-
1
-
-
0026095665
-
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
-
Bellacosa, A., Testa, J.R., Staal, S.P. and Tsichlis, P.N. (1991) A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science, 254, 274-277.
-
(1991)
Science
, vol.254
, pp. 274-277
-
-
Bellacosa, A.1
Testa, J.R.2
Staal, S.P.3
Tsichlis, P.N.4
-
2
-
-
0029127042
-
Molecular alterations of the akt2 oncogene in ovarian and breast carcinomas
-
Bellacosa, A. et al. (1995) Molecular alterations of the akt2 oncogene in ovarian and breast carcinomas. Int. J. Cancer, 64, 280-285.
-
(1995)
Int. J. Cancer
, vol.64
, pp. 280-285
-
-
Bellacosa, A.1
-
3
-
-
0018942383
-
Protein synthesis requires cell-surface contact while nuclear events respond to cell shape in anchorage dependent fibroblasts
-
Ben-Ze'ev, A., Farmer, S. and Penman, S. (1980) Protein synthesis requires cell-surface contact while nuclear events respond to cell shape in anchorage dependent fibroblasts. Cell. 21, 365-372.
-
(1980)
Cell
, vol.21
, pp. 365-372
-
-
Ben-Ze'ev, A.1
Farmer, S.2
Penman, S.3
-
4
-
-
0029160069
-
Protein kinase B (c-akt) in phosphatidylinositol 3-kinase signal transduction
-
Burgering, B.M.T. and Coffer, P.J. (1995) Protein kinase B (c-akt) in phosphatidylinositol 3-kinase signal transduction. Nature, 376, 599-602.
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Burgering, B.M.T.1
Coffer, P.J.2
-
5
-
-
0027938974
-
Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase
-
Chen, H.C. and Guan, J.L. (1994) Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc. Natl Acad. Sci. USA, 91, 10148-10152.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 10148-10152
-
-
Chen, H.C.1
Guan, J.L.2
-
6
-
-
0027939187
-
Integrin-mediated cell adhesion activates mitogen-activated protein kinases
-
Chen, Q., Kinch, M.S., Lin, T.H., Burridge, K. and Juliano, R.L. (1994) Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J. Biol. Chem., 269, 26602-26605.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 26602-26605
-
-
Chen, Q.1
Kinch, M.S.2
Lin, T.H.3
Burridge, K.4
Juliano, R.L.5
-
7
-
-
0001457668
-
Amplification of akt2 in human pancreatic cancer cells and inhibition of akt2 expression and tumorigenicity by antisense RNA
-
Cheng, J.Q., Ruggeri, B., Klein, W.M., Sonoda, G., Altomare, D.A., Watson, D.K. and Testa, J.R. (1996) Amplification of akt2 in human pancreatic cancer cells and inhibition of akt2 expression and tumorigenicity by antisense RNA. Proc. Natl Acad. Sci. USA, 93, 3636-3641.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 3636-3641
-
-
Cheng, J.Q.1
Ruggeri, B.2
Klein, W.M.3
Sonoda, G.4
Altomare, D.A.5
Watson, D.K.6
Testa, J.R.7
-
8
-
-
0028036684
-
The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells
-
Chong, L.D., Traynor-Kaplan, A., Bokoch, G.M. and Schwartz, M.A. (1994) The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell, 79, 507-513.
-
(1994)
Cell
, vol.79
, pp. 507-513
-
-
Chong, L.D.1
Traynor-Kaplan, A.2
Bokoch, G.M.3
Schwartz, M.A.4
-
9
-
-
0028178928
-
PDGF and insulin dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
-
Chung, J., Grammer, T.C., Lemon, K.P., Kazlauskas, A. and Blenis, J. (1994) PDGF and insulin dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature, 370, 71-75.
-
(1994)
Nature
, vol.370
, pp. 71-75
-
-
Chung, J.1
Grammer, T.C.2
Lemon, K.P.3
Kazlauskas, A.4
Blenis, J.5
-
10
-
-
17544364168
-
Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization
-
Clark, E.A. and Hynes, R.O. (1996) Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization. J. Biol. Chem., 271, 14814-14818.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 14814-14818
-
-
Clark, E.A.1
Hynes, R.O.2
-
11
-
-
0026006501
-
Molecular cloning and characterisation of a novel protein-serine kinase related to the cAMP-dependent and protein kinase C families
-
Coffer, P.J. and Woodgett, J.R. (1991) Molecular cloning and characterisation of a novel protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur. J. Biochem., 201, 475-481.
