The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells

Cancer Research

Volumn 59, Issue 21, 1999, Pages 5479-5482

  Maier, Daniel ^b   Jones, Graham ^b   Li, Xinwei ^d   Schönthal, Axel H ^d   Gratzl, Otmar ^b   Van Meir, Erwin G ^c   Merlo, Adrian ^a,b  

^a University ORL Clinic   (Switzerland)

^b Depts of Research and Neurosurgery   (Switzerland)

^c EMORY UNIVERSITY   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATASE; TRIPHOSPHOINOSITIDE;

ARTICLE; CANCER INHIBITION; CANCER INVASION; CELL MOTILITY; DEPHOSPHORYLATION; ENZYME PHOSPHORYLATION; GLIOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

BRAIN NEOPLASMS; CELL ADHESION MOLECULES; CELL MOVEMENT; DNA, COMPLEMENTARY; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MUTATION; NEOPLASM INVASIVENESS; PHENOTYPE; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0033229893     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L., Wang, S. I., Zheng, Z., Bose, S., Call, K. H., Tsou, H. C., Peacocke, M., Eng, C., and Parsons, R. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet., 16: 64-67, 1997.
2. Marsh, D. J., Dahia, P. L., Zheng, Z., Liaw, D., Parsons, R., and Eng, C. Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat. Genet., 16: 333-334, 1997.
3. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parsons, R. PTEN, a putative tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (Washington DC), 275: 1943-1947, 1997.
4. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D. H., and Tavtigian, S. V. Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15: 356-362, 1997.
5. Li, D-M., and Sun, H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor β. Cancer Res., 57: 2124-2129, 1997.
6. Di Cristofano, A., Pesce, B., Cordon-Cardo, C., and Pandolfi, P. P. PTEN is essential for embryonic development and tumor suppression. Nat. Genet., 19: 348-355, 1998.
7. Maehama, T., and Dixon, J. E. The tumor suppressor PTEN/MMAC1 dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem., 273: 13375-13378, 1998.
8. Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parson, R., and Tonks, N. PTEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc. Natl. Acad. Sci. USA, 94: 9052-9057, 1997.
9. Haas-Kogan, D., Shalev N., Wong, M., Gordon, M., Garret, J., and Stokoe, D. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC1. Curr. Biol., 8: 11195-11198, 1998.
10. Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., and Greenberg, M. E. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (Washington DC), 275: 661-665, 1997.
11. Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R., and Yamada, K. M. Inhibition of cell migration, spreading and focal adhesions by tumor suppressor PTEN. Science (Washington DC), 280: 1614-1617, 1998.
12. Tamura, M., Jianguo, G., Takino, T., and Yamada, K. M. Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130cas. Cancer Res., 59: 442-449, 1999.
13. 1 growth arrest in glioma cells. Cancer Res., 58: 5002-5008, 1998.
14. Teng, D. H., Hu, R., Lin, H., Davis, T., Iliev, D., Frye, C., Swedlund, B., Hansen, K. L., Vinson, V. L., Gumpper, K. L., Ellis, L., El-Naggar, A., Frazier, M., Jasser, S., Langford, L. A., Lee, J., Mills, G. B., Pershouse, M. A., Pollack, R. E., Tornos, C., Troncoso, P., Yung, W. K., Fujii, G., Berson, A., Bookstein, R., Bolen, J. B., Tavtigian, S. V., and Steck, P. A. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res., 57: 5221-5225, 1997.
15. Maehama, T., and Dixon, J. E. PTEN: a tumor suppressor that functions as a phospholipid phosphatase. Trends Cell Biol., 9: 125-128, 1999.
16. Devaux, B. C., O'Fallon, J. R., and Kelly, P. J. Resection, biopsy, and survival in malignant neoplasm. J. Neurosurg., 78: 767-775, 1993.
17. Lin, H., Bondy, M. L., Langford, L. A., Hess, K. R., Delcolos, G. L., Wu, X., Chan, W., Pershouse, M. A., Yung, W. K. A., and Steck, P. A. Allelic deletions analyses of MMAC1/PTEN and DMBTI loci in gliomas: relationship to prognostic significance. Clin. Cancer Res., 4: 2447-2454, 1998.
18. Maier, D., Zhang, Z., Taylor, E., Hamou, M. F., Gratzl, O., Van Meir, E. G., Scott, R. J., and Merlo, A. Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas. Oncogene, 16: 3331-3335, 1998.
19. ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol., 9: 469-479, 1999.
20. Furnari, F. B., Lin, H., Huang, H. S., and Cavenee, W. K. Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc. Acad. Nat. Sci. USA, 94: 12479-12484, 1997.
21. Baumann, G., Maier, D., Freuler, F., Tschopp, C., Baudisch, K., and Wienands, J. In vitro characterization of major ligands for Src homology 2 domains derived from protein tyrosine kinases, from the adaptor protein SHC and from GTPase-activating protein in Ramos B cells. Eur. J. Immunol., 24: 1799-1807, 1994.
22. Keely, P. J., Westwick, J. K., Whitehead, I. P., Der. C. J., and Parise, L. V. Cdc42 and rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature (Lond.), 390: 632-636, 1997.
23. Flint, A. J., Tiganis, T., Barford, D., and Tonks, N. Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases. Proc, Natl. Acad. Sci. USA, 94: 1680-1685, 1997.
24. Ramaswamy, S., Nakamura, N., Vazquez, F., Batt, D. B., Perera, S., Roberts, T. M., and Sellers, W. R. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc. Natl. Acad. Sci. USA, 96: 2110-2115, 1999.
25. Li, J., Simpson, L., Takahashi, M., Miliaresis, C., Myers, M. P., Tonks, N., and Parsons, R. The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the Akt/Protein kinase B oncogene. Cancer Res., 58: 5667-5672, 1998.
26. Morimoto, A. M., Berson, A. E., Fujii, G. H., Teng, D., Tavtigian, S., Bookstein, R., Steck, P. A., and Bolen, J. B. Phenotypic analysis of human glioma cells expressing the MMACa tumor suppressor phosphatase. Oncogene, 18: 1261-1266, 1999.