-
1
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Washington DC
-
Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittman, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parsons, R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (Washington DC), 275: 1943-1947, 1997.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
Bigner, S.H.11
Giovanella, B.C.12
Ittman, M.13
Tycko, B.14
Hibshoosh, H.15
Wigler, M.H.16
Parsons, R.17
-
2
-
-
0031001041
-
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor B
-
Li, D-M., and Sun, H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor B. Cancer Res., 57: 2124-2129, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 2124-2129
-
-
Li, D.-M.1
Sun, H.2
-
3
-
-
17144436629
-
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K. A., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D. H. F., and Tavtigian, S. V. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15: 356-362, 1997
-
(1997)
Nat. Genet.
, vol.15
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
Yung, W.K.A.4
Lin, H.5
Ligon, A.H.6
Langford, L.A.7
Baumgard, M.L.8
Hattier, T.9
Davis, T.10
Frye, C.11
Hu, R.12
Swedlund, B.13
Teng, D.H.F.14
Tavtigian, S.V.15
-
4
-
-
0002425663
-
Cowden syndrome
-
B. Vogelstein and K. W. Kinzler (eds.). New York: McGraw-Hill
-
Eng, C., and Parsons, R. Cowden syndrome. In: B. Vogelstein and K. W. Kinzler (eds.), The Genetic Basis of Human Cancer, pp. 519-526. New York: McGraw-Hill, 1998.
-
(1998)
The Genetic Basis of Human Cancer
, pp. 519-526
-
-
Eng, C.1
Parsons, R.2
-
5
-
-
0031883606
-
Genetics of Cowden syndrome: Through the looking glass of oncology
-
Eng, C. Genetics of Cowden syndrome: through the looking glass of oncology. Int. J. Oncol., 12: 701-710, 1998.
-
(1998)
Int. J. Oncol.
, vol.12
, pp. 701-710
-
-
Eng, C.1
-
6
-
-
0031004088
-
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
-
Liaw, D., Marsh, D. J., Li, J., Dahia, P. L. M., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacocke, M., Eng, C., and Parsons, R. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet., 16: 64-67, 1997.
-
(1997)
Nat. Genet.
, vol.16
, pp. 64-67
-
-
Liaw, D.1
Marsh, D.J.2
Li, J.3
Dahia, P.L.M.4
Wang, S.I.5
Zheng, Z.6
Bose, S.7
Call, K.M.8
Tsou, H.C.9
Peacocke, M.10
Eng, C.11
Parsons, R.12
-
7
-
-
0031203265
-
Germline mutations in PTEN are present in Bannayan-Zonana syndrome
-
Marsh, D. J., Dahia, P. L. M., Zheng, Z., Liaw, D., Parsons, R., Gorlin, R. J., and Eng, C. Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat. Genet., 16: 333-334, 1997.
-
(1997)
Nat. Genet.
, vol.16
, pp. 333-334
-
-
Marsh, D.J.1
Dahia, P.L.M.2
Zheng, Z.3
Liaw, D.4
Parsons, R.5
Gorlin, R.J.6
Eng, C.7
-
8
-
-
0032475861
-
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
-
Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Rulland, J., Penninger, J. M., Siderovski, D. P., and Mak, T. W. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell, 95: 1-20, 1998.
-
(1998)
Cell
, vol.95
, pp. 1-20
-
-
Stambolic, V.1
Suzuki, A.2
De La Pompa, J.L.3
Brothers, G.M.4
Mirtsos, C.5
Sasaki, T.6
Rulland, J.7
Penninger, J.M.8
Siderovski, D.P.9
Mak, T.W.10
-
9
-
-
0031870959
-
Pten is essential for embryonic development and tumour suppression
-
Di Cristofano, A., Pesce, B., Cordon-Cardo, C., and Pandolfi, P. P. Pten is essential for embryonic development and tumour suppression. Nat. Genet., 19: 348-355, 1998.
