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Volumn 100, Issue 12, 1997, Pages 3164-3172

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

Author keywords

Diabetes; Insulin receptor kinase; Insulin receptor substrate; Insulin resistance; Phosphatidylinositol 3 kinase

Indexed keywords

INSULIN; INSULIN RECEPTOR KINASE; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG;

EID: 2642683510     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119872     Document Type: Article
Times cited : (269)

References (47)
  • 1
    • 0016791569 scopus 로고
    • Insulin receptor deficiency in genetic and acquired obesity
    • Soll, A.H., C.R. Kahn, D.M. Neville, Jr., and J. Roth. 1975. Insulin receptor deficiency in genetic and acquired obesity. J. Clin. Invest. 56:769-780.
    • (1975) J. Clin. Invest. , vol.56 , pp. 769-780
    • Soll, A.H.1    Kahn, C.R.2    Neville Jr., D.M.3    Roth, J.4
  • 4
    • 0026459873 scopus 로고
    • Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation
    • King, P.A., E.D. Horton, M.F. Hirschman, and E.S. Horton. 1992. Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation. J. Clin. Invest. 90:1568-1575.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1568-1575
    • King, P.A.1    Horton, E.D.2    Hirschman, M.F.3    Horton, E.S.4
  • 5
    • 0015918902 scopus 로고
    • Insulin receptor interaction in the obese hyperglycemic mouse. A model of insulin resistance
    • Kahn, C.R., D.M. Neville, Jr., and J. Roth. 1973. Insulin receptor interaction in the obese hyperglycemic mouse. A model of insulin resistance. J. Biol. Chem. 248:244-250.
    • (1973) J. Biol. Chem. , vol.248 , pp. 244-250
    • Kahn, C.R.1    Neville Jr., D.M.2    Roth, J.3
  • 6
    • 0027484001 scopus 로고
    • Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus
    • Folli, F., M.J.A. Saad, J.M. Backer, and C.R. Kahn. 1993. Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus. J. Clin. Invest. 92:1787-1794.
    • (1993) J. Clin. Invest. , vol.92 , pp. 1787-1794
    • Folli, F.1    Saad, M.J.A.2    Backer, J.M.3    Kahn, C.R.4
  • 7
    • 0028904053 scopus 로고
    • Insulin action and the insulin signaling network
    • Cheatham, B., and C.R. Kahn. 1995. Insulin action and the insulin signaling network. Endocr. Rev. 16:117-142.
    • (1995) Endocr. Rev. , vol.16 , pp. 117-142
    • Cheatham, B.1    Kahn, C.R.2
  • 8
    • 0029135003 scopus 로고
    • New frontiers in insulin receptor substrate signaling
    • Myers, M.G., Jr., and M.F. White. 1995. New frontiers in insulin receptor substrate signaling. Trends Endocrinol. Metab. 6:209-215.
    • (1995) Trends Endocrinol. Metab. , vol.6 , pp. 209-215
    • Myers Jr., M.G.1    White, M.F.2
  • 11
    • 0028032895 scopus 로고
    • Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene
    • Araki, E., M.A. Lipes, M.E. Patti, J.C. Bruning, B.L. Haag, III, R.S. Johnson, and C.R. Kahn. 1994. Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene. Nature. 372:186-190.
    • (1994) Nature , vol.372 , pp. 186-190
    • Araki, E.1    Lipes, M.A.2    Patti, M.E.3    Bruning, J.C.4    Haag III, B.L.5    Johnson, R.S.6    Kahn, C.R.7
  • 13
  • 14
    • 0028308412 scopus 로고
    • Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase DNA synthesis and glucose transporter translocation
    • Cheatham, B., C.J. Vlahos, L. Cheatham, L. Wang, J. Blenis, and C.R. Kahn. 1994. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase DNA synthesis and glucose transporter translocation. Mol. Cell. Biol. 14:4902-4911.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4902-4911
    • Cheatham, B.1    Vlahos, C.J.2    Cheatham, L.3    Wang, L.4    Blenis, J.5    Kahn, C.R.6
  • 15
    • 0025064397 scopus 로고
    • Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase
    • Endemann, G., K. Yonezawa, and R.A. Roth. 1990. Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase. J. Biol. Chem. 265:396-400.
    • (1990) J. Biol. Chem. , vol.265 , pp. 396-400
    • Endemann, G.1    Yonezawa, K.2    Roth, R.A.3
  • 16
    • 0027437376 scopus 로고
    • Pleiotropic insulin signals are engaged by multisite phosphoryla-tion of IRS-1
    • Sun, X.J., D.L. Crimmins, M.G. Myers, Jr., M. Miralpeix, and M.F. White. 1993. Pleiotropic insulin signals are engaged by multisite phosphoryla-tion of IRS-1. Mol. Cell. Biol. 13:7418-7428.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7418-7428
    • Sun, X.J.1    Crimmins, D.L.2    Myers Jr., M.G.3    Miralpeix, M.4    White, M.F.5
  • 17
    • 0026668877 scopus 로고
    • Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3′-kinase upon its association with pp185 (IRS-1) in intact rat livers
    • Hadari, Y.R., E. Tzahar, O. Nadiv, P. Rothenberg, C.T. Roberts, Jr., D. LeRoith, Y. Yarden, and Y. Zick. 1992. Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3′-kinase upon its association with pp185 (IRS-1) in intact rat livers. J. Biol. Chem. 267:17483-17486.
    • (1992) J. Biol. Chem. , vol.267 , pp. 17483-17486
    • Hadari, Y.R.1    Tzahar, E.2    Nadiv, O.3    Rothenberg, P.4    Roberts Jr., C.T.5    Leroith, D.6    Yarden, Y.7    Zick, Y.8
  • 20
    • 0025727594 scopus 로고
    • cDNA cloning of a novel 85 kD protein that has SH2 domains and regulates binding of P13-kinase to the PDGF β-receptor
    • Escobedo, J.A., S. Navankasattusas, W.M. Kavanaugh, D. Milfay, V.A. Fried, and L.T. Williams. 1991. cDNA cloning of a novel 85 kD protein that has SH2 domains and regulates binding of P13-kinase to the PDGF β-receptor. Cell. 65:75-82.
    • (1991) Cell , vol.65 , pp. 75-82
    • Escobedo, J.A.1    Navankasattusas, S.2    Kavanaugh, W.M.3    Milfay, D.4    Fried, V.A.5    Williams, L.T.6
  • 22
    • 0025921611 scopus 로고
    • Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases
    • Skolnik, E.Y., B. Margolis, M. Mohammadi, E.J. Lowenstein, R. Fischer, A. Drepps, A. Ullrich, and J. Schlessinger. 1991. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell. 65:83-90.
    • (1991) Cell , vol.65 , pp. 83-90
    • Skolnik, E.Y.1    Margolis, B.2    Mohammadi, M.3    Lowenstein, E.J.4    Fischer, R.5    Drepps, A.6    Ullrich, A.7    Schlessinger, J.8
  • 23
    • 0028486018 scopus 로고
    • Phosphatidylinositol 3-kinase
    • Kapeller, R., and L.C. Cantley, Jr. 1994. Phosphatidylinositol 3-kinase. BioEssays. 16:565-576.
    • (1994) BioEssays , vol.16 , pp. 565-576
    • Kapeller, R.1    Cantley Jr., L.C.2
  • 24
    • 0029913340 scopus 로고    scopus 로고
    • Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain
    • Antonetti, D.A., P. Algenstaedt, and C.R. Kahn. 1996. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. Mol. Cell. Biol. 16:2195-2203.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2195-2203
    • Antonetti, D.A.1    Algenstaedt, P.2    Kahn, C.R.3
  • 26
    • 0030615068 scopus 로고    scopus 로고
    • p85α gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50α, p55α, and p85α, with different PI 3-kinase activity elevating responses to insulin
    • Inukai, K., M. Funaki, T. Ogihara, H. Katagiri, A. Kanda, M. Anai, Y. Fukushima, T. Hosaka, M. Suzuki, B.C. Shin, et al. 1997. p85α gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50α, p55α, and p85α, with different PI 3-kinase activity elevating responses to insulin. J. Biol. Chem. 272:7873-7882.
    • (1997) J. Biol. Chem. , vol.272 , pp. 7873-7882
    • Inukai, K.1    Funaki, M.2    Ogihara, T.3    Katagiri, H.4    Kanda, A.5    Anai, M.6    Fukushima, Y.7    Hosaka, T.8    Suzuki, M.9    Shin, B.C.10
  • 27
    • 0030271565 scopus 로고    scopus 로고
    • Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85α gene
