Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide

Journal of Biological Chemistry

Volumn 272, Issue 39, 1997, Pages 24252-24256

  Kurosu, Hiroshi ^a   Maehama, Tomohiko ^a   Okada, Taro ^a   Yamamoto, Toshiyoshi ^a   Hoshino, Shin Ichi ^a   Fukui, Yasuhisa ^a   Ui, Michio ^b   Hazeki, Osamu ^a   Katada, Toshiaki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MEMBRANE RECEPTOR; PEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE PHOSPHATASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; LIVER; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; REGULATORY MECHANISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANIMALS; COS CELLS; DNA, COMPLEMENTARY; ENZYME ACTIVATION; GTP-BINDING PROTEINS; LIVER; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PHOSPHOTYROSINE; RATS; RECOMBINANT PROTEINS;

ANIMALIA;

EID: 0030869757     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.39.24252     Document Type: Article

References (30)

1. Kapeller, R., and Cantley, L. C. (1994) BioEssays 16, 565-576
2. Fry, M. J. (1994) Biochim. Biophys. Acta 1226, 237-268
3. Serunian, L. A., Haber, M. T., Fukui, T., Kim, J. W., Rhee, S. G., Lowenstein, J. M., and Cantley, L. C. (1989) J. Biol. Chem. 264, 17809-17815
4. Toker, A., Meyer, M., Reddy, K. K., Falck, J. R., Aneja, R., Aneja, S., Parra, A., Burns, D. J., Ballas, L. M., and Cantley, L. C. (1994) J. Biol. Chem. 269, 32358-32367
5. Franke, T. F., Kaplan, D. R., Cantley, L. C., and Toker, A. (1997) Science 275, 665-668
6. Hammonds-Odie, L. P., Jackson, T. R., Profit, A. A., Blader, I. J., Turck, C. W., Prestwich, G. D., and Theibert, A. B. (1996) J. Biol. Chem. 271, 18859-18868
7. Klarlund, J. K., Guilherme, A., Holik, J. J., Virbasius, J. V., Chawla, A., and Czech, M. P. (1997) Science 275, 1927-1930
8. Tanaka, K., Imajoh-Ohmi, S., Sawada, T., Shirai, R., Hashimoto, Y., Iwasaki, S., Kaibuchi, K., Kanaho, Y., Shirai, T., Terada, Y., Kimura, K., Nagata, S., and Fukui, Y. (1997) Eur. J. Biochem. 245, 512-519
9. Backer, J. M., Myers, M. G., Jr., Shoelson, S. E., Chin, D. J., Sun, X.-J., Miralpeix, M., Hu, P., Margolis, B., Skolnik, E. Y., Schlessinger, J., and White, M. F. (1992) EMBO J. 11, 3469-3479
10. Rordorf, N. T., Van, H. D., Chen, D., White, M. F., and Backer, J. M. (1995) J. Biol. Chem. 270, 3662-3666
11. Hiles, I. D., Otsu, M., Volinia, S., Fry, M. J., Gout, I., Dhand, R., Panayotou, G., Ruiz-Larrea, F., Thompson, A., Totty, N. F., Hsuan, J. J., Courtneige, S. A., Parker, P. J., and Waterfield, M. D. (1992) Cell 70, 419-429
12. Hu, P., Mondino, A., Skolnik, E. Y., and Schlessinger, J. (1993) Mol. Cell. Biol. 13, 7677-7688
13. Vanhaesebroeck, B., Welham, M. J., Kotani, K., Stein, R., Warne, P. H., Zvelebil, M. J., Higashi, K., Volinia, S., Downward, J., and Waterfield, M. D. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 4330-4335
14. Stoyanov, B., Volinia, S., Hanck, T., Rubio, I., Loubtchenkov, M., Malek, D., Stoyanova, S., Vanhaesebroeck, B., Dhand, R., Nürnberg, B., Gierschik, P., Seedorf, K., Hsuan, J. J., Waterfield, M. D., and Wetzker, R. (1995) Science 269, 690-693
15. Stephens, L., Eguinoa, A., Erdjument-Bromage, H., Lui, M., Cooke, F., Coadwell, J., Smrcka, A., Thelen, M., Cadwallader, J., Tempst, P., and Hawkins, P. T. (1997) Cell 89, 105-114
16. Thomason, P. A., James, S. R., Casey, P. J., and Downes, C. P. (1994) J. Biol. Chem. 269, 16525-16528
17. Kurosu, H., Hazeki, O., Kukimoto, I., Honzawa, S., Shibasaki, M., Nakada, M., Ui, M., and Katada, T. (1995) Biochem. Biophys. Res. Commun. 216, 655-661
18. Okada, T., Hazeki, O., Ui, M., and Katada, T. (1996) Biochem. J. 317, 475-480
19. Stephens, L., Smrcka, A., Cooke, F. T., Jackson, T. R., Sternweis, P. C., and Hawkins, P. T. (1994) Cell 77, 83-93
20. Zhang, J., Zhang, J., Benovic, J. L., Sugai, M., Wetzker, R., Gout, I., and Rittenhouse, S. E. (1995) J. Biol. Chem. 270, 6589-6594
21. Tanaka, S., Matsuda, M., Nagata, S., Kurata, T., Nagashima, K., Shizawa, Y., and Fukui, Y. (1993) Jpn. J. Cancer Res. 84, 279-289
22. Carpenter, C. L., Duckworth, B. C., Auger, K. R., Cohen, B., Schaffhausen, B. S., and Cantley, L. C. (1990) J. Biol. Chem. 265, 19704-19711
23. Kontani, K., Takahashi, K., Inanobe, A., Ui, M., and Katada, T. (1992) Arch. Biochem. Biophys. 294, 527-533
24. Nishina, H., Nimota, K., Kukimoto, I., Maehama, T., Takahashi, K., Hoshino, S., Kanaho, Y., and Katada, T. (1995) J. Biochem. (Tokyo) 118, 1083-1089
25. Ui, M., Okada, T., Hazeki, K., and Hazeki, O. (1995) Trends Biochem. Sci. 20, 303-307
26. Vlahos, C. J., Matter, W. F., Hui, K. Y., and Brown, R. F. (1994) J. Biol. Chem. 269, 5241-5248
27. Stephens, L., Eguinoa, A., Corey, S., Jackson, T., and Hawkins, P. T. (1993) EMBO J. 12, 2265-2273
28. Ptasznik, A., Traynor-Kaplan, A., and Bokoch, G. M. (1995) J. Biol. Chem. 270, 19969-19973
29. Hawes, B. E., Luttrell, L. M., van Biesen, T., and Lefkowitz, R. J. (1996) J. Biol. Chem. 271, 12133-12136
30. Lopez-Ilasaca, M., Crespo, P., Pellici, P. G., Gutkind, J. S., and Wetzker, R. (1997) Science 275, 394-397