-
(1991)
Eur. J. Biochem.
, vol.201
, pp. 475-481
-
-
Coffer, P.J.1
Woodgett, J.R.2
-
12
-
-
0028228616
-
Activation of map kinase kinase is necessary and sufficient for pc12 differentiation and for transformation of NIH 3T3 cells
-
Cowley, S., Paterson, H., Kemp, P. and Marshall, C.J. (1994) Activation of map kinase kinase is necessary and sufficient for pc12 differentiation and for transformation of NIH 3T3 cells. Cell, 77, 841-852.
-
(1994)
Cell
, vol.77
, pp. 841-852
-
-
Cowley, S.1
Paterson, H.2
Kemp, P.3
Marshall, C.J.4
-
13
-
-
0028912932
-
AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation
-
Datta, K., Franke, T.F., Chan, T.O., Makris, A., Yang, S.-I., Kaplan, D.R., Morrison, D.K., Golemis, E.A. and Tsichlis, P.N. (1995) AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation. Mol. Cell. Biol., 15, 2304-2310.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 2304-2310
-
-
Datta, K.1
Franke, T.F.2
Chan, T.O.3
Makris, A.4
Yang, S.-I.5
Kaplan, D.R.6
Morrison, D.K.7
Golemis, E.A.8
Tsichlis, P.N.9
-
14
-
-
0029160096
-
Clusterin gene expression in apoptotic MDCK cells is dependent on the apoptosis inducing stimulus
-
Flach, R., Cattaruzza, M. and Koch-Brandt, C. (1995) Clusterin gene expression in apoptotic MDCK cells is dependent on the apoptosis inducing stimulus. Biochim. Biophys. Acta. 1268, 325-328.
-
(1995)
Biochim. Biophys. Acta.
, vol.1268
, pp. 325-328
-
-
Flach, R.1
Cattaruzza, M.2
Koch-Brandt, C.3
-
15
-
-
0018140371
-
The role of cell shape in growth control
-
Folkman, J. and Moscona, A. (1978) The role of cell shape in growth control. Nature, 273, 345-349.
-
(1978)
Nature
, vol.273
, pp. 345-349
-
-
Folkman, J.1
Moscona, A.2
-
16
-
-
0029079275
-
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
Franke, T.F., Yang, S.-I., Chan, T.O., Datta, K., Kazlauskas, A., Morrison, D.K., Kaplan, D.R. and Tsichlis, P.N. (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell, 81, 727-736.
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.-I.2
Chan, T.O.3
Datta, K.4
Kazlauskas, A.5
Morrison, D.K.6
Kaplan, D.R.7
Tsichlis, P.N.8
-
17
-
-
0028057613
-
Disruption of epithelial cell-matrix interactions induces apoptosis
-
Frisch, S.M. and Francis, H. (1994) Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol., 124, 619-626.
-
(1994)
J. Cell Biol.
, vol.124
, pp. 619-626
-
-
Frisch, S.M.1
Francis, H.2
-
18
-
-
0029739950
-
Control of adhesion-dependent cell survival by focal adhesion kinase
-
Frisch, S.M., Vuori, K., Ruoslahti, E. and Chan-Hui, P.-Y. (1996) Control of adhesion-dependent cell survival by focal adhesion kinase. J. Cell Biol. 134, 793-799.
-
(1996)
J. Cell Biol.
, vol.134
, pp. 793-799
-
-
Frisch, S.M.1
Vuori, K.2
Ruoslahti, E.3
Chan-Hui, P.-Y.4
-
19
-
-
0024315482
-
Acute pathological effects on rats of orally administered wortmannin-containing preparations and purified wortmannin from Fusarium oxysporum
-
Gunther, R., Abbas, H.K. and Mirocha, C.J. (1989) Acute pathological effects on rats of orally administered wortmannin-containing preparations and purified wortmannin from Fusarium oxysporum. Food Chem. Toxicol., 27, 173-179.
