Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 tax through NF-κB in apoptosis-resistant T-cell transfectants with Tax

Journal of Virology

Volumn 73, Issue 10, 1999, Pages 7981-7987

  Tsukahara, Tomonori ^a   Kannagi, Mari ^a,b   Ohashi, Takashi ^a   Kato, Hirotomo ^a   Arai, Masaaki ^a   Nunez, Gabriel ^c   Iwanaga, Youichi ^a   Yamamoto, Naoki ^a   Ohtani, Kiyoshi ^a   Nakamura, Masataka ^a   Fujii, Masahiro ^d  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d NIIGATA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; TAX PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; CELL GROWTH; CELL IMMORTALIZATION; GENE DELETION; GENETIC TRANSFECTION; HUMAN T CELL LEUKEMIA VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; TRANSACTIVATION;

EID: 0032827012     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.10.7981-7987.1999     Document Type: Article

References (57)

1. Akagi, T., H. Ono, and K. Shimotohno. 1995. Characterization of T cells immortalized by Tax1 of human T-cell leukemia virus type 1. Blood 86:4243-4249.
2. Akiyama, Y. 12 May 1998, posting date. TFSEARCH. [Online.] http: //pdap1.trc.rwcp.or.jp/research/db/TFSEARCH.html. [1 February 1999, last date accessed.]
3. Arai, M., M. Kannagi, M. Matsuoka, T. Sato, N. Yamamoto, and M. Fujii. 1998. Expression of FAP-1 (Fas-associated phosphatase) and resistance to Fas-mediated apoptosis in T cell lines derived from human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients. AIDS Res. Hum. Retroviruses 14:261-267.
4. L improves the viability of CTLL-2 cells without affecting their IL-2 proliferative response. Implications for the development of bioassays. J. Immunol. Methods 191:143-148.
5. L. Immunity 3:87-98.
6. Brauweiler, A., J. E. Garrus, J. C. Reed, and J. K. Nyborg. 1997. Repression of bax gene expression by the HTLV-1 Tax protein: implications for suppression of apoptosis in virally infected cells. Virology 231:135-140.
7. Chen, I. S., A. J. Cann, N. P. Shah, and R. B. Gaynor. 1985. Functional relation between HTLV-II x and adenovirus E1A proteins in transcriptional activation. Science 230:570-573.
8. Chlicchlia, K., G. Moldenhauer, P. T. Daniel, M. Busslinger, L. Gazzolo, V. Schirrmacher, and K. Khazaie. 1995. Immediate effects of reversible HTLV-1 tax function: T-cell activation and apoptosis. Oncogene 10:269-277.
9. Chu, Z. L., J. A. DiDonato, J. Hawiger, and D. W. Ballard. 1998. The Tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IκB kinases containing IKKα and IKKβ. J. Biol. Chem. 273:15891-15894.
10. Copeland, K. F., A. G. Haaksma, J. Goudsmit, P. H. Krammer, and J. L. Heeney. 1994. Inhibition of apoptosis in T cells expressing human T cell leukemia virus type I Tax. AIDS Res. Hum. Retroviruses 10:1259-1268.
11. Cory, S. 1995. Regulation of lymphocyte survival by the bcl-2 gene family. Annu. Rev. Immunol. 13:513-543.
12. Deng, G., and E. R. Podack. 1993. Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2. Proc. Natl. Acad. Sci. USA 90:2189-2193.
13. short is elevated following severe global ischemia in rat brains. Brain Res. 776:222-229.
14. Felber, B. K., H. Paskalis, C. Kleinman-Ewing, F. Wong-Staal, and G. N. Pavlakis. 1985. The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats. Science 229:675-679.
15. Fujii, M., T. Niki, T. Mori, T. Matsuda, M. Matsui, N. Nomura, and M. Seiki. 1991. HTLV-1 Tax induces expression of various immediate early serum responsive genes. Oncogene 6:1023-1029.
16. Fujisawa, J., M. Seiki, T. Kiyokawa, and M. Yoshida. 1985. Functional activation of the long terminal repeat of human T-cell leukemia virus type I by a trans-acting factor. Proc. Natl. Acad. Sci. USA 82:2277-2281.
17. Fujisawa, J., M. Toita, T. Yoshimura, and M. Yoshida. 1991. The indirect association of human T-cell leukemia virus tax protein with DNA results in transcriptional activation. J. Virol. 65:4525-4528.
