메뉴 건너뛰기




Volumn 15, Issue 10, 1996, Pages 2442-2451

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation

Author keywords

Phosphoinositide 3 kinase; Raf; Ras

Indexed keywords

PHOSPHATIDYLINOSITOL KINASE; RAS PROTEIN;

EID: 0029990003     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00602.x     Document Type: Article
Times cited : (506)

References (69)
  • 3
    • 0028234577 scopus 로고
    • N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localisation
    • Cadwallader,K.A., Paterson,H., MacDonald,S.G. and Hancock,J.F. (1994) N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localisation. Mol Cell. Biol., 14, 4722-4730.
    • (1994) Mol Cell. Biol. , vol.14 , pp. 4722-4730
    • Cadwallader, K.A.1    Paterson, H.2    MacDonald, S.G.3    Hancock, J.F.4
  • 4
    • 0027937264 scopus 로고
    • Cooperative interaction of S.pombe proteins required for mating and morphogenesis
    • Chang,E.C, Barr,M., Wang,Y., Jung,V., Xu,H.P. and Wigler,M.H. (1994) Cooperative interaction of S.pombe proteins required for mating and morphogenesis. Cell, 79, 131-141.
    • (1994) Cell , vol.79 , pp. 131-141
    • Chang, E.C.1    Barr, M.2    Wang, Y.3    Jung, V.4    Xu, H.P.5    Wigler, M.H.6
  • 5
    • 0026659046 scopus 로고
    • Rapamycin-FKBP specifically blocks growth-dependent activation of and signalling by the 70 kDa S6 protein kinases
    • Chung,J., Kuo,C.J., Crabtree,G.R. and Blenis,J. (1992) Rapamycin-FKBP specifically blocks growth-dependent activation of and signalling by the 70 kDa S6 protein kinases. Cell, 69, 1227-1236.
    • (1992) Cell , vol.69 , pp. 1227-1236
    • Chung, J.1    Kuo, C.J.2    Crabtree, G.R.3    Blenis, J.4
  • 7
    • 0029014973 scopus 로고
    • Reversal of raf-1 activation by purified and membrane associated protein phosphatases
    • Dent,P., Jelinek,J., Morrison,D.K., Weber,M.J. and Sturgill,T.W. (1995) Reversal of raf-1 activation by purified and membrane associated protein phosphatases. Science, 268, 1902-1906.
    • (1995) Science , vol.268 , pp. 1902-1906
    • Dent, P.1    Jelinek, J.2    Morrison, D.K.3    Weber, M.J.4    Sturgill, T.W.5
  • 11
    • 0025727594 scopus 로고
    • cDNA cloning of a novel 85 kDa protein that has SH2 domains and regulates binding of PB-kinase to the PDGF beta-receptor
    • Escobedo,J.A., Navankasattusas,S., Kavanaugh,W.M., Milfay,D., Fried, V.A. and Williams,L.T. (1991) cDNA cloning of a novel 85 kDa protein that has SH2 domains and regulates binding of PB-kinase to the PDGF beta-receptor. Cell, 65, 75-82.
    • (1991) Cell , vol.65 , pp. 75-82
    • Escobedo, J.A.1    Navankasattusas, S.2    Kavanaugh, W.M.3    Milfay, D.4    Fried, V.A.5    Williams, L.T.6
  • 12
    • 0024406286 scopus 로고
    • All ras proteins are polyisoprenylated but only some are palmitoylated
    • Hancock,J.F., Magee,A.I., Childs,J.E. and Marshall,C.J. (1989) All ras proteins are polyisoprenylated but only some are palmitoylated. Cell, 57, 1167-1177.
    • (1989) Cell , vol.57 , pp. 1167-1177
    • Hancock, J.F.1    Magee, A.I.2    Childs, J.E.3    Marshall, C.J.4
  • 13
    • 0025013547 scopus 로고
    • A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane
    • Hancock,J.F., Paterson,H. and Marshall,C.J. (1990) A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell. 63, 133-139.
    • (1990) Cell , vol.63 , pp. 133-139
    • Hancock, J.F.1    Paterson, H.2    Marshall, C.J.3
  • 16
    • 0027405017 scopus 로고
    • The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosine 368, tyrosine 580, and tyrosine 607 by the insulin receptor
    • Hayashi,H., Nishioka,Y., Kamohara,S., Kanai,F., Ishii,K., Fukui,Y., Shibasaki,F., Takenawa,T., Kido,H., Katsunuma,N. and Ebina,Y. (1993) The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosine 368, tyrosine 580, and tyrosine 607 by the insulin receptor. J. Biol. Chem., 268, 7107-7117.
    • (1993) J. Biol. Chem. , vol.268 , pp. 7107-7117
    • Hayashi, H.1    Nishioka, Y.2    Kamohara, S.3    Kanai, F.4    Ishii, K.5    Fukui, Y.6    Shibasaki, F.7    Takenawa, T.8    Kido, H.9    Katsunuma, N.10    Ebina, Y.11
  • 17
    • 0028795913 scopus 로고
    • Quantitative-analysis of the complex between p21(ras) and the ras-binding domain of the human raf-1 protein-kinase
    • Herrmann,C., Martin,G.A. and Wittinghofer,A. (1995) Quantitative-analysis of the complex between p21(ras) and the ras-binding domain of the human raf-1 protein-kinase. J. Biol. Chem., 270, 2901-2905.
    • (1995) J. Biol. Chem. , vol.270 , pp. 2901-2905
    • Herrmann, C.1    Martin, G.A.2    Wittinghofer, A.3
  • 19
    • 0028153277 scopus 로고
    • Activated ras interacts with the ral guanine-nucleotide dissociation stimulator
    • Hofer,F., Fields,S., Schneider,C. and Marlin,G.S. (1994) Activated ras interacts with the ral guanine-nucleotide dissociation stimulator. Proc. Natl Acad. Sci. USA, 91, 11089-11093.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 11089-11093
    • Hofer, F.1    Fields, S.2    Schneider, C.3    Marlin, G.S.4
  • 20
    • 0027361002 scopus 로고
    • Cloning of a novel ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85
    • Hu,P., Mondino,A., Skolnik,E.Y. and Schlessinger,J. (1993) Cloning of a novel ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Mol. Cell. Biol., 13, 7677-7688.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7677-7688
    • Hu, P.1    Mondino, A.2    Skolnik, E.Y.3    Schlessinger, J.4
  • 21
    • 0028918408 scopus 로고
    • Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
    • Hu,Q., Klippel,A., Muslin,A.J., Fantl,W.J. and Williams,L.T. (1995) Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science, 268, 100-102.
    • (1995) Science , vol.268 , pp. 100-102
    • Hu, Q.1    Klippel, A.2    Muslin, A.J.3    Fantl, W.J.4    Williams, L.T.5
  • 22
    • 0028122890 scopus 로고
    • Tyrosine-508 of the 85-kilodalton subunit of phosphatidylinositol 3-kinase is phosphorylated by the platelet-derived growth-factor receptor
    • Kavanaugh,W.M, Turck,C.W., Klippel,A. and Williams,L.T. (1994) Tyrosine-508 of the 85-kilodalton subunit of phosphatidylinositol 3-kinase is phosphorylated by the platelet-derived growth-factor receptor. Biochemistry, 33, 11046-11050.
    • (1994) Biochemistry , vol.33 , pp. 11046-11050
    • Kavanaugh, W.M.1    Turck, C.W.2    Klippel, A.3    Williams, L.T.4
  • 23
    • 0027986765 scopus 로고
    • Ral-gds family members interact with the effector loop of ras p21
    • Kikuchi,A., Demo,S.D., Ye,Z.H., Chen,Y.W. and Williams,L.T. (1994) Ral-gds family members interact with the effector loop of ras p21. Mol. Cell. Biol., 14, 7483-7491.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7483-7491
    • Kikuchi, A.1    Demo, S.D.2    Ye, Z.H.3    Chen, Y.W.4    Williams, L.T.5
  • 24
    • 0028670476 scopus 로고
    • Direct evidence that g(i)-coupled receptor stimulation of mitogen activated protein kinase is mediated by g beta gamma activation of p21(ras)
    • Koch,W.J., Hawes,B.E., Allen,L.F. and Lefkowitz,R.J. (1994) Direct evidence that g(i)-coupled receptor stimulation of mitogen activated protein kinase is mediated by g beta gamma activation of p21(ras). Proc. Natl Acad. Sci. USA, 91, 12706-12710.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 12706-12710
    • Koch, W.J.1    Hawes, B.E.2    Allen, L.F.3    Lefkowitz, R.J.4
  • 28
    • 0027311858 scopus 로고
    • Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
    • Kunz,J., Henriquez,R., Schneider,U., Deuter-Reinhard,M, Movva,N.R. and Hall,M.N. (1993) Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell, 73, 585-596.
