama, K.1    Nakata, H.2    Sasa, H.3    Arimura, S.4    Nishio, E.5    Watanabe, Y.6
  • 57
    • 0033104502 scopus 로고    scopus 로고
    • Autophosphorylation of p110δ phosphoinositide 3-kinase: A new paradigm for the regulation of lipid kinases in vitro and in vivo
    • Vanhaesebroeck, B., Higashi, K., Raven, C., Welham, M., Anderson, S., Brennan, P., Ward, S. G. and Waterfield, M. D. (1999b). Autophosphorylation of p110δ phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo. EMBO J. 18, 1292-1302.
    • (1999) EMBO J. , vol.18 , pp. 1292-1302
    • Vanhaesebroeck, B.1    Higashi, K.2    Raven, C.3    Welham, M.4    Anderson, S.B.P.5    Ward, S.G.6    Waterfield, M.D.7
  • 58
    • 0029046983 scopus 로고
    • Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
    • Wang, J., Auger, K. R., Jarvis, L., Shi, Y. and Roberts, T. M. (1995). Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase. J. Biol. Chem. 270, 12774-12780.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12774-12780
    • Wang, J.1    Auger, K.R.2    Jarvis, L.3    Shi, Y.4    Roberts, T.M.5
  • 59
    • 0032080114 scopus 로고    scopus 로고
    • Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes
    • Wang, Q., Bilan, P. J., Tsakiridis, T., Hinek, A. and Klip, A. (1998). Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes. Biochem. J. 331, 917-928.
    • (1998) Biochem. J. , vol.331 , pp. 917-928
    • Wang, Q.1    Bilan, P.J.2    Tsakiridis, T.3    Hinek, A.4    Klip, A.5
  • 61
    • 0028089005 scopus 로고
    • Membrane ruffling and chemotaxis transduced by the PDGF β-receptor require the binding site for phosphatidylinositol 3′ kinase
    • Wennström, S., Siegbahn, A., Yokote, K., Arvidsson, A. K., Heldin, C. H., Mori, S. and Claesson-Welsh, L. (1994b). Membrane ruffling and chemotaxis transduced by the PDGF β-receptor require the binding site for phosphatidylinositol 3′ kinase. Oncogene 9, 651-660.
    • (1994) Oncogene , vol.9 , pp. 651-660
    • Wennström, S.1    Siegbahn, A.2    Yokote, K.3    Arvidsson, A.K.4    Heldin, C.H.5    Mori, S.6    Claesson-Welsh, L.7
  • 62
    • 0028963084 scopus 로고
    • Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
    • Yao, R. and Cooper, G. M. (1995). Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267, 2003-2006.
    • (1995) Science , vol.267 , pp. 2003-2006
    • Yao, R.1    Cooper, G.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.