NF-κB activation by tumour necrosis factor requires tie Akt serine- threonine kinase

Nature

Volumn 401, Issue 6748, 1999, Pages 82-85

  Ozes, Osman Nidal ^a   Mayo, Lindsey D ^a   Gustin, Jason A ^a   Pfeffer, Susan R ^b   Pfeffer, Lawrence M ^b   Donner, David B ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; TUMOR NECROSIS FACTOR; AKT1 PROTEIN, HUMAN; CHUK PROTEIN, HUMAN; CHUK PROTEIN, MOUSE; DNA; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IKBKB PROTEIN, MOUSE; IKBKE PROTEIN, HUMAN; IKBKE PROTEIN, MOUSE; LEUKOCYTE ANTIGEN; NF KAPPA B KINASE; NF-KAPPA B KINASE; ONCOPROTEIN; THREONINE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL STRAIN 3T3; HELA CELL; HUMAN; METABOLISM; MOLECULAR GENETICS; MOUSE; PHOSPHORYLATION; PROTEIN BINDING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; CELL LINE; DNA; ENZYME ACTIVATION; HELA CELLS; HUMANS; I-KAPPA B KINASE; MICE; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; THREONINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033517189     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/43466     Document Type: Article

References (20)

1. DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E. & Karin, M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388, 548-554 (1997).
2. Regnier, C. H. et al. Identification and characterization of an IκB kinase. Cell 90, 373-383 (1997).
3. Mercurio, F. et al. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278, 860-866 (1997).
4. Woronicz, J. D., Gao, X., Rothe, M. & Goeddel, D. V. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278, 866-859 (1997).
5. Zandi, E., Rothwarf, D. M., Delhause, M., Hayakawa, M. & Karin, M. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91, 243-252 (1997).
6. Marte, B. M. & Downward, J. PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem. Sci. 22, 355-358 (1997).
7. Bauerle, P. A. & Baltimore, D. NF-κB: Ten years after. Cell 87, 13-20 (1996).
8. Wang, C.-Y., Mayo, M. W. & Baldwin, A. S. Jr TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274, 784-787 (1996).
9. Van Antwerp, D. J., Martin, S. J., Kafri, T., Green, D. R. & Verma, I. M. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274, 787-789 (1996).
10. Maniatis, T. Catalysis by a multiprotein IκB kinase complex. Science 278, 818-819 (1997).
11. Hsu, H., Shu, H.-B., Pan, M.-G. & Goeddel, D. V. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84, 299-308 (1996).
12. Malinin, N. L., Boldin, M. P., Kovalenko, A. V. & Wallach, D. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 385, 540-544 (1997).
13. Ling, L., Cao, Z. & Goeddel, D. V. NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176. Proc. Natl Acad. Sci. USA 95, 3792-3797 (1998).
14. Guo, D. & Donner, D. B. Tumour necrosis factor promotes phosphorylation and binding of IRS-1 to phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J. Biol. Chem. 271, 615-618 (1996).
15. Alessi, D. R., Caudwell, F. B., Andjelkovic, M., Hemmings, B. A. & Cohen, P. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p60 S6 kinase. FEBS Lett. 399, 333-338 (1996).
16. Tanaka, M. et al. Embryonic lethality, liver degeneration, and impaired NF-κB activation in IKK-β deficient mice. Immunity 10, 421-429 (1999).
17. Li, Q., Antwerp, D. V., Mercurio, F., Lee, K.-F. & Verma, I. M. Severe liver degeneration in mice lacking the IκB kinase 2 gene. Science 284, 321-326 (1999).
18. Hu, Y. et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα of IκB kinase. Science 284, 316-320 (1999).
19. Delhause, M., Hayakawa, M., Chen, Y. & Karin, M. Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science 284, 309-313 (1999).
20. Ruderman, N. B., Kapeller, R., white, M. F. & Cantley, L. C. Activation of phosphatidylinositol 3-kinase by insulin. Proc. Natl Acad. Sci. USA 87, 1411-1415 (1990).