    • (1993) Cell , vol.73 , pp. 585-596
    • Kunz, J.1    Henriquez, R.2    Schneider, U.3    Deuter-Reinhard, M.4    Movva, N.R.5    Hall, M.N.6
  • 29
    • 0026541143 scopus 로고
    • Activation of extracellular signal-regulated kinase ERK2 by p21ras oncoprotein
    • Leevers,S.J. and Marshall,C.J. (1992) Activation of extracellular signal-regulated kinase ERK2 by p21ras oncoprotein. EMBO J., 11, 569-574.
    • (1992) EMBO J. , vol.11 , pp. 569-574
    • Leevers, S.J.1    Marshall, C.J.2
  • 30
    • 0028272507 scopus 로고
    • Requirement for ras in raf activation is overcome by targeting raf to the plasma-membrane
    • Leevers,S.J., Paterson,H.F. and Marshall,C.J. (1994) Requirement for ras in raf activation is overcome by targeting raf to the plasma-membrane. Nature, 369, 411-414.
    • (1994) Nature , vol.369 , pp. 411-414
    • Leevers, S.J.1    Paterson, H.F.2    Marshall, C.J.3
  • 31
    • 0027383006 scopus 로고
    • The catalytic domain of the mouse sos1 gene product activates Ras proteins in vivo and in vitro
    • Liu,B.X., Wei,W. and Broek,D. (1993a) The catalytic domain of the mouse sos1 gene product activates Ras proteins in vivo and in vitro. Oncogene, 8, 3081-3084.
    • (1993) Oncogene , vol.8 , pp. 3081-3084
    • Liu, B.X.1    Wei, W.2    Broek, D.3
  • 32
    • 0027214258 scopus 로고
    • The v-src SH3 domain binds phosphatidylinositol 3′-kinase
    • Liu,X., Marengere,L.E.M., Koch,C.A. and Pawson,T. (1993b) The v-src SH3 domain binds phosphatidylinositol 3′-kinase. Mol. Cell. Biol., 13, 5225-232.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 5225-5232
    • Liu, X.1    Marengere, L.E.M.2    Koch, C.A.3    Pawson, T.4
  • 34
    • 0029006126 scopus 로고
    • Ras recruits raf-1 to the plasma-membrane for activation by tyrosine phosphorylation
    • Marais,R., Light,Y., Paterson,H.F. and Marshall,C.J. (1995) Ras recruits raf-1 to the plasma-membrane for activation by tyrosine phosphorylation. EMBO J, 14, 3136-3145.
    • (1995) EMBO J , vol.14 , pp. 3136-3145
    • Marais, R.1    Light, Y.2    Paterson, H.F.3    Marshall, C.J.4
  • 35
    • 0028152333 scopus 로고
    • MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
    • Marshall,C.J. (1994) MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr. Opin. Genet. Dev., 4, 82-89.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 82-89
    • Marshall, C.J.1
  • 36
    • 0027337519 scopus 로고
    • Complexes of Ras-GTP with Raf-1 and mitogen activated protein kinase kinase
    • Moodie,S.A., Willumsen,B.M., Weber,M.J. and Wolfman,A. (1993) Complexes of Ras-GTP with Raf-1 and mitogen activated protein kinase kinase. Science, 260, 1658-1661.
    • (1993) Science , vol.260 , pp. 1658-1661
    • Moodie, S.A.1    Willumsen, B.M.2    Weber, M.J.3    Wolfman, A.4
  • 38
    • 0024844959 scopus 로고
    • Expression and characterization of the Ha-ras p21 protein produced at high levels in the insect/baculovirus system
    • Page,M.J., Hall,A., Rhodes,S., Skinner,R.H., Murphy,V., Sydenham,M. and Lowe,P.N. (1989) Expression and characterization of the Ha-ras p21 protein produced at high levels in the insect/baculovirus system. J. Biol. Chem., 264, 19147-19154.
    • (1989) J. Biol. Chem. , vol.264 , pp. 19147-19154
    • Page, M.J.1    Hall, A.2    Rhodes, S.3    Skinner, R.H.4    Murphy, V.5    Sydenham, M.6    Lowe, P.N.7
  • 39
    • 0028198388 scopus 로고
    • Activation of phosphatidylinositol 3-kinase by src family kinase SH3 binding to the p85 subunit
    • Pleiman,C.M., Hertz,W.M. and Cambier,J.C. (1994) Activation of phosphatidylinositol 3-kinase by src family kinase SH3 binding to the p85 subunit. Science, 263, 1609-1612.