-
(1989)
Food Chem. Toxicol.
, vol.27
, pp. 173-179
-
-
Gunther, R.1
Abbas, H.K.2
Mirocha, C.J.3
-
20
-
-
0029278739
-
PDGF stimulates an increase in GTP-rac via activation of phosphoinositide 3-kinase
-
Hawkins, P.T. et al. (1995) PDGF stimulates an increase in GTP-rac via activation of phosphoinositide 3-kinase. Curr. Biol., 5, 393-403.
-
(1995)
Curr. Biol.
, vol.5
, pp. 393-403
-
-
Hawkins, P.T.1
-
21
-
-
0028153277
-
Activated ras interacts with the ral guanine-nucleotide dissociation stimulator
-
Hofer, F., Fields, S., Schneider, C. and Martin, G.S. (1994) Activated ras interacts with the ral guanine-nucleotide dissociation stimulator. Proc. Natl Acad. Sci. USA, 91, 11089-11093.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 11089-11093
-
-
Hofer, F.1
Fields, S.2
Schneider, C.3
Martin, G.S.4
-
22
-
-
0029562867
-
The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases
-
Hotchin, N.A. and Hall, A. (1995) The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J. Cell Biol. 131, 1857-1865.
-
(1995)
J. Cell Biol.
, vol.131
, pp. 1857-1865
-
-
Hotchin, N.A.1
Hall, A.2
-
23
-
-
0029993517
-
Specific binding of Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation
-
James, S.R., Downes, C.P., Gigg, R., Grove, S.J.A., Holmes, A.B. and Alessi, D.R. (1996) Specific binding of Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation. Biochem. J., 315, 709-713.
-
(1996)
Biochem. J.
, vol.315
, pp. 709-713
-
-
James, S.R.1
Downes, C.P.2
Gigg, R.3
Grove, S.J.A.4
Holmes, A.B.5
Alessi, D.R.6
-
24
-
-
0028818914
-
Involvement of Ral GTPase in v-src induced phospholipase-D activation
-
Jiang, H., Luo, J.Q., Urano, T., Frankel, P, Lu, Z.M., Foster, D.A. and Feig, L.A. (1995) Involvement of Ral GTPase in v-src induced phospholipase-D activation. Nature, 378, 409-412.
-
(1995)
Nature
, vol.378
, pp. 409-412
-
-
Jiang, H.1
Luo, J.Q.2
Urano, T.3
Frankel, P.4
Lu, Z.M.5
Foster, D.A.6
Feig, L.A.7
-
25
-
-
0025882091
-
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily
-
Jones, P.F., Jakubowicz, T., Pitossi, F.J., Maurer, F. and Hemmings, B.A. (1991) Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc. Natl Acad. Sci. USA, 88, 4171-4175.
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, pp. 4171-4175
-
-
Jones, P.F.1
Jakubowicz, T.2
Pitossi, F.J.3
Maurer, F.4
Hemmings, B.A.5
-
26
-
-
0030052368
-
Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of Ras
-
Joneson, T., White, M.A., Wigler, M.H. and Bar-Sagi, D. (1996) Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of Ras. Science, 271, 810-812.
