Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase

Science

Volumn 283, Issue 5400, 1999, Pages 390-392

  Suzuki, Harumi ^a   Terauchi, Yasuo ^a   Fujiwara, Mari ^a   Aizawa, Shinichi ^a   Yazaki, Yoshio ^a   Kadowaki, Takashi ^a   Koyasu, Shigeo ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD5 ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; ENZYME SUBUNIT; FLOW CYTOMETRY; GENE DISRUPTION; MOUSE; NONHUMAN; PERITONEUM CELL; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; X CHROMOSOME LINKAGE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIBODY FORMATION; ANTIGENS, CD5; ANTIGENS, LY; ANTIGENS, T-INDEPENDENT; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; BONE MARROW; CELL SURVIVAL; GENE TARGETING; IMMUNOLOGIC DEFICIENCY SYNDROMES; LINKAGE (GENETICS); LYMPHOCYTE COUNT; LYMPHOID TISSUE; MICE; MUTATION; PHENOTYPE; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; X CHROMOSOME;

ANIMALIA;

EID: 0033555829     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.283.5400.390     Document Type: Article

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41. We thank K. Takatsu for providing xid mice and H. Karasuyama, T. Kurosaki, and T. Ohteki for valuable discussions. Supported by grants-in-aid from the Ministry of Education, Science, Sports and Culture of Japan, a national grant-in-aid for the establishment of a high-tech research center in a private university, a grant from the Toray Science Foundation, and a grant from the Japan Society for the Promotion of Science (JSPS-RFTF 97L00701).