Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation

Science

Volumn 287, Issue 5455, 2000, Pages 1049-1052

  Hirsch, Emilio ^a   Katanaev, Vladimir L ^a   Garlanda, Cecilia ^a   Azzolino, Ornella ^a   Pirola, Luciano ^a   Silengo, Lorenzo ^a   Sozzani, Silvano ^a   Mantovani, Alberto ^a   Altruda, Fiorella ^a   Wymann, Matthias P ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; FORMYLMETHIONYLLEUCYLPHENYLALANINE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE B; RANTES; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THIOGLYCOLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL PERITONITIS; CELL MIGRATION; CELL MOTILITY; CHEMOTAXIS; CONTROLLED STUDY; INFLAMMATORY DISEASE; LEUKOCYTE FUNCTION; MOUSE; NEUTROPHIL; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RESPIRATORY BURST; STAPHYLOCOCCUS AUREUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CHEMOTACTIC FACTORS; CHEMOTAXIS; CHEMOTAXIS, LEUKOCYTE; ENZYME ACTIVATION; GENE TARGETING; HETEROTRIMERIC GTP-BINDING PROTEINS; ISOENZYMES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; PERITONITIS; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RESPIRATORY BURST; SIGNAL TRANSDUCTION;

ANIMALIA; BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

EID: 0034635452     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.287.5455.1049     Document Type: Article

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33. We thank L. Barberis, M. F. Brizzi, G. Bulgarelli-Leva, G. Frascaroli, W. Luini, G. Montrucchio, M. Laffargue, and R. Calvez for their support and assistance. We also thank G. Tarone, P. Defilippi, L. Fumagalli, and G. Topley for critically reading the manuscript; B. Vanhaesebroeck, R. Wetzker, A. Klippel, and B. Hemmings for antibodies; C. Dahinden for C5a; and B. Moser for chemokines. Supported by the Progetto Finalizzato Biotecnologie, CNR (project biotechnology), Associazione Italiana per la Ricerca sul Cancro (AIRC), San Salvatore Foundation, Telethon grant E 635, and Swiss National Science Foundation grant 31-50506.97.