-
(1998)
Nat. Genet.
, vol.19
, pp. 348-355
-
-
Di Cristofano, A.1
Pesce, B.2
Cordon-Cardo, C.3
Pandolfi, P.P.4
-
10
-
-
13144249184
-
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
-
Suzuki, A., de la Pompa, J. L., Stambolic, V., Elia, A. J., Sasaki, T., del Barco Barrantes, I., Ho, A., Wakeham, A., Itie, A., Khoo, W., Fukumoto, M., and Mak, T. W. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr. Biol., 8: 1169-1178, 1998.
-
(1998)
Curr. Biol.
, vol.8
, pp. 1169-1178
-
-
Suzuki, A.1
De La Pompa, J.L.2
Stambolic, V.3
Elia, A.J.4
Sasaki, T.5
Del Barco Barrantes, I.6
Ho, A.7
Wakeham, A.8
Itie, A.9
Khoo, W.10
Fukumoto, M.11
Mak, T.W.12
-
11
-
-
13044250465
-
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
-
Podsypanina, K., Ellenson, L. H., Nemes, A., Gu, J., Tamura, M., Yamada, K. M., Cordon-Cardo, C., Catoretti, G., Fisher, P. E., and Parsons, R. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc. Natl. Acad. Sci. USA, 96: 1563-1568, 1999.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 1563-1568
-
-
Podsypanina, K.1
Ellenson, L.H.2
Nemes, A.3
Gu, J.4
Tamura, M.5
Yamada, K.M.6
Cordon-Cardo, C.7
Catoretti, G.8
Fisher, P.E.9
Parsons, R.10
-
12
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger phosphoinositol 3,4,5-triphosphate
-
Maehama, T., and Dixon, J. E. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger phosphoinositol 3,4,5-triphosphate. J. Biol. Chem., 273: 13375-13378, 1998.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
13
-
-
0032486198
-
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
-
Washington DC
-
Tamura, M., Gu, J., Matsumoto, K., Aota, S-i., Parsons, R., and Yamada, K. M. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science (Washington DC), 280: 1614-1617, 1998.
-
(1998)
Science
, vol.280
, pp. 1614-1617
-
-
Tamura, M.1
Gu, J.2
Matsumoto, K.3
Aota, S.-I.4
Parsons, R.5
Yamada, K.M.6
-
14
-
-
0032431028
-
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells
-
Li, D. M., and Sun, H. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. Proc. Natl. Acad. Sci. USA, 95: 15406-15411, 1998.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15406-15411
-
-
Li, D.M.1
Sun, H.2
-
15
-
-
0032534963
-
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene
-
Li, J., Simpson, L., Takahashi, M., Miliaresis, C., Myers, M. P., Tonks, N., and Parsons, R. The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Res., 58: 5667-5672, 1998.
-
(1998)
Cancer Res.
, vol.58
, pp. 5667-5672
-
-
Li, J.1
Simpson, L.2
Takahashi, M.3
Miliaresis, C.4
Myers, M.P.5
Tonks, N.6
Parsons, R.7
-
16
-
-
3643119742
-
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells
-
Furnari, F. B., SuHuang, H-J., and Cavanee, W. K. The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. Cancer Res., 58: 5002-5008, 1998.
-
(1998)
Cancer Res.
, vol.58
, pp. 5002-5008
-
-
Furnari, F.B.1
Suhuang, H.-J.2
Cavanee, W.K.3
-
17
-
-
15644369261
-
Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer
-
Cheney, I. W., Johnson, D. E., Vaillancourt, M-T., Avanzini, J., Morimoto, A., Demers, G. W., Wills, K. N., Shabram, P. W., Bolen, J. B., Tavtigian, S. V., and Bookstein, R. Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer. Cancer Res., 58: 2331-2334, 1998.
-
(1998)
Cancer Res.
