Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

Genes and Development

Volumn 12, Issue 11, 1998, Pages 1610-1620

  Helgason, Cheryl D ^a   Damen, Jacqueline E ^a   Rosten, Patty ^a   Grewal, Rewa ^a   Sorensen, Poul ^b   Chappel, Suzanne M ^a   Borowski, Anita ^b   Jirik, Frank ^b   Krystal, Gerald ^a   Humphries, R Keith ^a,b  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Embryonic stem cells; Hemopoiesis; Knockout; SHIP; Signal transduction

Indexed keywords

PHOSPHATASE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; COLONY FORMING UNIT E; CYTOKINE PRODUCTION; EMBRYO; FLOW CYTOMETRY; GENE DISRUPTION; GENE TARGETING; HEMATOPOIESIS; HOMOZYGOSITY; LIFESPAN; LUNG DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SURVIVAL;

ANIMALIA;

EID: 2642684541     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.11.1610     Document Type: Article

References (31)

1. Cutler, R.L., L. Liu, J.E. Damen, and G. Krystal. 1993. Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells. J. Biol. Chem. 268: 21463-21465.
2. Damen, J.E., L. Liu, R.L. Cutler, and G. Krystal. 1993. Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein. Blood 82: 2296-2303.
3. Damen, J.E., L. Liu, P. Rosten, R.K. Humphries, A.B. Jefferson, P.W. Majerus, and G. Krystal. 1996. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. Proc. Natl. Acad. Sci. 93: 1689-1693.
4. Helgason, C.D., G. Sauvageau, H.J. Lawrence, C. Largman, and R.K. Humphries. 1996. Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cells differentiated in vitro. Blood 87: 2740-2749.
5. Jiao, H., W. Yang, K. Berrada, M. Tabrizi, L. Shultz, and T. Yi. 1997. Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: Detection of potential HCP substrates in GM-CSF signal transduction. Exp. Hematol. 25: 592-600.
6. Johnson, G.R., T.J. Gonda, D. Metcalf, I.K. Harihan, and S. Cory. 1989. A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor. EMBO J. 8: 441-448.
7. Kapeller, R. and L.C. Cantley. 1994. Phosphatidylinositol 3-kinase. Bioessays 16: 565-576.
8. Kavanaugh, W.M., D.A. Pot, S.M. Chin, M. Deuterreinhard, A B. Jefferson, F.A. Norris, F.R. Masiarz, L.S. Cousens, P.W. Majerus, and L.T. Williams. 1996. Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with SHC and GRB2. Curr. Biol. 6: 438-445.
9. Lioubin, M.N., G.M. Myles, K. Carlberg, D. Botwell, and L.R. Rohrschneider. 1994. SHC, GRB2, SOS1 and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells. Mol. Cell. Biol. 14: 5682-5691.
10. SHIP, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. Genes & Dev. 10: 1084-1095.
11. Liu L., J.E. Damen, R.L. Cutler, and G. Krystal. 1994. Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc. Mol. Cell. Biol. 14: 6926-6935.
12. Liu L., J.E. Damen, M.R. Hughes, I. Babic, F.R. Jirik, and G. Krystal. 1997a. The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis. J. Biol. Chem. 272: 8983-8988.
13. Liu, L., J.E. Damen, M.D. Ware, and G. Krystal. 1997b. Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2. J. Biol. Chem. 272: 10998-11001.
14. Liu, L., J.E. Damen, M. Ware, M. Hughes, and G. Krystal. 1997c. SHIP, a new player in cytokine-induced signaling. Leukemia 11: 181-184.
15. Marte, B.M. and I. Downward. 1997. PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biol. Sci. 22: 355-358.
16. Mortensen, R.M., D.A. Conner, S. Chao, A.A.T. Geisterfer-Lowrance, and J.G. Seidman. 1992. Production of homozygous mutant ES cells with a single targeting construct. Mol. Cell Biol. 12: 2391-2395.
17. Nadler, M.J.S., B. Chen, J.S. Anderson, H.H. Wortis, and B.G. Neel. 1997. Protein-tyrosine phosphatase SHP-1 is dispensable for FcγRIIB-mediated inhibition of B cell antigen receptor activation. J. Biol. Chem. 272: 20038-20043.
18. Ono, M., S. Bolland, P. Tempst, and J.V. Ravetch. 1996. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB. Nature 383: 263-966
19. Ono, M., H. Okada, S. Bolland, S. Yanagi, T. Kurosaki, and J.V. Ravetch. 1997. Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. Cell 90: 293-301.
20. Osborne M.A., G. Zenner, M. Lubinus, X. Zhang, Z. Songyang, L.C. Cantley, P. Majerus, P. Burn, and J.P. Kochan. 1996. The inositol 5′-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation. J. Biol. Chem. 271: 29271-29278.
21. Ravichandran, K.S., K.K. Lee, Z. Songyang, L.C. Cantley, P. Burn, and S.J. Burakoff. 1993. Interaction of shc with the zeta chain of the T cell receptor upon T cell activation. Science 262: 902-905.
22. Rebel, V.I., C.L. Miller, G.R. Thornbury, W.H. Dragowska, C.J. Eaves, and P.M. Lansdorp. 1996. A comparison of long-term repopulating hematopoietic cells in fetal liver and adult bone marrow from the mouse. Expt. Hematol. 24: 638-648.
23. Sattler, M., R. Salgia, G. Shrikhande, S. Verma, J.-L. Choi, L.R. Rohrschneider, and J.D. Griffin. 1997. The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors. Oncogene 15: 2379-2384.
24. Saxton, T.M., I. Van Ostveen, D. Botwell, R. Aebersold, and M.R. Gold. 1994. B cell antigen receptor cross-linking induces tyrosine phosphorylation of the p21ras oncoprotein activators SHC and SOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kD tyrosine-phosphorylated protein. J. Immunol. 153: 623-636.
25. Scharenberg, A.M. and J.-P. Kinet. 1996. The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP? Cell 87: 961-964.
26. Shultz, L.D., T.V. Rajan, and D.L. Greiner. 1997. Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency. Trends Biotechnol. 15: 302-307.
27. Tazi, A., F. Bouchonnet, M. Grandsaigne, L. Boumsell, A.J. Hance, and P. Soler. 1993. Evidence that granulocyte macrophage-colony-stimulating factor regulated the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers. J. Clin. Invest. 91: 566-576.
28. 3. J. Biol. Chem. 269: 32358-32367.
29. Tridandapani, S., T. Kelley, D. Cooney, M. Pradhan, and K.M. Coggeshall. 1997. Negative signaling in B cells: SHIP Grbs Shc. Immunol. Today 18: 424-427.
30. Tsui, F.W.L. and H.W. Tsui. 1994. Molecular basis of the moth-eaten phenotype. Immunol. Rev. 138: 185-206.
31. Yi, T.L., J.L. Cleveland, and J.N. Ihle. 1992. Protein tyrosine phosphatase containing SH2 domains: Characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13. Mol. Cell. Biol. 12: 836-846.