The coupling of α6β4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation

EMBO Journal

Volumn 16, Issue 9, 1997, Pages 2365-2375

  Mainiero, Fabrizio ^a,b   Murgia, Chiara ^a,c   Wary, Kishore K ^a,c   Curatola, Anna Maria ^a   Pepe, Angela ^a,c   Blumemberg, Miroslav ^a   Westwick, John K ^d   Der, Channing J ^d   Giancotti, Filippo G ^a,c  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Integrins; Keratinocytes; MAP kinase; Ras; Shc

Indexed keywords

INTEGRIN; LAMININ RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGENIC AGENT; RAS PROTEIN; WORTMANNIN; ALPHA6BETA4 INTEGRIN; DNA BINDING PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPITOPE; GRB2 PROTEIN, HUMAN; GRB2 PROTEIN, MOUSE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; LAMININ; MEMBRANE ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; NUCLEAR PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; RAS DEPENDENT MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; RAS-DEPENDENT MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE; SERUM RESPONSE FACTOR; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SRC HOMOLOGY 2 DOMAIN CONTAINING, TRANSFORMING PROTEIN 1; SRC HOMOLOGY 2 DOMAIN-CONTAINING, TRANSFORMING PROTEIN 1; TRANSCRIPTION FACTOR; TUMOR ANTIGEN; TUMOR MARKER; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; KERATINOCYTE; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSCRIPTION INITIATION; ANIMAL; CELL ADHESION; CELL CYCLE; CELL DIVISION; CELL STRAIN 3T3; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; GENETICS; HELA CELL; IMMEDIATE EARLY GENE; METABOLISM; MOUSE; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ANTIGENS, NEOPLASM; ANTIGENS, SURFACE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL ADHESION; CELL CYCLE; CELL DIVISION; DNA-BINDING PROTEINS; ENZYME ACTIVATION; EPITOPES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENES, IMMEDIATE-EARLY; GRB2 ADAPTOR PROTEIN; HELA CELLS; HUMANS; INTEGRIN ALPHA6BETA4; INTEGRINS; KERATINOCYTES; LAMININ; MAP KINASE KINASE KINASES; MICE; NUCLEAR PROTEINS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; SERUM RESPONSE FACTOR; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 0030980345     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.9.2365     Document Type: Article

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