, vol.58
, pp. 2331-2334
-
-
Cheney, I.W.1
Johnson, D.E.2
Vaillancourt, M.-T.3
Avanzini, J.4
Morimoto, A.5
Demers, G.W.6
Wills, K.N.7
Shabram, P.W.8
Bolen, J.B.9
Tavtigian, S.V.10
Bookstein, R.11
-
18
-
-
0032506011
-
The lipid phosphatase activity of PTEN is critical for its tumor suppressor function
-
Myers, M. P., Pass, I., Batty, I. H., van der Kaay, J., Storalov, J. P., Hemmings, B. A., Wigler, M. H., Downes, C. P., and Tonks, N. K. The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc. Natl. Acad. Sci. USA, 95: 13513-13518, 1998.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13513-13518
-
-
Myers, M.P.1
Pass, I.2
Batty, I.H.3
Van Der Kaay, J.4
Storalov, J.P.5
Hemmings, B.A.6
Wigler, M.H.7
Downes, C.P.8
Tonks, N.K.9
-
19
-
-
0029200766
-
The role of p53 in cell-cycle control and apoptosis
-
Leonard, C. J., Canman, C. E., and Kastan, M. B. The role of p53 in cell-cycle control and apoptosis. Important Adv. Oncol., 33-42, 1995.
-
(1995)
Important Adv. Oncol.
, pp. 33-42
-
-
Leonard, C.J.1
Canman, C.E.2
Kastan, M.B.3
-
20
-
-
0028844170
-
Apoptosis and the cell cycle
-
Evan, G. I., Brown, L., Whyte, M., and Harrington, E. Apoptosis and the cell cycle. Curr. Opin. Cell Biol., 7: 825-834, 1995.
-
(1995)
Curr. Opin. Cell Biol.
, vol.7
, pp. 825-834
-
-
Evan, G.I.1
Brown, L.2
Whyte, M.3
Harrington, E.4
-
21
-
-
0031265032
-
Current data on the role of the APC protein in the origin of colorectal cancer
-
Phila.
-
Bonneton, C., Larue, L., and Thiery, J. P. Current data on the role of the APC protein in the origin of colorectal cancer. Bull. Cancer (Phila.), 84: 1053-1060, 1997.
-
(1997)
Bull. Cancer
, vol.84
, pp. 1053-1060
-
-
Bonneton, C.1
Larue, L.2
Thiery, J.P.3
-
22
-
-
0029799144
-
Apoptosis and APC in colorectal tumorigenesis
-
Morin, P. J., Vogelstein, B., and Kinzler, K. W. Apoptosis and APC in colorectal tumorigenesis. Proc. Natl. Acad. Sci. USA, 93: 7950-7954, 1996.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 7950-7954
-
-
Morin, P.J.1
Vogelstein, B.2
Kinzler, K.W.3
-
23
-
-
0031974752
-
Allelic imbalance, including deletion of PTEN/MMAC1, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation
-
Marsh, D. J., Dahia, P. L. M., Coulon, V., Zheng, Z., Dorion-Bonnet, F., Call, K. M., Little, R., Lin, A. Y., Eeles, R. A., Goldstein, A. M., Hodgson, S. V., Richardson, A-L., Robinson, B. G., Weber, H. C., Longy, M., and Eng, C. Allelic imbalance, including deletion of PTEN/MMAC1, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation. Genes Chromosomes Cancer, 21: 61-69, 1998.
-
(1998)
Genes Chromosomes Cancer
, vol.21
, pp. 61-69
-
-
Marsh, D.J.1
Dahia, P.L.M.2
Coulon, V.3
Zheng, Z.4
Dorion-Bonnet, F.5
Call, K.M.6
Little, R.7
Lin, A.Y.8
Eeles, R.A.9
Goldstein, A.M.10
Hodgson, S.V.11
Richardson, A.-L.12
Robinson, B.G.13
Weber, H.C.14
Longy, M.15
Eng, C.16
-
24
-
-
0026720075
-
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
-
Gossen, M., and Bujard, H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA, 89: 5547-5551, 1992.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 5547-5551
-
-
Gossen, M.1
Bujard, H.2
-
25
-
-
0032567908
-
Overexpression of the transmembrane tyrosine phosphatase LAR activates the caspase pathway and induces apoptosis
-
Weng, L. P., Yuan, J., and Yu, Q. Overexpression of the transmembrane tyrosine phosphatase LAR activates the caspase pathway and induces apoptosis. Curr. Biol., 8: 247-256, 1998.
-
(1998)
Curr. Biol.
, vol.8
, pp. 247-256
-
-
Weng, L.P.1
Yuan, J.2
Yu, Q.3
-
26
-
-
0032857217
-
Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
-
Perren, A., Weng, L. P., Boag, A. H., Ziebold, U., Thakore, K., Dahia, P. L. M., Komminoth, P., Less, J. A., Mulligan, L. M., Mutter, G. L., and Eng, C. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. Am. J. Pathol., 155: 1253-1260, 1999.
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 1253-1260
-
-
Perren, A.1
Weng, L.P.2
Boag, A.H.3
Ziebold, U.4
Thakore, K.5
Dahia, P.L.M.6
Komminoth, P.7
Less, J.A.8
Mulligan, L.M.9
Mutter, G.L.10
Eng, C.11
-
27
-
-
0032898096
-
PTEN is inversely correlated with the cell survival factor PKB/Akt and is inactivated by diverse mechanisms in haematologic malignancies
-
Dahia, P. L. M., Aguiar, R. C. T., Alberta, J., Kum, J., Caron, S., Sills, H., Marsh, D. J. M., Freedman, A., Ritz, J., Stiles, C., and Eng, C. PTEN is inversely correlated with the cell survival factor PKB/Akt and is inactivated by diverse mechanisms in haematologic malignancies. Hum. Mol. Genet., 8: 185-193, 1999.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 185-193
-
-
Dahia, P.L.M.1
Aguiar, R.C.T.2
Alberta, J.3
Kum, J.4
Caron, S.5
Sills, H.6
Marsh, D.J.M.7
Freedman, A.8
Ritz, J.9
Stiles, C.10
Eng, C.11
-
28
-
-
0028027484
-
Inducible gene expression systems for higher eukaryotic cells
-
Gossen, M., Bonin, A. L., Freundlieb, S., and Bujard, H. Inducible gene expression systems for higher eukaryotic cells. Curr. Opin. Biotechnol., 5: 516-520, 1994.
-
(1994)
Curr. Opin. Biotechnol.
, vol.5
, pp. 516-520
-
-
Gossen, M.1
Bonin, A.L.2
Freundlieb, S.3
Bujard, H.4
-
29
-
-
0029022369
-
Transcriptional activation by tetracyclines in mammalian cells
-
Washington DC
-
Gossen, M., Freundlieb, S., Bender, G., Muller, G., Hillen, W., and Bujard, H. Transcriptional activation by tetracyclines in mammalian cells. Science (Washington DC), 268: 1756-1769, 1995.
-
(1995)
Science
, vol.268
, pp. 1756-1769
-
-
Gossen, M.1
Freundlieb, S.2
Bender, G.3
Muller, G.4
Hillen, W.5
Bujard, H.6
-
30
-
-
6844252284
-
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
-
Marsh, D. J., Coulon, V., Lunetta, K. L., Rocca-Serra, P., Dahia, P. L. M., Zheng, Z., Liaw, D., Caron, S., Duboué, B., Lin, A. Y., Richardson, A-L., Bonnetblanc, J-M., Bressieux, J-M., Cabarrot-Moreau, A., Chompret, A., Demange, L., Eeles, R. A., Yahanda, A. M., Fearon, E. R., Fricker, J-P., Gorlin, R. J., Hodgson, S. V., Huson, S., Lacombe, D., LePrat, F., Odent, S., Toulouse, C., Olopade, O. I., Sobol, H., Tishler, S., Woods, C. G., Robinson, B. G., Weber, H. C., Parsons, R., Peacocke, M., Longy, M., and Eng, C. Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation. Hum. Mol. Genet., 7: 507-515, 1998.
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 507-515
-
-
Marsh, D.J.1
Coulon, V.2
Lunetta, K.L.3
Rocca-Serra, P.4
Dahia, P.L.M.5
Zheng, Z.6
Liaw, D.7
Caron, S.8
Duboué, B.9
Lin, A.Y.10
Richardson, A.-L.11
Bonnetblanc, J.-M.12
Bressieux, J.-M.13
Cabarrot-Moreau, A.14
Chompret, A.15
Demange, L.16
Eeles, R.A.17
Yahanda, A.M.18
Fearon, E.R.19
Fricker, J.-P.20
Gorlin, R.J.21
Hodgson, S.V.22
Huson, S.23
Lacombe, D.24
LePrat, F.25
Odent, S.26
Toulouse, C.27
Olopade, O.I.28
Sobol, H.29
Tishler, S.30
Woods, C.G.31
Robinson, B.G.32
Weber, H.C.33
Parsons, R.34
Peacocke, M.35
Longy, M.36
Eng, C.37
more..
-
32
-
-
0031936353
-
Ras signalling and apoptosis
-
Downward, J. Ras signalling and apoptosis. Curr. Opin. Genet. Dev., 8: 49-54, 1998.
-
(1998)
Curr. Opin. Genet. Dev.
, vol.8
, pp. 49-54
-
-
Downward, J.1
-
33
-
-
0033563157
-
Adenovirus-mediated gene entry of MMAC1/PTEN to glioblastoma inhibits S phase entry by the recruitment of p27Kip2 and cyclin E/CDK2 complexes
-
Cheney, I. W., Neuteboom, S. T. C., Vaillancourt, M-T., Ramachandra, M., and Bookstein, R. Adenovirus-mediated gene entry of MMAC1/PTEN to glioblastoma inhibits S phase entry by the recruitment of p27Kip2 and cyclin E/CDK2 complexes. Cancer Res., 59: 2318-2323, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 2318-2323
-
-
Cheney, I.W.1
Neuteboom, S.T.C.2
Vaillancourt, M.-T.3
Ramachandra, M.4
Bookstein, R.5
-
34
-
-
0032403139
-
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis
-
Davies, M. A., Lu, Y., Sano, T., Fang, X., Tang, P., LaPuschin, R., Koul, D., Bookstein, R., Stokoe, D., Yung, W. K. A., Mills, G. B., and Steck, P. A. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Cancer Res., 58: 5285-5290, 1998.
-
(1998)
Cancer Res.
, vol.58
, pp. 5285-5290
-
-
Davies, M.A.1
Lu, Y.2
Sano, T.3
Fang, X.4
Tang, P.5
LaPuschin, R.6
Koul, D.7
Bookstein, R.8
Stokoe, D.9
Yung, W.K.A.10
Mills, G.B.11
Steck, P.A.12
-
35
-
-
0028912932
-
AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation
-
Data, K., Franke, T. F., Chan, T. O., Makris, A., Yang, S. I., Kaplan, D. R., Morrison, D. K., Golemis, E. A., and Tsichlis, P. AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation. Mol. Cell. Biol., 15: 2304-2310, 1995.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 2304-2310
-
-
Data, K.1
Franke, T.F.2
Chan, T.O.3
Makris, A.4
Yang, S.I.5
Kaplan, D.R.6
Morrison, D.K.7
Golemis, E.A.8
Tsichlis, P.9
-
36
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
Washington DC
-
Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., and Greenburg, M. R. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (Washington DC), 275: 661-665, 1997.