18. Geleziunas, R., S. Ferrell, X. Lin, Y. Mu, E. T. Cunningham, Jr., M. Grant, M. A. Connelly, J. E. Hambor, K. B. Marcu, and W. C. Greene. 1998. Human T-cell leukemia virus type 1 Tax induction of NF-κB involves activation of the IκB kinase alpha (IKKα) and IKKβ cellular kinases. Mol. Cell. Biol. 18:5157-65.
19. Gillis, S., and K. A. Smith. 1977. Long term culture of tumour-specific cytotoxic T cells. Nature 268:154-156. (Letter.)
20. Grillot, D. A., M. Gonzalez-Garcia, D. Ekhterae, L. Duan, N. Inohara, S. Ohta, M. F. Seldin, and G. Nunez. 1997. Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene. J. Immunol. 158:4750-4757.
21. Grossman, W. J., J. T. Kimata, F. H. Wong, M. Zutter, T. J. Ley, and L. Ratner. 1995. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA 92:1057-1061.
22. Gunning, P., J. Leavitt, G. Muscat, S. Y. Ng, and L. Kedes. 1987. A human β-actin expression vector system directs high-level accumulation of antisense transcripts. Proc. Natl. Acad. Sci. USA 84:4831-4835.
23. Hinuma, Y., K. Nagata, M. Hanaoka, M. Nakai, T. Matsumoto, K. I. Kinoshita, S. Shirakawa, and I. Miyoshi. 1981. Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc. Natl. Acad. Sci. USA 78:6476-6480.
24. Iwanaga, Y., T. Tsukahara, T. Ohashi, Y. Tanaka, M. Arai, M. Nakamura, K. Ohtani, Y. Koya, M. Kannagi, N. Yamamoto, and M. Fujii. 1999. Human T-cell leukemia virus type 1 Tax protein abrogates interleukin-2 dependence in a mouse T-cell line. J. Virol. 73:1271-1277.
25. Kiefer, M. C., M. J. Brauer, V. C. Powers, J. J. Wu, S. R. Umansky, L. D. Tomei, and P. J. Barr. 1995. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature 374:736-739.
26. Kishi, S., S. Saijyo, M. Arai, S. Karasawa, S. Ueda, M. Kannagi, Y. Iwakura, M. Fujii, and S. Yonehara. 1997. Resistance to fas-mediated apoptosis of peripheral T cells in human T lymphocyte virus type I (HTLV-1) transgenic mice with autoimmune arthropathy. J. Exp. Med. 186:57-64.
27. Matsumoto, K., K. Akashi, H. Shibata, M. Yutsudo, and A. Hakura. 1994. Single amino acid substitution (58Pro→Ser) in HTLV-1 tax results in loss of ras cooperative focus formation in rat embryo fibroblasts. Virology 200:813-815.
28. Matsumoto, K., H. Shibata, J. I. Fujisawa, H. Inoue, A. Hakura, T. Tsukahara, and M. Fujii. 1997. Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways. J. Virol. 71:4445-4451.
29. tax-1 with cellular oncoproteins in the induction of hematopoietic cell proliferation. Oncogene 12:2403-2408.
30. Nerenberg, M., S. H. Hinrichs, R. K. Reynolds, G. Khoury, and G. Jay. 1987. The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science 237:1324-1329.
31. Neuveut, C., K. G. Low, F. Maldarelli, I. Schmitt, F. Majone, R. Grassmann, and K. T. Jeang. 1998. Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. Mol. Cell. Biol. 18:3620-3632.
32. Nicot, C., T. Astier-Gin, and B. Guillemain. 1997. Activation of Bcl-2 expression in human endothelial cells chronically expressing the human T-cell lymphotropic virus type I. Virology 236:47-53.
33. Noel, P. J., L. H. Boise, J. M. Green, and C. B. Thompson. 1996. CD28 costimulation prevents cell death during primary T cell activation. J. Immunol. 157:636-642.
34. Petropoulos, C. J., I. Givol, and S. H. Hughes. 1996. Comparative analysis of the structure and function of the chicken c-myc and v-myc genes: v-myc is a more potent inducer of cell proliferation and apoptosis than c-myc. Oncogene 12:2611-2621.
35. Poiesz, B. J., F. W. Ruscetti, A. F. Gazdar, P. A. Bunn, J. D. Minna, and R. C. Gallo. 1980. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. USA 77:7415-7419.
36. Reed, J. C., H. Zha, C. Alme-Sempe, S. Takayama, and H. G. Wang. 1996. Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death. Adv. Exp. Med. Biol. 406:99-112.
37. Rosenblatt, J. D., S. Miles, J. C. Gasson, and D. Prager. 1995. Transactivation of cellular genes by human retroviruses. Curr. Top. Microbiol. Immunol. 193:25-49.
38. Rosenthal, N. 1987. Identification of regulatory elements of cloned genes with functional assays. Methods Enzymol. 152:704-720.
39. Schneider, U., H. U. Schwenk, and G. Bornkamm. 1977. Characterization of EBV-genome negative "null" and "T" cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma. Int. J. Cancer 19:521-526.
40. Seiki, M., J. Inoue, T. Takeda, A. Hikikoshi, M. Sato, and M. Yoshida. 1985. The p40x of human T-cell leukemia virus type I is a trans-acting activator of viral gene transcription. Jpn. J. Cancer Res. 76:1127-1131.
41. Smith, M. R., and W. C. Greene. 1990. Identification of HTLV-1 tax trans-activator mutants exhibiting novel transcriptional phenotypes. Genes Dev. 4:1875-1885. (Errata, 5:150, 1991; 9:2324, 1995.)
42. Sodroski, J. G., C. A. Rosen, and W. A. Haseltine. 1984. Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells. Science 225:381-385.
43. Sun, S. C., J. Elwood, C. Beraud, and W. C. Greene. 1994. Human T-cell leukemia virus type I Tax activation of NF-κ B/Rel involves phosphorylation and degradation of Iκ Bα and RelA (p65)-mediated induction of the c-rel gene. Mol. Cell. Biol. 14:7377-7384.
44. Suzuki, T., J. I. Fujisawa, M. Toita, and M. Yoshida. 1993. The trans-activator tax of human T-cell leukemia virus type 1 (HTLV-1) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-1. Proc. Natl. Acad. Sci. USA 90:610-614.
45. Suzuki, T., H. Hirai, J. Fujisawa, T. Fujita, and M. Yoshida. 1993. A trans-activator Tax of human T-cell leukemia virus type 1 binds to NF-κ B p50 and serum response factor (SRF) and associates with enhancer DNAs of the NF-κ B site and CArG box. Oncogene 8:2391-2397.
46. INK4A and counteracts its inhibitory activity towards CDK4. EMBO J. 15:1607-1614.
47. Tanaka, A., C. Takahashi, S. Yamaoka, T. Nosaka, M. Maki, and M. Hatanaka. 1990. Oncogenic transformation by the tax gene of human T-cell leukemia virus type 1 in vitro. Proc. Natl. Acad. Sci. USA 87:1071-1075.
48. Uhlik, M., L. Good, G. Xiao, E. W. Harhaj, E. Zandi, M. Karin, and S. C. Sun. 1998. NF-κB-inducing kinase and IκB kinase participate in human T-cell leukemia virus I Tax-mediated NF-κB activation. J. Biol. Chem. 273: 21132-21136.
49. Van Antwerp, D. J., S. J. Martin, T. Kafri, D. R. Green, and I. M. Verma. 1996. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274:787-789.
50. Wang, C. Y., M. W. Mayo, and A. S. Baldwin, Jr. 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274:784-787.
51. Wang, C. Y., M. W. Mayo, R. G. Korneluk, D. V. Goeddel, and A. S. Baldwin, Jr. 1998. NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-1AP2 to suppress caspase-8 activation. Science 281:1680-1683.
52. Wu, M., H. Lee, R. E. Bellas, S. L. Schauer, M. Arsura, D. Katz, M. J. FitzGerald, T. L. Rothslein, D. H. Sherr, and G. E. Sonenshein. 1996. Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO J. 15:4682-4690.
53. Wu, M. X., Z. Ao, K. V. Prasad, R. Wu, and S. F. Schlossman. 1998. IEX-1L, an apoptosis inhibitor involved in NF-κB-mediated cell survival. Science 281:998-1001.
54. Yamada, T., S. Yamaoka, T. Goto, M. Nakai, Y. Tsujimoto, and M. Hatanaka. 1994. The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein. J. Virol. 68:3374-3379.
55. Yin, M. J., L. B. Christerson, Y. Yamamoto, Y. T. Kwak, S. Xu, F. Mercurio, M. Barbosa, M. H. Cobb, and R. B. Gaynor. 1998. HTLV-I Tax protein binds to MEKK1 to stimulate IκB kinase activity and NF-κB activation. Cell 93:875-884.
56. Yoshida, M., T. Suzuki, J. Fujisawa, and H. Hirai. 1995. HTLV-1 oncoprotein tax and cellular transcription factors. Curr. Top. Microbiol. Immunol. 193:79-89.
57. Zhao, L. J., and C. Z. Giam. 1992. Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction. Proc. Natl. Acad. Sci. USA 89:7070-7074.