    • Fruman, D.A., L.C. Cantley, and C.L. Carpenter. 1996. Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85α gene. Genomics. 37:113-121.
    • (1996) Genomics , vol.37 , pp. 113-121
    • Fruman, D.A.1    Cantley, L.C.2    Carpenter, C.L.3
  • 29
    • 0038155702 scopus 로고    scopus 로고
    • Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IKS-1 null alleles
    • Bruning, J.C., J. Winnay, S. Bonner-Weir, S.I. Taylor, D. Accili, and C.R. Kahn. 1997. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IKS-1 null alleles. Cell. 88:561-572.
    • (1997) Cell , vol.88 , pp. 561-572
    • Bruning, J.C.1    Winnay, J.2    Bonner-Weir, S.3    Taylor, S.I.4    Accili, D.5    Kahn, C.R.6
  • 30
    • 0028198330 scopus 로고
    • The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity
    • Klippel, A., J.A. Escobedo, M. Hirano, and L.T. Williams. 1994. The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Mol. Cell. Biol. 14:2675-2685.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 2675-2685
    • Klippel, A.1    Escobedo, J.A.2    Hirano, M.3    Williams, L.T.4
  • 31
    • 0030028790 scopus 로고    scopus 로고
    • A Grb2-associated docking protein in EGF- and insulin-receptor signaling
    • Holgado-Madruga, M., D.R. Emlet, D.K. Moscatello, A.K. Godwin, and A.J. Wong. 1996. A Grb2-associated docking protein in EGF- and insulin-receptor signaling. Nature. 379:560-563.
    • (1996) Nature , vol.379 , pp. 560-563
    • Holgado-Madruga, M.1    Emlet, D.R.2    Moscatello, D.K.3    Godwin, A.K.4    Wong, A.J.5
  • 32
    • 0027417484 scopus 로고
    • The insulin-elicited 60-kD phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase
    • Lavan, B.E., and G.E. Lienhard. 1993. The insulin-elicited 60-kD phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase. J. Biol. Chem. 268:5921-5928.
    • (1993) J. Biol. Chem. , vol.268 , pp. 5921-5928
    • Lavan, B.E.1    Lienhard, G.E.2
  • 35
    • 0026471539 scopus 로고
    • Identification of a human src homology 2-containing protein-tyrosine-phosphatase: A putative homolog of Drosophila corkscrew
    • Freeman, R.M., Jr., J. Plutzky, and B.G. Neel. 1992. Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. Proc. Natl. Acad. Sci. USA. 89:11239-11243.
    • (1992) Proc. Natl. Acad. Sci. USA. , vol.89 , pp. 11239-11243
    • Freeman Jr., R.M.1    Plutzky, J.2    Neel, B.G.3
  • 36
    • 0027516706 scopus 로고
    • IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3′-kinase
    • Myers, M.G., Jr., X.J. Sun, B. Cheatham, B.R. Jachna, E.M. Glasheen, J.M. Backer, and M.F. White. 1993. IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3′-kinase. Endocrinology. 132:1421-1430.
    • (1993) Endocrinology , vol.132 , pp. 1421-1430
    • Myers Jr., M.G.1    Sun, X.J.2    Cheatham, B.3    Jachna, B.R.4    Glasheen, E.M.5    Backer, J.M.6    White, M.F.7
  • 37
    • 0027500821 scopus 로고
    • Expression, purification and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2
    • Sugimoto, S., R.J. Lechleider, S.E. Shoelson, B.G. Neel, and C.T. Walsh. 1994. Expression, purification and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2. J. Biol. Chem. 268:22771-22776.
    • (1994) J. Biol. Chem. , vol.268 , pp. 22771-22776
    • Sugimoto, S.1    Lechleider, R.J.2    Shoelson, S.E.3    Neel, B.G.4    Walsh, C.T.5
  • 38
    • 0026438979 scopus 로고
    • Regulation of insulin receptor substrate 1 in liver and muscle of animal models of insulin resistance
    • Saad, M.J.A., E. Araki, M. Miralpeix, P.L. Rothenberg, M.F. White, and C.R. Kahn. 1992. Regulation of insulin receptor substrate 1 in liver and muscle of animal models of insulin resistance. J. Clin. Invest. 90:1839-1849.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1839-1849
    • Saad, M.J.A.1    Araki, E.2    Miralpeix, M.3    Rothenberg, P.L.4    White, M.F.5    Kahn, C.R.6
