Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)K?

Nature

Volumn 406, Issue 6798, 2000, Pages 897-902

  Sasaki, Takehiko ^a   Irie Sasaki, Junko ^a   Horie, Yasuo ^f   Bachmaler, Kurt ^a   Fata, Jimmie E ^b   Li, Martin ^c   Suzuki, Akira ^a   Bouchard, Dennis ^a   Ho, Alexandra ^a   Redston, Mark ^d   Gallinger, Steven ^d   Khokha, Rama ^b   Mak, Tak W ^a   Hawkins, Phillip T ^e   Stephens, Len ^e   Scherer, Stephen W ^c   Tsao, Ming ^a   Penninger, Josef M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d MOUNT SINAI HOSPITAL   (Canada)

^e BABRAHAM INSTITUTE   (United Kingdom)

^f NONE

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON CARCINOGENESIS; COLORECTAL CARCINOMA; ENZYME ANALYSIS; GENE INACTIVATION; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0034710675     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35022585     Document Type: Article

References (24)

1. Toker, A. & Cantley, L. C. Signalling through the lipid products of phosphoinositide-3-OH kmase. Nature 387, 673-676 (1997).
2. Leevers, S. J., Vanhaesebroeck, B. & Waterfield, M. D. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr. Opin. Cell Biol. 11, 219-225 (1999).
3. Cantley, L. C. & Neel, B. G. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl Acad. Sci. USA 96, 4240-4245 (1999).
4. Maehama, T. & Dixon, J. E. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol. 9, 125-128 (1999).
5. Franke, T. F., Kaplan, D. R. & Cantley, L. C. P13K: downstream AKTion blocks apoptosis. Cell 88, 435-437 (1997).
6. Shayesteh, L. et al. PIK3CA is implicated as an oncogene in ovarian cancer. Nature Genet. 21, 99-102 (1999).
7. Di Cristofano, A., Pesce, B., Cordon-Cardo, C. & Pandolfi, P. P. Pten is essential for embryonic development and tumour suppression. Nature Genet. 19, 348-355 (1998).
8. Sasaki, T. et al. Function of P13K-γ in thymocyte development, T cell activation, and neutrophil migration. Science 287, 1040-1046 (2000).
9. Stoyanov, B. et al. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 269, 690-693 (1995).
10. Stephens, L. R. et al. The G βγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 89, 105-114 (1997).
11. Li, Z. et al. Roles of PLC-β2 and-β3 and PI3Kγ in chemoattractant-mediated signal transduction. Science 287, 1046-1049 (2000).
12. Hirsch, E. et al. Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation. Science 287, 1049-1053 (2000).
13. Kinzler, K. W. & Vogehtein, B. Lessons from hereditary colprectal cancer. Cell 87, 159-170 (1996).
14. MacPhee, M. et al. The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia. Cell 81, 957-966 (1995).
15. Bernstein, H. G., Keilhoff, G., Reiser, M., Freese, S. & Wetzker, R. Tissue distribution and subcellular localization of a G-protein activated phosphoinositide 3-kinase. An immunohistochemical study. Cell Mol. Biol. 44, 973-983 (1998).
16. White, R. L. Tumor suppressing pathways. Cell 92, 591-592 (1998).
17. Zhou, S., Kinzler, K. W. & Vogelstein, B. Going mad with Smads. N. Engl. J. Med. 341, 1144-1146 (1999).
18. -/- colon carcinoma. Science 275, 1784-1787 (1997).
19. He, T. C. et al. Identification of c-MYC as a target of the APC pathway. Science 281, 1509-1512 (1998).
20. Tetsu, O. & McCormick, F. β-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 422-426 (1999).
21. Groden, I. et al. Response of colon cancer cell lines to the introduction of APC, a colon-specific tumor suppressor gene. Cancer Res. 55, 1531-1539 (1995).
22. Boutron, M. C., Wilpart, M. & Faivre, J. Diet and colorectal cancer. Eur. J. Cancer Prev. 1, 13-20 (1991).
23. Rudolph, U. et al. Ulcerative colitis and adenocarcinoma of the colon in Gα2-deficient mice. Nature Genet. 10, 143-150 (1995).
24. Fata, J. E., Leco, K. I., Moorenead, R. A., Martin, D. C. & Khokha, R. Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development. Dev. Biol. 211, 238-254 (1999).