Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85α regulatory subunit

Molecular and Cellular Biology

Volumn 20, Issue 21, 2000, Pages 8035-8046

  Ueki, K ^a   Algenstaedt, P ^a   Mauvais Jarvis, F ^a   Kahn, C R ^a  

^a JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P50 ALPHA; PROTEIN P55; PROTEIN P55 ALPHA; PROTEIN P85; PROTEIN P85 ALPHA; PROTEIN SUBUNIT; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; GENE EXPRESSION; GLUCOSE TRANSPORT; HUMAN; MYOBLAST; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOVIRIDAE; ALTERNATIVE SPLICING; AMINO ACIDS; ANIMAL; BINDING SITES; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CATALYTIC DOMAIN; CELL LINE; DEOXYGLUCOSE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE TRANSFER TECHNIQUES; GLUCOSE; INSULIN; MODELS, BIOLOGICAL; PHOSPHOTYROSINE; PRECIPITIN TESTS; PROTEIN ISOFORMS; RATS; RECEPTOR, INSULIN; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS;

EID: 0033780412     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.21.8035-8046.2000     Document Type: Article

References (41)

1. Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats
2. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain
3. PI 3-kinase activation is required for insulin stimulation of glucose transport into L6 myotubes
4. Rac GTPase interacts specifically with phosphatidylinositol 3-kinase
5. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation
6. Intracellular localization of phosphatidylinositide 3-kinase and insulin receptor substrate-1 in adipocytes: Potential involvement of a membrane skeleton
7. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
8. Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance
9. Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes
10. Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene
11. Phosphoinositide kinases
12. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha
13. The GTPase dynamin binds to and is activated by a subset of SH3 domains
14. 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells
15. Intermolecular interactions of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase
16. Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase
17. Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2
18. A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK is generated by alternative splicing of the p85alpha gene
19. p85alpha Gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin
20. Banting lecture. Insulin action, diabetogenes, and the cause of type II diabetes
21. Overexpression of catalytic subunit p110alpha of phosphatidylinositol 3-kinase increases glucose transport activity with translocation of glucose transporters in 3T3-L1 adipocytes
22. Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-1) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
23. Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: Comparison with fat cells
24. Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase
25. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome
26. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin
27. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase
28. Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit
29. The structure and function of p55(PIK) reveal a new regulatory, subunit for phosphatidylinosito] 3-kinase
30. Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells
31. Phosphoinositide 3-kinase is required for insulin-induced but not for growth hormone- or hyperosmolarity-induced glucose uptake in 3T3-L1 adipocytes
32. Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action
33. Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle
34. Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
35. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
36. Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis
37. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
38. The insulin signaling system
39. Upstream mechanisms of glycogen synthase activation by insulin and insulin-like growth factor-I. Glycogen synthase activation is antagonized by wortmannin or LY294002 but not by rapamycin or by inhibiting p21ras
40. Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains
41. Regulation of the p85/p110 phosphatidylinositol 3'-kinase: Stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit