Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo

FASEB Journal

Volumn 14, Issue 7, 2000, Pages 895-903

  R Borlado, Luis ^a   Redondo, Clara ^b   Alvarez, Beatriz ^a   Jimenez, Concepcion ^a   Criado, Luis M ^a   Flores, Juana ^c   Marcos, Miguel A R ^a   Martinez A , Carlos ^a   Balomenos, Dimitrios ^a   Carrera, Ana C ^a,d  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Autoimmunity; Cancer; Lymphoproliferative disease; Phosphoinositide 3 kinase; PTEN

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CARCINOGENESIS; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; LYMPHOPROLIFERATIVE DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T CELL LYMPHOMA; TRANSGENIC MOUSE;

ANIMALIA; MAMMALIA; MUS MUSCULUS;

EID: 0034107671     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.14.7.895     Document Type: Article

References (36)

1. Fruman, D. A., Meyers, R. E., and Cantley, L. C. (1998) Phosphoinositide kinases. Annu. Rev. Biochem. 67, 481-507
2. Vanhaesebroek, B., Leevers, S., Panayotou, G., and Waterfield, M. D. (1997) Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem. Sci. 22, 267-272
3. Fruman, D. A., Snapper, S. B., Yballe, C. M., Davidson, L., Yu, J. Y., Alt, F. W., and Cantley, L. C. (1999) Impaired B cell development and proliferation in the absence of phosphoinositide 3-kinase p85α. Science 283, 393-396
4. Suzuki, H., Terauchi, Y., Fujiwara, M., Aizawa, S., Yazaki, Y., Kadowaki, T., and Koyasu, S. (1999) Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase. Science 283, 390-392
5. Shayesteh, L., Lu, Y., Kuo, W.-L., Baldocchi, R., Godfrey, T., Collins, C., Pinkel, D., Powell, B., Mills, G. B., and Gray, J. W. (1999) PIK3CA is implicated as an oncogene in ovarian cancer. Nat. Genet. 21, 99-102
6. Cantley, L. C., Neel, B. G. (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. USA 96, 4240-4245
7. Sun, H., Lesche, R., Li, D.-M, Liliental, J., Zhang, H., Gao, J., Gavrilova, N., Mueller, B., Liu, X , and Wu, H. (1999) PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-triphosphate and Akt/protein kinase B signaling pathway. Proc. Natl. Acad. Sci. USA 96, 6199-6204
8. Stambolic, V., Suzuki, A., de la Pompa, J.-L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P., and Mak, T. W. (1998) Negative regulation of PKB/AKT-dependent cell survival by the tumor suppressor PTEN. Cell 95, 29-39
9. Myers, M. P., Pass, I., Batty, I. H., Van der Kaay, Storalov, J. P., Hemmings, B. A., Wigler, M. H., Downes, P., and Tonks, N. K. (1998) The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc. Natl. Acad. Sci. USA 95, 13513-13518
10. 1 growth arrest in glioma cells. Cancer Res. 58, 5002-5008
11. Maehama, T., and Dixon, J. E. (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-triphosphate. J. Biol. Chem. 273, 13375-13378
12. Gu, J., Tamura, M., and Yamada, K. M. (1998) Tumor suppressor PTEN inhibits integrin-and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J. Cell Biol. 143, 1375-1383
13. Gu, J., Tamura, M., Pankov, R., Danen, E. H. J., Takino, T., Matsumoto, K., and Yamada, K. M. (1999) Shc and FAK differentially regulate cell motility and directionality. J. Cell Biol. 146, 389-403
14. Jiménez, C., Jones, D., R.-Viciana, P., González-G., A., Leonardo, E., Wennerström, S., Von Kobbe, C., Torán, J. L., R.-Borlado, L., Calvo, V., Copín, S., Albar, J. P., Gaspar, M. L., Diez, E., R.-Marcos, M. A., Downward, J., Martínez-A., C., Mérida, I., and Carrera, A. C. (1998) Identification and characterization of a new oncogene derived from the regulatory subunit of PI3K. EMBO J. 17, 743-753
15. +/- mice. Science 285, 2122-2125
16. Chaffin, K. E., Beals, C. R., Wilkie, T. M., Forbush, K. A., Simon, M. J., and Perlmutter, R. M. (1990) Dissection of thymocyte signalling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase. EMBO J. 9, 3821-3829
17. Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachni, S., Bronson, R. T., and Weinberg, R. A. (1994) Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1-7
18. González-García, A., Mérida, I, Martínez-A., C., and Carrera, A. C. (1997) Intermediate affinity interleukin-2 receptor mediates survival via a phosphatidylinositol 3-kinase dependent pathway. J. Biol. Chem. 272, 10220-10226
19. Burlingame, R. W., Rubin, R. L., Balderas, R. S., and Theofilopoulos, A. N. (1993) Genesis and evolution of anti-chromatin autoantibodies in murine lupus implicates T-cell dependent immunisation with self antigens. J. Clin. Invest. 91, 1687-1696
20. Tough, D. F., and Sprent, J. (1994) Turnover of naive and memory-phenotype cells. J. Exp. Med. 179, 1127-1135
21. Sprent, J., and Tough, D. F. (1994) Lymphocyte life span and memory. Science 265, 1395-1399
22. Hamann, D., Baars, P. A., Rep, M. H. G., Hooibrink, B., Kerkhof-Garde, S. R., Klein, M. R., and van Lier, R. A. W. (1997) Phenotypic and functional separation of memory and effector human CD8+ cells. J. Exp. Med. 186, 1407-1418
23. Swain, S. L., Croft, M., Dubey, C., Haynes, L., Rogers, P., Zhang, X., and Bradley, L. M. (1996) From naive to memory T cells. Immunol. Rev. 150, 143-167
24. Abbas, A. K., Murphy, K. M., and Sher, A. (1996) Functional diversity of helper T lymphocytes. Nature (London) 383, 787-793
25. Fadok, V. A., Voelker, D. R., Campbell, P. A. S., Cohen, J. J., Bratton, D. L., Henson, P. M. (1992) Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers the specific recognition and removal by macrophages. J. Immunol. 148, 2207-2216
26. Rodríguez-Viciana, P., Warne, P. H., Khwaja, A., Marte, B. M., Pappin, D., Das, P., Waterfield, M. D., Ridley, A., and Downward, J. (1997) Role of PI3K in cell transformation and control of the actin cytoskeleton by ras. Cell 89, 475-467
27. Podsypanina, K., Ellenson, L. H., Nemes, A., Gu, J., Tamura, M., Yamada, K., Cordon-Cardo, C., Catoretti, G., Fisher, P. E., and Parsons, R. (1999) Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc. Natl. Acad. Sci. USA 96, 1563-1568
28. Suzuki, A., de la Pompa J. L., Stambolic, V., Elia, A. J., Sasaki, T., del Barco Barrantes, I., Ho, A., Wakeham, A., Itie, A., Khoo, W., Fukumoto, M., and Mak, T. M. (1998) High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr. Biol. 8, 1169-1178
29. Remillard, B., Petrillo, R., Maslkinski, W., Tsudo, M., Strom, T. B., Cantley, L. C., and Varticovski, L. (1991) Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase. J. Biol. Chem. 266, 14167-14170
30. Brennan, P., Babbage, J. W., Burgering, M. T. Groner, B., Reif, K., and Cantrell, D. A. (1997) Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity 7, 679-689
31. Klinman, D. M., and Steinberg, A. D. (1995) Inquiry into murine and human lupus. Immunol. Rev. 144, 157-193
32. Nagata, S., and Suda, T. (1995) Fas and Fas ligand: lpr and gld mutations. Immunol. Today 16, 39-42
33. Tivol, E. A., Borrielo, F., Schweitzer, A. N., Lynch, W. P., Bluestone, J. A., and Sharpe, A. H. (1995) Loss of GTLL-4 leads to massive lymphoproliferation and fatal multiorgan destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547
34. Waterhouse, P., Penninger, J. M., Toimms, E., Wakeman, A., Shahinian, A., Lee, K. P., Thompson, G. B., Griesser, H., and Mak, T. W. (1995) Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270, 895-897
35. Keely, P. J., Westwick, J. K., Whitehead, I. P., Der, C. J., and Parise, L. V. (1997) cdc42 and rac-1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature (London) 390, 632-636
36. Di Cristofano, A., Pesce, B., Cordon-Cardo, C., and Pandolfi, P. P. (1998) Pten is essential for embryonic development and tumor suppression. Nat. Genet. 19, 348-355