Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 7, 2000, Pages 3207-3212

  Persad, Sujata ^a   Attwell, Sarah ^a   Gray, Virginia ^a   Delcommenne, Marc ^a   Troussard, Armelle ^a   Sanghera, Jasbinder ^c   Dedhar, Shoukat ^a,b  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c Kinetek Pharmaceuticals Inc   (Canada)

Author keywords

Cell adhesion; Phospholipid phosphatase; Serum; Tumor suppressor

Indexed keywords

INTEGRIN; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CANCER; WESTERN BLOTTING;

APOPTOSIS; CELL CYCLE; ENZYME ACTIVATION; HUMANS; MALE; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0034724443     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.7.3207     Document Type: Article

References (47)

1. Li, D. M. & Sun, H. (1997) Cancer Res. 57, 2124-2129.
2. Li, J., Yen, C., Liaw, D., Podyspanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C. Rodgers, L., McCombie, R., et al. (1997) Science 275, 1943-1947.
3. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., et al. (1997) Nat. Genet. 15, 356-362.
4. Rasheed, B. K., Stenzel, T. T., McLendon, R. E., Parsons, R., Friedman, A. H., Friedman, H. S., Bigner, D. D. & Bigner, S. H. (1997) Cancer Res. 57, 4187-4190.
5. Liu, W., James, C. D., Frederick, L., Alderete, B. E. & Jenkins, R. B. (1997) Cancer Res. 57, 5254-5257.
6. Guldberg, P., Thor Straten, P., Birck, A., Ahrenkiel, V., Kirkin, A. F. & Zeuthen, J. (1997) Cancer Res. 57, 3660-3663.
7. Cairns, P., Okahami, K., Halachmi, S., Halachmi, N., Esteller, M., Herman, J. G., Jen, J., Isaacs, W. B., Bova, G. S. & Sidransky, D. (1997) Cancer Res. 57, 4997-5000.
8. Teng, D. H., Hu, R., Lin, H., Davis, T., Iliev, D., Frye, C., Swedlund, B., Hansen, K. L., Vinson, V. L., Gumpper, K. L., et al. (1997) Cancer Res. 57, 5221-5225.
9. Tashiro, H., Blazes, M. S., Wu, R., Cho, K. R., Bose, S., Wang, S. I., Li, J., Parsons, R. & Ellenson, L. H. (1997) Cancer Res. 57, 3935-3940.
10. Kohno, T., Takahashi, M., Manda, R. & Yokota, J. (1998) Genes Chromosomes Cancer 22, 152-156.
11. Kong, D., Suzuki, A., Zou, T. T., Sakurada, A., Kemp, L. W., Wakatsuki, S., Yokoyama, T., Yamakawa, H., Furukawa, T., Sato, M., et al. (1997) Nat. Genet. 17, 143-144.
12. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacocke, M., et al. (1997) Nat. Genet. 16, 64-67.
13. Nelen, M. R., van Staveren, W. C., Peeters, E. A., Hassel, M. B., Gorlin, R. J., Hamm, H., Lindboe, C. F., Fryns, J. P., Sijmons, R. H., Woods, D. G., et al. (1997) Hum. Mol. Genet. 6, 1383-1387.
14. Tsou, H. C., Teng, D. H., Ping, X. L., Brancolini, V., Davis, T., Hu, R., Xie, X. X., Gruener, A. C., Schrager, C. A., Christiano, A. M., et al. (1997) Am. J. Hum. Genet. 61, 1036-1043.
15. Marsh, D. J., Roth, S., Lunetta, K. L., Hemminki, A., Dahia, P. L., Sistonen, P., Zheng, Z., Caron, S., van Orsouw, N. J., Bodmer, W. F., et al. (1997) Cancer Res. 57, 5017-5021.
16. Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P. & Mak, T. W. (1998) Cell 95, 29-39.
17. Di Cristofano, A., Pesce, B., Cordon-Cardo, C. & Pandolfi, P. P. (1998) Nat. Genet. 19, 348-355.
18. Chuang, J., Lin, D. C. & Lin, S. (1995) J. Cell Biol. 128, 1095-1109.
19. Maehama, T. & Dixon, J. E. (1998) J. Biol. Chem. 273, 13375-13378.
20. Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R. & Tonks, N. K. (1997) Proc. Natl. Acad. Sci. USA. 94, 9052-9057.
21. Furnari, F. B., Lin, H., Huang, H. S. & Cavanee, W. K. (1997) Proc. Natl. Acad. Sci. USA. 94, 12479-12784.
22. Cheney, I. W., Johnson, D. E., Vaillancourt, M. T., Avanzini, J., Morimoto, A., Demers, G. W., Wills, K. N., Shabram, P. W., Bolen, J. B., Tavtigian, S. V., et al. (1998) Cancer Res. 58, 2331-2334.
23. Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R. & Yamada, K. M. (1998) Science 280, 1624-1627.
24. Haas-Kogan, D., Shelev, N., Wong, M., Mills, G., Yount, G. & Stokoe, D. (1998) Curr. Biol. 8, 1195-1198.
25. Sun, H., Lesche, R., Li, D., Liliental, J., Zhang, H., Gao, J., Gavrilova, N., Mueller, B., Liu, X. & Wu, H. (1999) Proc. Natl. Acad. Sci. USA 96, 6199-6204.
26. Ramaswamy, S., Nakamura, N., Vasquez, F., Batt, D. B., Perera, S., Roberts, T. M. & Sellers, W. R. (1999) Proc. Natl. Acad. Sci. USA 96, 2110-2115.
27. Dalla, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y. & Greenberg, M. E. (1997) Cell 91, 231-241.
28. DelPeso, L., Gonzales-Garcia, M., Page, C., Hemera, R. & Nunez, N. (1997) Science 278, 687-689.
29. Kops, G. J., Ruiter, N. D., DeVries-Smits, A. M., Powell, D. R., Bos, J. L. & Burgering, B. M. (1999) Nature (London) 398, 630-634.
30. Cardone, M. H., Roy, N., Stennicke, H. R., Salvesen, G. S., Franke, T. F., Stanbridge, E., Frisch, S. & Reed, J. C. (1998) Science 282, 1318-1321.
31. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J. & Greenberg, M. E. (1999) Cell 96, 857-868.
32. Cantley, L. C. & Neel, B. G. (1999) Proc. Natl. Acad. Sci. USA 96, 4240-4245.
33. Downward, J. (1998) Curr. Opin. Cell Biol. 10, 262-267.
34. Balendran, A., Casamayor, A., Deak, M., Paterson, A., Gaffney, P., Currie, R., Downes, C. P. & Alessi, D. R. (1999) Curr. Biol. 9, 393-404.
35. Hannigan, G. E., Leung-Hagesteijn, C., Fitz-Gibbon, L., Coppolino, M., Radeva, G., Filmus, J., Bell, J. C. & Dedhar, S. (1996) Nature (London) 379, 91-96.
36. Delcommenne, M., Tan, C., Gray, V., Ruel, L., Woodgett, J. & Dedhar, S. (1998) Proc. Natl. Acad. Sci. USA 95, 11211-11216.
37. Li, F., Zhang, Y. & Wu, C. (1999) J. Cell. Sci. 112, 4589-4599.
38. Tu, Y., Li, F., Goicoechea, S. & Wu, C. (1999) Mol. Cell Biol. 19, 2425-2434.
39. Tu, Y., Li, F. & Wu. C. (1999) Mol. Biol. Cell 9, 3367-3382.
40. Radeva, G., Petrocelli, T., Behrend, E., Leung-Hagesteijn, C., Filmus, J., Slingerland, J. & Dedhar, S. (1997) J. Biol. Chem. 272, 13937-13944.
41. Wu, C. Keightley, S. Y., Leung-Hagesteijn, C.-Y., Radeva, G., Coppolino, M., Goicoechea, S., MacDonald, J. & Dedhar, S. (1998) J. Biol. Chem. 273, 528-538.
42. Novak, A., Hsu, S., Leung-Hagesteijn, C. Y., Radeva, G., PapKoff, J., Montesano, R., Roskelly, C., Grosschedl, R. & Dedhar, S. (1998) Proc. Natl. Acad. Sci. USA 95, 4374-4379.
43. Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P. H. & Download, J. (1997) EMBO J. 16, 2783-2793.
44. King, W. G., Mattaliono, M. B., Chan, T. O., Tsichlis, P. N. & Brugge, J. S. (1997) Mol. Cell Biol. 17, 4406-4418.
45. Thiagarajan, P. & Tait J. F. (1990) J. Biol. Chem. 265, 17420-17423.
46. Gu, J., Tamura, M. & Yamada, K. M. (1998) J. Cell Biol. 143, 1375-1383.
47. Troussard, A. A., Tan, C., Yoganathan, N. & Dedhar, S. (1999) Mol. Cell Biol. 19, 7420-7427.