-
(1996)
Science
, vol.271
, pp. 810-812
-
-
Joneson, T.1
White, M.A.2
Wigler, M.H.3
Bar-Sagi, D.4
-
27
-
-
0027452326
-
Stimulation of tyrosine phosphorylation and accumulation of GTP-bound p21ras upon antibody-mediated alpha 2 beta 1 integrin activation in T-lymphoblastic cells
-
Kapron-Bras, C., Fitz-Gibbon, L., Jeevaratnam, P., Wilkins, J. and Dedhar, S. (1993) Stimulation of tyrosine phosphorylation and accumulation of GTP-bound p21ras upon antibody-mediated alpha 2 beta 1 integrin activation in T-lymphoblastic cells. J. Biol. Chem., 268, 20701-20704.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 20701-20704
-
-
Kapron-Bras, C.1
Fitz-Gibbon, L.2
Jeevaratnam, P.3
Wilkins, J.4
Dedhar, S.5
-
29
-
-
0027986765
-
Ral-gds family members interact with the effector loop of ras p21
-
Kikuchi, A., Demo, S.D., Ye, Z.H., Chen, Y.W. and Williams, L.T. (1994) Ral-gds family members interact with the effector loop of ras p21. Mol. Cell. Biol. 14, 7483-7491.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 7483-7491
-
-
Kikuchi, A.1
Demo, S.D.2
Ye, Z.H.3
Chen, Y.W.4
Williams, L.T.5
-
30
-
-
0029831486
-
PDGF-dependent activation of PI3 kinase is regulated by receptor binding of SH2 domain-containing proteins which influence Ras activity
-
Klinghofer, R.A., Duckworth, B., Valius, M., Cantley, L. and Kazlauskas, A. (1996) PDGF-dependent activation of PI3 kinase is regulated by receptor binding of SH2 domain-containing proteins which influence Ras activity. Mol. Cell. Biol. 16, 5905-5914.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 5905-5914
-
-
Klinghofer, R.A.1
Duckworth, B.2
Valius, M.3
Cantley, L.4
Kazlauskas, A.5
-
31
-
-
0028500187
-
The activation of phosphatidylinositol 3-kinase by Ras
-
Kodaki, T., Wosholski, R., Hallberg, B., Rodiriguez-Viciana, P., Downward, J. and Parker, P.J. (1994) The activation of phosphatidylinositol 3-kinase by Ras. Curr. Biol., 4, 798-806.
-
(1994)
Curr. Biol.
, vol.4
, pp. 798-806
-
-
Kodaki, T.1
Wosholski, R.2
Hallberg, B.3
Rodiriguez-Viciana, P.4
Downward, J.5
Parker, P.J.6
-
32
-
-
0028264058
-
Involvement of phosphoinositide 3-kinase in insulin or IGF-1 induced membrane ruffling
-
Kotani, K. et al. (1994) Involvement of phosphoinositide 3-kinase in insulin or IGF-1 induced membrane ruffling. EMBO J., 13, 2313-2321.
-
(1994)
EMBO J.
, vol.13
, pp. 2313-2321
-
-
Kotani, K.1
-
33
-
-
0025193871
-
Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules
-
Krengel, U., Schlichting, L., Scherer, A., Schumann, R., Frech, M., John, J., Kabsch, W., Pai, E.F. and Wittinghofer, A. (1990) Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell, 62, 539-548.
-
(1990)
Cell
, vol.62
, pp. 539-548
-
-
Krengel, U.1
Schlichting, L.2
Scherer, A.3
Schumann, R.4
Frech, M.5
John, J.6
Kabsch, W.7
Pai, E.F.8
Wittinghofer, A.9
-
34
-
-
0026541143
-
Activation of extracellular signal-regulated kinase ERK2 by p21ras oncoprotein
-
Leevers, S.J. and Marshall, C.J. (1992) Activation of extracellular signal-regulated kinase ERK2 by p21ras oncoprotein. EMBO J., 11, 569-574.
-
(1992)
EMBO J.
, vol.11
, pp. 569-574
-
-
Leevers, S.J.1
Marshall, C.J.2
-
35
-
-
0028272507
-
Requirement for ras in raf activation is overcome by targeting raf to the plasma-membrane
-
Leevers, S.J., Paterson, H.F. and Marshall, C.J. (1994) Requirement for ras in raf activation is overcome by targeting raf to the plasma-membrane. Nature, 369, 411-114.
-
(1994)
Nature
, vol.369
, pp. 411-1114
-
-
Leevers, S.J.1
Paterson, H.F.2
Marshall, C.J.3
-
36
-
-
0029063175
-
Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest
-
Lin, H.J., Eviner, V., Prendergast, G.C. and White, E. (1995) Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest. Mol. Cell. Biol. 15, 4536-4544.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 4536-4544
-
-
Lin, H.J.1
Eviner, V.2
Prendergast, G.C.3
White, E.4
-
37
-
-
0028152333
-
MAP kinase kinase kinase. MAP kinase kinase and MAP kinase
-
Marshall, C.J. (1994) MAP kinase kinase kinase. MAP kinase kinase and MAP kinase. Curr. Opin. Genet. Dev., 4, 82-89.
-
(1994)
Curr. Opin. Genet. Dev.