    • (1994) Science , vol.263 , pp. 1609-1612
    • Pleiman, C.M.1    Hertz, W.M.2    Cambier, J.C.3
  • 40
    • 0028122345 scopus 로고
    • Prenylation of Ras proteins is required for efficient hSos1-promoted guanine nucleotide exchange
    • Porfiri,E., Evans,T., Chardin,P. and Hancock,J.F. (1994) Prenylation of Ras proteins is required for efficient hSos1-promoted guanine nucleotide exchange. J. Biol. Chem., 269, 22672-22677.
    • (1994) J. Biol. Chem. , vol.269 , pp. 22672-22677
    • Porfiri, E.1    Evans, T.2    Chardin, P.3    Hancock, J.F.4
  • 42
    • 0028903247 scopus 로고
    • An essential role for rac in ras transformation
    • Qiu,R.G., Chen,J., Kirn,D., McCormick,F. and Symons,M. (1995) An essential role for rac in ras transformation. Nature, 374, 457-459.
    • (1995) Nature , vol.374 , pp. 457-459
    • Qiu, R.G.1    Chen, J.2    Kirn, D.3    McCormick, F.4    Symons, M.5
  • 43
    • 0025729730 scopus 로고
    • The Raf serine/threonine kinases
    • Rapp,U.R. (1991) The Raf serine/threonine kinases. Oncogene. 6, 495-500.
    • (1991) Oncogene , vol.6 , pp. 495-500
    • Rapp, U.R.1
  • 44
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • Ridley,A., Paterson,H.F., Johnston,C.L., Diekmann,D. and Hall,A. (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell, 70, 401-410.
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 45
    • 0028584245 scopus 로고
    • The phosphatidylinosilol 3-kinase a is required for DNA synthesis induced by some, but not all, growth factors
    • Roche,S., Koegl,M. and Courtneidge,S.A. (1994) The phosphatidylinosilol 3-kinase a is required for DNA synthesis induced by some, but not all, growth factors. Proc. Natl Acad. Sci. USA, 91, 9185-9189.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 9185-9189
    • Roche, S.1    Koegl, M.2    Courtneidge, S.A.3
  • 47
    • 0029077563 scopus 로고
    • Direct interaction between ras and the kinase domain of mitogen activated protein kinase kinase kinase (mekkl)
    • Russell,M., Lange-Carter,C. and Johnson,G.L. (1995) Direct interaction between ras and the kinase domain of mitogen activated protein kinase kinase kinase (mekkl). J. Biol. Chem., 270, 11757-11760.
    • (1995) J. Biol. Chem. , vol.270 , pp. 11757-11760
    • Russell, M.1    Lange-Carter, C.2    Johnson, G.L.3
  • 48
    • 0028239893 scopus 로고
    • RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
    • Sabatini,D.M., Erdjument-Bromage,H., Lui,M,. Tempst,P. and Snyder,S.H. (1994) RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell, 78, 35-43.
    • (1994) Cell , vol.78 , pp. 35-43
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Lui, M.3    Tempst, P.4    Snyder, S.H.5
  • 50
    • 0027905021 scopus 로고
    • Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
    • Schu,P.V., Takegawa,K., Fry,M.J., Stack,J.H., Waterfield,M.D. and Emr,S.D. (1993) Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science, 260, 88-91.
    • (1993) Science , vol.260 , pp. 88-91
    • Schu, P.V.1    Takegawa, K.2    Fry, M.J.3    Stack, J.H.4    Waterfield, M.D.5    Emr, S.D.6
  • 51
    • 0025921611 scopus 로고
    • Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor lyrosine kinases
    • Skolnik,E.Y., Margolis,B., Mohammadi,M., Lowenstein,E., Fischer,R., Drepps,A., Ullrich,A. and Schlessinger,J. (1991) Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor lyrosine kinases. Cell, 65, 83-90.
    • (1991) Cell , vol.65 , pp. 83-90
    • Skolnik, E.Y.1    Margolis, B.2    Mohammadi, M.3    Lowenstein, E.4    Fischer, R.5    Drepps, A.6    Ullrich, A.7    Schlessinger, J.8
  • 53
    • 0028577298 scopus 로고
    • Identification of the guanine-nucleotide dissociation stimulator for ral as a putative effector molecule of r-ras, h-ras. k-ras, and rap
    • Spaargaren,M. and Bischoff,J.R. (1994) Identification of the guanine-nucleotide dissociation stimulator for ral as a putative effector molecule of r-ras, h-ras. k-ras, and rap. Proc. Natl Acad. Sci. USA. 91, 12609-12613.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 12609-12613
    • Spaargaren, M.1    Bischoff, J.R.2
  • 54
    • 0027366440 scopus 로고
    • Agonist-stimulated synthesis of phosphatidylinosilol(3,4,5)-trisphosphate: A new intracellular signalling system
    • Stephens,L.R., Jackson,T.R. and Hawkins,P.T. (1993) Agonist-stimulated synthesis of phosphatidylinosilol(3,4,5)-trisphosphate: a new intracellular signalling system. Biochim. Biophys. Acta, 1179, 27-75.
