The Gβγ/sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

Cell

Volumn 89, Issue 1, 1997, Pages 105-114

  Stephens, L R ^a   Eguinoa, A ^a   Erdjument Bromage, H ^b   Lui, M ^b   Cooke, F ^a   Coadwell, J ^a   Smrcka, A S ^c   Thelen, M ^d   Cadwallader, K ^e   Tempst, P ^b   Hawkins, P T ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF ROCHESTER   (United States)

^d UNIVERSITY OF BERN   (Switzerland)

^e ONYX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; SWINE;

ANIMALIA; INSECTA; MAMMALIA; SUS SCROFA;

EID: 0030887632     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80187-7     Document Type: Article

References (37)

1. Arcaro, A., and Wymann, M.P. (1993). Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidyl 3,4,5 trisphosphate in neutrophil responses. Biochem. J. 296, 297-301.
2. Auger, K.R., Serunian, L.A., Soltoff, S.P., Libby, P., and Cantley, L.C. (1989). PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 57, 167-175.
3. Burgering, B.M.T., and Coffer, P.J. (1995). Protein kinase B and phosphatidylinositol 3-kinase signal transduction. Nature 376, 599-602.
4. Carpenter, C.C., Auger, K.R., Chaudhuri, M., Yoakim, M., Schaffhausen, B., Schoelson, S., and Cantley, L.C. (1993). Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85 kDa subunit. J. Biol. Chem. 268, 9478-9483.
5. Chomczynski, P., and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
6. Chung, J., Grammar, T.C., Lemon, K.P., Kazlanskas, A., and Blenis, J. (1994). PDGF and insulin-dependent pp70 S6K activation mediated by phosphatidylinositol-3-OH kinase. Nature 370, 71-74.
7. Elicone, G., Lui, M., Geromanos, S., Erdjument-Bromage, H., and Tempst, P. (1994). Microbore reversed-phase high performance liquid chromatographic purification of peptides for combined chemical sequencing-laser-desorption mass spectrometric analysis. J. Chromatogr. 676, 121-137.
8. Erdjument-Bromage, H., Lui, M., Sabatini, D.M., Snyder, S.H., and Tempst, P. (1994). High-sensitivity sequencing of large proteins: partial structure of the rapamycin-FKBP 12 target. Protein Sci. 3, 2435-2446.
9. Franke, T., Yang, S., Chan, T.O., Datta, K., Kazlauskas, A., Morrison, D.K., Kaplan, D.R., and Tsichlis, P.N. (1995). The protein kinase encoded by Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727-736.
10. Geromanos, S., Casteels, P., Elicone, C., Powell, M., and Tempst, P. (1994). Combined Edman-chemical and laser-desorption mass spectrometric approaches to micro peptide sequencing: optimization and applications. In Techniques in Protein Chemistry V, J.W. Crabb, ed. (San Diego, CA: Academic Press), pp. 143-150.
11. Hara, K., Yonezawa, K., Sakaue, H., Ando, A., Kotani, K., Kitamwure, T., Kitamura, Y., Ueda, H., Stephens, L., Jackson, T.R., et al. (1994). 1-phosphatidylinositol 3-kinase activity is required for insulin stimulated glucose transport but not for Ras activation on CHO cells. Proc. Natl. Acad. Sci. USA 91, 7415-7419.
12. Hiles, I.D., Otsu, M., Volinia, S., Fry, M.J., Gout, I., Dhand, R., Panayotou, G., Ruiz-Larrea, F., Thompson, A., Totty, N.F., et al. (1992). Phosphatidylinositol 3-kinase: structure and expression of the 110 kDa catalytic subunit. Cell 70, 419-429.
13. Hu, P., Mondino, A., Scholnik, E.Y., and Schlessinger, J. (1993). Cloning of a novel, ubiquitously-expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Mol. Cell. Biol. 13, 7677-7688.
14. Inukai, K., Anai, M., Breda, E.V., Hosaka, T., Katazin, H., Funaki, M., Fukushima, Y., Ogihara, T., Tazaki, Y., Kikuchi, M., et al. (1996). A novel 55 kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55 PIK is generated by alternative splicing of the p85α gene. J. Biol. Chem. 271, 5317-5320.
15. 125I]-iodowortmannin: identification of Gβγ-sensitive isoform as a complex composed of 46 kDa and 100 kDa subunits. Biochem. Biophys. Res. Comm. 216, 655-661.
16. Lee, S.B., and Rhee, S.G. (1995). Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes. Curr. Biol. 7, 193-189.
17. Lui, M., Tempst, P., and Erdjument-Bromage, H. (1996). Methodical analysis of protein-nitrocellulose interactions to design a refined digestion protocol. Anal. Biochem. 241, 156-166.