, vol.4
, pp. 82-89
-
-
Marshall, C.J.1
-
39
-
-
0343266106
-
PI 3-kinase and PKB/Akt act as an effector pathway for R-Ras
-
Marte, B.M., Rodriguez-Viciana, P., Wennström, S., Warne, P.H. and Downward, J. (1996) PI 3-kinase and PKB/Akt act as an effector pathway for R-Ras. Curr. Biol., 7, 63-70.
-
(1996)
Curr. Biol.
, vol.7
, pp. 63-70
-
-
Marte, B.M.1
Rodriguez-Viciana, P.2
Wennström, S.3
Warne, P.H.4
Downward, J.5
-
40
-
-
0029130410
-
Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes
-
McCarthy, S.A., Samuels, M.L., Pritchard, C.A., Abraham, J.A. and McMahon, M. (1995) Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes. Genes Dev., 9, 1953-1964.
-
(1995)
Genes Dev.
, vol.9
, pp. 1953-1964
-
-
McCarthy, S.A.1
Samuels, M.L.2
Pritchard, C.A.3
Abraham, J.A.4
McMahon, M.5
-
41
-
-
0027296039
-
The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion
-
McGlade, J., Brunkhorst, B., Anderson, D.M.G., Settleman, J., Dedhar, S., Rozakis-Adcock, M., Chen, L.B. and Pawson, T. (1993) The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. EMBO J., 12, 3073-3081.
-
(1993)
EMBO J.
, vol.12
, pp. 3073-3081
-
-
McGlade, J.1
Brunkhorst, B.2
Anderson, D.M.G.3
Settleman, J.4
Dedhar, S.5
Rozakis-Adcock, M.6
Chen, L.B.7
Pawson, T.8
-
42
-
-
0027176804
-
Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown
-
McNamee, H.P, Ingber, D.E. and Schwartz, M.A. (1993) Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J. Cell Biol., 121, 673-678.
-
(1993)
J. Cell Biol.
, vol.121
, pp. 673-678
-
-
McNamee, H.P.1
Ingber, D.E.2
Schwartz, M.A.3
-
43
-
-
0027451706
-
The extracellular matrix as a cell survival factor
-
Meredith, J.E., Fazeli, B. and Schwartz, M.A. (1993) The extracellular matrix as a cell survival factor. Mol. Biol. Cell, 4, 953-961.
-
(1993)
Mol. Biol. Cell
, vol.4
, pp. 953-961
-
-
Meredith, J.E.1
Fazeli, B.2
Schwartz, M.A.3
-
44
-
-
0028168073
-
Activation of p70/p85 S6 kinase by a pathway independent of p21ras
-
Ming, X.F., Burgering, B.M.T., Wennström, S., Claesson-Welsh, L., Heldin, C.-H., Bos, J.L., Kozma, S.C. and Thomas, G. (1994) Activation of p70/p85 S6 kinase by a pathway independent of p21ras. Nature, 371, 426-429.
-
(1994)
Nature
, vol.371
, pp. 426-429
-
-
Ming, X.F.1
Burgering, B.M.T.2
Wennström, S.3
Claesson-Welsh, L.4
Heldin, C.-H.5
Bos, J.L.6
Kozma, S.C.7
Thomas, G.8
-
45
-
-
0030026693
-
Requirement for phosphatidylinositol 3′-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor
-
Minshall, C., Arkins, S., Freund, G.G. and Kelley, K.W. (1996) Requirement for phosphatidylinositol 3′-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor. J. Immunol., 156, 939-947.
-
(1996)
J. Immunol.
, vol.156
, pp. 939-947
-
-
Minshall, C.1
Arkins, S.2
Freund, G.G.3
Kelley, K.W.4
-
46
-
-
0028855838
-
Matrix/integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2
-
Morino, N. et al. (1995) Matrix/integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2. J. Biol. Chem., 270, 269-273.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 269-273
-
-
Morino, N.1
-
47
-
-
0027535742
-
Activation of the C isozyme of protein kinase C by phosphatidylinositol (3,4,5) trisphosphate
-
Nakanishi, H., Brewer, K.M. and Exton, J.H. (1993) Activation of the C isozyme of protein kinase C by phosphatidylinositol (3,4,5) trisphosphate. J. Biol. Chem., 268, 13-16.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 13-16
-
-
Nakanishi, H.1
Brewer, K.M.2
Exton, J.H.3
-
48
-
-
0029965695
-
Integrin-mediated signalling: Regulation by protein tyrosine kinases and small GTP-binding proteins
-
Parsons, J.T. (1996) Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins. Curr. Opin. Cell Biol., 8, 146-152.