  • 39
    • 0027489828 scopus 로고
    • Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats
    • Saad, M.J.A., F. Folli, J.A. Kahn, and C.R. Kahn. 1993. Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats. J. Clin. Invest. 92:2065-2072.
    • (1993) J. Clin. Invest. , vol.92 , pp. 2065-2072
    • Saad, M.J.A.1    Folli, F.2    Kahn, J.A.3    Kahn, C.R.4
  • 40
    • 0028957037 scopus 로고
    • Identification of a 190 kD protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1
    • Tobe, K., H. Tamemoto, T. Yamauchi, S. Aizawa, Y. Yazaki, and T. Kadowaki. 1995. Identification of a 190 kD protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1. J. Biol. Chem. 270:5698-5701.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5698-5701
    • Tobe, K.1    Tamemoto, H.2    Yamauchi, T.3    Aizawa, S.4    Yazaki, Y.5    Kadowaki, T.6
  • 41
    • 0030848782 scopus 로고    scopus 로고
    • A novel 160 kD phosphotyrosinc protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family
    • Lavan, B.E., V.R. Fantin, E.T. Chang, W.S. Lane, S.R. Keller, and G.E. Lienhard. 1997. A novel 160 kD phosphotyrosinc protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family. J. Biol. Chem. 272:21403-21407.
    • (1997) J. Biol. Chem. , vol.272 , pp. 21403-21407
    • Lavan, B.E.1    Fantin, V.R.2    Chang, E.T.3    Lane, W.S.4    Keller, S.R.5    Lienhard, G.E.6
  • 42
    • 0029080520 scopus 로고
    • Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells
    • Tomiyama, K., H. Nakata, H. Sasa, S. Arimura, E. Nishio, and Y. Watanabe. 1995. Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells. Biochem. Biophys. Res. Commun. 212:263-269.
    • (1995) Biochem. Biophys. Res. Commun. , vol.212 , pp. 263-269
    • Tomiyama, K.1    Nakata, H.2    Sasa, H.3    Arimura, S.4    Nishio, E.5    Watanabe, Y.6
  • 43
    • 0029741689 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells
    • Kaliman, P., F. Vinals, X. Testar, M. Palacin, and A. Zorzano. 1996. Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells. J. Biol. Chem. 271:19146-19151.
    • (1996) J. Biol. Chem. , vol.271 , pp. 19146-19151
    • Kaliman, P.1    Vinals, F.2    Testar, X.3    Palacin, M.4    Zorzano, A.5
  • 44
    • 0029671058 scopus 로고    scopus 로고
    • Hepatocyte growth factor-induced proliferation of primary hepatocytes is mediated by activation of phosphatidylinositol 3-kinase
    • Skouteris, G.G., and E. Georgakopoulos. 1996. Hepatocyte growth factor-induced proliferation of primary hepatocytes is mediated by activation of phosphatidylinositol 3-kinase. Biochem. Biophys. Res. Commun. 218:229-233.
    • (1996) Biochem. Biophys. Res. Commun. , vol.218 , pp. 229-233
    • Skouteris, G.G.1    Georgakopoulos, E.2
  • 46
    • 0027322636 scopus 로고
    • Altered pattern of insulin receptor isotypes in skeletal muscle membranes of Type II (non-insulin-dependent) diabetic subjects
    • Kellerer, M., G. Sesti, E. Seffer, B. Obermaier-Kusser, D.E. Pongratz, L. Mosthaf, and H.U. Haring. 1993. Altered pattern of insulin receptor isotypes in skeletal muscle membranes of Type II (non-insulin-dependent) diabetic subjects. Diabetologia. 36:628-632.
    • (1993) Diabetologia , vol.36 , pp. 628-632
    • Kellerer, M.1    Sesti, G.2    Seffer, E.3    Obermaier-Kusser, B.4    Pongratz, D.E.5    Mosthaf, L.6    Haring, H.U.7
  • 47
    • 0025801714 scopus 로고
    • Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients
    • Mosthaf, L., B. Vogt, H.U. Haring, and A. Ullrich. 1991. Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients. Proc. Natl. Acad. Sci. USA. 88:4728-4730.
    • (1991) Proc. Natl. Acad. Sci. USA. , vol.88 , pp. 4728-4730
    • Mosthaf, L.1    Vogt, B.2    Haring, H.U.3    Ullrich, A.4


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