    • (1993) Biochim. Biophys. Acta , vol.1179 , pp. 27-75
    • Stephens, L.R.1    Jackson, T.R.2    Hawkins, P.T.3
  • 55
    • 0028334738 scopus 로고
    • A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits
    • Stephens,L., Smrcka,A., Cooke,F.T., Jackson,T.R., Sternweis,P.C. and Hawkins,P.T. (1994) A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits. Cell, 77, 83-93.
    • (1994) Cell , vol.77 , pp. 83-93
    • Stephens, L.1    Smrcka, A.2    Cooke, F.T.3    Jackson, T.R.4    Sternweis, P.C.5    Hawkins, P.T.6
  • 56
    • 0028241533 scopus 로고
    • Activation of raf as a result of recruitment to the plasma-membrane
    • Stokoe,D., MacDonald,S.G., Cadwallader,K., Symons,M. and Hancock,J.F. (1994) Activation of raf as a result of recruitment to the plasma-membrane. Science, 264, 1463-1467.
    • (1994) Science , vol.264 , pp. 1463-1467
    • Stokoe, D.1    MacDonald, S.G.2    Cadwallader, K.3    Symons, M.4    Hancock, J.F.5
  • 59
    • 0029023942 scopus 로고
    • Rho-family GTPases bind to phosphoinositide kinases
    • Tolias,K.F., Cantley,L.C. and Carpenter,C.L. (1995) Rho-family GTPases bind to phosphoinositide kinases. J. Biol. Chem., 270, 17656-17659.
    • (1995) J. Biol. Chem. , vol.270 , pp. 17656-17659
    • Tolias, K.F.1    Cantley, L.C.2    Carpenter, C.L.3
  • 62
    • 0027250250 scopus 로고
    • Mammalian Ras interacts directly with the serine/threonine kinase Raf
    • Vojlek,A.B., Hollenberg,S.M. and Cooper,J.A. (1993) Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell. 74, 205-214.
    • (1993) Cell , vol.74 , pp. 205-214
    • Vojlek, A.B.1    Hollenberg, S.M.2    Cooper, J.A.3
  • 63
    • 0025806672 scopus 로고
    • byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype
    • Wang,Y., Xu.H.-P., Riggs,M., Rodgers,L. and Wigler,M. (1991) byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype. Mol. Cell. Biol., 11, 3554-3563.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 3554-3563
    • Wang, Y.1    Xu, H.-P.2    Riggs, M.3    Rodgers, L.4    Wigler, M.5
  • 64
    • 0027200883 scopus 로고
    • Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
    • Warne,P.H., Vicinia,P.R. and Downward,J. (1993) Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature, 364, 352-355.
    • (1993) Nature , vol.364 , pp. 352-355
    • Warne, P.H.1    Vicinia, P.R.2    Downward, J.3
  • 66
    • 0028089005 scopus 로고
    • Membrane ruffling and chemotaxis transduced by the PDGF receptor require the binding site for phosphatidylinositol 3′ kinase
    • Wennström.S., Siegbahn,A., Yokote,K., Arvidsson,A.-K., Heldin,C.-H., Mori,S. and Claesson-Welsh,L. (1994b) Membrane ruffling and chemotaxis transduced by the PDGF receptor require the binding site for phosphatidylinositol 3′ kinase. Oncogene, 9, 651-660.
    • (1994) Oncogene , vol.9 , pp. 651-660
    • WennströmS1    Siegbahn, A.2    Yokote, K.3    Arvidsson, A.-K.4    Heldin, C.-H.5    Mori, S.6    Claesson-Welsh, L.7
  • 69
    • 0028338545 scopus 로고
    • Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85
    • Zheng,Y., Bagrodia,S. and Cerione,R.A. (1994) Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. J. Biol. Chem, 269, 18727-18730.
    • (1994) J. Biol. Chem , vol.269 , pp. 18727-18730
    • Zheng, Y.1    Bagrodia, S.2    Cerione, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.