New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

Molecular and Cellular Biology

Volumn 20, Issue 19, 2000, Pages 7109-7120

  Gu, H ^a   Maeda, H ^a   Moon, J J ^a   Lord, J D ^a   Yoakim, M ^a   Nelson, B H ^a   Neel, B G ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL PROLIFERATION; CELL SURFACE; CELL SURVIVAL; ENZYME ACTIVATION; GENE ACTIVATION; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITES; CYTOKINES; ENZYME ACTIVATION; INTERLEUKIN-2; INTERLEUKIN-3; LEUKEMIA, PRE-B-CELL; MICE; NEOPLASM PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033826512     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.19.7109-7120.2000     Document Type: Article

References (63)

1. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
2. Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation
3. Revealing mechanisms for SH2 domain-mediated regulation of the protein tyrosine phosphatase SHP-2
4. Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A): Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells
5. SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation: Identification of potential binding sites and substrates
6. Shc associates with the IL3 receptor b subunit, SHIP and Gab2 following IL-3 stimulation: Contribution of Shc PTB and SH2 domains
7. Not all Shc's roads lead to Ras
8. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
9. Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit
10. Purification and characterization of phosphoinositide 3-kinase from rat liver
11. Association of STATs with relatives and friends
12. Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling
13. Interleukin-3 induces association of the protein-tyrosine phosphatase SHP2 and phosphatidylinositol 3-kinase with a 100-kDa tyrosine-phosphorylated protein in hemopoietic cells
14. Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor
15. Ras signaling and apoptosis
16. PI3K: Downstream AKTion blocks apoptosis
17. A new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-phosphatidylinositol 3-kinase in human T lymphocytes
18. A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3
19. Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells
20. Cloning of p97/Gab2, the major SHP-2 binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
21. Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase
22. A Grb2-associated docking protein in EGF- and insulin-receptor signalling
23. Grb2-associated binder-1 mediates phosphstidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor
24. Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase
25. The roles of Jaks and Stats in cytokine signaling
26. Signaling by the cytokine receptor superfamily
27. The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor
28. Definition of the role of tyrosine residues of the common β subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor
29. Granulocyte-macrophage colony-stimulating factor provokes ras activation and transcription of c-fos through different modes of signaling
30. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
31. Secondary mutation maintains the transformed state in BaF3 cells with inducible BCR/ABL expression
32. PH domains: Diverse sequences with a common fold recruit signaling molecules to the cell surface
33. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
34. p150(Ship), a signal transduction molecule with inositol polyphosphate-5-phosphatase activity
35. The IL-2 receptor promotes proliferation, bcl-2 and bcl-x induction, but not cell viability through the adapter molecule
36. The c-Cbl oncoprotein
37. The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase
38. A conserved inositol phospholipid binding site within the Pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis
39. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice
40. Altered thymic positive selection and intracellular signals in Cbl-deficient mice
41. Protein tyrosine phosphatases in signal transduction
42. Association of the multisubstrate docking protein Gabl with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356
43. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors
44. Signaling domains of the βc chain of the GM-CSF/IL-3/IL-5 receptor
45. Signaling functions of the tyrosine residues in the bc chain of the granulocyte-macrophage colony-stimulating factor receptor
46. Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor
47. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains
48. Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling
49. A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
50. Activated ERK2 interacts with and phosphorylates the docking protein GAB1
51. Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: Phosphatidylnositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating factor
52. The MAPK signaling cascade
53. Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway
54. Interleukin 3-dependent survival by the Akt protein kinase
55. Signalling through the lipid products of phosphoinositide-3-OH kinase
56. SH2-dependent association of phosphatidylinositol 3'-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain
57. Uncoupling II-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death
58. Genetic analysis of protein tyrosine phosphatases
59. Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
60. Engagement of Gab1 and Gab2 in erythropoietin signaling
61. Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
62. Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl
63. Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1