-
(1997)
Science
, vol.275
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
Segal, R.A.7
Kaplan, D.R.8
Greenburg, M.R.9
-
37
-
-
0030904561
-
The PI-3 kinase/Akt signaling pathway delivers an anti-apoptotic signal
-
Kennedy, S. G., Wagner, A. J., Conzen, S. D., Jordan, J., Bellacosa, A., Tsichlis, P., and Hay, N. The PI-3 kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev., 11: 701-713, 1997.
-
(1997)
Genes Dev.
, vol.11
, pp. 701-713
-
-
Kennedy, S.G.1
Wagner, A.J.2
Conzen, S.D.3
Jordan, J.4
Bellacosa, A.5
Tsichlis, P.6
Hay, N.7
-
38
-
-
0031034574
-
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase and Akt
-
Kulik, G., Klippel, A., and Weber, M. J. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase and Akt. Mol. Cell. Biol., 17: 1595-1606, 1997.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1595-1606
-
-
Kulik, G.1
Klippel, A.2
Weber, M.J.3
-
39
-
-
0028963084
-
Requirement for phosphatidylinositol 3-kinase in the prevention of apoptosis by nerve growth factor
-
Washington DC
-
Yao, R., and Cooper, G. M. Requirement for phosphatidylinositol 3-kinase in the prevention of apoptosis by nerve growth factor. Science (Washington DC), 267: 2003-2006, 1995.
-
(1995)
Science
, vol.267
, pp. 2003-2006
-
-
Yao, R.1
Cooper, G.M.2
-
40
-
-
0030728479
-
Growth suppression of glioma cells by PTEN requires a functional catalytic domain
-
Fumari, F. B., Lin, H., Huang, H-J. S., and Cavanee, W. K. Growth suppression of glioma cells by PTEN requires a functional catalytic domain. Proc. Natl. Acad. Sci. USA, 94: 12479-12484, 1997.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 12479-12484
-
-
Fumari, F.B.1
Lin, H.2
Huang, H.-J.S.3
Cavanee, W.K.4
-
41
-
-
0032483009
-
In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma
-
Robertson, G. P., Furnari, F. B., Miele, M. E., Glendening, M. J., Welch, D. R., Fountain, J. W., Lugo, T. G., Huang, H. J., and Cavanee, W. K. In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma. Proc. Natl. Acad. Sci. USA, 95: 9418-9423, 1998.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 9418-9423
-
-
Robertson, G.P.1
Furnari, F.B.2
Miele, M.E.3
Glendening, M.J.4
Welch, D.R.5
Fountain, J.W.6
Lugo, T.G.7
Huang, H.J.8
Cavanee, W.K.9
-
42
-
-
0032911889
-
Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p17(S6K)-independent signaling in growth factor stimulated NIH 3T3 fibroblasts
-
Takuwa, N., Fukui, Y., and Takuwawa, Y. Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p17(S6K)-independent signaling in growth factor stimulated NIH 3T3 fibroblasts. Mol. Cell. Biol., 19: 1346-1358, 1999.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1346-1358
-
-
Takuwa, N.1
Fukui, Y.2
Takuwawa, Y.3
-
43
-
-
0030666921
-
Mitogenic signaling of insulin-like growth factor I in human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase
-
Dufourny, B., Ablas, J., van Teeffelen, H. A., van Schaik, F. M., van den Burg, B., Steenbergh, P. H., and Sussenbach, J. S. Mitogenic signaling of insulin-like growth factor I in human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase. J. Biol. Chem., 272: 31163-31171, 1997.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 31163-31171
-
-
Dufourny, B.1
Ablas, J.2
Van Teeffelen, H.A.3