-
(1996)
Curr. Opin. Cell Biol.
, vol.8
, pp. 146-152
-
-
Parsons, J.T.1
-
49
-
-
0026759874
-
Rapamycin-induced inhibition of the 70 kilodalton S6 protein kinase
-
Price, D.J., Grove, J.R., Calvo, V., Avruch, J. and Bierer, B.E. (1992) Rapamycin-induced inhibition of the 70 kilodalton S6 protein kinase. Science, 257, 973-977.
-
(1992)
Science
, vol.257
, pp. 973-977
-
-
Price, D.J.1
Grove, J.R.2
Calvo, V.3
Avruch, J.4
Bierer, B.E.5
-
50
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
Rodriguez-Viciana, P., Warne, P.H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M.J., Waterfield, M.D. and Downward, J. (1994) Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature, 370, 527-532.
-
(1994)
Nature
, vol.370
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, R.3
Vanhaesebroeck, B.4
Gout, I.5
Fry, M.J.6
Waterfield, M.D.7
Downward, J.8
-
51
-
-
0029990003
-
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
-
Rodriguez-Viciana, P., Warne, P.H., Vanhaesebroeck, B., Waterfield, M.D. and Downward, J. (1996) Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J., 15, 2442-2451.
-
(1996)
EMBO J.
, vol.15
, pp. 2442-2451
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Vanhaesebroeck, B.3
Waterfield, M.D.4
Downward, J.5
-
52
-
-
0030911052
-
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
-
in press
-
Rodriguez-Viciana, P., Warne, P.H., Khwaja, A., Marte, B.M., Pappin, D.J., Das, P., Waterfield, M.D., Ridley, A. and Downward, J. (1997) Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell, in press.
-
(1997)
Cell
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Khwaja, A.3
Marte, B.M.4
Pappin, D.J.5
Das, P.6
Waterfield, M.D.7
Ridley, A.8
Downward, J.9
-
53
-
-
0028834557
-
Role of phosphatidylinositol 3-OH kinase activity in the inhibition of apoptosis in haemopoietic cells: Phosphatidylinositol 3-OH kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating factor
-
Scheid, M.P., Lauener, R.W. and Duronio, V. (1995) Role of phosphatidylinositol 3-OH kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating factor. Biochem. J., 312, 159-162.
-
(1995)
Biochem. J.
, vol.312
, pp. 159-162
-
-
Scheid, M.P.1
Lauener, R.W.2
Duronio, V.3
-
54
-
-
0028609382
-
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
-
Schlaepfer, D.D., Hanks, S.K., Hunter, T. and van der Geer, P. (1994) Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature, 372, 786-791.
-
(1994)
Nature
, vol.372
, pp. 786-791
-
-
Schlaepfer, D.D.1
Hanks, S.K.2
Hunter, T.3
Van Der Geer, P.4
-
55
-
-
0026587137
-
Implication of GAP in Ras-dependent transactivation of a polyoma enhancer sequence
-
Schweighoffer, F., Barlat, I., Chevalier-Multon, M.-C. and Tocque, B. (1992) Implication of GAP in Ras-dependent transactivation of a polyoma enhancer sequence. Science, 256, 825-827.
-
(1992)
Science
, vol.256
, pp. 825-827
-
-
Schweighoffer, F.1
Barlat, I.2
Chevalier-Multon, M.-C.3
Tocque, B.4
-
56
-
-
0028577298
-
Identification of the guanine-nucleotide dissociation stimulator for ral as a putative effector molecule of r-ras, h-ras, k-ras, and rap
-
Spaargaren, M. and Bischoff, J.R. (1994) Identification of the guanine-nucleotide dissociation stimulator for ral as a putative effector molecule of r-ras, h-ras, k-ras, and rap. Proc. Natl Acad. Sci. USA, 91, 12609-12613.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 12609-12613
-
-
Spaargaren, M.1
Bischoff, J.R.2
-
57
-
-
0014418101
-
Anchorage and growth regulation in normal and virus-transformed cells
-
Stoker, M., O'Neill, C. Berryman, S. and Waxman, V. (1968) Anchorage and growth regulation in normal and virus-transformed cells. Int. J. Cancer, 3, 683-693.
-
(1968)
Int. J. Cancer
, vol.3
, pp. 683-693
-
-
Stoker, M.1
O'Neill, C.2
Berryman, S.3
Waxman, V.4
-
58
-
-
0028321727
-
Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes
-
Thelen, M., Wymann, M.P. and Langen, H. (1994) Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes. Proc. Natl Acad. Sci. USA, 91, 4960-4964.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 4960-4964
-
-
Thelen, M.1
Wymann, M.P.2
Langen, H.3
-
59
-
-
0028560447
-
Activation of protein kinase C family members by the novel phosphoinositides PI-3,4-P2 and PI-3,4,5-P3
-
Toker, A. et al. (1994) Activation of protein kinase C family members by the novel phosphoinositides PI-3,4-P2 and PI-3,4,5-P3. J. Biol. Chem., 269, 32358-32367.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 32358-32367
-
-
Toker, A.1
-
60
-
-
0030022174
-
Ral-GTPases mediate a distinct downstream signaling pathway from ras that facilitates cellular-transformation
-
Urano, T, Emkey, R. and Feig, L.A. (1996) Ral-GTPases mediate a distinct downstream signaling pathway from ras that facilitates cellular-transformation. EMBO J., 15, 810-816.
-
(1996)
EMBO J.
, vol.15
, pp. 810-816
-
-
Urano, T.1
Emkey, R.2
Feig, L.A.3
-
61
-
-
0029884657
-
Mouse p170 is a novel phosphatidylinositol 3-kinase containing a c2 domain
-
Virbasius, J.V., Guilherme, A. and Czech, M.P. (1996) Mouse p170 is a novel phosphatidylinositol 3-kinase containing a c2 domain. J. Biol. Chem., 271, 13304-13307.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 13304-13307
-
-
Virbasius, J.V.1
Guilherme, A.2
Czech, M.P.3
-
62
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos, C.J., Matter, W.F., Hui, K.Y. and Brown, R.F. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem., 269, 5241-5248.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
63
-
-
0028999052
-
Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation
-
Weng, Q.P., Andrabi, K., Klippel, A., Kozlowski, M.T., Williams, L.T. and Avruch, J. (1995) Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation. Proc. Natl Acad. Sci. USA, 92, 5744-5748.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 5744-5748
-
-
Weng, Q.P.1
Andrabi, K.2
Klippel, A.3
Kozlowski, M.T.4
Williams, L.T.5
Avruch, J.6
-
64
-
-
0028948382
-
Multiple ras functions can contribute to mammalian-cell transformation
-
White, M.A., Nicolette, C., Minden, A., Polverino, A., Vanaelst, L., Karin, M. and Wigler, M.H. (1995) Multiple ras functions can contribute to mammalian-cell transformation. Cell, 80, 533-541.
-
(1995)
Cell
, vol.80
, pp. 533-541
-
-
White, M.A.1
Nicolette, C.2
Minden, A.3
Polverino, A.4
Vanaelst, L.5
Karin, M.6
Wigler, M.H.7
-
65
-
-
0028963084
-
Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
-
Yao, R.J. and Cooper, G.M. (1995) Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science, 267, 2003-2006.
-
(1995)
Science
, vol.267
, pp. 2003-2006
-
-
Yao, R.J.1
Cooper, G.M.2
-
66
-
-
0029834691
-
Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity
-
Yao, R. and Cooper, G.M. (1996) Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity. Oncogene, 13, 343-351.
-
(1996)
Oncogene
, vol.13
, pp. 343-351
-
-
Yao, R.1
Cooper, G.M.2
-
67
-
-
0028904784
-
Integrin-dependent activation of MAP kinase: A link to shape-dependent cell proliferation
-
Zhu, X. and Assoian, R.K. (1995) Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol. Biol. Cell, 6, 273-282.
-
(1995)
Mol. Biol. Cell
, vol.6
, pp. 273-282
-
-
Zhu, X.1
Assoian, R.K.2
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