18. MacDougall, L.K., Damin, J., and Waterfield, M.D. (1995). A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction. Curr. Biol. 5, 1404-1415.
19. Morris, A.J., Rudge, S.A., Mahlum, C.E., and Jenco, J.M. (1995). Regulation of phosphoinositide 3-kinase by G protein βγ subunits in a rat osteosarcoma cell line. Mol. Pharm. 48, 532-539.
20. c-src complexes and PI3K-kinase. Cell 65, 91-104.
21. Pons, S., Asano, T., Glasheen, E., Miralpeix, M., Zhang, Y., Fisher, T. L., Myers, M.G., Sun, X.J., and White, M.F. (1995). The structure and function of p55PIK reveal a new regulatory subunit of phosphatidylinositol 3-kinase. Mol. Cell. Biol. 15, 4453-4465.
22. Ptasznik, A., Prossnitz, E.R., Yoshikawa, D., Smrcka, A., Traynor Kaplan, A.E., and Bokoch, G.M. (1996). A tyrosine kinase signalling pathway accounts for the majority of phosphatidylinositol (3,4,5)Ins phosphate formation in chemoattractant-stimulated human neutrophils. J. Biol. Chem. 271, 25204-25207.
23. Songyang, Z., Shoelson, S.E., Chauduri, M., Gish, G., Pawson, T., Haswer, W.G., et al. (1993). SH2 domains recognize specific phosphopeptide sequences. Cell 72, 767-778.
24. Stephens, L.R., Hughes, K.T., and Irvine, R.F. (1991). Pathway of phosphotidylinositol (3,4,5)-trisphosphate synthesis in activated neutrophils. Nature (Lond.) 351, 33-39.
25. Stephens, L., Eguinoa, A., Corey, S., Jackson, T., and Hawkins, P.T. (1993). Receptor stimulated accumulation of phosphatidylinositol(3,4,5)Ins phosphate by G-protein mediated pathways in human myeloid derived cells. EMBO J. 12, 2265-2273.
26. Stephens, L., Smrcka, A., Cooke, F.T., Jackson, T.J., Sternweis, P., and Hawkins, P.T. (1994). A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits. Cell 77, 83-93.
27. Sternweis, P.C., and Pang, C.H. (1990). Preparation of G-proteins and their subunits. In Receptor Effector Coupling: A Practical Approach, E.G. Hulme, ed. (New York: Oxford University Press), pp.1-30.
28. Stoyanov, B., Volinia, S., Hanck, T., Rubio, I., Loubtechenkov, M., Malek, D., Stoyanova, S., Vanhaesenbroeck, B., Dhand, R., Nurnberg, B., et al. (1995). Cloning and characterisation of a G-protein activated human phosphoinositide 3-kinase. Science 269, 690-693.
29. Tempst, P., Link, A.J., Riviere, L.R., Fleming, M., and Elicone, C. (1990). Internal sequence analysis of proteins separated on polyacrylamide gels at the sub-microgram level: improved methods, applications and gene cloning strategies. Electrophoresis 11, 537-553.
30. Tempst, P., Geromanos, S., Elicone, C., and Erdjument-Bromage, H. (1994). Improvements in microsequencer performance for low picomole sequence analysis. Meth. Companion Meth. Enzymol. 6, 284-261.
31. Thelen, M., Wymann, M.P., and Langen, H. (1994). Wortmannin binds specifically to L-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein coupled signalling in neutrophil leukocytes. Proc. Natl. Acad. Sci. USA 91, 4960-4964.
32. Thomason, P.A., James, S.R., Casey, P.J., and Downes, C.P. (1994). AG protein βγ subunit-responsive phosphoinositide-3-kinase activity in human platelet cytosol. J. Biol. Chem. 269, 16525-16528.
33. Traynor-Kaplan, A.E., Harris, A., Thompson, B., Taylor, P., and Sklar, L.A. (1988). An inositol tetrakisphosphate-containing phospholipid in activated neutrophils. Nature (Lond.) 334, 353-356.
34. Wennström, S., Hawkins, P.T., Cooke, F., Hara, K., Yonezawa, K., Kasuga, M., Jackson, T., Claesson-Welsh, L., and Stephens, L. (1994). Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr. Biol. 4, 385-393.
35. Whitman, M., Downes, C.P. Keeler, M., Keller, T. and Cantley, L.C. (1988). Type I phosphatidylinositol kinase makes a no.vel inositol phospholipid, phohphatidylinositol-3-phosphate. Nature 332, 644-646.
36. Yano, H., Nakanashi, S., Kimura, K., Hani, N., Saitoh, Y., Fumkui, Y., Nonomura, Y., and Matsuda, Y. (1993). Inhibition of histamine secretion by wortmannin through the blockage of phosphatidylinositol 3-kinase in RBL-2H3 cells. J. Biol. Chem. 268, 25846-25856.
37. Zvelebil M.J., MacDougall, L., Leevers, S., Volinia, S., Vanhaesebroeck, B., Gout, I., Panayotou, G., Damin, J., Stein, R., Pages, F., et al. (1996). Structural and functional diversity of PI3Ks. Phil. Trans. R. Soc. (Lond.) B 351, 217-223.