Van Schaik, F.M.4
Van Den Burg, B.5
Steenbergh, P.H.6
Sussenbach, J.S.7
-
44
-
-
0032571084
-
Phosphatidylinositol 3-kinase inhibitors block aortic smooth muscle cell proliferation in mid-late G1 phase: Effect on cyclin-dependent kinase 2 and the inhibitory protein p27KIP1
-
Bacqueville, D., Casagrande, F., Perret, B., Chap, H., Darbon, J. M., and Breton-Douillon, M. Phosphatidylinositol 3-kinase inhibitors block aortic smooth muscle cell proliferation in mid-late G1 phase: effect on cyclin-dependent kinase 2 and the inhibitory protein p27KIP1. Biochem. Biophys. Res. Commun., 244: 630-636, 1998.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.244
, pp. 630-636
-
-
Bacqueville, D.1
Casagrande, F.2
Perret, B.3
Chap, H.4
Darbon, J.M.5
Breton-Douillon, M.6
-
45
-
-
0030769913
-
Phosphatidylinositol 3 kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation of endothelial cells
-
Kanda, S., Hodgkin, M. N., Woodfield, R. J., Wkelam, M. J., Thomas, G., and Claesson-Welsh, L. Phosphatidylinositol 3 kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation of endothelial cells. J. Biol. Chem., 272: 23347-23353, 1997.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 23347-23353
-
-
Kanda, S.1
Hodgkin, M.N.2
Woodfield, R.J.3
Wkelam, M.J.4
Thomas, G.5
Claesson-Welsh, L.6
-
46
-
-
0027336002
-
p70sk6 function is essential for G1 progression
-
Lond.
-
Lane, H. A., Fernandez, A., Lamb, N. J., and Thomas, G. p70sk6 function is essential for G1 progression. Nature (Lond.), 363: 170-172, 1993.
-
(1993)
Nature
, vol.363
, pp. 170-172
-
-
Lane, H.A.1
Fernandez, A.2
Lamb, N.J.3
Thomas, G.4
-
47
-
-
0030890933
-
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
-
Ahmed, N. N., Grimes, H. L., Bellacosa, A., Chan, T. O., and Tsichlis, P. N. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc. Natl. Acad. Sci. USA, 94: 3627-3632, 1997.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 3627-3632
-
-
Ahmed, N.N.1
Grimes, H.L.2
Bellacosa, A.3
Chan, T.O.4
Tsichlis, P.N.5
-
48
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
-
Brunei, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell, 98: 857-868, 1999.
-
(1999)
Cell
, vol.98
, pp. 857-868
-
-
Brunei, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
49
-
-
0030300180
-
Inhibition of pp125FAK in cultured fibroblasts results in apoptosis
-
Hungerford, J. E., Compton, M. T., Matter, M. L., Hoffstrom, B. G., and Otey, C. A. Inhibition of pp125FAK in cultured fibroblasts results in apoptosis. J. Cell Biol., 135: 1383-1390, 1996.
-
(1996)
J. Cell Biol.
, vol.135
, pp. 1383-1390
-
-
Hungerford, J.E.1
Compton, M.T.2
Matter, M.L.3
Hoffstrom, B.G.4
Otey, C.A.5
-
50
-
-
0031950790
-
BRCA1: A review of structure and putative function
-
Paterson, J. W. BRCA1: a review of structure and putative function. Dis. Markers, 13: 261-274, 1998.
-
(1998)
Dis. Markers
, vol.13
, pp. 261-274
-
-
Paterson, J.W.1
-
51
-
-
0029948779
-
Induction of apoptosis by the tumor suppressor protein BRCA1
-
Shao, N., Chai, Y. L., Shyam, E., Reddy, P., and Rao, V. N. Induction of apoptosis by the tumor suppressor protein BRCA1. Oncogene, 13: 1-7, 1996.
-
(1996)
Oncogene
, vol.13
, pp. 1-7
-
-
Shao, N.1
Chai, Y.L.2
Shyam, E.3
Reddy, P.4
Rao, V.N.5
|